The pause-initiation limit restricts transcription activation in human cells.

Eukaryotic gene transcription is often controlled at the level of RNA polymerase II (Pol II) pausing in the promoter-proximal region. Pausing Pol II limits the frequency of transcription initiation ('pause-initiation limit'), predicting that the pause duration must be decreased for transcriptional activation. To test this prediction, we conduct a genome-wide kinetic analysis of the heat shock response in human cells. We show that the pause-initiation limit restricts transcriptional activation at most genes. Gene activation generally requires the activity of the P-TEFb kinase CDK9, which decreases the duration of Pol II pausing and thereby enables an increase in the productive initiation frequency. The transcription of enhancer elements is generally not pause limited and can be activated without CDK9 activity. Our results define the kinetics of Pol II transcriptional regulation in human cells at all gene classes during a natural transcription response

A quantum central limit theorem for non-equilibrium systems: Exact local relaxation of correlated states

We prove that quantum many-body systems on a one-dimensional lattice locally relax to Gaussian states under non-equilibrium dynamics generated by a bosonic quadratic Hamiltonian. This is true for a large class of initial states - pure or mixed - which have to satisfy merely weak conditions concerning the decay of correlations. The considered setting is a proven instance of a situation where dynamically evolving closed quantum systems locally appear as if they had truly relaxed, to maximum entropy states for fixed second moments. This furthers the understanding of relaxation in suddenly quenched quantum many-body systems. The proof features a non-commutative central limit theorem for non-i.i.d. random variables, showing convergence to Gaussian characteristic functions, giving rise to trace-norm closeness. We briefly relate our findings to ideas of typicality and concentration of measure.Comment: 27 pages, final versio

Measuring entanglement in condensed matter systems

We show how entanglement may be quantified in spin and cold atom many-body systems using standard experimental techniques only. The scheme requires no assumptions on the state in the laboratory and a lower bound to the entanglement can be read off directly from the scattering cross section of Neutrons deflected from solid state samples or the time-of-flight distribution of cold atoms in optical lattices, respectively. This removes a major obstacle which so far has prevented the direct and quantitative experimental study of genuine quantum correlations in many-body systems: The need for a full characterization of the state to quantify the entanglement contained in it. Instead, the scheme presented here relies solely on global measurements that are routinely performed and is versatile enough to accommodate systems and measurements different from the ones we exemplify in this work.Comment: 6 pages, 2 figure

An Economic Assessment of the Myanmar Rice Sector: Current Developments and Prospects

In this study, the Myanmar rice economy is described in the context of the current political situation and state of national economic development. The forces that are changing rice production and exports are identified; however, the rate of development involves a complex integration of government intervention and politics, as well as availability of resources. Probable scenarios for rice production and export are projected based on recent growth trends and expected infrastructure development. The Arkansas Global Rice Model is used to integrate the Myanmar rice sector with the global rice market in developing projections

Acoustic Optimization for Anti-Phase Asymmetric Rotor

This investigation seeks to optimize the implementation of anti-phase alternating trailing edge (TE) patterns for rotor noise suppression. The design objective is to maximize reduction of noise perceived by the community while maintaining the aerodynamic thrust. Computations using a three-dimensional Unsteady-Reynolds-Averaged-Navier-Stokes (URANS) with k-w Shear Stress Transport (SST) turbulence model and Ffowcs-Williams and Hawkings (FW-H) formula are used to obtain aerodynamic thrust and far-field noise level. A parametric acoustic study of 13 configurations of KDE rotor with variable alternating trailing edge period, alternating trailing edge length, and trailing edge deflection angle is conducted. The best design candidate for the KDE rotor has a four-period TE waveform which results in a reduction in far-field noise level of 2.1 dB in the hover condition and a reduction of 1.1 dB in the forward flight condition at 9.7 m/s. A further parametric acoustic study is conducted for a different rotor manufactured by APC. Six APC rotor design candidates are simulated. The best design candidate 4H for the APC rotor results in a reduction in far-field noise level of 4.0 dB in the hover condition and a reduction of 1.3 dB in the forward flight condition at 9.7 m/s. A series of acoustic experiments in the Penn State University (PSU) anechoic chamber have been conducted. In the forward flight condition at 9.7 m/s, the APC anti-phase 4H rotor offers clear evidence of noise suppression capability across a wide range of the azimuthal angle. In the broadband frequency range of 2000-4000 Hz, the APC anti-phase 4H rotor produces as much as 6 dB noise reduction. The experimental results appear to confirm the noise suppression capability of the proposed anti-phase rotor design concepts