Electrons on a spherical surface: Physical properties and hollow spherical clusters

We discuss thephysical properties of a non interacting electron gas constrained to a spherical surface. In particular we consider its chemical potentials, its ionization potential,and its electric static polarizability. All these properties are discussed analytically as functions of the number N of electrons. The trends obtained with increasing N are compared with those of the corresponding properties experimentally measured or theoretically evaluated for quasi spherical hollow atomic and molecular clusters. Most of the properties investigated display similar trends, characterized by a prominence of shell effects. This leads to the de\ufb01nition of a scale-invariant distribution of magic numbers which follows a power law with critical exponent 120.5. We conclude that our completely mechanistic and analytically tractable model can be useful for the analysis of self-assembling complex systems

Revision of the Student Adaptation to College Questionnaire (SACQ) for Use with Italian Students

Background: This multistudy report was aimed at examining the psychometric properties in the Italian context of the Student Adaptation College Questionnaire (SACQ) that represents the most important self-report measure for assessing how students adjust to university. Methods: Three studies were conducted in order to revise and improve the instrument for being more efficient in measuring adjustment to university. Results: The final result was the SACQ-SF consisting in 12 item assessing three dimensions: a) student’s perception of one’s study skills (Studying); b) student’s sense of satisfaction with courses and programs (Satisfaction with curriculum); c) student’s evaluation of the degree to which he has social skills and is making new friends (Social adjustment). Conclusions: Convergent and construct validity may be considered also adequate. In sum, the SACQSF can be considered a promising valuable and efficient instrument in measuring adjustment to university in the Italian context, and probably in the European one too. Further, as a brief instrument, it can be easily administered and used as a quick screening tool

Adolescents' Ethnic Hate Speech Exposure and Ethnic Bullying Perpetration: The Moderating Role of Tolerance Towards Diversity and Gender

Information and Communication Technologies have become powerful tools for adolescents, but they have enabled a huge number of online risks, such as being exposed to Online Hate Speech (OHS). High exposure to hateful content has been linked to despicable offline actions, including hate crimes. However, there is a lack of studies considering the associations with certain specific forms, such as the perpetration of bullying. The purpose of this study was to fill this gap in the literature by analysing the associations between exposure to OHS targeting ethnic minorities and ethnic bullying perpetration, and considering the potential moderating role of tolerance towards diversity and of gender. Participants were 960 high school students (53.6% females; Mage = 15 years, SD = 0.59). Data were collected in January/February 2020, before the first lockdown due to the Covid-19 pandemic. Findings suggest that being exposed to ethnic OHS is significantly, but weakly, associated with traditional ethnic bullying perpetration. Moreover, this association is moderated by tolerance towards diversity and by gender. In particular, for male adolescents, at low and middle levels of tolerance, higher ethnic OHS exposure is not associated with a higher tendency to perpetrate bullying toward peers with a different ethnicity. For females, instead, tolerance is not a moderator in the relationship between ethnic OHS exposure and ethnic bullying perpetration. Results are discussed in terms of their practical implications

High-order harmonic generation in fullerenes using few-and multi-cycle pulses of different wavelengths

We present the results of experimental and theoretical studies of high-order harmonic generation (HHG) in plasmas containing fullerenes using pulses of different duration and wavelength. We find that the harmonic cutoff is extended in the case of few-cycle pulses (3.5 fs, 29th harmonic) compared to longer laser pulses (40 fs, 25th harmonic) at the same intensity. Our studies also include HHG in fullerenes using 1300 and 780 nm multicycle (35 and 40 fs) pulses. For 1300 nm pulses, an extension of the harmonic cutoff to the 41st order was obtained, with a decrease in conversion efficiency that is consistent with theoretical predictions based on wave packet spreading for single atoms. Theoretical calculations of fullerene harmonic spectra using the single active electron approximation were carried out for both few-cycle and multicycle pulses

Targeting epigenetic alterations in cancer stem cells

Oncogenes or tumor suppressor genes are rarely mutated in several pediatric tumors and some early stage adult cancers. This suggests that an aberrant epigenetic reprogramming may crucially affect the tumorigenesis of these tumors. Compelling evidence support the hypothesis that cancer stem cells (CSCs), a cell subpopulation within the tumor bulk characterized by selfrenewal capacity, metastatic potential and chemo-resistance, may derive from normal stem cells (NSCs) upon an epigenetic deregulation. Thus, a better understanding of the specific epigenetic alterations driving the transformation from NSCs into CSCs may help to identify efficacious treatments to target this aggressive subpopulation. Moreover, deepening the knowledge about these alterations may represent the framework to design novel therapeutic approaches also in the field of regenerative medicine in which bioengineering of NSCs has been evaluated. Here, we provide a broad overview about: 1) the role of aberrant epigenetic modifications contributing to CSC initiation, formation and maintenance, 2) the epigenetic inhibitors in clinical trial able to specifically target the CSC subpopulation, and 3) epigenetic drugs and stem cells used in regenerative medicine for cancer and diseases

Shoulder muscle activity in sport climbing in naturally chosen and corrected shoulder positions

Objective: The aim of the study was to determine electromyographic activity of the scapula stabilizing muscles in naturally chosen and corrected shoulder positions in typical static climbing postures. Methods: Six male participants undertook surface electromyography measurement in four climbing postures for two different shoulder positions. The activity of the lower, middle and upper trapezius, serratus anterior, pectoralis major, and sternocleidomastoid was recorded. Electromyographic activity was expressed as the percentage of maximal voluntary contraction (MVC) for each muscle. Results: Climbing postures induced higher activation of middle and lower trapezius in corrected shoulder positions (35.3 ± 11.8 and 61.7 ± 15.4% MVC respectively) than in naturally chosen shoulder positions (18.4 ± 8.9 and 30.1 ± 13.8% MVC respectively). The highest activity of the middle and lower trapezius was found in postures with the arm in external rotation and 90° abduction and in an overhanging posture. Low activation was stated for the other muscles in both shoulder conditions. Conclusion: Results showed that climbers naturally elevate the shoulder during typical static postures. Corrected shoulder positions induce higher activation of the scapula stabilizing muscles than naturally chosen shoulder positions.N/

On the Hidden Order in URu2_{2}Si2_{2} --- Antiferro Hexadecapole Order and its Consequences

An antiferro ordering of an electric hexadecapole moment is discussed as a promising candidate for the long standing mystery of the hidden order phase in URu$_{2}$Si$_{2}$. Based on localized $f$-electron picture, we discuss the rationale of the selected multipole and the consequences of the antiferro hexadecapole order of $xy(x^{2}-y^{2})$ symmetry. The mean-field solutions and the collective excitations from them explain reasonably significant experimental observations: the strong anisotropy in the magnetic susceptibility, characteristic behavior of pressure versus magnetic field or temperature phase diagrams, disappearance of inelastic neutron-scattering intensity out of the hidden order phase, and insensitiveness of the NQR frequency at Ru-sites upon ordering. A consistency with the strong anisotropy in the magnetic responses excludes all the multipoles in two-dimensional representations, such as $(O_{yz},O_{zx})$. The expected azimuthal angle dependences of the resonant X-ray scattering amplitude are given. The $(x^{2}-y^{2})$-type antiferro quadrupole should be induced by an in-plane magnetic field along $[110]$, which is reflected in the thermal expansion and the elastic constant of the transverse $(c_{11}-c_{12})/2$ mode. The $(x^{2}-y^{2})$-type [$(xy)$-type] antiferro quadrupole is also induced by applying the uniaxial stress along $[110]$ direction [$[100]$ direction]. A detection of these induced antiferro quadrupoles under the in-plane magnetic field or the uniaxial stress using the resonant X-ray scattering provides a direct redundant test for the proposed order parameter.Comment: 10 pages, 10 figures, 5 table

The Potential Role of Butyrate in the Pathogenesis and Treatment of Autoimmune Rheumatic Diseases

The gut microbiota is a complex ecosystem of microorganisms residing in the human gastrointestinal tract, playing a crucial role in various biological processes and overall health maintenance. Dysbiosis, an imbalance in the composition and function of the gut microbiota, is linked to systemic autoimmune diseases (SAD). Short-chain fatty acids (SCFAs), especially butyrate, produced by the gut microbiota through the fermentation of dietary fibers, play a significant role in immunomodulation and maintaining intestinal homeostasis. Butyrate is essential for colonocyte energy, anti-inflammatory responses, and maintaining intestinal barrier integrity. Studies show reduced butyrate-producing bacteria in SAD patients, suggesting that increasing butyrate levels could have therapeutic benefits. Butyrate’s anti-inflammatory effects and its potential therapeutic role have been studied in rheumatoid arthritis, Sjogren’s syndrome, systemic lupus erythematosus, systemic sclerosis, and Behçet’s disease. Despite promising in vitro and animal model results, human studies are limited, and the optimal strategies for modulating dysbiosis in SADs remain elusive. This review explores the current evidence on the immunoregulatory role of butyrate and its potential therapeutic effects in SAD