Class 2 design update for the family of commuter airplanes

This is the final report of seven on the design of a family of commuter airplanes. This design effort was performed in fulfillment of NASA/USRA grant NGT-8001. Its contents are as follows: (1) the class 1 baseline designs for the commuter airplane family; (2) a study of takeoff weight penalties imposed on the commuter family due to implementing commonality objectives; (3) component structural designs common to the commuter family; (4) details of the acquisition and operating economics of the commuter family, i.e., savings due to production commonality and handling qualities commonality are determined; (5) discussion of the selection of an advanced turboprop propulsion system for the family of commuter airplanes, and (6) a proposed design for an SSSA controller design to achieve similar handling for all airplanes. Final class 2 commuter airplane designs are also presented

語い教授における対話スクリプトを使ったオーセンティックな話言葉の規範の使用

This investigate teaching pragmatic competence, specifically the appropriate register. The subjects were 34 2nd year EFL students enrolled in "Basic Conversation", over one semester, at a Japanese national university. Students wrote and performed 4 scripted dialogues as part of an ABAB single case study where the intervention was focusing exercises of optimal features of the oral register authentic NS dialogues. Comparison of the baseline and subsequent scripts using the Wilcoxon Signed Ranks Test (non-parametric) showed a significant increase in the use of spoken features. Student feedback and instructor observation also provided corroboration. The results point to the utility of authentic materials in the Japanese EFL classroom.本研究は、適切な語い使用という語用論的能力の教授について考察するものである。被験者は日本の国立大学における34人のEFL学習者で、Basic Conversation の授業を履修する学生である。彼らは、ABAB single case study の中で4つの対話スクリプトについて記述、実演を行い、実験の処遇として、オーセンティックなNSの対話における口語的な語いの主な特徴の使用についての活動が含まれる。Wilcoxon Singled Ranks Test によって、話し言葉の特徴の使用について、処遇の有無による有意差があることが分かった。本研究の結果は、日本人EFL学習者のクラスにおけるオーセンティック・マテリアルの使用の有用性を示したものとなっている

Observational Limit on Gravitational Waves from Binary Neutron Stars in the Galaxy

Using optimal matched filtering, we search 25 hours of data from the LIGO 40-m prototype laser interferometric gravitational-wave detector for gravitational-wave chirps emitted by coalescing binary systems within our Galaxy. This is the first test of this filtering technique on real interferometric data. An upper limit on the rate R of neutron star binary inspirals in our Galaxy is obtained: with 90% confidence, R\u3c0.5h−1. Similar experiments with LIGO interferometers will provide constraints on the population of tight binary neutron star systems in the Universe

TGIF1 physiological levels limit β-cell distress and neonatal diabetes

TGIF1 belongs to the superfamily of homeodomain proteins, which regulate a wide variety of biological functions, including cell stemness and specification of cell fate during early development. Perhaps surprisingly, we found that enforced expression in pancreatic progenitor cells during embryogenesis resulted in severe diabetes, hinting at the possibility that TGIF1 might regulate pancreas development. Subsequent genetic experiments targeting β-cells showed that TGIF1 affected β-cell function and homeostasis. Transcriptomic analysis revealed that TGIF1 expression inhibits the expression of essential components of UPR signaling, underscoring a potential mechanism in which TGIF1 disrupts protein folding and secretion. Congruently, TGIF1 expression led to a dramatic disorganization of insulin within β-cells, accumulating as large aggregates, and was associated with decreased insulin secretion. Subsequent in vitro experiments showed that TGIF1 expression led to accumulation of insulin aggregates in the ER, thereby causing ER stress and concurrent impairment in insulin processing and secretion. In further support to these findings, conditional deletion of TGIF1 in pancreatic progenitor cells was also associated with hyperglycemia and diabetes, reinforcing the notion that TGIF1 physiological levels are instrumental to maintaining the balance between UPR and ER in β-cells. Finally, we serendipitously found that enforced expression of TGIF1 in β-cells recapitulated the cardinal hallmarks of neonatal diabetes, shedding important insights into mechanistic paradigms of this enigmatic condition

A gene transcription signature associated with hormone independence in a subset of both breast and prostate cancers

<p>Abstract</p> <p>Background</p> <p>The development of resistance to hormone therapy in both breast and prostate cancers is attributed to tens of thousands of patient deaths every year.</p> <p>Results</p> <p>From analyses of global gene expression profile data, a nonrandom amount of overlap was observed between the set of genes associated with estrogen receptor negative (ER-), hormone independent breast cancer and the set of genes associated with androgen independent (AI) prostate cancer. A set of 81 genes was identified that were differentially expressed between ER- and ER+ clinical breast tumors and breast cancer cell lines and that showed concordant expression in AI versus AS (androgen sensitive) prostate cell lines. This common gene signature of hormone independence was used to identify a subset of clinically localized primary prostate tumors that shared extensive similarities in gene transcription with both ER- breast and AI prostate cell lines and that tended to show concurrent deactivation of the androgen signaling pathway. Both ER- breast and AI prostate cell lines were significantly enriched for transcriptional targets of signaling via epidermal growth factor receptor (EGFR).</p> <p>Conclusion</p> <p>This study indicates that the growth- and survival-promoting functions of hormone receptors can be bypassed in a subset of both breast and prostate cancers by the same growth factor signaling pathways, which holds implications for the use of targeted therapy regimens.</p

Keeping Secrets from Ourselves: Understanding Self-deception Through Theory, Evidence and Application

Self-deception is a difficult concept to share with students. Although few students find it implausible that they are capable of keeping secrets from themselves, the social theory, application, and practical demonstration of self-deception is far from straightforward. This work offers a three-step approach to teach a theoretically-grounded, evidence-based, and application-reinforced understanding of self-deception. Rooted in work on identity by Mead (1934), the approach outlined here engages with interdisciplinary case studies derived from social psychology (Greenwald, McGhee and Schwartz 1998) and behavioral economics (Ariely 2012). The theory and case studies build toward a peer evaluation that offers students a concrete demonstration of self-deception with implications at the individual- and group-level

Academic Freedom

n/

Community Partner Indicators of Engagement: An Action Research Study on Campus-Community Partnership

The central purpose of this research study was to develop common indicators of engagement for civic initiatives between institutions of higher education and their community organization partners. The unique aspect of this study was that the indicators were generated by the community organizations participating as stakeholders in campus-community partnerships. Using an action research methodology that involved eleven community organization participants from the health and wellness sector, the study advocated for research that provided a deeper understanding of the perspectives of community organizations. Findings suggested that significant divides existed in core civic areas dealing with service-learning, relevance of academic research, and equitable treatment of community partners. The study produced a formal set of community partner indicators of engagement that were developed by the participants in the study and disseminated to higher education leaders. The indicators illustrated the expectations of community partners that engaged in civic partnerships with higher education. Additionally, the study provided an analysis of the literature on civic engagement, identifying a lack of empirical research concerned with the perspectives of community organization partners. The electronic version of the dissertation is accessible at the OhioLINK ETD center http://www.ohiolink.edu/etd/