Antibacterial Coatings for Medical Devices based on Glass Polyalkenoate Cement Chemistry

A biofilm is an accumulation of micro-organisms and their extracellular products forming a structured community on a surface. Biofilm formation on medical devices has severe health consequences as bacteria growing in this lifestyle are tolerant to both host defense mechanisms and antibiotic therapies. However, silver and zinc ions inhibit the attachment and proliferation of immature biofilms. The objective of this study is to evaluate whether it is possible to produce silver and zinc-containing glass polyalkenoate cement (GPC) coatings for medical devices that have antibacterial activity and which may therefore inhibit biofilm formation on a material surface. Two silver and zinc-containing GPC coatings (A and B) were synthesised and coated onto Ti6Al4V discs. Their handling properties were characterised and atomic absorption spectrometery was employed to determine zinc and silver ion release with coating maturation up to 30 days. The antibacterial properties of the coatings were also evaluated against Staphylococcus aureus and a clinical isolate of Pseudomonas aeruginosa using an agar diffusion assay method. The majority of the zinc and silver ions were released within the first 24 h; both coatings exhibited antibacterial effect against the two bacterial strains, but the effect was more intense for B which contained more silver and less zinc than A. Both coatings produced clear zones of inhibition with each of the two organisms tested. In this assay, Ps. aeruginosa was more sensitive than S. aureus. The diameters of these zones were reduced after the coating had been immersed in water for varying periods due to the resultant effect on ion release. © 2008 Springer Science+Business Media, LLC

Practices and perceptions of strength and conditioning in female golf: a survey study of touring professional players

The aim of the study was to provide an understanding of current practices and perceptions of strength and conditioning (S&C) training in female touring professionals. A cross-sectional, explorative survey was undertaken and contained 30 questions separated into four sections: i) general participant information, ii) S&C practices, iii) Likert scale questions on S&C for golf performance, and iv) knowledge and awareness of S&C. A total of 102 players completed the survey with a combination of multiple-choice questions (MCQs), open-ended questions, and Likert Scale style questions utilised throughout. Results showed that ≥ 94% of players believed that strength and power in both the lower and upper body, in addition to flexibility, were the most important physical characteristics to complement golf shot metrics (e.g., clubhead speed [CHS], ball speed, carry distance, etc.). However, 26% of players conducted S&C training only in the off-season, with 21% suggesting that they had a fear of injury from S&C training. When considering the barriers to undertaking S&C training, the most common reasons included time constraints (20%) and players wanting to prioritise golf practice (15%). Finally, 58% of players believed that training in the weight room should replicate the golf swing. Although it is positive to see that the main physical characteristics for golf are well-understood by professional players, it is also evident that further education and knowledge translation is required relating to the application of S&C training for performance enhancement and injury risk mitigation purposes

Brighter prospects? Assessing the franchise advantage using census data

This paper uses Census micro data to examine how starting a business as a franchise rather than an independent business affects its survival and growth prospects. We assess factors that influence the decision to become a franchisee and use various empirical approaches to correct for selection bias in our performance analyses. We find that franchised businesses on average exhibit higher survival rates than independent businesses, but importantly, the difference is small compared to claims in the trade press. The effect is also short lived: conditional on surviving a year or two, we no longer find survival (or growth) differences. We then explore two potential sources for this small survival advantage, namely franchisors’ screening process and the benefits arising from the brand and business know-how provided by franchisors. We find evidence that both of the sources contribute to the franchising advantage

String Theory and Cosmology

We discuss the main cosmological implications of considering string-loop effects and a potential for the dilaton in the lowest order string effective action. Our framework is based on the effective model arising from regarding homogeneous and isotropic dilaton, metric and Yang-Mills field configurations. The issues of inflation, entropy crisis and the Polonyi problem as well as the problem of the cosmological constant are discussed.Comment: 7 pages, plain Tex, no figure

Cosmology with a TeV mass GUT Higgs

The most natural way to break the GUT gauge symmetry is with a Higgs field whose vacuum expectation value is of order 10^{16}\,\mbox{GeV} but whose mass is of order $10^2$ to 10^3\,\mbox{GeV}. This can lead to a cosmological history radically different from what is usually assumed to have occurred between the standard inflationary and nucleosynthesis epochs, which may solve the gravitino and Polonyi/moduli problems in a natural way.Comment: 4 pages, revte

Cosmological Constraints on Late-time Entropy Production

We investigate cosmological effects concerning the late-time entropy production due to the decay of non-relativistic massive particles. The thermalization process of neutrinos after the entropy production is properly solved by using the Boltzmann equation. If a large entropy production takes place at late time t$\simeq$ 1 sec, it is found that a large fraction of neutrinos cannot be thermalized. This fact loosens the tight constraint on the reheating temperature T_R from the big bang nucleosynthesis and T_R could be as low as 0.5 MeV. The influence on the large scale structure formation and cosmic microwave background anisotropies is also discussed.Comment: 4 pages, using RevTeX and five postscript figures, comments added, to appear in Phys. Rev. Let

Data acquisition software for the CMS strip tracker

The CMS silicon strip tracker, providing a sensitive area of approximately 200 m2 and comprising 10 million readout channels, has recently been completed at the tracker integration facility at CERN. The strip tracker community is currently working to develop and integrate the online and offline software frameworks, known as XDAQ and CMSSW respectively, for the purposes of data acquisition and detector commissioning and monitoring. Recent developments have seen the integration of many new services and tools within the online data acquisition system, such as event building, online distributed analysis, an online monitoring framework, and data storage management. We review the various software components that comprise the strip tracker data acquisition system, the software architectures used for stand-alone and global data-taking modes. Our experiences in commissioning and operating one of the largest ever silicon micro-strip tracking systems are also reviewed

Monitoring the CMS strip tracker readout system

The CMS Silicon Strip Tracker at the LHC comprises a sensitive area of approximately 200 m2 and 10 million readout channels. Its data acquisition system is based around a custom analogue front-end chip. Both the control and the readout of the front-end electronics are performed by off-detector VME boards in the counting room, which digitise the raw event data and perform zero-suppression and formatting. The data acquisition system uses the CMS online software framework to configure, control and monitor the hardware components and steer the data acquisition. The first data analysis is performed online within the official CMS reconstruction framework, which provides many services, such as distributed analysis, access to geometry and conditions data, and a Data Quality Monitoring tool based on the online physics reconstruction. The data acquisition monitoring of the Strip Tracker uses both the data acquisition and the reconstruction software frameworks in order to provide real-time feedback to shifters on the operational state of the detector, archiving for later analysis and possibly trigger automatic recovery actions in case of errors. Here we review the proposed architecture of the monitoring system and we describe its software components, which are already in place, the various monitoring streams available, and our experiences of operating and monitoring a large-scale system

A Framework to Manage the Complex Organisation of Collaborating: Its Application to Autonomous Systems

In this paper we present an analysis of the complexities of large group collaboration and its application to develop detailed requirements for collaboration schema for Autonomous Systems (AS). These requirements flow from our development of a framework for collaboration that provides a basis for designing, supporting and managing complex collaborative systems that can be applied and tested in various real world settings. We present the concepts of "collaborative flow" and "working as one" as descriptive expressions of what good collaborative teamwork can be in such scenarios. The paper considers the application of the framework within different scenarios and discuses the utility of the framework in modelling and supporting collaboration in complex organisational structures

Thermal Inflation and the Moduli Problem

In supersymmetric theories a field can develop a vacuum expectation value $M \gg 10^3\,{\rm GeV}$, even though its mass $m$ is of order $10^2$ to $10^3\,{\rm GeV}$. The finite temperature in the early Universe can hold such a field at zero, corresponding to a false vacuum with energy density $V_0 \sim m^2 M^2$. When the temperature falls below $V_0^{1/4}$, the thermal energy density becomes negligible and an era of thermal inflation begins. It ends when the field rolls away from zero at a temperature of order $m$, corresponding to of order 10 $e$-folds of inflation which does not affect the density perturbation generated during ordinary inflation. Thermal inflation can solve the Polonyi/moduli problem if $M$ is within one or two orders of magnitude of $10^{12}\,{\rm GeV}$.Comment: Revised version to appear in Phys Rev D. Improved discussion of the possible effect of parametric resonance. Latex, 31 page