3,850 research outputs found
Highly charged ions: optical clocks and applications in fundamental physics
Recent developments in frequency metrology and optical clocks have been based
on electronic transitions in atoms and singly charged ions as references. These
systems have enabled relative frequency uncertainties at a level of a few parts
in . This accomplishment not only allows for extremely accurate time
and frequency measurements, but also to probe our understanding of fundamental
physics, such as variation of fundamental constants, violation of the local
Lorentz invariance, and forces beyond the Standard Model of Physics. In
addition, novel clocks are driving the development of sophisticated technical
applications. Crucial for applications of clocks in fundamental physics are a
high sensitivity to effects beyond the Standard Model and Einstein's Theory of
Relativity and a small frequency uncertainty of the clock. Highly charged ions
offer both. They have been proposed as highly accurate clocks, since they
possess optical transitions which can be extremely narrow and less sensitive to
external perturbations compared to current atomic clock species. The selection
of highly charged ions in different charge states offers narrow transitions
that are among the most sensitive ones for a change in the fine-structure
constant and the electron-to-proton mass ratio, as well as other new physics
effects. Recent advances in trapping and sympathetic cooling of highly charged
ions will in the future enable high accuracy optical spectroscopy. Progress in
calculating the properties of selected highly charged ions has allowed the
evaluation of systematic shifts and the prediction of the sensitivity to the
"new physics" effects. This article reviews the current status of theory and
experiment in the field.Comment: 53 pages, 16 figures, submitted to RM
Résistance de certaines populations de Culex pipiens (L.) au Chlorpyrifos (DursbanR) en Languedoc-Roussillon (France)
Thermally activated delayed fluorescence in neutral and cationic copper(I) complexes with the 2-(4-Thiazolyl)benzimidazole ligand
Cationic [Cu(P^P)(Htbz)]PF6 [P^P = xantphos, dpephos; Htbz = 2-(4-thiazolyl)benzimidazole] and the corresponding neutral complexes [Cu(P^P)(tbz)], obtained through deprotonation of the diimine ligand, have been synthesized with the aim of analyzing the role of the diphosphane and Htbz deprotonation in the emissive properties of these complexes. For the study of the diphosphane effect, the luminescence properties of these compounds have been compared with those of the reported analogous derivatives with Htbz and carborane diphosphanes. Complexes [Cu(P^P)(Htbz)]PF6 (P^P = xantphos, dpephos) and [Cu(dpephos)(tbz)] display thermally activated delayed fluorescence, which has been studied, revealing a ΔE(S1–T1) between 658 and 455 cm–1. Theoretical calculations indicate different origins for the absorptions, leading to the observed emissions
Band gap control via tuning of inversion degree in CdInS spinel
Based on theoretical arguments we propose a possible route for controlling
the band-gap in the promising photovoltaic material CdInS. Our
\textit{ab initio} calculations show that the experimental degree of inversion
in this spinel (fraction of tetrahedral sites occupied by In) corresponds
approximately to the equilibrium value given by the minimum of the theoretical
inversion free energy at a typical synthesis temperature. Modification of this
temperature, or of the cooling rate after synthesis, is then expected to change
the inversion degree, which in turn sensitively tunes the electronic band-gap
of the solid, as shown here by accurate screened hybrid functional
calculations.Comment: In press in Applied Physics Letters (2012); 4 pages, 2 figures, 1
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PND8 COST-EFFECTIVENESS AND BUDGET IMPACT ANALYSIS OF SUBCUTANEOUS INTERFERON BETA-1A FOR RELAPSING-REMITTING MULTIPLE SCLEROSIS IN SPAIN
Decay rate measurement of the first vibrationally excited state of MgH in a cryogenic Paul trap
We present a method to measure the decay rate of the first excited
vibrational state of simple polar molecular ions being part of a Coulomb
crystal in a cryogenic linear Paul trap. Specifically, we have monitored the
decay of the == towards the ==
level in MgH by saturated laser excitation of the ==-== transition followed by state selective
resonance enhanced two-photon dissociation out of the == level. The technique enables the determination of decay rates, and
thus absorption strengths, with an accuracy at the few percent level.Comment: 5 pages, 4 figure
PND8 COST-EFFECTIVENESS AND BUDGET IMPACT ANALYSIS OF SUBCUTANEOUS INTERFERON BETA-1A FOR RELAPSING-REMITTING MULTIPLE SCLEROSIS IN SPAIN
Effect of Progesterone, Cortisol and Dhea on the ITR of maedivisna virus transcripcional activity
Estudios previos sugieren que, al igual que en otras infecciones por retrovirus, las hormonas esteroideas serían capaces de dirigir la expresión del virus de Maedi-Visna (MVV) mediante la interacción con los Elementos de Respuesta a Hormona (HRE) de la región promotora/reguladora LTR (Repeticiones Largas Terminales) del genoma del provirus. El objetivo de este trabajo fue la evaluación del efecto del cortisol, progesterona y dehidroepiandrosterona (DHEA) sobre la capacidad transcripcional de la región LTR de MVV mediante ensayos de transfección en fibroblastos ovinos con plásmidos pAcGFP (que contiene el gen para la GFP, proteína verde fluorescente) en los que se había clonado la región U3-cap del LTR de distintas cepas de MVV. La actividad transcripcional del LTR se evaluó a través de la cuantificación de la expresión de la GFP por citometría de flujo con las distintas concentraciones de cada hormona tras 48 horas de incubación. En la mayoría de los ensayos se observó un claro efecto inhibitorio de la transcripción del LTR a elevadas concentraciones hormonales, disminuyendo el efecto a medida que se diluía la hormona, llegando incluso en el caso de cortisol y de DHEA a producirse un incremento de la expresión a partir de 10-7M. En general no se pudo asociar una diferente respuesta con el origen de la cepa estudiada lo que sugiere que no está relacionado con los distintos orígenes/tropismos de los virus. Estos datos sugieren la presencia de un sitio HRE capaz de responder a estimulación hormonal en el LTR de MVV.Previous studies suggest that steroid hormones may direct the expression of Maedi-Visna virus (MVV), as has been observed in other retroviral infections. This would be achieved through the promoter/regulator region of the LTR (long terminal repeats) of the proviral genome, which would contain hormone responsive elements (HRE). The aim of this study was to evaluate the effect of cortisol, progesterone and dehydroepiandrosterone (DHEA) on the transcriptional ability of the MVV LTR region. For this, sheep fibroblasts were transfected with pAcGFP plasmids (containing the gene for green fluorescent protein, GFP) in which the U3-cap region of the LTR of different strains of MVV had been cloned. Different concentrations of each hormone were added to transfected cells and the transcriptional activity of the LTR was evaluated after 48 hours of incubation by quantifying the expression of GFP by flow cytometry. A clear inhibitory effect of the transcriptional ability of the LTR was observed in most of the assays at high hormonal concentrations. This effect decreased with the increasing dilutions of the hormones, to the point that GFP expression was above baseline in cells transfected with several of the plasmids and treated with dilutions above 10-7M of cortisol and DHEA. In general terms, a different response could not be associated to the origin of the strain under study, suggesting that the effect of steroids is not related to the different origins/tropisms of the virus. These data suggest the presence of a hormone responsive element (HRE) in the MVV LTR able to respond to hormonal stimulation
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