False positive probabilties for all Kepler Objects of Interest: 1284 newly validated planets and 428 likely false positives

We present astrophysical false positive probability calculations for every Kepler Object of Interest (KOI)---the first large-scale demonstration of a fully automated transiting planet validation procedure. Out of 7056 KOIs, we determine that 1935 have probabilities <1% to be astrophysical false positives, and thus may be considered validated planets. 1284 of these have not yet been validated or confirmed by other methods. In addition, we identify 428 KOIs likely to be false positives that have not yet been identified as such, though some of these may be a result of unidentified transit timing variations. A side product of these calculations is full stellar property posterior samplings for every host star, modeled as single, binary, and triple systems. These calculations use 'vespa', a publicly available Python package able to be easily applied to any transiting exoplanet candidate.Comment: 20 pages, 8 figures. Published in ApJ. Instructions to reproduce results can be found at https://github.com/timothydmorton/koi-fp

Low Frequency Tilt Seismology with a Precision Ground Rotation Sensor

We describe measurements of the rotational component of teleseismic surface waves using an inertial high-precision ground-rotation-sensor installed at the LIGO Hanford Observatory (LHO). The sensor has a noise floor of 0.4 nrad$/ \sqrt{\rm Hz}$ at 50 mHz and a translational coupling of less than 1 $\mu$rad/m enabling translation-free measurement of small rotations. We present observations of the rotational motion from Rayleigh waves of six teleseismic events from varied locations and with magnitudes ranging from M6.7 to M7.9. These events were used to estimate phase dispersion curves which shows agreement with a similar analysis done with an array of three STS-2 seismometers also located at LHO

Central exclusive production of longlived gluinos at the LHC

We examine the possibility of producing gluino pairs at the LHC via the exclusive reaction pp -> p+gluino+gluino+p in the case where the gluinos are long lived. Such long lived gluinos are possible if the scalar super-partners have large enough masses. We show that it may be possible to observe the gluinos via their conversion to R-hadron jets and measure their mass to better than 1% accuracy for masses below 350 GeV with 300/fb of data.Comment: 13 pages, 9 figures. Minor corrections to version

Constraining Neutron-Star Matter with Microscopic and Macroscopic Collisions

Interpreting high-energy, astrophysical phenomena, such as supernova explosions or neutron-star collisions, requires a robust understanding of matter at supranuclear densities. However, our knowledge about dense matter explored in the cores of neutron stars remains limited. Fortunately, dense matter is not only probed in astrophysical observations, but also in terrestrial heavy-ion collision experiments. In this work, we use Bayesian inference to combine data from astrophysical multi-messenger observations of neutron stars and from heavy-ion collisions of gold nuclei at relativistic energies with microscopic nuclear theory calculations to improve our understanding of dense matter. We find that the inclusion of heavy-ion collision data indicates an increase in the pressure in dense matter relative to previous analyses, shifting neutron-star radii towards larger values, consistent with recent NICER observations. Our findings show that constraints from heavy-ion collision experiments show a remarkable consistency with multi-messenger observations and provide complementary information on nuclear matter at intermediate densities. This work combines nuclear theory, nuclear experiment, and astrophysical observations, and shows how joint analyses can shed light on the properties of neutron-rich supranuclear matter over the density range probed in neutron stars

Seismic topographic scattering in the context of GW detector site selection

In this paper, we present a calculation of seismic scattering from irregular surface topography in the Born approximation. Based on US-wide topographic data, we investigate topographic scattering at specific sites to demonstrate its impact on Newtonian-noise estimation and subtraction for future gravitational-wave detectors. We find that topographic scattering at a comparatively flat site in Oregon would not pose any problems, whereas scattering at a second site in Montana leads to significant broadening of wave amplitudes in wavenumber space that would make Newtonian-noise subtraction very challenging. Therefore, it is shown that topographic scattering should be included as criterion in the site-selection process of future low-frequency gravitational-wave detectors.Comment: 16 pages, 7 figure

Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor.

We recently isolated a cDNA clone encoding a functional platelet thrombin receptor that defined a unique mechanism of receptor activation. Thrombin cleaves its receptor's extracellular amino terminal extension, unmasking a new amino terminus that functions as a tethered peptide ligand and activates the receptor. A novel peptide mimicking this new amino terminus was a full agonist for platelet secretion and aggregation, suggesting that this unusual mechanism accounts for platelet activation by thrombin. Does this mechanism also mediate thrombin's assorted actions on non-platelet cells? We now report that the novel thrombin receptor agonist peptide reproduces thrombin-induced events (specifically, phosphoinositide hydrolysis and mitogenesis) in CCL-39 hamster lung fibroblasts, a naturally thrombin-responsive cell line. Moreover, these thrombin-induced events could be recapitulated in CV-1 cells, normally poorly responsive to thrombin, after transfection with human platelet thrombin receptor cDNA. Our data show that important thrombin-induced cellular events are mediated by the same unusual mechanism of receptor activation in both platelets and fibroblasts, very likely via the same or very similar receptors

Observations of the GRB afterglow ATLAS17aeu and its possible association with GW170104

We report the discovery and multi-wavelength data analysis of the peculiar optical transient, ATLAS17aeu. This transient was identified in the skymap of the LIGO gravitational wave event GW170104 by our ATLAS and Pan-STARRS coverage. ATLAS17aeu was discovered 23.1hrs after GW170104 and rapidly faded over the next 3 nights, with a spectrum revealing a blue featureless continuum. The transient was also detected as a fading x-ray source by Swift and in the radio at 6 and 15 GHz. A gamma ray burst GRB170105A was detected by 3 satellites 19.04hrs after GW170104 and 4.10hrs before our first optical detection. We analyse the multi-wavelength fluxes in the context of the known GRB population and discuss the observed sky rates of GRBs and their afterglows. We find it statistically likely that ATLAS17aeu is an afterglow associated with GRB170105A, with a chance coincidence ruled out at the 99\% confidence or 2.6$\sigma$. A long, soft GRB within a redshift range of $1 \lesssim z \lesssim 2.9$ would be consistent with all the observed multi-wavelength data. The Poisson probability of a chance occurrence of GW170104 and ATLAS17aeu is $p=0.04$. This is the probability of a chance coincidence in 2D sky location and in time. These observations indicate that ATLAS17aeu is plausibly a normal GRB afterglow at significantly higher redshift than the distance constraint for GW170104 and therefore a chance coincidence. However if a redshift of the faint host were to place it within the GW170104 distance range, then physical association with GW170104 should be considered.Comment: 16 pages, 6 figures, accepted to Ap

Rural/Nonrural Differences in Colorectal Cancer Incidence in the United States, 1998--2001

BACKGROUND. Few studies of colorectal cancer incidence by rural, suburban, and metropolitan residence have been published. METHODS. The authors examined colorectal cancer incidence among men and women in U.S. counties classified as rural, suburban, and metropolitan for the period 1998–2001. They examined rural/suburban/metropolitan differences in incidence by age, race, Hispanic ethnicity, stage at diagnosis, histology, and percentage of the total county population below the poverty level, using data from the CDC’s National Program of Cancer Registries, the NCI’s Surveillance, Epidemiology, and End Results Program, and the 2000 U.S. Census. RESULTS. A total of 495,770 newly diagnosed or incident cases of colorectal cancer were included in this analysis (249,919 among men and 245,851 among women). Over the period 1998–2001, the colorectal cancer incidence rates among men tended to be lower among those who resided in rural areas, for each of the subgroups examined, with the exception of Asians and Pacific Islanders and those living in more affluent counties. Among women aged 75 years and older, the colorectal cancer incidence rates tended to be lower among rural than metropolitan or suburban residents, though the differences were slight. In multivariate analysis, the incidence of colorectal cancer was higher in metropolitan, suburban, and rural areas for blacks than that for whites (incidence rate ratios [RR] = 1.12, 1.07, and 1.06, respectively, all P \u3c 0.015). CONCLUSIONS. This study suggests that black men who reside in metropolitan areas have a higher risk of colorectal cancer than black men who reside in rural areas. This finding suggests the need for diverse approaches for reducing colorectal cancer when targeting rural compared with metropolitan areas

Exoplanet Catalogues

One of the most exciting developments in the field of exoplanets has been the progression from 'stamp-collecting' to demography, from discovery to characterisation, from exoplanets to comparative exoplanetology. There is an exhilaration when a prediction is confirmed, a trend is observed, or a new population appears. This transition has been driven by the rise in the sheer number of known exoplanets, which has been rising exponentially for two decades (Mamajek 2016). However, the careful collection, scrutiny and organisation of these exoplanets is necessary for drawing robust, scientific conclusions that are sensitive to the biases and caveats that have gone into their discovery. The purpose of this chapter is to discuss and demonstrate important considerations to keep in mind when examining or constructing a catalogue of exoplanets. First, we introduce the value of exoplanetary catalogues. There are a handful of large, online databases that aggregate the available exoplanet literature and render it digestible and navigable - an ever more complex task with the growing number and diversity of exoplanet discoveries. We compare and contrast three of the most up-to-date general catalogues, including the data and tools that are available. We then describe exoplanet catalogues that were constructed to address specific science questions or exoplanet discovery space. Although we do not attempt to list or summarise all the published lists of exoplanets in the literature in this chapter, we explore the case study of the NASA Kepler mission planet catalogues in some detail. Finally, we lay out some of the best practices to adopt when constructing or utilising an exoplanet catalogue.Comment: 14 pages, 6 figures. Invited review chapter, to appear in "Handbook of Exoplanets", edited by H.J. Deeg and J.A. Belmonte, section editor N. Batalh

Cataclysmic Variables in the First Year of the Zwicky Transient Facility

Using selection criteria based on amplitude, time, and color, we have identified 329 objects as known or candidate cataclysmic variables (CVs) during the first year of testing and operation of the Zwicky Transient Facility. Of these, 90 are previously confirmed CVs, 218 are strong candidates based on the shape and color of their light curves obtained during 3–562 days of observation, and the remaining 21 are possible CVs but with too few data points to be listed as good candidates. Almost half of the strong candidates are within 10 deg of the galactic plane, in contrast to most other large surveys that have avoided crowded fields. The available Gaia parallaxes are consistent with sampling the low mass transfer CVs, as predicted by population models. Our follow-up spectra have confirmed Balmer/helium emission lines in 27 objects, with four showing high-excitation He ii emission, including candidates for an AM CVn, a polar, and an intermediate polar. Our results demonstrate that a complete survey of the Galactic plane is needed to accomplish an accurate determination of the number of CVs existing in the Milky Way