Acceleration predicts energy expenditure in a fat, flightless, diving bird

Funding The project was supported logistically by the French Polar Institute and funded by the PEW fellowship to Y.R.-C., the WWF-UK, and the Zone Atelier Antarctique et Terres Australes from the CNRS. D.M.W. received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska‐Curie Individual Fellowship Grant Agreement No. 748026.Peer reviewedPublisher PD

HAMAP in 2013, new developments in the protein family classification and annotation system

HAMAP (High-quality Automated and Manual Annotation of Proteins—available at http://hamap.expasy.org/) is a system for the classification and annotation of protein sequences. It consists of a collection of manually curated family profiles for protein classification, and associated annotation rules that specify annotations that apply to family members. HAMAP was originally developed to support the manual curation of UniProtKB/Swiss-Prot records describing microbial proteins. Here we describe new developments in HAMAP, including the extension of HAMAP to eukaryotic proteins, the use of HAMAP in the automated annotation of UniProtKB/TrEMBL, providing high-quality annotation for millions of protein sequences, and the future integration of HAMAP into a unified system for UniProtKB annotation, UniRule. HAMAP is continuously updated by expert curators with new family profiles and annotation rules as new protein families are characterized. The collection of HAMAP family classification profiles and annotation rules can be browsed and viewed on the HAMAP website, which also provides an interface to scan user sequences against HAMAP profile

The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases

The SIB Swiss Institute of Bioinformatics (www.isb-sib.ch) provides world-class bioinformatics databases, software tools, services and training to the international life science community in academia and industry. These solutions allow life scientists to turn the exponentially growing amount of data into knowledge. Here, we provide an overview of SIB's resources and competence areas, with a strong focus on curated databases and SIB's most popular and widely used resources. In particular, SIB's Bioinformatics resource portal ExPASy features over 150 resources, including UniProtKB/Swiss-Prot, ENZYME, PROSITE, neXtProt, STRING, UniCarbKB, SugarBindDB, SwissRegulon, EPD, arrayMap, Bgee, SWISS-MODEL Repository, OMA, OrthoDB and other databases, which are briefly described in this article

Grossesse et hyperthyroïdie

après un rappel sur l'anatomie et la physiologie de la glande thyroïde, l'auteur s'intéresse à la fonction thyroïdienne au cours de la grossesse. Ainsi, l'existence d'une hyperthyroïdie chez la femme enceinte aura des effets sur le déroulement de la grossesse. par ailleurs, la grossesse elle-même, influencera l'évolution de l'hyperthyroïdie. La 3ème partie de ce travail répertorie les différentes étiologies conduisant à une hyperthyroïdie pendant la grossesse. la maladie de Basedow représente à elle seule 85% de ces étiologies. Dans une 4ème partie, sont décrites les recommandations qui doivent être appliquées en terme de prise en charge et de surveillance de ces patientes. La 5ème partie de ce travail fait état des complications maternelles et fœales que peut entraîner une hyperthyroïdie non contrôlée au cours de la grossesse. Pour terminer, l'auteur fait le point sur les moyens thérapeutiques disponibles ainsi que sur leurs conséquences fœtales.CLERMONT FD-BCIU-Santé (631132104) / SudocLYON1-BU Santé (693882101) / SudocSudocFranceF

Prise médicamenteuse et allaitement

CLERMONT FD-BCIU-Santé (631132104) / SudocLYON1-BU Santé (693882101) / SudocSudocFranceF