A Sensitive Search for [N II]205 μm Emission in a z = 6.4 Quasar Host Galaxy

We present a sensitive search for the 3P1 → 3P0 ground-state fine structure line at 205 μm of ionized nitrogen ([N II]205μm) in one of the highest-redshift quasars (J1148+5251 at z = 6.42) using the IRAM 30 m telescope. The line is not detected at a (3σ) depth of 0.47 Jy km s^−1, corresponding to a [N II]205μm luminosity limit of L[N II] 7) using the Atacama Large Millimeter/submillimeter Array, for which the highly excited rotational transitions of CO will be shifted outside the accessible (sub-)millimeter bands

A Molecular Einstein Ring at z=4.12: Imaging the Dynamics of a Quasar Host Galaxy Through a Cosmic Lens

We present high-resolution (0.3") Very Large Array (VLA) imaging of the molecular gas in the host galaxy of the high redshift quasar PSS J2322+1944 (z=4.12). These observations confirm that the molecular gas (CO) in the host galaxy of this quasar is lensed into a full Einstein ring, and reveal the internal dynamics of the molecular gas in this system. The ring has a diameter of ~1.5", and thus is sampled over ~20 resolution elements by our observations. Through a model-based lens inversion, we recover the velocity gradient of the molecular reservoir in the quasar host galaxy of PSS J2322+1944. The Einstein ring lens configuration enables us to zoom in on the emission and to resolve scales down to ~1 kpc. From the model-reconstructed source, we find that the molecular gas is distributed on a scale of 5 kpc, and has a total mass of M(H2)=1.7 x 10^10 M_sun. A basic estimate of the dynamical mass gives M_dyn = 4.4 x 10^10 (sin i)^-2 M_sun, that is, only ~2.5 times the molecular gas mass, and ~30 times the black hole mass (assuming that the dynamical structure is highly inclined). The lens configuration also allows us to tie the optical emission to the molecular gas emission, which suggests that the active galactic nucleus (AGN) does reside within, but not close to the center of the molecular reservoir. Together with the (at least partially) disturbed structure of the CO, this suggests that the system is interacting. Such an interaction, possibly caused by a major `wet' merger, may be responsible for both feeding the quasar and fueling the massive starburst of 680 M_sun/yr in this system, in agreement with recently suggested scenarios of quasar activity and galaxy assembly in the early universe.Comment: 9 pages, 7 figures, to appear in ApJ (accepted June 27, 2008

350 μm dust emission from high-redshift quasars

We report detections of six high-redshift (1.8 ≤ z ≤ 6.4), optically luminous, radio-quiet quasars at 350 μm, using the SHARC II bolometer camera at the Caltech Submillimeter Observatory. Our observations double the number of high-redshift quasars for which 350 μm photometry is available. By combining the 350 μm measurements with observations at other submillimeter/millimeter wavelengths, for each source we have determined the temperature of the emitting dust (ranging from 40 to 60 K) and the far-infrared luminosity [(0.6-2.2) × 10^(13) L⊙]. The combined mean spectral energy distribution of all high-redshift quasars with two or more rest-frame far-infrared photometric measurements is best fit with a graybody with temperature of 47 ± 3 K and a dust emissivity power-law spectral index of β = 1.6 ± 0.1. This warm dust component is a good tracer of the starburst activity of the quasar host galaxy. The ratio of the far-infrared to radio luminosities of infrared-luminous, radio-quiet high-redshift quasars is consistent with that found for local star-forming galaxies

ALMA Imaging of Gas and Dust in a Galaxy Protocluster at Redshift 5.3: [CII] Emission in "Typical" Galaxies and Dusty Starbursts ~1 Billion Years after the Big Bang

We report interferometric imaging of [CII] and OH emission toward the center of the galaxy protocluster associated with the z=5.3 submillimeter galaxy (SMG) AzTEC-3, using the Atacama Large (sub)Millimeter Array (ALMA). We detect strong [CII], OH, and rest-frame 157.7 um continuum emission toward the SMG. The [CII] emission is distributed over a scale of 3.9 kpc, implying a dynamical mass of 9.7 x 10^10 Msun, and a star formation rate (SFR) surface density of Sigma_SFR = 530 Msun/yr/kpc2. This suggests that AzTEC-3 forms stars at Sigma_SFR approaching the Eddington limit for radiation pressure supported disks. We find that the OH emission is slightly blueshifted relative to the [CII] line, which may indicate a molecular outflow associated with the peak phase of the starburst. We also detect and dynamically resolve [CII] emission over a scale of 7.5 kpc toward a triplet of Lyman-break galaxies with moderate UV-based SFRs in the protocluster at ~95kpc projected distance from the SMG. These galaxies are not detected in the continuum, suggesting far-infrared SFRs of <18-54 Msun/yr, consistent with a UV-based estimate of 22 Msun/yr. The spectral energy distribution of these galaxies is inconsistent with nearby spiral and starburst galaxies, but resembles those of dwarf galaxies. This is consistent with expectations for young starbursts without significant older stellar populations. This suggests that these galaxies are significantly metal-enriched, but not heavily dust-obscured, "normal" star-forming galaxies at z>5, showing that ALMA can detect the interstellar medium in "typical" galaxies in the very early universe.Comment: 15 pages, 12 figures, 4 tables, to appear in ApJ (accepted October 15, 2014

Cephalexin: In Vitro and in Vivo Studies

Cephalexin, a derivative of cephalosporin C, produces high serum and urine concentrations after oral administration. In addition, it shows good activity in vitro against most gram-positive and some gram-negative organisms. This study reports the in vitro susceptibility to cephalexin of a series of clinical isolates, the serum levels and urine concentrations in human volunteers and the results of its use in infections due to susceptible organisms. Results of in vitro susceptibility testing reveal that cephalexin was effective against most strains of the gram-positive organisms tested — group A streptococci, pneumococci, and staphylococci — although the MIC\u27s are higher than those found for cephaloridine and ampicillin, with the one exception being penicillinase producing staphylococcus against which ampicillin is ineffective. Cephalexin is effective against most strains of indole-negative proteus, Klebsiella and E. coli, but all strains of enterobacter show resistance. Forty-seven patients with a variety of clinical illnesses were treated with cephalexin. Five of 14 patients with urinary tract infections were cured and nine had a remission followed by a bacteriologic relapse. All patients with soft tissue infection were cured as were nine of 12 patients with pneumonia. Of the three patients with pneumonia who were not cured, one improved, while two were classified as treatment failures. Similarly, 11 of 12 patients with streptococcal pharyngitis had a clinical remission, although in three, the organism was isolated after therapy. One patient with an associated coagulase-positive staphylococci cultured from the pharynx failed to respond to treatment

Rubella Immunization of Adult Females Using HPV-77 DK-12 Live Attenuated Rubella Virus

This study demonstrates the serologic response as measured by the HAl test and the side reactions of the HPV-77 DK-12 live rubella vaccine in a small group of adult females. One hundred percent seroconversion was obtained using this vaccine. The mean titers obtained in two separate time periods post-vaccination are higher than those reported for several other rubella virus vaccines. A 66% occurrence of joint symptomatology was recorded post-vaccination with a mean duration of 11.6 days; 24% of women who received placebo reported joint complaints which had a mean duration of 2.0 days. The difference between these two rates is somewhat greater than that reported for other HPV-77 strain vaccines and the average duration of these complaints is longer. The other symptoms reported postvaccination seemed insignificant when comparing both the placebo and the vaccine group. One woman became pregnant three months after vaccination and was subsequently therapeutically aborted. At the time of therapeutic abortion, attempts were unsuccessful to recover rubella virus from the products of conception and cervical swabs

A Method of Hospital Infection Surveillance Incorporating the Use of the Computer

The records of all patients in the hospital on a particular date were studied for hospital-acquired infections. Results were compared with a continuing surveillance based on discharge reporting. Collection of data was programmed for analysis by using the hospital computer. Thirteen per cent of the patients manifested an infection after admission, but before or on the survey day. Results elsewhere are similar. Areas of the hospital with a relatively higher incidence of infection did not have clusters of particular pathogens