A MODEL OF THE STUBBLE REPLACEMENT DECISION FOR FLORIDA SUGARCANE GROWERS

Crop Production/Industries,

Managing for change: May 3, 1989

Bi-weekly newsletter of University Hospital's Change Project, provided to managers at the hospital

Managing for change: October 11, 1989

Bi-weekly newsletter of University Hospital's Change Project, provided to managers at the hospital

The Ursinus Weekly, December 17, 1969

Special centennial issue: Ursinus College\u27s 100th Anniversary, 1869-1969 • Editorial: The first hundred years • Focus: Nora Shuler Helfferich, Ursinus College\u27s oldest living alumnus • Reprinted articles: Pa. Governor Martin salutes President McClure and college at ceremony commemorating seventy-fifth anniversary; Ursinus adopts a war time program; Ursinus recipient of new gateway; Apology for peace; Freshman coed evaluates customs, finds friendly spirit on U.C. campus; Customs are savored; Chaperon, Why? Who?; WSGA is frowning on dungarees, slacks for Ursinus campus wear; When Shriner shrieks Ursinus sheiks come dashing from each dorm; Freshman President snatched by Sophs; Ursinus offers special class • Freeland Hall: Don\u27t let it be forgot • Ursinus raises $2,350,000;$550,000 still needed • Search into history substantiates claim of second oldest graduate that Freeland was everything • Ursinus administrators analyze past, present, and future • 1969 season climaxes 76 years • Mangan wins little All-American mention • Bears\u27 football since 1893 • Ray Gurzynski pilots Bear Harriers to 45-4 mark, two championships • Fifty years of girls\u27 field hockey at UC: Bearites to Snell-belles and champs • Albert leads UC Harriers to MAC championship • Footmen end season with 6-win record • 1969 MAC grid statistics • Concise history of Ursinus College: 1869 - present • Ursinus College: One century old, before and afterhttps://digitalcommons.ursinus.edu/weekly/1153/thumbnail.jp

Differential trajectories of hypometabolism across cognitively-defined Alzheimer’s disease subgroups

Disentangling biologically distinct subgroups of Alzheimer’s disease (AD) may facilitate a deeper understanding of the neurobiology underlying clinical heterogeneity. We employed longitudinal [18F]FDG-PET standardized uptake value ratios (SUVRs) to map hypometabolism across cognitively-defined AD subgroups. Participants were 384 amyloid-positive individuals with an AD dementia diagnosis from ADNI who had a total of 1028 FDG-scans (mean time between first and last scan: 1.6 ± 1.8 years). These participants were categorized into subgroups on the basis of substantial impairment at time of dementia diagnosis in a specific cognitive domain relative to the average across domains. This approach resulted in groups of AD-Memory (n = 135), AD-Executive (n = 8), AD-Language (n = 22), AD-Visuospatial (n = 44), AD-Multiple Domains (n = 15) and AD-No Domains (for whom no domain showed substantial relative impairment; n = 160). Voxelwise contrasts against controls revealed that all AD-subgroups showed progressive hypometabolism compared to controls across temporoparietal regions at time of AD diagnosis. Voxelwise and regions-of-interest (ROI)-based linear mixed model analyses revealed there were also subgroup-specific hypometabolism patterns and trajectories. The AD-Memory group had more pronounced hypometabolism compared to all other groups in the medial temporal lobe and posterior cingulate, and faster decline in metabolism in the medial temporal lobe compared to AD-Visuospatial. The AD-Language group had pronounced lateral temporal hypometabolism compared to all other groups, and the pattern of metabolism was also more asymmetrical (left < right) than all other groups. The AD-Visuospatial group had faster decline in metabolism in parietal regions compared to all other groups, as well as faster decline in the precuneus compared to AD-Memory and AD-No Domains. Taken together, in addition to a common pattern, cognitively-defined subgroups of people with AD dementia show subgroup-specific hypometabolism patterns, as well as differences in trajectories of metabolism over time. These findings provide support to the notion that cognitively-defined subgroups are biologically distinct

TOI-150: A transiting hot Jupiter in the TESS southern CVZ

We report the detection of a hot Jupiter ($M_{p}=1.75_{-0.17}^{+0.14}\ M_{J}$,$R_{p}=1.38\pm0.04\ R_{J}$) orbiting a middle-aged star ($\log g=4.152^{+0.030}_{-0.043}$) in the Transiting Exoplanet Survey Satellite (TESS) southern continuous viewing zone ($\beta=-79.59^{\circ}$). We confirm the planetary nature of the candidate TOI-150.01 using radial velocity observations from the APOGEE-2 South spectrograph and the Carnegie Planet Finder Spectrograph, ground-based photometric observations from the robotic Three-hundred MilliMeter Telescope at Las Campanas Observatory, and Gaia distance estimates. Large-scale spectroscopic surveys, such as APOGEE/APOGEE-2, now have sufficient radial velocity precision to directly confirm the signature of giant exoplanets, making such data sets valuable tools in the TESS era. Continual monitoring of TOI-150 by TESS can reveal additional planets and subsequent observations can provide insights into planetary system architectures involving a hot Jupiter around a star about halfway through its main-sequence life.Comment: 13 pages, 3 figures, 2 tables, accepted to ApJ

The Ursinus Weekly, March 6, 1969

Officers inducted; Emig emphasizes new responsibility • American dream, brotherhood highlight Festival of the Arts • USGA officers interviewed; Communication gap stressed • Placement interviews scheduled • 200 attend Lorelei; Fischer crowned king • Semi-formal ball highlights junior-senior weekend • Editorial: Potpourri - Or, Could this ever happen here? • State set to punish protestors; Laws threaten civil liberties • Letters to the editor • Remark • Lantern literary lapse termed titanic bomb • Staying out of uniform: A practical guide for the Ursinus male, part I • Whose risk? • Columnist proposes solution to UC\u27s dearth of black students • Albright draws Fifth Dimension • Racism symposium set for March 20 with Lincoln Univ. • Dorm lounges opened; Slacks rule slackened • Rice discusses status for Phi Beta Kappa • Ursinus grapplers rally to win over Drexel, 22-13 • New gym complex to include pool • Carson paces Bearettes over Gettysburg • Badminton team wins six in row • Trackmen run at Swarthmore and Delaware • Gillespie hits 37 points to lead Bears over Swarthmore in finale • Girl swimmers win over Penn and Elizabethtown • Junior varsity hoopmen finish with 11-6 record • Dickinson frat system defended • UC celebrates centennial with unique innovation • Forum features Howellhttps://digitalcommons.ursinus.edu/weekly/1171/thumbnail.jp

Differential patterns of gray matter volumes and associated gene expression profiles in cognitively-defined Alzheimer's disease subgroups

The clinical presentation of Alzheimer’s disease (AD) varies widely across individuals but the neurobiological mechanisms underlying this heterogeneity are largely unknown. Here, we compared regional gray matter (GM) volumes and associated gene expression profiles between cognitively-defined subgroups of amyloid-β positive individuals clinically diagnosed with AD dementia (age: 66 ± 7, 47% male, MMSE: 21 ± 5). All participants underwent neuropsychological assessment with tests covering memory, executive-functioning, language and visuospatial-functioning domains. Subgroup classification was achieved using a psychometric framework that assesses which cognitive domain shows substantial relative impairment compared to the intra-individual average across domains, which yielded the following subgroups in our sample; AD-Memory (n = 41), AD-Executive (n = 117), AD-Language (n = 33), AD-Visuospatial (n = 171). We performed voxel-wise contrasts of GM volumes derived from 3Tesla structural MRI between subgroups and controls (n = 127, age 58 ± 9, 42% male, MMSE 29 ± 1), and observed that differences in regional GM volumes compared to controls closely matched the respective cognitive profiles. Specifically, we detected lower medial temporal lobe GM volumes in AD-Memory, lower fronto-parietal GM volumes in AD-Executive, asymmetric GM volumes in the temporal lobe (left < right) in AD-Language, and lower GM volumes in posterior areas in AD-Visuospatial. In order to examine possible biological drivers of these differences in regional GM volumes, we correlated subgroup-specific regional GM volumes to brain-wide gene expression profiles based on a stereotactic characterization of the transcriptional architecture of the human brain as provided by the Allen human brain atlas. Gene-set enrichment analyses revealed that variations in regional expression of genes involved in processes like mitochondrial respiration and metabolism of proteins were associated with patterns of regional GM volume across multiple subgroups. Other gene expression vs GM volume-associations were only detected in particular subgroups, e.g., genes involved in the cell cycle for AD-Memory, specific sets of genes related to protein metabolism in AD-Language, and genes associated with modification of gene expression in AD-Visuospatial. We conclude that cognitively-defined AD subgroups show neurobiological differences, and distinct biological pathways may be involved in the emergence of these differences

Synchrony of change in depressive symptoms, health status, and quality of life in persons with clinical depression

BACKGROUND: Little is known about longitudinal associations among measures of depression, mental and physical health, and quality of life (QOL). We followed 982 clinically depressed persons to determine which measures changed and whether the change was synchronous with change in depressive symptoms. METHODS: Data were from the Longitudinal Investigation of Depression Outcomes (LIDO). Depressive symptoms, physical and mental health, and quality of life were measured at baseline, 6 weeks, 3 months, and 9 months. Change in the measures was examined over time and for persons with different levels of change in depressive symptoms. RESULTS: On average, all of the measures improved significantly over time, and most were synchronous with change in depressive symptoms. Measures of mental health changed the most, and physical health the least. The measures of change in QOL were intermediate. The 6-week change in QOL could be explained completely by change in depressive symptoms. The instruments varied in sensitivity to changes in depressive symptoms. CONCLUSION: In clinically depressed persons, measures of physical health, mental health, and quality of life showed consistent longitudinal associations with measures of depressive symptoms

Strengthening the food systems governance evidence base : Supporting commensurability of research through a systematic review of methods

Governance of food systems is a poorly understood determinant of food security. Much scholarship on food systems governance is non-empirical, while existing research is often case study-based and theoretically and methodologically incommensurable. This frustrates aggregation of evidence and generalisation. We undertook a systematic review of methods used in food systems governance research with a view to identifying a core set of indicators for future research. We gathered literature through a structured consultation and sampling from recent reviews. Indicators were identified and classified according to the levels and sectors they investigate. We found a concentration of indicators in food production at local to national levels and a sparseness in distribution and consumption. Unsurprisingly, many indicators of institutional structure were found, while agency-related indicators are moderately represented. We call for piloting and validation of these indicators and for methodological development to fill gaps identified. These efforts are expected to support a more consolidated future evidence base and eventual meta-analysis