On alpha stable distribution of wind driven water surface wave slope

We propose a new formulation of the probability distribution function of wind driven water surface slope with an $\alpha$-stable distribution probability. The mathematical formulation of the probability distribution function is given under an integral formulation. Application to represent the probability of time slope data from laboratory experiments is carried out with satisfactory results. We compare also the $\alpha$-stable model of the water surface slopes with the Gram-Charlier development and the non-Gaussian model of Liu et al\cite{Liu}. Discussions and conclusions are conducted on the basis of the data fit results and the model analysis comparison.Comment: final version of the manuscript: 25 page

Knowlesi malaria in Vietnam

The simian malaria parasite Plasmodium knowlesi is transmitted in the forests of Southeast Asia. Symptomatic zoonotic knowlesi malaria in humans is widespread in the region and is associated with a history of spending time in the jungle. However, there are many settings where knowlesi transmission to humans would be expected but is not found. A recent report on the Ra-glai population of southern central Vietnam is taken as an example to help explain why this may be so

Cell surface localization of tissue transglutaminase is dependent on a fibronectin-binding site in its N-terminal beta-sandwich domain

Increasing evidence indicates that tissue transglutaminase (tTG) plays a role in the assembly and remodeling of extracellular matrices and promotes cell adhesion. Using an inducible system we have previously shown that tTG associates with the extracellular matrix deposited by stably transfected 3T3 fibroblasts overexpressing the enzyme. We now show by confocal microscopy that tTG colocalizes with pericellular fibronectin in these cells, and by immunogold electron microscopy that the two proteins are found in clusters at the cell surface. Expression vectors encoding the full-length tTG or a N-terminal truncated tTG lacking the proposed fibronectin-binding site (fused to the bacterial reporter enzyme β-galactosidase) were generated to characterize the role of fibronectin in sequestration of tTG in the pericellular matrix. Enzyme-linked immunosorbent assay style procedures using extracts of transiently transfected COS-7 cells and immobilized fibronectin showed that the truncation abolished fibronectin binding. Similarly, the association of tTG with the pericellular matrix of cells in suspension or with the extracellular matrix deposited by cell monolayers was prevented by the truncation. These results demonstrate that tTG binds to the pericellular fibronectin coat of cells via its N-terminal β-sandwich domain and that this interaction is crucial for cell surface association of tTG

On being a mentor

This article explores issues relating to mentoring students, particularly ophthalmic nursing students. It highlights the importance of mentorship in learning in practice, which in turn is critical to students' education in a competency-based profession. It considers the factors essential in successful mentoring, including two-way feedback, and the importance of mentors understanding the nature of the psychological processes involved and how to assess students' learning and competencies. It also highlights the crucial gate-keeping role of mentors in ensuring that students are fit to practise, and the importance of nurse mentors themselves being fit to practise

A Bayesian Analogue of Gleason's Theorem

We introduce a novel notion of probability within quantum history theories and give a Gleasonesque proof for these assignments. This involves introducing a tentative novel axiom of probability. We also discuss how we are to interpret these generalised probabilities as partially ordered notions of preference and we introduce a tentative generalised notion of Shannon entropy. A Bayesian approach to probability theory is adopted throughout, thus the axioms we use will be minimal criteria of rationality rather than ad hoc mathematical axioms.Comment: 14 pages, v2: minor stylistic changes, v3: changes made in-line with to-be-published versio