A Window into Practice: Examining Elementary Writing Methods Instruction

We know very little about what happens in elementary literacy methods courses, particularly those that focus on writing instruction. In this study, we offer a window into writing methods instruction, examining three pedagogies of practice used by experienced teacher educators (TEs) across one U.S. state —representations, decompositions, and approximations of practice (Grossman, Compton, Igra, Ronfeldt, Shahan, & Williamson, 2009). We found a variety of ways that instructors use these pedagogies of practice, both in isolation and in combination, in their instruction. We provide implications and suggestions for the support and development of elementary writing methods TEs

A Study of Nine High-Redshift Clusters of Galaxies: IV. Photometry and Sp ectra of Clusters 1324+3011 and 1604+4321

New photometric and spectroscopic observations of galaxies in the directions of three distant clusters are presented as part of our on-going high-redshift cluster survey. The clusters are CL1324+3011 at z = 0.76, CL1604+4304 at z = 0.90, and CL1604+4321 at z = 0.92. The observed x-ray luminosities in these clusters are at least a factor of 3 smaller than those observed in clusters with similar velocity dispersions at z <= 0.4. These clusters contain a significant population of elliptical-like galaxies, although these galaxies are not nearly as dominant as in massive clusters at z <= 0.5. We also find a large population of blue cluster members. Defining an active galaxy as one in which the rest equivalent width of [OII] is greater than 15 Angstroms, the fraction of active cluster galaxies, within the central 1.0 Mpc, is 45%. In the field population, we find that 65% of the galaxies with redshifts between z = 0.40 and z = 0.85 are active, while the fraction is 79% for field galaxies at z > 0.85. The star formation rate normalized by the rest AB B-band magnitude, SFRN, increases as the redshift increases at a given evolving luminosity. At a given redshift, however, SFRN decreases linearly with increasing luminosity indicating a remarkable insensitivity of the star formation rate to the intrinsic luminosity of the galaxy over the range -18 >= ABB >= -22. Cluster galaxies in the central 1 Mpc regions exhibit depressed star formation rates. We are able to measure significant evolution in the B-band luminosity function over the range 0.1 <= z <= 1. The characteristic luminosity increases by a factor of 3 with increasing redshift over this range.Comment: 64 pages, 18 figures, accepted for publication in the Astronomical Journal on May 25, 2001. Scheduled to appear in Sept 2001 issu

Evaluation of European-based polygenic risk score for breast cancer in Ashkenazi Jewish women in Israel

To date, most BC GWASs have been performed Background Polygenic risk score (PRS), calculated in individuals of European (EUR) ancestry, and based on genome-wide association studies (GWASs), the generalisation of EUR-based PRS to other can improve breast cancer (BC) risk assessment. populations is a major challenge. In this study, we examined the performance of EUR-based BC PRS models in Ashkenazi Jewish (AJ) women. Methods We generated PRSs based on data on EUR women from the Breast Cancer Association Consortium (BCAC). We tested the performance of the PRSs in a cohort of 2161 AJ women from Israel (1437 cases and 724 controls) from BCAC (BCAC cohort from Israel (BCAC-IL)). In addition, we tested the performance of these EUR-based BC PRSs, as well as the established 313-SNP EUR BC PRS, in an independent cohort of 181 AJ women from Hadassah Medical Center (HMC) in Israel. Results In the BCAC-IL cohort, the highest OR per 1 SD was 1.56 (±0.09). The OR for AJ women at the top 10% of the PRS distribution compared with the middle quintile was 2.10 (±0.24). In the HMC cohort, the OR per 1 SD of the EUR-based PRS that performed best in the BCAC-IL cohort was 1.58±0.27. The OR per 1 SD of the commonly used 313-SNP BC PRS was 1.64 (±0.28). Conclusions Extant EUR GWAS data can be used for generating PRSs that identify AJ women with markedly elevated risk of BC and therefore hold promise for improving BC risk assessment in AJ women

Evaluation of European-based polygenic risk score for breast cancer in Ashkenazi Jewish women in Israel

Background Polygenic risk score (PRS), calculated based on genome-wide association studies (GWASs), can improve breast cancer (BC) risk assessment. To date, most BC GWASs have been performed in individuals of European (EUR) ancestry, and the generalisation of EUR-based PRS to other populations is a major challenge. In this study, we examined the performance of EUR-based BC PRS models in Ashkenazi Jewish (AJ) women. Methods We generated PRSs based on data on EUR women from the Breast Cancer Association Consortium (BCAC). We tested the performance of the PRSs in a cohort of 2161 AJ women from Israel (1437 cases and 724 controls) from BCAC (BCAC cohort from Israel (BCAC-IL)). In addition, we tested the performance of these EUR-based BC PRSs, as well as the established 313-SNP EUR BC PRS, in an independent cohort of 181 AJ women from Hadassah Medical Center (HMC) in Israel. Results In the BCAC-IL cohort, the highest OR per 1 SD was 1.56 (±0.09). The OR for AJ women at the top 10% of the PRS distribution compared with the middle quintile was 2.10 (±0.24). In the HMC cohort, the OR per 1 SD of the EUR-based PRS that performed best in the BCAC-IL cohort was 1.58±0.27. The OR per 1 SD of the commonly used 313-SNP BC PRS was 1.64 (±0.28). Conclusions Extant EUR GWAS data can be used for generating PRSs that identify AJ women with markedly elevated risk of BC and therefore hold promise for improving BC risk assessment in AJ women

A Window into Practice: Examining Elementary Writing Methods Instruction

We know very little about what happens in elementary literacy methods courses, particularly those that focus on writing instruction. In this study, we offer a window into writing methods instruction, examining three pedagogies of practice used by experienced teacher educators (TEs) across one U.S. state —representations, decompositions, and approximations of practice (Grossman, Compton, Igra, Ronfeldt, Shahan, & Williamson, 2009). We found a variety of ways that instructors use these pedagogies of practice, both in isolation and in combination, in their instruction. We provide implications and suggestions for the support and development of elementary writing methods TEs

PDJ amplicon in triple negative breast cancer

Abstract Amplification of chromosome 9p24.1 targeting PD-L1, PD-L2, and JAK2 (PDJ amplicon) is present in subsets of triple negative breast cancers (TNBCs) and is associated with poor clinical outcomes. However, the prevalence of PDJ+ TNBCs varies extensively across studies applying different methods for interrogating samples of interest. To rigorously assess the prevalence of PDJ amplicons in TNBC, its prognostic value and whether it is enriched by chemotherapy, we interrogated 360 TNBC samples including 74 surgical resections from patients treated in the neoadjuvant setting, and tissue microarrays (TMAs) with 31 cases from African American women and 255 resected non-metastatic cases, with a 3 color fluorescence in situ hybridization (FISH) assay targeting the 9p24.1 PDJ amplicon, 9q24.3, and 9q34.1. Samples with mean PDJ signal of > 4.5 copies, and ratios of PDJ/9q24 ≥ 2 and/or PDJ/9q34.1 ≥ 2 were called amplified (PDJ+). Correlative analyses included the association of tumor infiltrating lymphocytes (TILs) with PDJ amplicons in TNBCs. In addition, we investigated intratumor copy number of PDJ amplicons in PDJ+ and PDJ− TNBCs. Matched pre- and post-neoadjuvant treatment biopsies were available from patients (n = 6) to evaluate the effects of therapy on PDJ status. Our study provides a rigorous analysis of the prevalence, distribution, and clinical correlatives of the PDJ amplicon in TNBC