Handbook for estimating toxic fuel hazards

Computer program predicts, from readily available meteorological data, concentration and dosage fields downwind from ground-level and elevated sources of toxic fuel emissions. Mathematical model is applicable to hot plume rise from industrial stacks and should also be of interest to air pollution meteorologists

Geometrical Expression for the Angular Resolution of a Network of Gravitational-Wave Detectors

We report for the first time general geometrical expressions for the angular resolution of an arbitrary network of interferometric gravitational-wave (GW) detectors when the arrival-time of a GW is unknown. We show explicitly elements that decide the angular resolution of a GW detector network. In particular, we show the dependence of the angular resolution on areas formed by projections of pairs of detectors and how they are weighted by sensitivities of individual detectors. Numerical simulations are used to demonstrate the capabilities of the current GW detector network. We confirm that the angular resolution is poor along the plane formed by current LIGO-Virgo detectors. A factor of a few to more than ten fold improvement of the angular resolution can be achieved if the proposed new GW detectors LCGT or AIGO are added to the network. We also discuss the implications of our results for the design of a GW detector network, optimal localization methods for a given network, and electromagnetic follow-up observations.Comment: 13 pages, for Phys. Rev.

The prevalence and burden of subthreshold generalized anxiety disorder: A systematic review

Background: To review the prevalence and impact of generalized anxiety disorder (GAD) below the diagnostic threshold and explore its treatment needs in times of scarce healthcare resources.Methods: A systematic literature search was conducted until January 2013 using PUBMED/MEDLINE, PSYCINFO, EMBASE and reference lists to identify epidemiological studies of subthreshold GAD, i.e. GAD symptoms that do not reach the current thresholds of DSM-III-R, DSM-IV or ICD-10. Quality of all included studies was assessed and median prevalences of subthreshold GAD were calculated for different subpopulations.Results: Inclusion criteria led to 15 high-quality and 3 low-quality epidemiological studies with a total of 48,214 participants being reviewed. Whilst GAD proved to be a common mental health disorder, the prevalence for subthreshold GAD was twice that for the full syndrome. Subthreshold GAD is typically persistent, causing considerably more suffering and impairment in psychosocial and work functioning, benzodiazepine and primary health care use, than in non-anxious individuals. Subthreshold GAD can also increase the risk of onset and worsen the course of a range of comorbid mental health, pain and somatic disorders; further increasing costs. Results are robust against bias due to low study quality.Conclusions: Subthreshold GAD is a common, recurrent and impairing disease with verifiable morbidity that claims significant healthcare resources. As such, it should receive additional research and clinical attention. © 2014 Haller et al.; licensee BioMed Central Ltd

Cobalt-Catalyzed Hydrosilylation of Carbon Dioxide to the Formic Acid, Formaldehyde, and Methanol Level—How to Control the Catalytic Network?

The selective hydrosilylation of carbon dioxide (CO2) to either the formic acid, formaldehyde, or methanol level using a molecular cobalt(II) triazine complex can be controlled based on reaction parameters such as temperature, CO2 pressure, and concentration. Here, we rationalize the catalytic mechanism that enables the selective arrival at each product platform. Key reactive intermediates were prepared and spectroscopically characterized, while the catalytic mechanism and the energy profile were analyzed with density functional theory (DFT) methods and microkinetic modeling. It transpired that the stepwise reduction of CO2 involves three consecutive catalytic cycles, including the same cobalt(I) triazine hydride complex as the active species. The increasing kinetic barriers associated with each reduction step and the competing hydride transfer steps in the three cycles corroborate the strong influence of the catalyst environment on the product selectivity. The fundamental mechanistic insights provide a consistent description of the catalytic system and rationalize, in particular, the experimentally verified opportunity to steer the reaction toward the formaldehyde product as the chemically most challenging reduction level

Structural basis of human transcription–DNA repair coupling

Transcription-coupled DNA repair removes bulky DNA lesions from the genome1,2 and protects cells against ultraviolet (UV) irradiation3. Transcription-coupled DNA repair begins when RNA polymerase II (Pol II) stalls at a DNA lesion and recruits the Cockayne syndrome protein CSB, the E3 ubiquitin ligase, CRL4CSA and UV-stimulated scaffold protein A (UVSSA)3. Here we provide five high-resolution structures of Pol II transcription complexes containing human transcription-coupled DNA repair factors and the elongation factors PAF1 complex (PAF) and SPT6. Together with biochemical and published3,4 data, the structures provide a model for transcription–repair coupling. Stalling of Pol II at a DNA lesion triggers replacement of the elongation factor DSIF by CSB, which binds to PAF and moves upstream DNA to SPT6. The resulting elongation complex, ECTCR, uses the CSA-stimulated translocase activity of CSB to pull on upstream DNA and push Pol II forward. If the lesion cannot be bypassed, CRL4CSA spans over the Pol II clamp and ubiquitylates the RPB1 residue K1268, enabling recruitment of TFIIH to UVSSA and DNA repair. Conformational changes in CRL4CSA lead to ubiquitylation of CSB and to release of transcription-coupled DNA repair factors before transcription may continue over repaired DNA

Calculations of the Local Density of States for some Simple Systems

A recently proposed convolution technique for the calculation of local density of states is described more thouroughly and new results of its application are presented. For separable systems the exposed method allows to construct the ldos for a higher dimensionality out of lower dimensional parts. Some practical and theoretical aspects of this approach are also discussed.Comment: 5 pages, 3 figure

Solitary Dust--Acoustic Waves in a Plasma with Two-Temperature Ions and Distributed Grain Size

The propagation of weakly nonlinear dust--acoustic waves in a dusty plasma containing two ion species with different temperatures is explored. The nonlinear equations describing both the quadratic and cubic plasma nonlinearities are derived. It is shown that the properties of dust--acoustic waves depend substantially on the grain size distribution. In particular, for solitary dust--acoustic waves with a positive potential to exist in a plasma with distributed grain size, it is necessary that the difference between the temperatures of two ion species be large that that in the case of unusized grains.Comment: 16 pages, 6 figure

Processed Strong-Motion Records from the Limón, Costa Rica Earthquake of 22 April 1991

Están disponibles los registros digitales obtenidos para uso de los investigadores interesados en estudiar la severidad del terremoto desde el punto de vista instrumental. Se incluyen los acelerogramas obtenidos con equipo Kinemetrics SMA-1 y sus correspondientes integraciones, velocidades y desplazamientos. Se trata de archivos de caracteres ASCII fácilmente legible por medio de diferentes rutinas de análisis de datos.Strong-motion records were recovered from 15 accelerographs at 14 stations operated by the Strong Motion Instrumentation Program of the Earthquake Engineering Laboratory (EEL) at the University of Costa Rica (Santana and others, 1991) following the damaging Limón, Costa Rica earthquake of April 22, 1991. The sites range in epicentral distance from 73 to 160 km; peak horizontal accelerations at ground level ranged from 0.03 to 0.27 g. The accelerograms are characterized by long duration of strong shaking, of approximately 30 seconds. An extensive strong motion data set from a moment magnitude (Mw) 7.5 earthquake is rare. Because of the importance of these data not only to Costa Rica but also to California, the California Strong Motion Instrumentation Program (CSMIP), in cooperation with the University of Costa Rica, digitized and processed these data for distribution to engineers, seismologists and others concerned with the seismic safety problem. This processed data is the second extensive set of data from an earthquake with magnitude between the magnitude 7 Lorna Prieta earthquake and the magnitude 7.8 Chile and Tabas, Iran earthquakes.Universidad de Costa Rica/[]/UCR/Costa RicaUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ingeniería::Instituto Investigaciones en Ingeniería (INII

The structure of a dimeric form of SARS-CoV-2 polymerase

The coronavirus SARS-CoV-2 uses an RNA-dependent RNA polymerase (RdRp) to replicate and transcribe its genome. Previous structures of the RdRp revealed a monomeric enzyme composed of the catalytic subunit nsp12, two copies of subunit nsp8, and one copy of subunit nsp7. Here we report an alternative, dimeric form of the enzyme and resolve its structure at 5.5 Å resolution. In this structure, the two RdRps contain only one copy of nsp8 each and dimerize via their nsp7 subunits to adopt an antiparallel arrangement. We speculate that the RdRp dimer facilitates template switching during production of sub-genomic RNAs