Risk factors of persistent adolescent thinness: findings from the UK millennium cohort study

Background Thinness during adolescence can increase the risk of adverse health outcomes across the life-course and impede development. There is limited research examining the prevalence and determinants of persistent adolescent thinness in the United Kingdom (UK). We used longitudinal cohort data to investigate determinants of persistent adolescent thinness. Methods We analyzed data from 7,740 participants in the UK Millennium Cohort Study at ages 9 months, 7, 11, 14 and 17 years. Persistent thinness was defined as thinness at ages 11, 14 and 17; thinness was defined as an age- and sex-adjusted Body Mass Index (BMI) of less than 18.5 kg/m2. In total, 4,036 participants, classified either as persistently thin or at a persistent healthy weight, were included in the analyses. Logistic regression analyses were conducted to examine associations between 16 risk factors and persistent adolescent thinness by sex. Results The prevalence of persistent thinness among adolescents was 3.1% (n = 231). Among males (n = 115), persistent adolescent thinness was significantly associated with non-white ethnicity, low parental BMI, low birthweight, low breastfeeding duration, unintended pregnancy, and low maternal education. Among females (n = 116), persistent adolescent thinness was significantly associated with non-white ethnicity, low birthweight, low self-esteem, and low physical activity. However, after adjusting for all risk factors, only low maternal BMI (OR: 3.44; 95% CI:1.13, 10.5), low paternal BMI (OR: 22.2; 95% CI: 2.35, 209.6), unintended pregnancy (OR: 2.49; 95% CI: 1.11, 5.57) and low self-esteem (OR: 6.57; 95% CI: 1.46,29.7) remained significantly associated with persistent adolescent thinness among males. After adjustment for all risk factors, not reaching the recommended physical activity levels (OR: 4.22; 95% CI: 1.82, 9.75) remained significantly associated with persistent adolescent thinness among females. No appreciable associations were found between persistent adolescent thinness and sex, premature birth, smoking during pregnancy, income, maternal postnatal depression, mother-infant attachment or socio-emotional difficulties (p > 0.05). Conclusion Persistent adolescent thinness is not rare and appears to be associated with both physical and mental health factors, with some sex specific differences. Healthy weight initiatives should consider the full weight spectrum. Further research is required to understand thinness at a population level, including among those whose BMI changes during child and adolescent development

Is earlier obesity associated with poorer executive functioning later in childhood? Findings from the Millennium Cohort Study

BACKGROUND: Children affected with overweight or obesity have been associated with having lower educational achievement compared to peers who are non-overweight/obese. One of the drivers of this association could be a link between obesity and poorer executive function. Evidence is limited to small, cross-sectional studies which lack adjustment for important common causes. OBJECTIVE: We investigate the association between weight status and executive function longitudinally in mid-childhood, accounting for potential common causes. METHODS: Linear regression analyses were conducted to examine associations between weight status between 5 and 7 years and executive functioning at 11 years in members of the Millennium Cohort Study (n = 7739), accounting for a wide range of potential common causes. Age- and sex-specific International Obesity Taskforce cut-points for body mass index (BMI) were used. Executive function, including decision-making, impulsivity and spatial working memory, was assessed using the Cambridge Neuropsychological Test Automated Battery. RESULTS: There were no unadjusted associations between weight status and decision-making or impulsivity. After adjustment for all potential common causes, there was a lack of consistent evidence to support an association between persistent obesity (including overweight) between 5 and 7 years and spatial working memory task at 11 years. CONCLUSIONS: We found little evidence that poorer spatial working memory contributes to the association of children with obesity having lower educational achievement

Everything you always wanted to know about dictionaries (but were afraid to ask): A Massive Open Online Course

© Lexicography in Global Contexts. We have created a Massive Open Online Course (MOOC) about dictionaries and dictionary-making, to be hosted by FutureLearn. This paper discusses the design and development of this course, which is pitched at high school and undergraduate level participants as well as language enthusiasts around the world. The MOOC will answer questions such as: how dictionaries are made and how this process has changed over time; what goes into a dictionary and who decides; and what kinds of language evidence underpin the information which dictionaries provide. Participants will be encouraged to compare the quantity and quality of information in different types of dictionary, and will investigate corpus-based and computational lexicographic methods. It will also consider dictionary users' attitudes and common misconceptions, taking into account the requirements and habits of English language learners as well as fluent speakers. By the end of the course, participants will know about some of the latest trends in lexicographic research, the roles of language technology, corpora and crowdsourcing in the dictionary compilation process, the range of possible dictionary entry components, lexicographical choices and computational methods surrounding the selection and ordering of word meanings, and the content and wording of definitions

Mild Behavioral Impairment as a Marker of Cognitive Decline in Cognitively Normal Older Adults

This is the author accepted manuscript. the final version is available from Elsevier via the DOI in this recordObjective: Mild Behavioral Impairment (MBI) is a neurobehavioural syndrome characterized by later life emergent neuropsychiatric symptoms (NPS) which represent an at-risk state for incident cognitive decline and dementia in people with Mild Cognitive Impairment. We undertook a study to determine whether MBI was associated with progressive changes in neuropsychological performance in people without significant cognitive impairment. Methods: 9,931 older adults enrolled in the PROTECT study who did not have MCI or dementia undertook a comprehensive neuropsychological battery measuring attention, reasoning, executive function and working memory at baseline and one year. MBI was ascertained using self-administration of the MBI-C at one year, and participants grouped according to MBI status: no symptoms, intermediate neuropsychiatric symptoms and MBI. All assessments were completed online and data analyzed using MMRM ANOVA. Results: 949 (10%) people had MBI. These individuals had significantly worse cognitive performance at baseline and significantly greater decline over one year in the four composites cognitive scores measuring attentional intensity (F(2,8578)=3.97,p=0.019), sustained attention (F(2,8578)=18.63, p<.0001), attentional fluctuation (F(2,8578)=10.13, p=<.0001) and working memory F(2,9895)=13.1, p<.0001. Conclusions: Our novel findings show that MBI is associated with faster decline in attention and working memory in this cognitively normal sample. MBI may be an earlier marker of neurodegenerative disease than MCI, captured at the stage of SCD or before, raising the possibility that MBI represents a novel target for dementia clinical trials or prevention strategies.National Institute for Health Research (NIHR

Depression in individuals who subsequently develop inflammatory bowel disease: a population-based nested case-control study.

OBJECTIVE: Depression is a potential risk factor for developing IBD. This association may be related to GI symptoms occurring before diagnosis. We aimed to determine whether depression, adjusted for pre-existing GI symptoms, is associated with subsequent IBD. DESIGN: We conducted a nested case-control study using the Clinical Practice Research Datalink identifying incident cases of UC and Crohn's disease (CD) from 1998 to 2016. Controls without IBD were matched for age and sex. We measured exposure to prevalent depression 4.5-5.5 years before IBD diagnosis. We created two sub-groups with prevalent depression based on whether individuals had reported GI symptoms before the onset of depression. We used conditional logistic regression to derive ORs for the risk of IBD depending on depression status. RESULTS: We identified 10 829 UC cases, 4531 CD cases and 15 360 controls. There was an excess of prevalent depression 5 years before IBD diagnosis relative to controls (UC: 3.7% vs 2.7%, CD 3.7% vs 2.9%). Individuals with GI symptoms prior to the diagnosis of depression had increased adjusted risks of developing UC and CD compared with those without depression (UC: OR 1.47, 95% CI 1.21 to 1.79; CD: OR 1.41, 95% CI 1.04 to 1.92). Individuals with depression alone had similar risks of UC and CD to those without depression (UC: OR 1.13, 95% CI 0.99 to 1.29; CD: OR 1.12, 95% CI 0.91 to 1.38). CONCLUSIONS: Depression, in the absence of prior GI symptoms, is not associated with subsequent development of IBD. However, depression with GI symptoms should prompt investigation for IBD

Electron Capture Dissociation Mass Spectrometry of Tyrosine Nitrated Peptides

In vivo protein nitration is associated with many disease conditions that involve oxidative stress and inflammatory response. The modification involves addition of a nitro group at the position ortho to the phenol group of tyrosine to give 3-nitrotyrosine. To understand the mechanisms and consequences of protein nitration, it is necessary to develop methods for identification of nitrotyrosine-containing proteins and localization of the sites of modification.Here, we have investigated the electron capture dissociation (ECD) and collision-induced association (CID) behavior of 3-nitrotyrosine-containing peptides. The presence of nitration did not affect the CID behavior of the peptides. For the doubly-charged peptides, addition of nitration severely inhibited the production of ECD sequence fragments. However, ECD of the triply-charged nitrated peptides resulted in some singly-charged sequence fragments. ECD of the nitrated peptides is characterized by multiple losses of small neutral species including hydroxyl radicals, water and ammonia. The origin of the neutral losses has been investigated by use of activated ion (AI) ECD. Loss of ammonia appears to be the result of non-covalent interactions between the nitro group and protonated lysine side-chains

‘I think I'm more free with them'—Conflict, Negotiation and Change in Intergenerational Relations in African Families Living in Britain

While the family is increasingly being recognised as pivotal to migration, there remain too few studies examining how migration impacts on intergenerational relationships. Although traditional intergenerational gaps are intensified by migration, arguably there has been an over-emphasis on the divisions between ‘traditional’ parents and ‘modern’ children at the expense of examining the ways in which both generations adapt. As Foner and Dreby [2011. “Relations Between the Generations in Immigrant Families.” Annual Review of Sociology 37: 545–564] stress, the reality of post-migration intergenerational relations is inevitably more complex, requiring the examination of both conflict and cooperation. This article contributes to this growing literature by discussing British data from comparative projects on intergenerational relations in African families (in Britain, France and South Africa). It argues that particular understandings can be gained from examining the adaptation of parents and parenting strategies post-migration and how the reconfiguration of family relations can contribute to settlement. By focusing on how both parent and child generations engage in conflict and negotiation to redefine their relationships and expectations, it offers insight into how families navigate and integrate the values of two cultures. In doing so, it argues that the reconfiguration of gender roles as a result of migration offers families the space to renegotiate their relationships and make choices about what they transmit to the next generation

Translanguaging and translation: the construction of social difference across city spaces

This paper considers the construction of social difference in the interactions of a couple as they communicate at home and work, with one another, their colleagues, and strangers in a superdiverse English city. In our linguistic ethnographic approach we observed, wrote field notes, audio-recorded key participants, took photographs, made video-recordings, and conducted interviews. We documented the role translanguaging and translation played and showed how these social practices varied across the city’s spatial realms as different kinds of relationships are brought into play. While the interactions can be thematically characterized as broadly about money, business, and commerce, they can also be said to draw on widely circulating discourses about social and linguistic difference. We found that the construction of difference varied qualitatively by the distance and intimacy of the relationships in play. We also found that a translanguaging repertoire was particularly evident in navigating sensitive cultural activities, attitudes and beliefs. This points to the usefulness of translanguaging to signpost an openness to, and interest in, social and linguistic diversity in the market place, where buying and selling are the order of the day

Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status

Supporting Information is available online at: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.12404#support-information-section .Copyright © 2023 The Authors. Introduction: Despite the association of vitamin D deficiency with incident dementia, the role of supplementation is unclear. We prospectively explored associations between vitamin D supplementation and incident dementia in 12,388 dementia-free persons from the National Alzheimer's Coordinating Center. Methods: Baseline exposure to vitamin D was considered D+; no exposure prior to dementia onset was considered D−. Kaplan–Meier curves compared dementia-free survival between groups. Cox models assessed dementia incidence rates across groups, adjusted for age, sex, education, race, cognitive diagnosis, depression, and apolipoprotein E (APOE) ε4. Sensitivity analyses examined incidence rates for each vitamin D formulation. Potential interactions between exposure and model covariates were explored. Results: Across all formulations, vitamin D exposure was associated with significantly longer dementia-free survival and lower dementia incidence rate than no exposure (hazard ratio = 0.60, 95% confidence interval: 0.55–0.65). The effect of vitamin D on incidence rate differed significantly across the strata of sex, cognitive status, and APOE ε4 status. Discussion: Vitamin D may be a potential agent for dementia prevention. Highlights: * In a prospective cohort study, we assessed effects of Vitamin D on dementia incidence in 12,388 participants from the National Alzheimer's Coordinating Center dataset. * Vitamin D exposure was associated with 40% lower dementia incidence versus no exposure. * Vitamin D effects were significantly greater in females versus males and in normal cognition versus mild cognitive impairment. * Vitamin D effects were significantly greater in apolipoprotein E ε4 non-carriers versus carriers. * Vitamin D has potential for dementia prevention, especially in the high-risk strata.The NACC database is funded by NIA/NIH grant U24-AG072122. NACC data are contributed by the NIA-funded ADRCs: P30-AG019610 (PI Eric Reiman, MD), P30-AG013846 (PI Neil Kowall, MD), P50-AG008702 (PI Scott Small, MD), P50-AG025688 (PI Allan Levey, MD, PhD), P50-AG047266 (PI Todd Golde, MD, PhD), P30-AG010133 (PI Andrew Saykin, PsyD), P50-AG005146 (PI Marilyn Albert, PhD), P50-AG005134 (PI Bradley Hyman, MD, PhD), P50-AG016574 (PI Ronald Petersen, MD, PhD), P50-AG005138 (PI Mary Sano, PhD), P30-AG008051 (PI Thomas Wisniewski, MD), P30-AG013854 (PI Robert Vassar, PhD), P30-AG008017 (PI Jeffrey Kaye, MD), P30AG010161 (PI David Bennett, MD), P50 AG047-366 (PI Victor Henderson, MD, MS), P30-AG010129 (PI Charles DeCarli, MD), P50-AG016573 (PI Frank LaFerla, PhD), P50-AG005131 (PI James Brewer, MD, PhD), P50-AG023501 (PI Bruce Miller, MD), P30-AG035982 (PI Russell Swerdlow, MD), P30-AG028383 (PI Linda Van Eldik, PhD), P30-AG053760 (PI Henry Paulson, MD, PhD), P30-AG010124 (PI John Trojanowski, MD, PhD), P50-AG005133 (PI Oscar Lopez, MD), P50-AG005142 (PI Helena Chui, MD), P30-AG012300 (PI Roger Rosenberg, MD), P30-AG049638 (PI Suzanne Craft, PhD), P50-AG005136 (PI Thomas Grabowski, MD), P50-AG033514 (PI Sanjay Asthana, MD, FRCP), P50-AG005681 (PI John Morris, MD), P50-AG047270 (PI Stephen Strittmatter, MD, PhD). Zahinoor Ismail is by the Canadian Institutes of Health Research (BCA2633). Maryam Ghahremani is supported by the Mathison Centre Postdoctoral Fellowship in Mental Health at the University of Calgary, Canada. This study was supported by the National Institute for Health and Care Research Exeter Biomedical Research Centre