Decay Modes of Intersecting Fluxbranes

Just as the single fluxbrane is quantum mechanically unstable to the nucleation of a locally charged spherical brane, so intersecting fluxbranes are unstable to various decay modes. Each individual element of the intersection can decay via the nucleation of a spherical brane, but uncharged spheres can also be nucleated in the region of intersection. For special values of the fluxes, however, intersecting fluxbranes are supersymmetric, and so are expected to be stable. We explicitly consider the instanton describing the decay modes of the two--element intersection (an F5-brane in the string theory context), and show that in dimensions greater than four the action for the decay mode of the supersymmetric intersection diverges. This observation allows us to show that stable intersecting fluxbranes should also exist in type 0A string theory.Comment: 19 pages, 6 figures. References adde

An approach to cork oak forest management planning: a case study in southwestern Portugal

This paper presents results of research aiming at the development of tools that may enhance cork oak (Quercus suber L.) forest management planning. Specifically, it proposes an hierarchical approach that encompasses the spatial classification of a cork oak forest and the temporal scheduling of cork harvests. The use of both geographical information systems and operations research techniques is addressed. Emphasis is on the achievement of cork even flow objectives. Results from an application to a case study in the Charneca Plioce´nica of Ribatejo in southern Portugal encompassing a cork oak forest extending over 4.8 thousand ha are discussed. They suggest that the proposed approach is capable of effective spatial classification of cork oak management units. They further suggest that it may be used to select optimal cork even flow scheduling strategies. Results also show that the proposed approach may lead to a substantial increase in net present value when compared to traditional approaches to cork oak forest management planning

A New Cosmological Scenario in String Theory

We consider new cosmological solutions with a collapsing, an intermediate and an expanding phase. The boundary between the expanding (collapsing) phase and the intermediate phase is seen by comoving observers as a cosmological past (future) horizon. The solutions are naturally embedded in string and M-theory. In the particular case of a two-dimensional cosmology, space-time is flat with an identification under boost and translation transformations. We consider the corresponding string theory orbifold and calculate the modular invariant one-loop partition function. In this case there is a strong parallel with the BTZ black hole. The higher dimensional cosmologies have a time-like curvature singularity in the intermediate region. In some cases the string coupling can be made small throughout all of space-time but string corrections become important at the singularity. This happens where string winding modes become light which could resolve the singularity. The new proposed space-time casual structure could have implications for cosmology, independently of string theory.Comment: 28 pages, 3 figures; v2: Added new subsection relating two-dimensional model to BTZ black hole, typos corrected and references added; v3: minor corrections, PRD versio

(Twisted) Toroidal Compactification of pp-Waves

The maximally supersymmetric type IIB pp-wave is compactified on spatial circles, with and without an auxiliary rotational twist. All spatial circles of constant radius are identified. Without the twist, an S$^1$ compactification can preserve 24, 20 or 16 supercharges. $T^2$ compactifications can preserve 20, 18 or 16 supercharges; $T^3$ compactifications can preserve 18 or 16 supercharges and higher compactifications preserve 16 supercharges. The worldsheet theory of this background is discussed. The T-dual and decompactified type IIA and M-theoretic solutions which preserve 24 supercharges are given. Some comments are made regarding the AdS parent and the CFT description.Comment: 22 pages REVTeX 4 and AMSLaTeX. v3: References and a paragraph on nine dimensional Killing spinors were added. v4: A few typos corrected and a footnote was modifie

Particle Pair Production in Cosmological General Relativity

The Cosmological General Relativity (CGR) of Carmeli, a 5-dimensional (5-D) theory of time, space and velocity, predicts the existence of an acceleration a_0 = c / tau due to the expansion of the universe, where c is the speed of light in vacuum, tau = 1 / h is the Hubble-Carmeli time constant, where h is the Hubble constant at zero distance and no gravity. The Carmeli force on a particle of mass m is F_c = m a_0, a fifth force in nature. In CGR, the effective mass density rho_eff = rho - rho_c, where rho is the matter density and rho_c is the critical mass density which we identify with the vacuum mass density rho_vac = -rho_c. The fields resulting from the weak field solution of the Einstein field equations in 5-D CGR and the Carmeli force are used to hypothesize the production of a pair of particles. The mass of each particle is found to be m = tau c^3 / 4 G, where G is Newton's constant. The vacuum mass density derived from the physics is rho_vac = -rho_c = -3 / (8 pi G tau^2). The cosmic microwave background (CMB) black body radiation at the temperature T_o = 2.72548 K which fills that volume is found to have a relationship to the ionization energy of the Hydrogen atom. Define the radiation energy epsilon_gamma = (1 - g) m c^2 / N_gamma, where (1-g) is the fraction of the initial energy m c^2 which converts to photons, g is a function of the baryon density parameter Omega_b and N_gamma is the total number of photons in the CMB radiation field. We make the connection with the ionization energy of the first quantum level of the Hydrogen atom by the hypothesis epsilon_gamma = [(1 - g) m c^2] / N_gamma = alpha^2 mu c^2 / 2, where alpha is the fine-structure constant and mu = m_p f / (1 + f), where f= m_e / m_p with m_e the electron mass and m_p the proton mass.Comment: 14 pages, 0 figures. The final publication is available at springerlink.co

Evaluation of Nanoparticle Uptake iii Co-culture Cancer Modeis

Co-culture models are currently bridging the gap between classical cultures and in vivo animal models. Exploring this novel approach unlocks the possibility to mimic the tumor microenvironment in vitro, through the establishment of cancer-stroma synergistic interactions. Notably, these organotypic models offer a perfect platform for the development and pre-clinical evaluation of candidate nanocarriers loaded with anti-tumoral drugs in a high throughput screening mode, with lower costs and absence of ethical issues. However, this evaluation was until now limited to co-culture systems established with precise cell ratios, not addressing the natural cell heterogeneity commonly found in different tumors. Therefore, herein the multifunctional nanocarriers efficiency was characterized in various fibroblast-MCF-7 co-culture systems containing different cell ratios, in order to unravel key design parameters that influence nanocarrier performance and the therapeutic outcome. The successful establishment of the co-culture models was confirmed by the tissue-like distribution of the different cells in culture. Nanoparticles incubation in the various co-culture systems reveals that these nanocarriers possess targeting specificity for cancer cells, indicating their suitability for being used in this illness therapy. Additionally, by using different co-culture ratios, different nanoparticle uptake profiles were obtained. These findings are of crucial importance for the future design and optimization of new drug delivery systems, since their real targeting capacity must be addressed in heterogenous cell populations, such as those found in tumors.PEst-OE/EGEJUI4D5G/201

Braess's Paradox in Wireless Networks: The Danger of Improved Technology

When comparing new wireless technologies, it is common to consider the effect that they have on the capacity of the network (defined as the maximum number of simultaneously satisfiable links). For example, it has been shown that giving receivers the ability to do interference cancellation, or allowing transmitters to use power control, never decreases the capacity and can in certain cases increase it by $\Omega(\log (\Delta \cdot P_{\max}))$, where $\Delta$ is the ratio of the longest link length to the smallest transmitter-receiver distance and $P_{\max}$ is the maximum transmission power. But there is no reason to expect the optimal capacity to be realized in practice, particularly since maximizing the capacity is known to be NP-hard. In reality, we would expect links to behave as self-interested agents, and thus when introducing a new technology it makes more sense to compare the values reached at game-theoretic equilibria than the optimum values. In this paper we initiate this line of work by comparing various notions of equilibria (particularly Nash equilibria and no-regret behavior) when using a supposedly "better" technology. We show a version of Braess's Paradox for all of them: in certain networks, upgrading technology can actually make the equilibria \emph{worse}, despite an increase in the capacity. We construct instances where this decrease is a constant factor for power control, interference cancellation, and improvements in the SINR threshold ($\beta$), and is $\Omega(\log \Delta)$ when power control is combined with interference cancellation. However, we show that these examples are basically tight: the decrease is at most O(1) for power control, interference cancellation, and improved $\beta$, and is at most $O(\log \Delta)$ when power control is combined with interference cancellation

Obstetrician's risk perception on the prescription of magnesium sulfate in severe preeclampsia and eclampsia: a qualitative study in Brazil

Magnesium sulfate (MgSO4) is the drug of choice for the prevention and control of seizures in the management of severe preeclampsia/eclampsia. Several barriers have been iden-tified in the use of MgSO4, especially in low and middle-income settings. Objective To describe the obstetrician's perception on possible reasons for underutilizing magnesium sulfate to treat preeclampsia/eclampsia. Method A qualitative clinical study, based on phenomenological reference by semi-structured inter-views and open-ended discussions with obstetricians of the public healthcare system in pri-mary care units (PCU) and referral maternity hospitals (RMH), in a southeastern Brazilian city. Results Fear of drug toxicity was the major cause for not prescribing the medication in PCU. Fear was justified by insufficient technical, structural and organizational resources of healthcare facilities and by a shortage of physicians properly trained for adequate drug use. Conclusion Fear of toxicity of magnesium sulfate was the main barrier towards timely and proper drug use. Periodic skill development and training of obstetricians, along with integration of the medical team in the work environment may contribute to decrease fear, ensuring safety of drug prescription and thus possibly reducing adverse outcomes related to PE.Introduction Magnesium sulfate (MgSO4) is the drug of choice for the prevention and control of seizures in the management of severe preeclampsia/eclampsia. Several barriers have been iden-tified in the use of MgSO4, especially in low and middle-income set123sem informaçãosem informaçã

T-duality in M-theory and supermembranes

The (q_1,q_2) SL(2,Z) string bound states of type IIB superstring theory admit two inequivalent (T-dual) representations in eleven dimensions in terms of a fundamental 2-brane. In both cases, the spectrum of membrane oscillations can be determined exactly in the limit $g^2\to \infty$, where $g^2$ is the type IIA string coupling. We find that the BPS mass formulas agree, and reproduce the BPS mass spectrum of the $(q_1,q_2)$ string bound state. In the non-BPS sector, the respective mass formulas apply in different corners of the moduli space. The axiomatic requirement of T-duality in M-theory permits to derive a discrete mass spectrum in a (thin torus) region where standard supermembrane theory undergoes instabilities.Comment: harvmac, 9 page

D-Brane Probe and Closed String Tachyons

We consider a D-brane probe in unstable string background associated with flux branes. The twist in spacetime metric reponsible for the supersymmetry breaking is shown to manifest itself in mixing of open Wilson lines with the phases of some adjoint matter fields, resulting in a nonlocal and nonsupersymmetric form of Yang-Mills theory as the probe dynamics. This provides a setup where one can study fate of a large class of unstable closed string theories that include as a limit type 0 theories and various orbifolds of type II and type 0 theories. We discuss the limit of ${\bf C}/Z_n$ orbifold in some detail and speculate on couplings with closed string tachyons.Comment: LaTeX, 17 pages, typos fixed, references update