19,388 research outputs found
Intrusive origin of the Sudbury Igneous Complex: Structural and sedimentological evidence
In recent years, many geoscientists have come to believe that the Sudbury event was exogenic rather than endogenic. Critical to a recent exogenic hypothesis is the impact melt origin of the Sudbury Igneous Complex (SIC). Such origin implies that the SIC was emplaced before deposition of the Whitewater Group, in contrast to origins in which the SIC postdates the lithification of the Onaping Formation. Structural and sedimentological evidence is summarized herein that supports an intrusion of the SIC after lithification of all Whitewater Group strata, and conflicts with the hypothesis advanced by other researchers
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Improved Co I Log(gf) Values and Abundance Determinations in the Photospheres of the Sun and Metal-Poor Star HD 84937
New emission branching fraction measurements for 898 lines of the first spectrum of cobalt (Co I) are determined from hollow cathode lamp spectra recorded with the National Solar Observatory 1 m Fourier transform spectrometer on Kitt Peak, AZ and a high-resolution echelle spectrometer. Published radiative lifetimes from laser induced fluorescence measurements are combined with the branching fractions to determine accurate absolute atomic transition probabilities for the 898 lines. Hyperfine structure (hfs) constants for levels of neutral Co in the literature are surveyed and selected values are used to generate complete hfs component patterns for 195 transitions of Co I. These new laboratory data are applied to determine the Co abundance in the Sun and metal-poor star HD 84937, yielding log epsilon(Co) = 4.955 +/- 0.007 (sigma = 0.059) based on 82 Co I lines and log epsilon(Co) = 2.785 +/- 0.008 (sigma = 0.065) based on 66 Co I lines, respectively. A Saha or ionization balance test on the photosphere of HD 84937 is performed using 16 UV lines of Co II, and good agreement is found with the Co I result in this metal-poor ([Fe I/H] = -2.32, [Fe II/H] = -2.32) dwarf star. The resulting value of [Co/Fe]= +0.14 supports a rise of Co/Fe at low metallicity that has been suggested in other studies.NASA NNX10AN93GNSF AST-1211055, AST-1211585McDonald Observator
Clinical and cost-effectiveness of capecitabine and tegafur with uracil for the treatment of metastatic colorectal cancer: systematic review and economic evaluation
Objectives:
To evaluate the clinical and costeffectiveness
of capecitabine and tegafur with uracil
(UFT/LV) as first-line treatments for patients with
metastatic colorectal cancer, as compared with 5-
fluorouracil/folinic acid (5-FU/FA) regimens.
Data sources: Electronic databases, reference lists of
relevant articles and sponsor submissions were also
consulted.
Review methods:
Systematic searches, selection
against criteria and quality assessment were performed
to obtain data from relevant studies. Costs were
estimated through resource-use data taken from the
published trials and the unpublished sponsor
submissions. Unit costs were taken from published
sources, where available. An economic evaluation was
undertaken to compare the cost-effectiveness of
capecitabine and UFT/LV with three intravenous 5-
FU/LV regimens widely used in the UK: the Mayo, the
modified de Gramont regimen and the inpatient de
Gramont regimens.
Results:
The evidence suggests that treatment with
capecitabine improves overall response rates and has
an improved adverse effect profile in comparison with
5-FU/LV treatment with the Mayo regimen, with the
exception of hand–foot syndrome. Time to disease
progression or death after treatment with UFT/LV in
one study appears to be shorter than after treatment
with 5-FU/LV with the Mayo regimen, although it also
had an improved adverse effect profile. Neither
capecitabine nor UFT/LV appeared to improve healthrelated
quality of life. Little information on patient
preference was available for UFT/LV, but there was
indicated a strong preference for this over 5-FU/LV.
The total cost of capecitabine and UFT/LV treatments
were estimated at £2111 and £3375, respectively,
compared with the total treatment cost for the Mayo
regimen of £3579. Cost estimates were also presented
for the modified de Gramont and inpatient de Gramont
regimens. These were £3684 and £6155, respectively.
No survival advantage was shown in the RCTs of the
oral drugs against the Mayo regimen. Cost savings of
capecitabine and UFT/LV over the Mayo regimen were
estimated to be £1461 and £209, respectively. Drug
acquisition costs were higher for the oral therapies
than for the Mayo regimen, but were offset by lower
administration costs. Adverse event treatment costs
were similar across the three regimens. It was inferred
that there was no survival difference between the oral
drugs and the de Gramont regimens. Cost savings of
capecitabine and UFT/LV over the modified de
Gramont regimen were estimated to be £1353 and
£101, respectively, and over the inpatient de Gramont
regimen were estimated to be £4123 and £2870,
respectively.
Conclusions:
The results show that there are cost
savings associated with the use of oral therapies. No
survival difference has been proven between the oral
drugs and the Mayo regimen. In addition, no evidence
of a survival difference between the Mayo regimen and
the de Gramont regimens has been identified.
However, improved progression-free survival and an
improved adverse event profile have been shown for
the de Gramont regimen over the Mayo regimen.
Further research is recommended into the following
areas: quality of life data should be included in trials of
colorectal cancer treatments; the place of effective oral
treatments in the treatment of colorectal cancer, the
safety mechanisms needed to ensure compliance and
the monitoring of adverse effects; the optimum
duration of treatment; the measurement of patient
preference; and a phase III comparative trial of
capecitabine and UFT/LV versus modified de Gramont
treatment to determine whether there was any survival
advantage and to collate the necessary economic data
Galactic Cosmochronometry from Radioactive Elements in the Spectra of Very Old Metal-Poor Stars
In a short review of neutron-capture elemental abundances in Galactic halo
stars, emphasis is placed on the use of these elements to estimate the age of
the Galactic halo. Two prominent characteristics of neutron-capture elements in
halo stars are their large star-to-star scatter in the overall abundance level
with respect to lighter elements, and the dominance of r-process abundance
patterns at lowest stellar metallicities. The r-process abundance signature
potentially allows the direct determination of the age of the earliest Galactic
halo nucleosynthesis events, but further developments in r-process theory, high
resolution spectroscopy of very metal-poor stars, and in basic atomic data are
needed to narrow the uncertainties in age estimates. Attention is brought to
the importance of accurate transition probabilities in neutron-capture element
cosmochronometry. Recent progress in the transition probabilities of rare earth
elements is discussed, along with suggestions for future work on other species.Comment: 19 pages, 5 figures; To appear in Physica Script
X-ray absorption spectra at the Ca-L-edge calculated within multi-channel multiple scattering theory
We report a new theoretical method for X-ray absorption spectroscopy (XAS) in
condensed matter which is based on the multi-channel multiple scattering theory
of Natoli et al. and the eigen-channel R-matrix method. While the highly
flexible real-space multiple scattering (RSMS) method guarantees a precise
description of the single-electron part of the problem, multiplet-like electron
correlation effects between the photo-electron and localized electrons can be
taken account for in a configuration interaction scheme. For the case where
correlation effects are limited to the absorber atom, a technique for the
solution of the equations is devised, which requires only little more
computation time than the normal RSMS method for XAS. The new method is
described and an application to XAS at the Ca -edge in bulk Ca, CaO
and CaF is presented.Comment: 10 pages, 4 figures, submitted to Phys. Rev.
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