Creating commons: PhotoVoice philosophy in a third space

Teach Toledo is a program that the authors co-coordinate using community assets to create a third space to confront systemic racism’s impact on teacher education programs and facilitate hybridity (Bhaba, 1994). Diverse student cohort members use their lived experience as the base for their individual and shared urban educational philosophies, coordinated in a first-year horizontally and vertically integrated curriculum including written compositions and a PhotoVoice project. “Creating commons” refers not only to provision of a third space as a common space where private experiences can be combined to create a hybrid, new understanding, but also to the creative act of fashioning and communicating a common purpose, i.e., a common philosophy of education. In this paper the authors ask: How can faculty and students develop a shared philosophy of possibility for urban education? What value can be gained from grounding teacher education in shared philosophy

Coordination of Nucleases and Helicases during DNA Replication and Double-strand Break Repair

Nucleases and helicases are involved in numerous steps in DNA replication and repair. Nucleases act on intermediates in DNA replication created by DNA polymerases (Chapter 4) and helicases (Chapter 3). They can create substrates for repair as in Okazaki fragment processing (OFP) and homologous recombination. They can also create substrates for activation of a checkpoint response, or participate in downregulation of checkpoints. In the special case of telomere replication, they are also involved in essential processing steps (Chapter 8). Nucleases known to act during DNA replication include Dna2, Rad27, Mre11, Sae2, Exo1, RNaseH, Yen1 andMus81/Mms4. Of these, Dna2, Exo1 and Mre11 are of particular interest because they have been identified as crucial activities that initiate repair of double-strand breaks (DSBs) by homologous recombination and thus form an intrinsic link between DNA replication and repair of DSBs derived from replication fork failure. The action of the nucleases is coordinated with those of a number of helicases and is discussed here in the context of a network of their interactions that combine to maintain genome integrity during DNA replication

Student characteristics and self-concept of secondary career and technical education students in a north central Texas region

Self-concept, discussed as a scholarly topic since the time of Socrates and Plato, is an important theoretical construct in education because self-concept is considered to be a desirable trait and a facilitator of positive future behavior. The purpose of this study was to examine the relationship between the characteristics of students enrolled in career and technical education (CTE) programs and students' self-concept scores as measured by specific subscales from the Self-Description Questionnaire (SDQ). A total of 196 male and 89 female secondary students (Grades 9-12) enrolled in arts, audio/video technology and communications cluster courses in North Central Texas school districts participated in the study. Student characteristic variables of interest were age, gender, CTE program enrollment, and participation in CTE. The self-concept subscales analyzed were General, Academic, Verbal, Math, and Problem Solving. A canonical correlation analysis was conducted using the four student characteristic variables as predictors of the five self-concept variables to evaluate the multivariate shared relationship between the two variable sets. The full model across all functions explained about 23% of the variance between the variable sets. Function 1 explained 15% of the shared variance and Function 2 explained 7% of the variance that remained. This study detected a relationship between specific student characteristics and self-concept as measured on certain domain-specific first-order factors. Gender and participation in CTE were found to be related to verbal self-concept and problem-solving self-concept. Results suggest that females in arts-based CTE programs have a higher verbal self-concept than their male counterparts; male students have a higher problem-solving self-concept. Results further suggest that students with a high level of participation in CTE also have high verbal and problem-solving self-concepts

Coordination of Nucleases and Helicases during DNA Replication and Double-strand Break Repair

Nucleases and helicases are involved in numerous steps in DNA replication and repair. Nucleases act on intermediates in DNA replication created by DNA polymerases (Chapter 4) and helicases (Chapter 3). They can create substrates for repair as in Okazaki fragment processing (OFP) and homologous recombination. They can also create substrates for activation of a checkpoint response, or participate in downregulation of checkpoints. In the special case of telomere replication, they are also involved in essential processing steps (Chapter 8). Nucleases known to act during DNA replication include Dna2, Rad27, Mre11, Sae2, Exo1, RNaseH, Yen1 andMus81/Mms4. Of these, Dna2, Exo1 and Mre11 are of particular interest because they have been identified as crucial activities that initiate repair of double-strand breaks (DSBs) by homologous recombination and thus form an intrinsic link between DNA replication and repair of DSBs derived from replication fork failure. The action of the nucleases is coordinated with those of a number of helicases and is discussed here in the context of a network of their interactions that combine to maintain genome integrity during DNA replication

Managing resources in later life: older people's experience of change and continuity

This report explores the changing lives of older people and shows how resources are used to manage change and maintain stability. An ageing population continues to be of policy concern, in relation to meeting the needs of older people now, and for future welfare provision. This research explores how older people plan, use and value the different resources available to them. Resources are broadly defined, to explore the relative value of different structural, social and individual resources and how they interlink. This holistic overview highlights the complexity of older people’s lives, the variety of resources that people draw on to help manage change and the work involved in maintaining continuity and preventing change. In-depth interviews with people (aged 65–84 at the first interview) were conducted two years apart to explore their changing needs and resources as they move through later life

Strategies for thiazole/oxazole-modified microcin discovery

Natural products continue to be an important source of therapeutically-relevant compounds. With the advent of inexpensive genome sequencing it has become apparent that bacteria produce a larger array of natural products than was previously believed. This new wealth in sequence data has potential to be helpful for the discovery of novel compounds by using genome mining. Although strategies of genome mining have become more efficient and capable of identifying novel biosynthetic gene clusters, it remains difficult to correlate gene clusters with natural products. In this dissertation I discuss limitations with the current methods of genome mining and correlating individual natural products with gene clusters. Furthermore, I characterize a rapidly growing family of natural products, the thiazole/oxazole-modified microcins (TOMMs), and discuss novel methods used to correlate the gene clusters to natural products from this family of metabolites. In chapter 2, I establish the sequence diversity and structural capability of bacteria and archaea to produce TOMM natural products. This genome mining characterization was used to identify nine novel classes of TOMMs, including one class from archaeal producers. In chapter 3, I discuss the utilization of genetic techniques to identify and isolate the TOMM natural product from the archaeal species Sulfolobus acidocaldarius. I demonstrate that although genetic manipulation has been previously used for the identification of natural products, comparative metabolomics is difficult to use for routine identification of low-abundance natural products such as the TOMM from S. acidocaldarius. Very few methods have been created to identify natural products from particular gene clusters. Therefore, in chapter 4, I discuss the creation of a novel method for the rapid identification of natural products following bioinformatics prioritization of antibiotic producing strains. This method utilizes the combination of genome mining and the chemical reactivity of natural products to discover new compounds. Dehydrated amino acids are modified residues commonly found in natural products such as TOMMs. I utilize the mild electrophilic chemical reactivity of dehydrated amino acids to label these natural products using a soft nucleophilic probe. These labeled natural products were easily detected using comparative mass spectrometry. Bacterial strains were prioritized by the genome mining established in chapter 2 to reduce the screening time to find a novel natural product. This dissertation presents the addition of novel genome mining and natural product discovery techniques to increase the discovery and production of therapeutically-relevant compounds

An exemplar of GP commissioning and child and adolescent mental health service partnership: Cambridge 1419 young people's service

Purpose – The purpose of this paper is to draw attention to commissioning and service structures enabling implementation of evidence-based cost-effective care as illustrated by the “1419” young people’s service treating mild to moderate severity mental health difficulties in teenagers old 14 to 19 years. The authors describe relevant local contextual factors: “relational commissioning”, demand capacity planning and a receptive and safe clinical context. Design/methodology/approach – The authors used a participant observer qualitative research design to describe commissioning and service design. Treatment outcomes were analysed using a quantitative design and found significant improvement in service user mental health and daily function. These results will be reported elsewhere. Findings – The dynamics and structures described here enabled clear shared goals between service user, service purchaser, service provider and service partners. The goals and design of the service were not static and were subject to ongoing development using routine outcome measures and conversations between referrers, commissioners, service users and within the team about what was and was not working. Research limitations/implications – The methods are limited by the lack of a prospective systematic evaluation of the implementation process and by the time limitations of the service. Practical implications – Implementation of whole system change such as that envisioned by Children and Young People’s Improving Access to Psychological Therapies requires consideration of local context and process of implementation. The authors suggest key factors: consideration of “relational commissioning” with purchasers, providers and service users designing services together; case-level collaboration between services and partner agencies; smaller child and adolescent mental health teams eliminating competing task demands, permitting speed of action, providing psychological safety for staff, promoting shared goals and innovation; rigorous demand/capacity planning to inform funding. Social implications – The failings of child and adolescent mental health services (CAMHS) are detailed in the Department of Health report “Future in mind: promoting, protecting and improving our children and young people’s mental health and wellbeing” (2015). The aims of the report are contingent on the ability of local health providers to implement its recommendations. The authors provide a theoretical approach to enable this implementation. Originality/value – To date there are no published papers addressing the key characteristics enabling implementation of evidence-based practice within CAMHS. The unique experience in forming the“1419” service has important implications nationally and brings together evidence of an effective service within a theoretical underpinned context. Cambridgeshire and Peterborough NHS Foundation TrustThis is the author accepted manuscript. The final version is available from Emerald Publishing Group via http://dx.doi.org/10.1108/JICA-08-2015-003

Use of Drawings to Explore US Women's Perspectives on Why People Might Decline HIV Testing

The purpose of this research is to explore through drawings and verbal descriptions women's perspectives about reasons why persons might decline human immunodeficiency virus (HIV) testing. We asked 30 participants to draw a person that would NOT get tested for HIV and then explain drawings. Using qualitative content analysis, we extracted seven themes. We found apprehension about knowing the result of an HIV test to be the most commonly identified theme in women's explanations of those who would not get tested. This technique was well received and its use is extended to HIV issues