Systematic review of topical treatments for fungal infections of the skin and nails of the feet

OBJECTIVE: To identify and synthesise the evidence for efficacy and cost effectiveness of topical treatments for superficial fungal infections of the skin and nails of the feet. DESIGN: Systematic review. INTERVENTIONS: Topical treatments for superficial fungal infections. MAIN OUTCOME MEASURES: Cure confirmed by culture and microscopy for skin and by culture for nails in patients with clinically diagnosed fungal infections. RESULTS: Of 126 trials identified in 121 papers, 72 (57.1%) met the inclusion criteria. Placebo controlled trials yielded pooled relative risks of failure to cure skin infections: allylamines (0.30, 95% confidence interval 0.24 to 0.38); azoles (0.54, 0.42 to 0.68); undecenoic acid (0.28, 0.11 to 0.74); and tolnaftate (0.46, 0.17 to 1.22). Although meta-analysis of 11 trials comparing allylamines and azoles showed a relative risk of failure to cure of 0.88 (0.78 to 0.99) in favour of allylamines, there was evidence of language bias. Seven reports in English favoured allylamines (0.79, 0.69 to 0.91), but four reports in foreign languages showed no difference between the two drugs (1.01, 0.90 to 1.13). Neither trial of nail infections showed significant differences between alternative topical treatments. CONCLUSIONS: Allylamines, azoles, and undecenoic acid were efficacious in placebo controlled trials. There are sufficient comparative trials to judge relative efficacy only between allylamines and azoles. Allylamines cure slightly more infections than azoles but are much more expensive than azoles. The most cost effective strategy is first to treat with azoles or undecenoic acid and to use allylamines only if that fails

Applications of Synchrotron-Source IR Spectroscopy for the Investigation of Insect Wings

Synchrotron-source infrared (IR) spectroscopy offers an effective method to characterise the chemical composition across surfaces. The intense light source allows the detection of trace quantities of different chemical components with a superior signal-to-noise ratio, while the highly collimated light enables high-resolution spatial mapping of the chemical distribution. In this chapter, we introduce synchrotron-source IR spectroscopy, using the infrared microspectroscopy (IRM) beamline at the Australian Synchrotron as an example. We then discuss the use of synchrotron-source IR spectroscopy to analyse insect wings in terms of experimental setup and a summary of the results in two different modes of operation, transmission and attenuated total reflection (ATR). Insect wings possess unique anti-wetting, self-cleaning, anti-biofouling and bactericidal properties and provide inspiration for biomimetic surfaces on synthetic materials which possess similar properties, useful in a range of industries

Riding the wake of a merging galaxy cluster

Using WHT OASIS integral field unit observations, we report the discovery of a thin plume of ionised gas extending from the brightest cluster galaxy in Abell 2146 to the sub-cluster X-ray cool core which is offset from the BCG by ~37 kpc. The plume is greater than 15 kpc long and less than 3 kpc wide. This plume is unique in that the cluster it is situated in is currently undergoing a major galaxy cluster merger. The brightest cluster galaxy is unusually located behind the X-ray shock front and in the wake of the ram pressure stripped X-ray cool core and evidence for recent disruption to the BCG is observed. We examine the gas and stellar morphology, the gas kinematics of the BCG and their relation to the X-ray gas. We propose that a causal link between the ionised gas plume and the offset X-ray cool core provides the simplest explanation for the formation of the plume. An interaction or merger between the BCG and another cluster galaxy is probably the cause of the offset.Comment: 14 pages, 18 figures, accepted for publication in MNRA

The X-ray luminous cluster underlying the z = 1.04 quasar PKS1229-021

We present a 100 ks Chandra observation studying the extended X-ray emission around the powerful z=1.04 quasar PKS1229-021. The diffuse cluster X-ray emission can be traced out to ~15 arcsec (~120 kpc) radius and there is a drop in the calculated hardness ratio inside the central 5 arcsec consistent with the presence of a cool core. Radio observations of the quasar show a strong core and a bright, one-sided jet leading to the SW hot spot and a second hot spot visible on the counter-jet side. Although the wings of the quasar PSF provided a significant contribution to the total X-ray flux at all radii where the extended cluster emission was detected, we were able to accurately subtract off the PSF emission using ChaRT and marx simulations. The resulting steep cluster surface brightness profile for PKS1229-021 appears similar to the profile for the FRII radio galaxy 3C444, which has a similarly rapid surface brightness drop caused by a powerful shock surrounding the radio lobes (Croston et al.). Using a model surface brightness profile based on 3C444, we estimated the total cluster luminosity for PKS1229-021 to be L_X ~ 2 x 10^{44} erg/s. We discuss the difficulty of detecting cool core clusters, which host bright X-ray sources, in high redshift surveys.Comment: 10 pages, 9 figures, accepted by MNRA

ELIMINATING CONSERVATISM IN THE PIPING SYSTEM ANALYSIS PROCESS THROUGH APPLICATION OF A SUITE OF LOCALLY APPROPRIATE SEISMIC INPUT MOTIONS

Seismic analysis is of great importance in the evaluation of nuclear systems due to the heavy influence such loading has on their designs. Current Department of Energy seismic analysis techniques for a nuclear safety-related piping system typically involve application of a single conservative seismic input applied to the entire system [1]. A significant portion of this conservatism comes from the need to address the overlapping uncertainties in the seismic input and in the building response that transmits that input motion to the piping system. The approach presented in this paper addresses these two sources of uncertainty through the application of a suite of 32 input motions whose collective performance addresses the total uncertainty while each individual motion represents a single variation of it. It represents an extension of the soil-structure interaction analysis methodology of SEI/ASCE 43-05 [2] from the structure to individual piping components. Because this approach is computationally intensive, automation and other measures have been developed to make such an analysis efficient. These measures are detailed in this paper

Gut inflammation provides a respiratory electron acceptor for Salmonella.

Salmonella enterica serotype Typhimurium (S. Typhimurium) causes acute gut inflammation by using its virulence factors to invade the intestinal epithelium and survive in mucosal macrophages. The inflammatory response enhances the transmission success of S. Typhimurium by promoting its outgrowth in the gut lumen through unknown mechanisms. Here we show that reactive oxygen species generated during inflammation react with endogenous, luminal sulphur compounds (thiosulphate) to form a new respiratory electron acceptor, tetrathionate. The genes conferring the ability to use tetrathionate as an electron acceptor produce a growth advantage for S. Typhimurium over the competing microbiota in the lumen of the inflamed gut. We conclude that S. Typhimurium virulence factors induce host-driven production of a new electron acceptor that allows the pathogen to use respiration to compete with fermenting gut microbes. Thus the ability to trigger intestinal inflammation is crucial for the biology of this diarrhoeal pathogen

Computer Components and Systems

Contains reports on three research projects.United States Navy, Bureau of Ships (Contract NObsr 77603

Clones of \u3cem\u3eStreptococcus zooepidemicus\u3c/em\u3e from Outbreaks of Hemorrhagic Canine Pneumonia and Associated Immune Responses

Acute hemorrhagic pneumonia caused by Streptococcus zooepidemicus has emerged as a major disease of shelter dogs and greyhounds. S. zooepidemicus strains differing in multilocus sequence typing (MLST), protective protein (SzP), and M-like protein (SzM) sequences were identified from 9 outbreaks in Texas, Kansas, Florida, Nevada, New Mexico, and Pennsylvania. Clonality based on 2 or more isolates was evident for 7 of these outbreaks. The Pennsylvania and Nevada outbreaks also involved cats. Goat antisera against acutely infected lung tissue as well as convalescent-phase sera reacted with a mucinase (Sz115), hyaluronidase (HylC), InlA domain-containing cell surface-anchored protein (INLA), membrane-anchored protein (MAP), SzP, SzM, and extracellular oligopeptide-binding protein (OppA). The amino acid sequences of SzP and SzM of the isolates varied greatly. The szp and szm alleles of the closely related Kansas clone (sequence type 129 [ST-129]) and United Kingdom isolate BHS5 (ST-123) were different, indicating that MLST was unreliable as a predictor of virulence phenotype. Combinations of conserved HylC and serine protease (ScpC) and variable SzM and SzP proteins of S. zooepidemicus strain NC78 were protectively immunogenic for mice challenged with a virulent canine strain. Thus, although canine pneumonia outbreaks are caused by different strains of S. zooepidemicus, protective immune responses were elicited in mice by combinations of conserved or variable S. zooepidemicus proteins from a single strain