Exposure of Escherichia coli to low-frequency vibrations

Low frequency mechanical vibration effects on biochemical mutant formation in E. col

Growth of Staphylococcus aureus in a null magnetic field environment

Growth of Staphylococcus in magnetic field environmen

The role of mentoring in the preparation of church planters of reproducing churches

https://place.asburyseminary.edu/ecommonsatsdissertations/1174/thumbnail.jp

Protein Ontology: A controlled structured network of protein entities

The Protein Ontology (PRO; http://proconsortium.org) formally defines protein entities and explicitly represents their major forms and interrelations. Protein entities represented in PRO corresponding to single amino acid chains are categorized by level of specificity into family, gene, sequence and modification metaclasses, and there is a separate metaclass for protein complexes. All metaclasses also have organism-specific derivatives. PRO complements established sequence databases such as UniProtKB, and interoperates with other biomedical and biological ontologies such as the Gene Ontology (GO). PRO relates to UniProtKB in that PRO’s organism-specific classes of proteins encoded by a specific gene correspond to entities documented in UniProtKB entries. PRO relates to the GO in that PRO’s representations of organism-specific protein complexes are subclasses of the organism-agnostic protein complex terms in the GO Cellular Component Ontology. The past few years have seen growth and changes to the PRO, as well as new points of access to the data and new applications of PRO in immunology and proteomics. Here we describe some of these developments

The Right to a Safe and Healthy Birth

The right to a safe and healthy birth is included in the declaration of human rights- the intrinsic allowances that humans are obligated to be protected by on a global scale. These rights, however, for some pregnant women have been submersed by lack of transportation, education and skilled birth attendants. Financial constraints and difficulty in obtaining adequate healthcare are also issues of concern. A review of literature pertaining to three different countries, the United States, China and India will be examined in light of safe and healthy birthing techniques for women worldwide. These countries were chosen due to their diverse injustice issues as it pertains to birthing rights. Education and advocacy efforts in relation to reproductive rights on a global scale will be discussed. Review of the literature not only reveals grave injustices for women and children but it also illuminates ways in which individuals can get involved to help promote the right to a safe and healthy birth. Several movements will be highlighted in order to provide the audience with practical advocacy, education, and relief effort implementations

FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice

Nonalcoholic fatty liver disease (NAFLD), a leading cause of liver dysfunction, is a metabolic disease that begins with steatosis. Sphingolipid metabolites, particularly ceramide and sphingosine-1-phosphate (S1P), have recently received attention for their potential roles in insulin resistance and hepatic steatosis. FTY720/fingolimod, a prodrug for the treatment of multiple sclerosis, is phosphorylated in vivo to its active phosphorylated form by sphingosine kinase 2 and has been shown to interfere with the actions of S1P and to inhibit ceramide biosynthesis. Therefore, in this study we investigated the effects of FTY720 in a diet-induced animal model of NAFLD (DIAMOND) that recapitulates the hallmarks of the human disease. The oral administration of FTY720 to these mice fed a high-fat diet and sugar water improved glucose tolerance and reduced steatosis. In addition to decreasing liver triglycerides, FTY720 also reduced hepatic sphingolipid levels, including ceramides, monohexosylceramides, and sphingomyelins, particularly the C16:0 and C24:1 species, as well as S1P and dihydro-S1P. FTY720 administration decreased diet-induced fatty acid synthase (FASN) expression in DIAMOND mice without affecting other key enzymes in lipogenesis. FTY720 had no effect on the expression of SREBP-1c, which transcriptionally activates FASN. However, in agreement with the notion that the active phosphorylated form of FTY720 is an inhibitor of histone deacetylases, FTY720-P accumulated in the liver, and histone H3K9 acetylation was markedly increased in these mice. Hence, FTY720 might be useful for attenuating FASN expression and triglyceride accumulation associated with steatosis. Keywords: lipogenesis; sphingolipids; sphingosine-1-phosphate

“some kind of thing it aint us but yet its in us”: David Mitchell, Russell Hoban, and metafiction after the millennium

This article appraises the debt that David Mitchell’s Cloud Atlas owes to the novels of Russell Hoban, including, but not limited to, Riddley Walker. After clearly mapping a history of Hoban’s philosophical perspectives and Mitchell’s inter-textual genre-impersonation practice, the article assesses the degree to which Mitchell’s metatextual methods indicate a nostalgia for by-gone radical aesthetics rather than reaching for new modes of its own. The article not only proposes several new backdrops against which Mitchell’s novel can be read but also conducts the first in-depth appraisal of Mitchell’s formal linguistic replication of Riddley Walker

Imaging X-Ray Polarimetry Explorer (IXPE) Risk Management

The Imaging X-ray Polarimetry Explorer (IXPE) project is an international collaboration to build and fly a polarization sensitive X-ray observatory. The IXPE Observatory consists of the spacecraft and payload. The payload is composed of three X-ray telescopes, each consisting of a mirror module optical assembly and a polarization-sensitive X-ray detector assembly; a deployable boom maintains the focal length between the optical assemblies and the detectors. The goal of the IXPE Mission is to provide new information about the origins of cosmic X-rays and their interactions with matter and gravity as they travel through space. IXPE will do this by exploiting its unique capability to measure the polarization of X-rays emitted by cosmic sources. The collaboration for IXPE involves national and international partners during design, fabrication, assembly, integration, test, and operations. The full collaboration includes NASA Marshall Space Flight Center (MSFC), Ball Aerospace, the Italian Space Agency (ASI), the Italian Institute of Astrophysics and Space Planetology (IAPS)/Italian National Institute of Astrophysics (INAF), the Italian National Institute for Nuclear Physics (INFN), the University of Colorado (CU) Laboratory for Atmospheric and Space Physics (LASP), Stanford University, McGill University, and the Massachusetts Institute of Technology. The goal of this paper is to discuss risk management as it applies to the IXPE project. The full IXPE Team participates in risk management providing both unique challenges and advantages for project risk management. Risk management is being employed in all phases of the IXPE Project, but is particularly important during planning and initial execution-the current phase of the IXPE Project. The discussion will address IXPE risk strategies and responsibilities, along with the IXPE management process which includes risk identification, risk assessment, risk response, and risk monitoring, control, and reporting

Shoreline change along sheltered coastlines: Insights from the neuse river estuary, NC, USA

Coastlines are constantly changing due to both natural and anthropogenic forces, and climate change and associated sea level rise will continue to reshape coasts in the future. Erosion is not only apparent along oceanfront areas; shoreline dynamics in sheltered water bodies have also gained greater attention. Additional estuarine shoreline studies are needed to better understand and protect coastal resources. This study uses a point-based approach to analyze estuarine shoreline change and associated parameters, including fetch, wave energy, elevation, and vegetation, in the Neuse River Estuary (NRE) at two contrasting scales, Regional (whole estuary) and Local (estuary partitioned into eight sections, based on orientation and exposure). With a mean shoreline-change rate of -0.58 m yr-1, the majority (93%) of the NRE study area is eroding. Change rates show some variability related to the land-use land-cover classification of the shoreline. Although linear regression analysis at the Regional Scale did not find significant correlations between shoreline change and the parameters analyzed, trends were determined from Local Scale data. Specifically, erosion rates, fetch, and wave exposure increase in the down-estuary direction, while elevation follows the opposite trend. Linear regression analysis between mean fetch and mean shoreline-change rates at the Local Scale provide a first-order approach to predict shoreline-change rates. The general trends found in the Local Scale data highlight the presence of underlying spatial patterns in shoreline-change rates within a complex estuarine system, but Regional Scale analysis suggests shoreline composition also has an important influence