Associação entre adiposidade, parâmetros metabólicos e marcadores inflamatórios em adolescentes do sexo feminino

Orientadora: Profª. Drª Rosana Bento RadominskiDissertação (mestrado)- Universidade Federal do Paraná, Setor de Ciências da Saúde, Programa de Pós-Graduação em Segurança Alimentar e Nutricional. Defesa: Curitiba, 25/11/2014Inclui referênciasResumo: A obesidade aumentou de forma expressiva nas ultimas decadas, especialmente na populacao pediatrica. Estudos que avaliaram a distribuicao de gordura corporal em adultos demonstraram que a adiposidade central se correlaciona com alteracoes metabolicas e com processo inflamatorio subclinico que podem resultar em resistencia a insulina, hipertensao arterial e dislipidemia; fatores estes implicados no aumento do risco de doencas cardiovasculares e diabetes. O objetivo do presente estudo foi verificar a associacao entre indicadores de adiposidade central e total com parametros metabolicos e inflamatorios em adolescentes do sexo feminino. A amostra foi composta por 53 meninas de 13 a 17 anos de uma escola publica na cidade de Curitiba. Os indicadores de adiposidade estudados foram indice de massa corporal (IMC), circunferencia de cintura (CC), massa gorda (MG), gordura troncular (GT) e percentual de gordura. A composicao corporal foi obtida por absorciometria por dupla emissao de raios-x (DXA). Os parametros metabolicos e inflamatorios analisados foram pressao arterial sistolica (PAS) e diastolica (PAD), glicemia, insulina, HOMA1-IR, perfil lipidico, proteina C reativa (PCR), interleucina 6 (IL-6), fator de necrose tumoral-ƒ¿ (TNF-ƒ¿), leptina, adiponectina e resistina. Utilizaram-se a correlacao de Pearson e a regressao linear bivariada e multipla, considerando-se p .0,05. Houve correlacao positiva significativa entre todos os indicadores de adiposidade com PAS, PAD, insulina, HOMA1-IR, PCR e leptina. Os triglicerideos se correlacionaram positivamente apenas com IMC e CC e a adiponectina apresentou correlacao negativa com o IMC. TNF-ƒ¿ e IL-6 nao se associaram as variaveis estudadas, assim como a glicemia, colesterol total, colesterol HDL e LDL. O IMC apresentou associacao positiva significativa com a maioria dos parametros estudados nesta populacao, comparavel aquelas obtidas com a medida da CC e a medida direta da adiposidade pela DXA, e ate o momento parece ser suficiente para detectar, nesta faixa etaria, individuos em risco de complicacoes da obesidade. Palavras-chave: Adolescentes, Obesidade, Gordura abdominal, Risco cardiovascularAbstract: Obesity has increased significantly in recent decades, especially in the pediatric population. Studies evaluating the distribution of body fat in adults have shown that abdominal adiposity is strongly correlated with metabolic changes and subclinical inflammation that may result in insulin resistance, hypertension and dyslipidemia; these factors are implicated in increased risk of cardiovascular disease and diabetes. The aim of this study was to investigate the association between total and central adiposity in female adolescents. The sample consisted of 53 adolescents aged 13 to 17 years of a public school in the city of Curitiba. The indicators of adiposity studied were body mass index (BMI), waist circumference (WC), trunk fat mass, total fat mass and fat percentage measured by dual-energy X-ray absorptiometry (DXA). The metabolic and inflammatory parameters studied were systolic blood pressure (SBP), diastolic blood pressure (DBP), glucose, insulin, HOMA1-IR, lipids, reactive c protein (RCP), interleukin-6 (IL-6), TNF-ƒ¿, leptin, adiponectin and resistin. PearsonLs correlation and multiple bivariate linear regression were used considering p value .0,05. There was a significant positive, correlation between all indicators of adiposity with SBP, DBP, insulin, HOMA1-IR, RCP and leptin. Triglycerides were positively correlated with BMI and WC, and adiponectin correlated negatively with BMI. TNF-ƒ¿, IL-6, glucose, total cholesterol, HDL and LDL cholesterol did not correlate to the studied variables. BMI showed a significant association with most of the parameters studied in this population, comparable to those obtained with the measurement of WC and the direct measure of adiposity by DXA, and so far, seems to be sufficient to detect in this age group, individuals with risk of obesity complications. Key-words: Adolescents, Obesity, Abdominal adiposity, Cardiovascular ris

Association between adiposity indicators, metabolic parameters and inflammatory markers in a sample of female adolescents

The aim of this study was to investigate the association between total and abdominal adiposity with metabolic parameters and inflammatory markers, in female adolescents. The sample consisted of 53 adolescents aged 13 to 17 years from a public school in Curitiba, Brazil. The adiposity indicators studied were body mass index (BMI), waist circumference (WC), trunk fat mass (TKFM), total fat mass (TFM) and body fat percentage (BF%) measured by dual-energy X-ray absorptiometry. The metabolic and inflammatory parameters studied were systolic blood pressure (SBP), diastolic blood pressure (DBP), glucose, insulin, homeostasis model assessment index for insulin resistance (HOMA-IR), lipids, C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), leptin, adiponectin and resistin. Eighty percent of WC variation, 87% of TKFM and TFM, and 73% of BF% were predicted by BMI variation. There was a significant positive correlation between all indicators of adiposity with SBP, DBP, insulin, HOMA-IR, CRP and leptin. Triglycerides were positively correlated with BMI and WC, and adiponectin correlated negatively with BMI. TNF-α, IL-6, glucose, total cholesterol, and high- and low-density lipoprotein cholesterol did not correlate to the studied variables. BMI showed a significant association with most of the parameters studied, and WC was slightly better than BMI to predict insulin resistance in this specific population.59432533

Association Between Adiposity Indicators, Metabolic Parameters And Inflammatory Markers In A Sample Of Female Adolescents

Objective: The aim of this study was to investigate the association between total and abdominal adiposity with metabolic parameters and inflammatory markers, in female adolescents. Subjects and methods: The sample consisted of 53 adolescents aged 13 to 17 years from a public school in Curitiba, Brazil. The adiposity indicators studied were body mass index (BMI), waist circumference (WC), trunk fat mass (TKFM), total fat mass (TFM) and body fat percentage (BF%) measured by dual-energy X-ray absorptiometry. The metabolic and inflammatory parameters studied were systolic blood pressure (SBP), diastolic blood pressure (DBP), glucose, insulin, homeostasis model assessment index for insulin resistance (HOMA-IR), lipids, C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), leptin, adiponectin and resistin. Results: Eighty percent of WC variation, 87% of TKFM and TFM, and 73% of BF% were predicted by BMI variation. There was a significant positive correlation between all indicators of adiposity with SBP, DBP, insulin, HOMA-IR, CRP and leptin. Triglycerides were positively correlated with BMI and WC, and adiponectin correlated negatively with BMI. TNF-alpha, IL-6, glucose, total cholesterol, and high-and low-density lipoprotein cholesterol did not correlate to the studied variables. Conclusion: BMI showed a significant association with most of the parameters studied, and WC was slightly better than BMI to predict insulin resistance in this specific population.594325334Fundacao Araucari

Association Between Adiposity Indicators, Metabolic Parameters And Inflammatory Markers In A Sample Of Female Adolescents.

The aim of this study was to investigate the association between total and abdominal adiposity with metabolic parameters and inflammatory markers, in female adolescents. The sample consisted of 53 adolescents aged 13 to 17 years from a public school in Curitiba, Brazil. The adiposity indicators studied were body mass index (BMI), waist circumference (WC), trunk fat mass (TKFM), total fat mass (TFM) and body fat percentage (BF%) measured by dual-energy X-ray absorptiometry. The metabolic and inflammatory parameters studied were systolic blood pressure (SBP), diastolic blood pressure (DBP), glucose, insulin, homeostasis model assessment index for insulin resistance (HOMA-IR), lipids, C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), leptin, adiponectin and resistin. Eighty percent of WC variation, 87% of TKFM and TFM, and 73% of BF% were predicted by BMI variation. There was a significant positive correlation between all indicators of adiposity with SBP, DBP, insulin, HOMA-IR, CRP and leptin. Triglycerides were positively correlated with BMI and WC, and adiponectin correlated negatively with BMI. TNF-α, IL-6, glucose, total cholesterol, and high- and low-density lipoprotein cholesterol did not correlate to the studied variables. BMI showed a significant association with most of the parameters studied, and WC was slightly better than BMI to predict insulin resistance in this specific population.59325-33

Association between adiposity indicators, metabolic parameters and inflammatory markers in a sample of female adolescents

Objective The aim of this study was to investigate the association between total and abdominal adiposity with metabolic parameters and inflammatory markers, in female adolescents.Subjects and methods The sample consisted of 53 adolescents aged 13 to 17 years from a public school in Curitiba, Brazil. The adiposity indicators studied were body mass index (BMI), waist circumference (WC), trunk fat mass (TKFM), total fat mass (TFM) and body fat percentage (BF%) measured by dual-energy X-ray absorptiometry. The metabolic and inflammatory parameters studied were systolic blood pressure (SBP), diastolic blood pressure (DBP), glucose, insulin, homeostasis model assessment index for insulin resistance (HOMA-IR), lipids, C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), leptin, adiponectin and resistin.Results Eighty percent of WC variation, 87% of TKFM and TFM, and 73% of BF% were predicted by BMI variation. There was a significant positive correlation between all indicators of adiposity with SBP, DBP, insulin, HOMA-IR, CRP and leptin. Triglycerides were positively correlated with BMI and WC, and adiponectin correlated negatively with BMI. TNF-α, IL-6, glucose, total cholesterol, and high- and low-density lipoprotein cholesterol did not correlate to the studied variables.Conclusion BMI showed a significant association with most of the parameters studied, and WC was slightly better than BMI to predict insulin resistance in this specific population