Risk and Emotion Among Healthy Volunteers in Clinical Trials

Theorized as objective or constructed, risk is recognized as unequally distributed across social hierarchies. Yet the process by which social forces shape risk and risk emotions remains unknown. The pharmaceutical industry depends on healthy individuals to voluntarily test early-stage, investigational drugs in exchange for financial compensation. Emblematic of risk in late modernity, Phase I testing is a rich site for examining how class and race shape configurations of emotion and risk. Using interview data from 178 healthy trial participants, this article examines emotion and risk as mutually constituting processes linked to biographical context and social structure. Biographical events like economic insecurity and incarceration influence how risk is felt by providing comparative experiences of felt risk and felt benefits. Such events, in turn, are structured by class-based and racial inequalities, linking class and race positions to primary emotional experiences of risk

How do Black Bream move through the fish gate on the Vasse Surge Barrier?

This study determined how Black Bream used the fish gate on the Vasse Surge Barrier by tagging them state of the art internal electronic tags. The tags, known as PIT tags, detected fish that passaged upstream and downstream through the fish gate over an 18 month period in 2017 and 2018. The local community helped us tag and release 322 Black Bream. The study revealed that movements through the fish gate were unrelated to spawning activity of this species and supported early work that the Vasse Estuary is not a key breeding site; instead they use the Deadwater to reproduce. Up until May 2018, Bream passaged through the fish gate 440 times (265 downstream and 175 upstream). Black Bream preferred to passage when the water velocity in the fish gate chute were lowest, which occurred when the water levels upstream and downstream of the surge barrier were relatively similar. When the dissolved oxygen upstream of the surge barrier was good, fewer fish passaged downstream to the Wonnerup Inlet although this was a relatively weak effect. However, the dissolved oxygen around the Vasse Suge Barrier during the current analysis period was relatively high compared to other years and therefore we anticipate that the effect of low dissolved oxygen on fish passage would be even stronger in those years. They also preferred to pass downstream through the fish gate during the evening, whereas upstream passages mostly occurred during the dawn and dusk periods. The findings greatly increase our understanding of the conditions that Black Bream require or prefer to use the fish gate on the Vasse Surge Barrier. However, as the PIT tags last for 20 years, additional data analysis is recommended to compare the factors influencing the passage of the species over multiple years of fish gate operation; including those years that experience poor oxygen levels. It is also recommended that additional fish PIT tagging occur, including other species, so that long-term fish passage through the structure may be further quantified

Possible Cosmological Implications of the Quark-Hadron Phase Transition

We study the quark-hadron phase transition within an effective model of QCD, and find that in a reasonable range of the main parameters of the model, bodies with quark content between $10^{-2}$ and 10 solar masses can have been formed in the early universe. In addition, we show that a significant amount of entropy is released during the transition. This may imply the existence of a higher baryon number density than what is usually expected at temperatures above the QCD scale. The cosmological QCD transition may then provide a natural way for decreasing the high baryon asymmetry created by an Affleck-Dine like mechanism down to the value required by primordial nucleosynthesis.Comment: 19 pages, LaTeX, 5 Postscript figures included. Submitted to Journal of Physics

New CMB Power Spectrum Constraints from MSAMI

We present new cosmic microwave background (CMB) anisotropy results from the combined analysis of the three flights of the first Medium Scale Anisotropy Measurement (MSAM1). This balloon-borne bolometric instrument measured about 10 square degrees of sky at half-degree resolution in 4 frequency bands from 5.2 icm to 20 icm with a high signal-to-noise ratio. Here we present an overview of our analysis methods, compare the results from the three flights, derive new constraints on the CMB power spectrum from the combined data and reduce the data to total-power Wiener-filtered maps of the CMB. A key feature of this new analysis is a determination of the amplitude of CMB fluctuations at $\ell \sim 400$. The analysis technique is described in a companion paper by Knox.Comment: 9 pages, 6 included figure

Singularity structure of the pi N scattering amplitude in a meson-exchange model up to energies W < 2.0 GeV

Within the previously developed Dubna-Mainz-Taipei meson-exchange model, the singularity structure of the pi N scattering amplitudes has been investigated. For all partial waves up to F waves and c.m. energies up to W = 2 GeV, the T-matrix poles have been calculated by three different techniques: analytic continuation into the complex energy plane, speed-plot and the regularization method. For all 4-star resonances, we find a perfect agreement between the analytic continuation and the regularization method. We also find resonance poles for resonances that are not so well established, but in these cases the pole positions and residues obtained by analytic continuation can substantially differ from the results predicted by the speed-plot and regularization methods.Comment: 21 pages, 4 figures, 4 table

Peering into the pharmaceutical “pipeline”: Investigational drugs, clinical trials, and industry priorities

In spite of a growing literature on pharmaceuticalization, little is known about the pharmaceutical industry’s investments in research and development (R&D). Information about the drugs being developed can provide important context for existing case studies detailing the expanding – and often problematic – role of pharmaceuticals in society. To access the pharmaceutical industry’s pipeline, we constructed a database of drugs for which pharmaceutical companies reported initiating clinical trials over a five-year period (July 2006-June 2011), capturing 2,477 different drugs in 4,182 clinical trials. Comparing drugs in the pipeline that target diseases in high-income and low-income countries, we found that the number of drugs for diseases prevalent in high-income countries was 3.46 times higher than drugs for diseases prevalent in low-income countries. We also found that the plurality of drugs in the pipeline were being developed to treat cancers (26.2%). Interpreting our findings through the lens of pharmaceuticalization, we illustrate how investigating the entire drug development pipeline provides important information about patterns of pharmaceuticalization that are invisible when only marketed drugs are considered