The occurrence of dental caries is associated with atherosclerosis

OBJECTIVE: Previous studies have suggested that marginal periodontitis is a risk factor for developing atherosclerosis. The objective of this study was to determine whether caries may also be associated with atherosclerosis. METHODS: The computed tomography data sets of 292 consecutive patients, 137 women and 155 men with a mean age of 54.1±17.3 years, were analyzed. Caries were quantified based on the number of decayed surfaces of all the teeth, and periodontitis was quantified on the basis of the horizontal bone loss in the jaw. The presence of chronic apical periodontitis (CAP) was assessed, and the aortic atherosclerotic burden was quantified using a calcium scoring method. RESULTS: The patients wit

Orthodontic Treatment Need of Austrian Schoolchildren in the Mixed Dentition Stage

Malocclusal traits can impair dental health and aesthetical appearance. The index of orthodontic treatment need (IOTN) identifies the patients who benefit the most from orthodontic treatment. The aim of this study was to assess the malocclusion frequencies and the orthodontic treatment need among Austrian children in the mixed dentition stage, since there is no pre-existing data from Austria. In the present study, 157 children aged between 8 and 10 years were examined. Following an anamnesis questionnaire, which included a question about the parents' perceived treatment need, the children were examined clinically and dental impressions were taken. The sagittal molar relationship, overjet, overbite and the presence of cross- or scissor bite were registered. The treatment need was assessed using the dental health component (DHC) of the index of orthodontic treatment need (IOTN). 64.3% (95% CI [56.8, 71.8]) of the children showed Angle class I molar relation, 33.1% (95% CI [25.8, 40.5]) class II and 2.5% (95% CI [0.1, 5.0]) Angle class III relation. Crossbite was found in 36.3% (95% CI [28.8, 43.8]) of the participants. A treatment need for medical reasons (IOTN 4 or 5) was found in 30.6% (95% CI [23.4, 37.8]). There was no statistically significant relationship between objective treatment need and the parents' perception. The malocclusion frequencies and the treatment need assessed in the present study appeared to be comparable to those assessed in other countries. The data supports the opinion that orthodontic screening is important and necessary at this stage of dental development, also due to the discordance between objective and perceived treatment need

Nrf2 in the Field of Dentistry with Special Attention to NLRP3

The aim of this review article was to summarize the functional implications of the nuclear factor E2-related factor or nuclear factor (erythroid-derived 2)-like 2 (Nrf2), with special attention to the NACHT (nucleotide-binding oligomerization), LRR (leucine-rich repeat), and PYD (pyrin domain) domains-containing protein 3 (NLRP3) inflammasome in the field of dentistry. NLRP3 plays a crucial role in the progression of inflammatory and adaptive immune responses throughout the body. It is already known that this inflammasome is a key regulator of several systemic diseases. The initiation and activation of NLRP3 starts with the oral microbiome and its association with the pathogenesis and progression of several oral diseases, including periodontitis, periapical periodontitis, and oral squamous cell carcinoma (OSCC). The possible role of the inflammasome in oral disease conditions may involve the aberrant regulation of various response mechanisms, not only in the mouth but in the whole body. Understanding the cellular and molecular biology of the NLRP3 inflammasome and its relationship to Nrf2 is necessary for the rationale when suggesting it as a potential therapeutic target for treatment and prevention of oral inflammatory and immunological disorders. In this review, we highlighted the current knowledge about NLRP3, its likely role in the pathogenesis of various inflammatory oral processes, and its crosstalk with Nrf2, which might offer future possibilities for disease prevention and targeted therapy in the field of dentistry and oral health

Curve of Spee and Second Mandibular Premolar Agenesis—Present Knowledge and Future Perspectives

Background: We investigated the relationship between the mandibular Curve of Spee (COS) and a persisting primary second mandibular molar (ppM2) due to an agenesis of the second mandibular premolar, using a digital software technique. Methods: Digital dental casts were obtained from 200 patients at the Department of Orthodontics in Innsbruck and Vienna, Austria. Patients (age-, gender-, and malocclusion-matched) were equally divided into two groups (n = 100) according to the existence of a ppM2. COS depth, overjet, overbite, and angle-classification were measured digitally using the OnyxCeph3TM (version 3.2.147) software. ANOVA and Kruskal–Wallis tests were used to analyze relationships. For statistical analyses, p p < 0.01 as highly significant. Results were visualized with box plots and bar charts. Results: The deepest COS was present in patients with a ppM2. Furthermore, a positive correlation was shown between COS depth and angle-class II, between COS depth and age, as well as between COS depth and overbite. No gender differences could be observed. Conclusions: In our study population the COS depth was dependent on whether there is a ppM2 due to an agenesis of a second mandibular premolar or not, as well as on the malocclusion in sagittal direction

The occurrence of dental caries is associated with atherosclerosis

OBJECTIVE: Previous studies have suggested that marginal periodontitis is a risk factor for developing atherosclerosis. The objective of this study was to determine whether caries may also be associated with atherosclerosis. METHODS: The computed tomography data sets of 292 consecutive patients, 137 women and 155 men with a mean age of 54.1±17.3 years, were analyzed. Caries were quantified based on the number of decayed surfaces of all the teeth, and periodontitis was quantified on the basis of the horizontal bone loss in the jaw. The presence of chronic apical periodontitis (CAP) was assessed, and the aortic atherosclerotic burden was quantified using a calcium scoring method. RESULTS: The patients with <1 caries surfaces/tooth had a lower atherosclerotic burden (0.13±0.61 mL) than patients with ≥1 caries surfaces/tooth. The atherosclerotic burden was greater in patients with a higher number of lesions with pulpal involvement and more teeth with chronic apical periodontitis. In the logistical regression models, age (Wald 49.3), number of caries per tooth (Wald 26.4), periodontitis (Wald 8.6), and male gender (Wald 11) were found to be independent risk factors for atherosclerosis. In the linear regression analyses, age and the number of decayed surfaces per tooth were identified as influencing factors associated with a higher atherosclerotic burden, and the number of restorations per tooth was associated with a lower atherosclerotic burden. CONCLUSION: Dental caries, pulpal caries, and chronic apical periodontitis are associated positively, while restorations are associated inversely, with aortic atherosclerotic burden. Prospective studies are required to confirm these observations and answer the question of possible causality