4,643 research outputs found
Tuning localized plasmons in nanostructured substrates for surface-enhanced Raman scattering
Comprehensive reflectivity mapping of the angular dispersion of nanostructured arrays comprising of inverted pyramidal pits is demonstrated. By comparing equivalently structured dielectric and metallic arrays, diffraction and plasmonic features are readily distinguished. While the diffraction features match expected theory, localised plasmons are also observed with severely flattened energy dispersions. Using pit arrays with identical pitch, but graded pit dimensions, energy scaling of the localised plasmon is observed. These localised plasmons are found to match a simple model which confines surface plasmons onto the pit sidewalls thus allowing an intuitive picture of the plasmons to be developed. This model agrees well with a 2D finite-difference time-domain simulation which shows the same dependence on pit dimensions. We believe these tuneable plasmons are responsible for the surface-enhancement of the Raman scattering (SERS) of an attached layer of benzenethiol molecules. Such SERS substrates have a wide range of applications both in security, chemical identification, environmental monitoring and healthcare
Antimicrobial Efficacy of an Innovative Emulsion of Medium Chain Triglycerides against Canine and Feline Periodontopathogens
The Online 'othering' of transgendering and non-binary people
In this chapter we provide an exposition and critical analysis of some ways in which transgender people are âotheredâ online and attempts to resist or challenge this. This is achieved through the discursive analysis of 1756 online comments made in response to ten YouTube videos concerning âgender neutral toiletsâ. Three themes were developed: âGender neutral toilets as sites of sexual dangerâ; âClaiming victimhood: Gender neutral toilets as undermining the rights of cisgender peopleâ; and âThe delegitimisation and othering of transgender peopleâ. The theme on delegitimisation and othering is elaborated in detail. It consists of subthemes concerning the invocation of nature and biology to construct transgender people as challenging the given order; the mobilisation of religious and moral values and norms; the delegitimisation of transgender people by constructing them as psychopathological; and the construction of transgenderism as a âmodern trendâ created by media and social media. The discursive resources used in othering transgender people overlap with those that have long been used in the offline denigration of sexual minority groups. We conclude that sexual and gender non-conformity is responded to with a limited set of tropes that delegitimise and other non-conforming people in culturally recognisable ways. We note that the framing of effective resistance to anti-transgender, othering online talk is not straightforward but calls for creative, evidence-based, contextually-informed discursive labour
The development and application of a normative framework for considering uncertainty and variability in economic evaluation
The focus of this thesis is in the development and application of a normative framework for handling both variability and uncertainty in making decisions using economic evaluation. The framework builds on the recent work which takes an intuitive Bayesian approach to handling uncertainty as well as adding a similar approach for the handling of variability. The technique of stratified cost effectiveness analysis is introduced as an innovative, intuitive and theoretically sound basis for consideration of variability with respect to cost effectiveness. The technique requires the identification of patient strata where there are differences between strata but individual strata are relatively homogenous. For handling uncertainty, the normative framework requires a twofold approach. First, the cost effectiveness of therapies within each patient stratum must be assessed using probabilistic analysis. Secondly, techniques for estimation of the expected value of perfect information should be applied to determine an efficient research plan for the disease of interest. For the latter, a new technique for estimating EVPI based on quadrature is described which is both accurate and allows simpler calculation of the expected value of sample information. In addition the unit normal loss integral method previously ignored as a method of estimating EVPPI is shown to be appropriate in specific circumstances. The normative framework is applied to decisions relating to the public funding of the treatment of osteoporosis in the province of Ontario. The optimal limited use criteria would be to fund treatment with alendronate for women aged 75 years and over with previous fracture and 77 years and over with no previous fracture. An efficient research plan would fund a randomised controlled trial comparing etidronate to no therapy with a sample size of 640. Certain other research studies are of lesser value. Subsequent to the analysis contained in this thesis, the province of Ontario revised there limited use criteria to be broadly in line with the conclusions of this analysis. Thus, the application of the framework to this area demonstrates both its feasibility and acceptability. The normative framework developed in this thesis provides an optimal solution for decision makers in terms of handling uncertainty and variability in economic evaluation. Further research refining methods for estimating information value and considering other forms of uncertainty within models will enhance the framework.EThOS - Electronic Theses Online ServiceUniversity of Ottawa : Ottawa Health Research InstituteGBUnited Kingdo
Estimating the potential impact of the Australian government's reformulation targets on household sugar purchases
BACKGROUND: Countries around the world are putting in place sugar reformulation targets for packaged foods to reduce excess sugar consumption. The Australian government released its voluntary sugar reformulation targets for nine food categories in 2020. We estimated the potential impact of these targets on household sugar purchases and examined differences by income. For comparison, we also modelled the potential impact of the UK sugar reduction targets on per capita sugar purchases as the UK has one of the most comprehensive sugar reduction strategies in the world. METHODS: Grocery purchase data from a nationally representative consumer panel (n=7,188) in Australia was linked with a large database (FoodSwitch) with product-specific sugar content information for packaged foods (n=25,261); both datasets were collected in 2018. Potential reductions in per capita sugar purchases were calculated overall and by food category. Differences in sugar reduction across income level were assessed by analysis of variance. RESULTS: In 2018, the total sugar acquired from packaged food and beverage purchases consumed at-home was 56.1 g/day per capita. Australia's voluntary reformulation targets for sugar covered 2,471/25,261 (9.8%) unique products in the FoodSwitch dataset. Under the scenario that all food companies adhered to the voluntary targets, sugar purchases were estimated to be reduced by 0.9 g/day per capita, which represents a 1.5% reduction in sugar purchased from packaged foods. However, if Australia adopted the UK targets, over twice as many products would be covered (n=4,667), and this would result in a more than four times greater reduction in sugar purchases (4.1 g/day per capita). It was also estimated that if all food companies complied with Australia's voluntary sugar targets, reductions to sugar would be slightly greater in low-income households compared with high-income households by 0.3 g/day (95%CI 0.2 - 0.4 g/day, p<0.001). CONCLUSIONS: Sugar-reduction policies have the potential to substantially reduce population sugar consumption and may help to reduce health inequalities related to excess sugar consumption. However, the current reformulation targets in Australia are estimated to achieve only a small reduction to sugar intakes, particularly in comparison to the UK's sugar reduction program
Recommended from our members
Fluoride-Salt-Cooled High-Temperature Reactor (FHR) Using British Advanced Gas-Cooled Reactor (AGR) Refueling Technology and Decay Heat Removal Systems That Prevent Salt Freezing
The FHR uses graphite-matrix coated-particle fuel (same as high-temperature gas-cooled reactors (HTGRs)) and a clean liquid salt coolant. It delivers heat to industry or the power cycle at temperatures between 600 and 700°C with higher average heat delivery temperatures than other reactors. The liquid- salt-coolant melting point is above 450°C. The high minimum temperatures present refueling challenges and require special features to control temperaturesâavoiding excessively high temperatures and freezing of the coolant that could impact decay heat cooling systems. We describe herein a pre-conceptual FHR design that addresses many of these challenges by adopting features from the British AGR and alternative decay heat cooling systems. The basis for specific design choices are described.
The AGRs are carbon-dioxide cooled and graphite-moderated reactors that use cylindrical fuel subassemblies with vertical refueling at 650°Câmeeting FHR high-temperature refueling requirements. The 14 AGRs have operated for many decades. The AGR uses 8 cylindrical fuel sub-assemblies each a meter tall coupled axially together by a metal stringer to create a long fuel assembly. The stringer assemblies are in vertical channels in a graphite core that provides neutron moderation. This geometric core design is compatible with an FHR using graphite-matrix coated-particle fuel. The FHR uses a once- through fuel cycle. The design minimizes used nuclear fuel volumes relative to other FHR and HTGR designs. The primary system is inside a secondary liquid-salt-filled tank that (1) provides an added heat sink for decay heat, (2) helps ensure no freezing of primary system salt, and (3) helps ensure no major fuel failures in a beyond-design-basis accident. The refueling standpipes above each stringer fuel assembly in the AGR core with modifications can be used in an FHR for refueling and provide efficient heat transfer between the primary system and the secondary liquid-salt-filled tank. The passive decay heat removal system uses heat-pipes that turn on and off at a preset temperature to avoid overheating the core in a reactor accident and avoid freezing the salt coolant as decay heat decreases after reactor shutdown
An investigation into CLIL-related sections of EFL coursebooks : issues of CLIL inclusion in the publishing market
The current ELT global coursebook market has embraced CLIL as a weak form of bilingual education and an innovative component to include in General English coursebooks for EFL contexts. In this paper I investigate how CLIL is included in ELT coursebooks aimed at
teenaged learners, available to teachers in Argentina. My study is based on the content analysis of four series which include a section advertised as CLIL-oriented. Results suggest that such sections are characterised by (1) little correlation between featured subject specific content and school curricula in L1, (2) oversimplification of contents, and (3) dominance of reading skills development and lower-order thinking tasks. Through this study, I argue that
CLIL components become superficial supplements rather than a meaningful attempt to promote weak forms of bilingual education
The effects of a supermarket-based intervention on the nutritional quality of private-label foods: a prospective study
Private-label products, products owned by supermarkets, are a growing area of the food supply. The aim of this study was to assess the effect of an intervention that provided an Australian supermarket ('intervention supermarket') with comparative nutrition data to improve the healthiness of their private-label range. Between 2015 and 2016, the intervention supermarket received reports that ranked the nutritional quality of their products against competitors. Changes in the nutrient content (sodium, sugar, saturated fat, energy and Health Star Rating) of products from the intervention supermarket between 2015 and 2018 were compared against changes achieved for three comparators (private-label products from two other supermarkets and branded products). The intervention supermarket achieved a significantly greater reduction in the sodium content of their products relative to all three comparators, which ranged between -104 and -52 mg/100 g (all p 0.05). Providing comparative nutrition information to a supermarket may be ineffective in improving the healthiness of their private-label products, likely due to competing factors that play a role in the decision-making process behind product reformulation and product discontinuation/innovation
Foreign Direct Investments in Business Services: Transforming the VisegrĂĄd Four Region into a Knowledge-based Economy?
Foreign direct investments (FDIs) in the service sector are widely attributed an important role in bringing more skill-intensive activities into the Visegrad Four (V4). This regionâcomprising Poland, the Czech Republic, Hungary and Slovakiaârelied heavily on FDIs in manufacturing, which was often found to generate activities with limited skill content. This contribution deconstructs the chaotic concept of âbusiness servicesâ by analysing the actual nature of service sector activities outsourced and offshored to the V4. Using the knowledge-based economy (KBE) as a benchmark, the paper assesses the potential of service sector outsourcing in contributing to regional competitiveness by increasing the innovative capacity. It also discusses the role of state policies towards service sector FDI (SFDI). The analysis combines data obtained from case studies undertaken in service sector outsourcing projects in V4 countries. Moreover, it draws on interviews with senior employees of investment promotion agencies and publicly available data and statistics on activities within the service sector in the region. It argues that the recent inward investments in business services in the V4 mainly utilize existing local human capital resources, and their contribution to the development of the KBE is limited to employment creation and demand for skilled labour
- âŠ