Evolution of Mobile Device Use in Clinical Settings

In September 2014, Wolters Kluwer, Medical Research completed its second annual survey of end user search and access behavior with professional health information. The questionnaire addressed changes in clinical workflows resulting from the increased use of mobile devices in clinical settings. Through comparison with prior year’s data, we contemplate changes in how specific use cases fit with specific devices, the effect of multiple screens on usage behavior, and how users value different content types in the mobile environment. With responses from over 12,000 users (approximately 4,000 physicians, 3,400 nurses, and the remainder medical students, faculty, and other provider groups), we identified a drastic 20% year‐over‐year increase in the number of professionals that routinely access “three screens” (tablet, smartphone, and desktop) for professional purposes. Significantly, the findings strongly support the notion that “more screens = more access,” as both smartphones and tablets are becoming increasingly embedded, for a wider range of activities, in the clinical workflow. Concurrently, increased demand for mobile access to healthcare information is creating new challenges for medical librarians. Faced with budget constraints and intensified scrutiny over spending decisions, librarians must balance demands for electronic and print resources while collaborating with IT departments to ensure mobile device access, support, and privacy adherence. Based on survey data, we conclude with “win‐win” opportunities for librarians and vendors to work more closely together to increase the effectiveness of mobile initiatives, including the need for more comprehensive usage statistics and more flexible licensing models

Effects of surface wettability on (001)-WO and (100)-WSe: A spin-polarized DFT-MD study

An extensive understanding of WO and WSe bulk crystalline structures and explicit solvent effects on (001)-WO and (100)-WSe facets are essential for design of efficient (photo) electrocatalysts. The atomistic level understanding of both WO and WSe bulk solids and how water solvation processes occur on WO and WSe facets are nowadays characterized by a noticeable lack of knowledge. Herein, forefront Density Functional Theory-based molecular dynamics have been conducted for assessing the role of an explicit water environment in the characterization of solid surfaces. Water at the interface and H-bonds environment, as well as WO and WSe surface activity, will be described in terms of surface wettability and interfacial water dynamics, revealing the relevance of treating explicitly liquid water and its dynamics in assessing catalytic features. We provide pieces of evidence of the hydrophobic character shown by (001)-WO and (100)-WSe facets. A preferential in-plane hydration structure of the first water layer has been detected at both (001)-WO and (100)-WSe water interface, in which the electric dipole moment of water molecules is re-oriented in a sort of 2-dimensional H-bond network. Bulk property calculations of WO and WSe are also provided

Developmental expression of a functional TASK-1 2P domain K+ channel in embryonic chick heart

<p>Abstract</p> <p>Background</p> <p>Background K⁺channels are the principal determinants of the resting membrane potential (RMP) in cardiac myocytes and thus, influence the magnitude and time course of the action potential (AP).</p> <p>Methods</p> <p>RT-PCR and <it>in situ </it>hybridization are used to study the distribution of TASK-1 and whole-cell patch clamp technique is employed to determine the functional expression of TASK-1 in embryonic chick heart.</p> <p>Results</p> <p>Chicken TASK-1 was expressed in the early tubular heart, then substantially decreased in the ventricles by embryonic day 5 (ED5), but remained relatively high in ED5 and ED11 atria. Unlike TASK-1, TASK-3 was uniformly expressed in heart at all developmental stages. <it>In situ </it>hybridization studies further revealed that TASK-1 was expressed throughout myocardium at Hamilton-Hamburger stages 11 and 18 (S11 & S18) heart. In ED11 heart, TASK-1 expression was more restricted to atria. Consistent with TASK-1 expression data, patch clamp studies indicated that there was little TASK-1 current, as measured by the difference currents between pH 8.4 and pH 7.4, in ED5 and ED11 ventricular myocytes. However, TASK-1 current was present in the early embryonic heart and ED11 atrial myocytes. TASK-1 currents were also identified as 3 μM anandamide-sensitive currents. 3 μM anandamide reduced TASK-1 currents by about 58% in ED11 atrial myocytes. Zn²⁺(100 μM) which selectively inhibits TASK-3 channel at this concentration had no effect on TASK currents. In ED11 ventricle where TASK-1 expression was down-regulated, I_K1was about 5 times greater than in ED11 atrial myocytes.</p> <p>Conclusion</p> <p>Functional TASK-1 channels are differentially expressed in the developing chick heart and TASK-1 channels contribute to background K⁺conductance in the early tubular embryonic heart and in atria. TASK-1 channels act as a contributor to background K⁺current to modulate the cardiac excitability in the embryonic heart that expresses little I_K1.</p

Cities as Living Labs : Increasing the impact of investment in the circular economy for sustainable cities

Aim of the study. From innovation system and policy development point of view, it is vital to understand the impact and added value of EU-funded projects especially in context of the complex societal challenges such as circular economy in cities. By definition Circular Economy (CE) promotes resource minimisation and the adoption of cleaner technologies while maintaining the value of products, materials and resources in the economy for as long as possible and minimizing waste generation. Living Lab (LL) is an open innovation ecosystem based on a systematic user co-creation approach that integrates public and private, research and innovation activities in communities, placing citizens at the centre of innovation with the help of various approaches, instruments, methods, and tools

El dopaje en el deporte y sus repercusiones en la empresa

En esta monografía se demuestra la implicación que le trae a una empresa relacionada con el deporte una mala decisión de un atleta. Espero que con ella pueda resaltar la importancia que tienen los valores y la competencia limpia en dos campos que me apasionan: el deporte y la administración de empresas. Mi trabajo de grado es una pequeña muestra del mundo al que espero dedicar mi vida y con él quisiera contribuir a que se generen mejores decisiones por parte de los deportistas y directivos para lograr que el negocio prospere de la mano de una imagen sólida y basada en los más altos valores humanos.¿Qué es el dopaje?. Sustancias utilizadas. Agentes Anabolizantes. Hormonas Péptidas y Factores de Crecimiento. Agonistas Beta-2. Moduladores Hormonales y Metabólicos. Diuréticos y Otros Agentes Enmascarantes. Antidopaje y Controles. La Agencia Mundial Antidopaje (AMA). Procedimiento para las pruebas Antidopaje. Casos Históricos. Fútbol. Béisbol de Grandes Ligas. Ciclismo. Deportes Olímpicos. La otra cara de la moneda: Legalizar el Dopaje. Repercusiones del dopaje en las Empresas. Recomendaciones.Administrador de EmpresasPregrad

Two Novel Dinuclear Cobalt Polypyridyl Complexes in Electro- and Photocatalysis for Hydrogen Production: Cooperativity Increases Performance

Syntheses and mechanisms of two dinuclear Co-polypyridyl catalysts for the H2 evolution reaction (HER) were reported and compared to their mononuclear analogue (R1). In both catalysts, two di-(2,2’-bipyridin-6-yl)-methanone units were linked by either 2,2’-bipyridin-6,6’-yl or pyrazin-2,5-yl. Complexation with CoII gave dinuclear compounds bridged by pyrazine (C2) or bipyridine (C1). Photocatalytic HER gave turnover numbers (TONs) of up to 20000 (C2) and 7000 (C1) in water. Electrochemically, C1 was similar to the R1, whereas C2 showed electronic coupling between the two Co centers. The E(CoII/I) split by 360 mV into two separate waves. Proton reduction in DMF was investigated for R1 with [HNEt3](BF4) by simulation, foot of the wave analysis, and linear sweep voltammetry (LSV) with in-line detection of H2. All methods agreed well with an (E)ECEC mechanism and the first protonation being rate limiting (≈104 m−1 s−1). The second reduction was more anodic than the first one. pKa values of around 10 and 7.5 were found for the two protonations. LSV analysis with H2 detection for all catalysts and acids with different pKa values [HBF4, pKa(DMF)≈3.4], intermediate {[HNEt3](BF4), pKa(DMF)≈9.2} to weak [AcOH, pKa(DMF)≈13.5] confirmed electrochemical H2 production, distinctly dependent on the pKa values. Only HBF4 protonated CoI intermediates. The two metals in the dualcore C2 cooperated with an increase in rate to a competitive 105 m−1 s−1 with [HNEt3](BF4). The overpotential decreased compared to R1 by 100 mV. Chronoamperometry established high stabilities for all catalysts with TONlim of 100 for R1 and 320 for C1 and C2