PASOKification: Fall of the European Center Left or a Transformation of the System

The party systems of Europe since 1945 have been defined by the division between one large center-left and one large center-right party with usually smaller parties of the center, left, or right. However, in the 21st century and especially since 2010, the center-left has seen its support plunge across Europe with a few notable exceptions. The Socialist Party of France in 2017 held the presidency and controlled the National Assembly. Nevertheless, not even three years later, the party is on the verge of extinction and beset by numerous splits. The Social Democratic Party of Germany has seen its support plunge and is faces challenges from the left by the Greens and the right by the Alternative for Germany (AfD). The question is then what explains this rapid and sometimes very sudden decline. Is there a longer-term shift in European party systems away from larger center-left parties to new alternatives, or is there another explanation? This article proposes that changing values have resulted in further political polarization. Voters are now concerned with identity and immigration issues, while materialist values have been deemphasized in recent years. Using a case study method, we analyze situations in Britain, France, Germany, and Italy and attempt to find common patterns and find answers to what is happening. We ultimately find that internal issues like lack of coherent messaging, poor leadership, and internal division have likely compounded the effects of political polarization and undermined the party\u27s efforts to restore their electoral prospects

An investigation into the diagnostic accuracy, reliability, acceptability and safety of a novel device for Continuous Ambulatory Vestibular Assessment (CAVA)

Dizziness is a common condition that is responsible for a significant degree of material morbidity and burden on health services. It is usually episodic and short-lived, so when a patient presents to their clinician, examination is normal. The CAVA (Continuous Ambulatory Vestibular Assessment) device has been developed to provide continuous monitoring of eye-movements, allowing insight into the physiological parameters present during a dizziness attack. This article describes the first clinical investigation into the medical and technical aspects of this new diagnostic system. Seventeen healthy subjects wore the device near continuously for up to thirty days, artificially inducing nystagmus on eight occasions. 405 days’ worth of data was captured, comprising around four billion data points. A computer algorithm developed to detect nystagmus demonstrated a sensitivity of 99.1% (95% CI: 95.13% to 99.98%) and a specificity of 98.6% (95% CI: 96.54% to 99.63%). Eighty-two percent of participants wore the device for a minimum of eighty percent of each day. Adverse events were self-limiting and mostly the consequence of skin stripping from the daily replacement of the electrodes. The device was shown to operate effectively as an ambulatory monitor, allowing the reliable detection of artificially induced nystagmus

1D convolutional neural networks for detecting nystagmus

Vertigo is a type of dizziness characterised by the subjective feeling of movement despite being stationary. One in four individuals in the community experience symptoms of dizziness at any given time, and it can be challenging for clinicians to diagnose the underlying cause. When dizziness is the result of a malfunction in the inner-ear, the eyes flicker and this is called nystagmus. In this article we describe the first use of Deep Neural Network architectures applied to detecting nystagmus. The data used in these experiments was gathered during a clinical investigation of a novel medical device for recording head and eye movements. We describe methods for training networks using very limited amounts of training data, with an average of 11 mins of nystagmus across four subjects, and less than 24 hours of data in total, per subject. Our methods work by replicating and modifying existing samples to generate new data. In a cross-fold validation experiment, we achieve an average F1 score of 0.59 (SD = 0.24) across all four folds, showing that the methods employed are capable of identifying periods of nystagmus with a modest degree of accuracy. Notably, we were also able to identify periods of pathological nystagmus produced by a patient during an acute attack of Ménière's Disease, despite training the network on nystagmus that was induced by different means

Nystagmus during an acute Ménière's attack: From prodrome to recovery

OBJECTIVE: We are currently undertaking a clinical investigation to evaluate the diagnostic capability of a system for detecting periods of pathological dizziness. This article presents an analysis of the data captured during an acute attack of Ménière's disease. DESIGN: The Continuous Ambulatory Vestibular Assessment (CAVA) device is worn by patients in the community, and continuously records eye and head movement data (vestibular telemetry). STUDY SAMPLE: A 53-year-old lady with a fifteen-year history of left-sided unilateral Ménière's disease. RESULTS: The patient wore the device nearly continuously for thirty days. The data revealed a three-hour long attack of vertigo consisting of four separate phases of nystagmus. The duration, beat-direction and slow phase velocity of the nystagmus evolved through time. The first phase contained isolated nystagmus beats which preceded the patient's record of the vertigo attack onset but coincided with anticipation of an impending vertigo attack. CONCLUSIONS: CAVA provides a unique insight into the physiological parameters present during episodes of dizziness. Here, it has provided the first full example of an acute Ménière's attack, including a period of prodrome. These findings have implications for the prediction of vertigo attack onset, for the diagnosis of Ménière's disease and other diseases resulting in dizziness

Aviram-Ratner rectifying mechanism for DNA base pair sequencing through graphene nanogaps

We demonstrate that biological molecules such as Watson-Crick DNA base pairs can behave as biological Aviram-Ratner electrical rectifiers because of the spatial separation and weak hydrogen bonding between the nucleobases. We have performed a parallel computational implementation of the ab-initio non-equilibrium Green's function (NEGF) theory to determine the electrical response of graphene---base-pair---graphene junctions. The results show an asymmetric (rectifying) current-voltage response for the Cytosine-Guanine base pair adsorbed on a graphene nanogap. In sharp contrast we find a symmetric response for the Thymine-Adenine case. We propose applying the asymmetry of the current-voltage response as a sensing criterion to the technological challenge of rapid DNA sequencing via graphene nanogaps

Towards providing an automated approach to differentiating the nystagmus of Ménière’s Disease, Vestibular Migraine and Benign Paroxysmal Positional Vertigo

Objective: The diagnosis of vertigo is challenging, particularly as patients usually present while asymptomatic. We have developed an ambulatory medical device that allows vestibular telemetry to record eye movements over a 30-day period to aid the diagnosis of vertigo. We have undertaken proof-of-concept work to identify unique properties of nystagmus that could be used to differentiate between three of the most common causes of vertigo: Ménière's disease, vestibular migraine, and Benign Paroxysmal Positional Vertigo. Patients: We analyze the nystagmus from patients with a diagnosis of Ménière's disease, vestibular migraine, and Benign Paroxysmal Positional Vertigo. Intervention(s): Our vestibular telemetry system includes a wearable, ambulatory monitor which continuously records horizontal and vertical eye-movements, as well as three-axis movements of the head. Main Outcome Measure(s): Horizontal and vertical eye-movement data, and three-axis head positioning data. Results: Sixteen participants were enrolled onto the study and three reported experiencing rotatory vertigo during their 30-day trial, confirmed by the presence of nystagmus in their eye-movement traces. Vestibular telemetry revealed distinct differences between the nystagmus produced during an acute Ménière's attack, and attacks of vestibular migraine and Benign Paroxysmal Positional Vertigo. Attack frequency, nystagmus duration, whether the nystagmus onset was motion provoked, nystagmus direction, slow phase velocity, and slow phase duration were found to be discriminatory features that could be exploited to allow an automated diagnosis to be made. Conclusions: The data provided by vestibular telemetry can be used to differentiate between different inner-ear causes of dizziness

Executive Order of 1870

This Executive Order, issued by President Ulysses S. Grant on April 12, 1870, established the Fort Berthold Reservation. In addition to Grant’s Executive Order, this document includes a series of letters, proposals, and endorsements for the creation of a reservation for the Mandan, Hidatsa, and Arikara. Importantly, this document also contains the original map outlining the proposed boundaries and the president’s diagram which significantly reducing the size of the reservation.https://commons.und.edu/indigenous-gov-docs/1195/thumbnail.jp

Reconstructing animated eye movements from electrooculography data to aid the diagnosis of vestibular disorders

Objective: To develop a method of visualising electrooculography data to improve the interpretability of nystagmus eye-movements captured using the Continuous Ambulatory Vestibular Assessment (CAVA®) device. Design: We are currently undertaking a clinical investigation to evaluate the capabilities of the CAVA® device to detect periods of pathological nystagmus. The work presented here was undertaken using unblinded data obtained from the preliminary phase of this investigation. Study sample: One patient with Ménière’s disease and one with Benign Paroxysmal Positional Vertigo. Results: Using the electrooculography data captured by the CAVA® device, we reconstructed 2D animations of patients’ eye movements during attacks of vertigo. We were able to reanimate nystagmus produced as a consequence of two conditions. Concurrent video footage showed that the animations were visually very similar to the patient’s actual eye-movements, excepting torsional eye-movements. Conclusions: The reconstructed animations provide an alternative presentation modality, enabling clinicians to largely interpret electrooculography data as if they were present during a vertigo attack. We were able to recreate nystagmus from attacks experienced in the community rather than a clinical setting. This information provides an objective record of a patient’s nystagmus and could be used to complement a full neurotologic history when considering diagnosis and treatment options

Clinical techniques and technology: Vestibular telemetry

When a patient presents to a clinician with dizziness, it can be difficult for the patient to describe their symptoms in a clear manner, and clinical examination often yields entirely normal results. Ideally, it would be favorable to measure key physiological parameters during their episodes of dizziness. From a clinical perspective, this would allow a more timely and more accurate diagnosis. From a research perspective, it would allow a greater understanding of how the vestibular system malfunctions as a consequence of vestibular disease. The authors of this report have been funded by the UK Medical Research Council to develop and test a novel technology to measure, record, and analyze key physiological parameters provided by the dizzy individual during an episode of dizziness while active in the community. We provide the context to evolving work in this field, the outcome of preliminary studies, and a consideration of future opportunities

Exploring the links between star formation and minor companions around isolated galaxies

Previous studies have shown that galaxies with minor companions exhibit an elevated star formation rate. We reverse this inquiry, constructing a volume-limited sample of \simL\star (Mr \leq -19.5 + 5 log h) galaxies from the Sloan Digital Sky Survey that are isolated with respect to other luminous galaxies. Cosmological simulations suggest that 99.8% of these galaxies are alone in their dark matter haloes with respect to other luminous galaxies. We search the area around these galaxies for photometric companions. Matching strongly star forming (EW(H{\alpha})\geq 35 \AA) and quiescent (EW(H{\alpha})< 35 \AA) samples for stellar mass and redshift using a Monte Carlo resampling technique, we demonstrate that rapidly star-forming galaxies are more likely to have photometric companions than other galaxies. The effect is relatively small; about 11% of quiescent, isolated galaxies have minor photometric companions at radii \leq 60 kpc h$^{-1}$ kpc while about 16% of strongly star-forming ones do. Though small, the cumulative difference in satellite counts between strongly star-forming and quiescent galaxies is highly statistically significant (PKS = 1.350 \times10$^{-3}$) out to to radii of \sim 100 h$^{-1}$ kpc. We discuss explanations for this excess, including the possibility that \sim 5% of strongly star-forming galaxies have star formation that is causally related to the presence of a minor companion.Comment: 7 pages, 6 figures, submitted to MNRA