10,210 research outputs found
A quantum central limit theorem for non-equilibrium systems: Exact local relaxation of correlated states
We prove that quantum many-body systems on a one-dimensional lattice locally
relax to Gaussian states under non-equilibrium dynamics generated by a bosonic
quadratic Hamiltonian. This is true for a large class of initial states - pure
or mixed - which have to satisfy merely weak conditions concerning the decay of
correlations. The considered setting is a proven instance of a situation where
dynamically evolving closed quantum systems locally appear as if they had truly
relaxed, to maximum entropy states for fixed second moments. This furthers the
understanding of relaxation in suddenly quenched quantum many-body systems. The
proof features a non-commutative central limit theorem for non-i.i.d. random
variables, showing convergence to Gaussian characteristic functions, giving
rise to trace-norm closeness. We briefly relate our findings to ideas of
typicality and concentration of measure.Comment: 27 pages, final versio
Hamster-to-rat heart and liver xenotransplantation with FK506 plus antiproliferative drugs
Heterotopic hamster hearts transplanted to unmodified LEW rats underwent humoral rejection in 3 days. Survival was prolonged to a median of 4 days with 2 mg/kg/day FK506. As monotherapy, 15 mg/kg/day cyclophosphamide greatly prolonged graft survival-far more than could be accomplished with RS-61443, brequinar (BQR), mizoribine, methotrexate, or deoxyspergualin. However, when FK506 treatment, which was ineffective alone, was combined with a short induction course (14 or 30 days) of subtherapeutic BQR, RS-61443, or cyclophosphamide, routine survival of heart xenografts was possible for as long as the daily FK506 was continued. In addition, a single large dose of 80 mg/kg cyclophosphamide 10 days preoperatively allowed routine cardiac xenograft survival under FK506. The ability of these antimetabolites to unmask the therapeutic potential of FK506 correlated, although imperfectly, with the prevention of rises of preformed heterospecific cytotoxic antibodies immediately postoperatively. As an adjunct to FK506, azathioprine was of marginal value, whereas mizoribine, methotrexate, and deoxyspergualin (DSPG) were of intermediate efficacy. After orthotopic hepatic xenotransplantation, the perioperative survival of the liver with its well-known resistance to antibodies was less dependent than the heart on the antimetabolite component of the combined drug therapy, but the unsatisfactory results with monotherapy of FK506, BQR, RS-61443, or cyclophosphamide were changed to routine success by combining continuous FK506 with a short course of any of the other drugs. Thus, by breaking down the antibody barrier to xenotransplantation with these so-called antiproliferative drugs, it has been possible with FK506 to transplant heart and liver xenografts with consistent long-term survival of healthy recipients
Parametric instabilities in magnetized multicomponent plasmas
This paper investigates the excitation of various natural modes in a
magnetized bi-ion or dusty plasma. The excitation is provided by parametrically
pumping the magnetic field. Here two ion-like species are allowed to be fully
mobile. This generalizes our previous work where the second heavy species was
taken to be stationary. Their collection of charge from the background neutral
plasma modifies the dispersion properties of the pump and excited waves. The
introduction of an extra mobile species adds extra modes to both these types of
waves. We firstly investigate the pump wave in detail, in the case where the
background magnetic field is perpendicular to the direction of propagation of
the pump wave. Then we derive the dispersion equation relating the pump to the
excited wave for modes propagating parallel to the background magnetic field.
It is found that there are a total of twelve resonant interactions allowed,
whose various growth rates are calculated and discussed.Comment: Published in May 2004; this is a late submission to the archive. 14
pages, 8 figure
Nucleosome-CHD4 chromatin remodeller structure maps human disease mutations
Chromatin remodelling plays important roles in gene regulation during development, differentiation and in disease. The chromatin remodelling enzyme CHD4 is a component of the NuRD and ChAHP complexes that are involved in gene repression. Here we report the cryo-electron microscopy (cryo-EM) structure of Homo sapiens CHD4 engaged with a nucleosome core particle in the presence of the non-hydrolysable ATP analogue AMP-PNP at an overall resolution of 3.1 Å. The ATPase motor of CHD4 binds and distorts nucleosomal DNA at superhelical location (SHL) +2, supporting the 'twist defect' model of chromatin remodelling. CHD4 does not induce unwrapping of terminal DNA, in contrast to its homologue Chd1, which functions in gene activation. Our structure also maps CHD4 mutations that are associated with human cancer or the intellectual disability disorder Sifrim-Hitz-Weiss syndrome
Entanglement genesis by ancilla-based parity measurement in 2D circuit QED
We present an indirect two-qubit parity meter in planar circuit quantum
electrodynamics, realized by discrete interaction with an ancilla and a
subsequent projective ancilla measurement with a dedicated, dispersively
coupled resonator. Quantum process tomography and successful entanglement by
measurement demonstrate that the meter is intrinsically quantum non-demolition.
Separate interaction and measurement steps allow commencing subsequent data
qubit operations in parallel with ancilla measurement, offering time savings
over continuous schemes.Comment: 5 pages, 4 figures; supplemental material with 5 figure
Hydrodynamic Waves in Regions with Smooth Loss of Convexity of Isentropes. General Phenomenological Theory
General phenomenological theory of hydrodynamic waves in regions with smooth
loss of convexity of isentropes is developed based on the fact that for most
media these regions in p-V plane are anomalously small. Accordingly the waves
are usually weak and can be described in the manner analogous to that for weak
shock waves of compression. The corresponding generalized Burgers equation is
derived and analyzed. The exact solution of the equation for steady shock waves
of rarefaction is obtained and discusses.Comment: RevTeX, 4 two-column pages, no figure
A joint time-dependent density-functional theory for excited states of electronic systems in solution
We present a novel joint time-dependent density-functional theory for the
description of solute-solvent systems in time-dependent external potentials.
Starting with the exact quantum-mechanical action functional for both electrons
and nuclei, we systematically eliminate solvent degrees of freedom and thus
arrive at coarse-grained action functionals which retain the highly accurate
\emph{ab initio} description for the solute and are, in principle, exact. This
procedure allows us to examine approximations underlying popular embedding
theories for excited states. Finally, we introduce a novel approximate action
functional for the solute-water system and compute the solvato-chromic shift of
the lowest singlet excited state of formaldehyde in aqueous solution, which is
in good agreement with experimental findings.Comment: 11 page
Biased tomography schemes: an objective approach
We report on an intrinsic relationship between the maximum-likelihood
quantum-state estimation and the representation of the signal. A quantum
analogy of the transfer function determines the space where the reconstruction
should be done without the need for any ad hoc truncations of the Hilbert
space. An illustration of this method is provided by a simple yet practically
important tomography of an optical signal registered by realistic binary
detectors.Comment: 4 pages, 3 figures, accepted in PR
Effects of Microstructural Heterogeneity in Cement Excelsior Board
Heterogeneity in the properties and arrangement of constituents can have an important effect on a composite's properties. This paper evaluates the effects of variability in wood strand dimensions, mechanical properties, and orientation on the engineering properties of cement excelsior board. The finite element method is used to analyze a heterogeneous three-dimensional microstructure of strands, predicting elastic and strength properties. Results suggest that variability in strand mechanical properties can significantly lower composite tensile and compressive strengths, while composite stiffness is not affected. The model also predicts that relatively modest alignment of strands can lead to significant increases in composite strength and stiffness in the direction of alignment
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