Temporomandibular Joint Internal Derangement: Association With Headache, Joint Effusion, Bruxism, And Joint Pain

Aim: The aim of the present study was to assess the correlation of temporomandibular joint internal derangement (TMJ ID) in patients with the presence of headache, bruxism, and joint pain using magnetic resonance imaging (MRI). Methods and Materials: This study evaluated 42 joints in 42 patients; 21 patients diagnosed with unilateral TMJ ID and a history of headaches and 21 patients diagnosed with unilateral TMD ID without a history of headaches. Signs of headache, bruxism, and joint pain were diagnosed clinically and were also obtained from the patient's history. Sixteen joints in 16 patients without signs or symptoms of TMD or headache were included as a control group. All patients underwent bilateral MRI of the TMJ to evaluate the disc position and the presence of joint effusion. Data were analyzed using Chi-square and Fischer's exact tests. Results: Bruxing behavior was most frequently reported by patients with headaches (p<0.0125). Eighty-five percent of subjects with headaches also reported joint pain. A significant association was found between headache and TMJ effusion (p<0.0125). Patients with more severe disc displacement also had a higher frequency of effusion (p=0.001). Conclusion: The results suggest joint effusion may have a role in the pathogenesis of headache in TMJ ID. Clinical Significance: Temporomandibular joint effusion on MRI may serve as a biological marker of headache associated with TMD and could be helpful for diagnostic classification and treatment follow up.96916McNeill, C., Management of temporomandibular disorders: Concepts and controversies (1997) J Prosthet Dent, 77, pp. 510-522McNeill, C., Mohl, N.D., Rugh, J.D., Tanaka, T.T., Temporomandibular disorders: Diagnosis, management, education, and research. 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Tensor Coding For Cdma-mimo Wireless Communication Systems

In this paper, we propose a tridimensional tensor coding for multiple-inputmultiple-output (MIMO) communication systems. This coding allows spreading and multiplexing the transmitted symbols in both space and time domains, owing the use of two allocation matrices. Assuming flat Rayleigh fading channels, the signals received by K receive antennas during P time blocks, composed of N symbol periods each, with J chips per symbol, forma fourth-order tensor that satisfies a new constrained tensor model. A two-step alternating least squares (ALS) algorithm is proposed for blindly and jointly estimating the channel and the transmitted symbols. The performance of the proposed blind receiver is evaluated by means of computer simulations. © EURASIP, 2011.101105De Almeida, A.L.F., Favier, G., Mota, J.C.M., A constrained factor decomposition with application to mimo antenna systems (2008) IEEE Transactions on Signal Processing, 56 (6), pp. 2429-2442De Almeida, A.L.F., Favier, G., Mota, J.C.M., Constrained tensor modeling approach to blind multipleantenna cdma schemes (2008) IEEE Transactions on Signal Processing, 56 (6), pp. 2417-2428De Almeida, A.L.F., Favier, G., Mota, J.C.M., Multiuser mimo system using block space-time spreading and tensor modeling (2008) Signal Processing, 88 (10), pp. 2388-2402De Almeida, A.L.F., Favier, G., Mota, J.C.M., Space-time spreading-multiplexing for mimo wireless communication systems using the paratuck-2 tensor model (2009) Signal Processing, 89 (11), pp. 2103-2116De Baynast, A., De Lathauwer, L., Aazhang, B., Blind parafac receivers for multiple access-multiple antenna systems (2003) Proc. IEEE 58th Fall Vehicular Technology Conf. (VTC 2003), 2, pp. 1128-1132De Lathauwer, L., De Baynast, A., Blind deconvolution of DS-CDMA signals by means of decomposition in rank-(1,L,L) terms (2008) IEEE Transactions on Signal Processing, 56 (4), pp. 1562-1571Nion, D., Sidiropoulos, N.D., Adaptive algorithms to track the PARAFAC decomposition of a thirdorder tensor (2009) IEEE Transactions on Signal Processing, 57 (6), pp. 2299-2310Sidiropoulos, N.D., Budampati, R.S., Khatri-rao space-time codes (2002) IEEE Transactions on Signal Processing, 50 (10), pp. 2396-2407Sidiropoulos, N.D., Giannakis, G.B., Bro, R., Blind parafac receivers for ds-cdma systems (2000) IEEE Transactions on Signal Processing, 48 (3), pp. 810-823Zheng, L., Tse, D.N.C., Diversity and multiplexing:A fundamental tradeoff in multiple-antenna channels (2003) IEEE Transactions on Information Theory, 49 (5), pp. 1073-109

The Association Between Periodontal Disease And Seizure Severity In Refractory Epilepsy Patients

Purpose Periodontal diseases are common in most populations and affect people at all socioeconomic levels. Evidence suggests that patients with epilepsy actually have higher risks of dental disease and increased oral health needs, but the frequency and consequences of poor controlled seizures on dental and periodontal health have not been reported before. We aimed to assess the impact of seizure frequency on periodontal status and oral hygiene in a sample of epilepsy patients. Methods One hundred and nine consecutive patients treated for epilepsy at the outpatient clinic of our University Hospital were invited to take part in an oral examination to determine their periodontal disease status, together with a control group. In addition, seizure frequency and use of medication were documented. Results In logistic regression model, patients were significantly more susceptible to bad oral hygiene, gingivitis and periodontitis that controls (p < 0.001); seizure frequency was significantly related to bad oral hygiene (p = 0.010), gingivitis (p < 0.001) and periodontitis (p < 0.001). Tooth brushing habits and presence of caries were associated with oral health in patients group. Conclusion Our study found a significant positive correlation between periodontal disease and seizure severity. Epilepsy patients need to focus more on their oral health and quality of oral hygiene. © 2013 British Epilepsy Association.233227230Kinane, D.F., Causation and pathogenesis of periodontal disease (2001) Periodontology, 25, pp. 8-20Einarson, S., Gerdin, E.W., Hugoson, A., Oral health impact on quality of life in an adult Swedish population (2009) Acta Odontologica Scandinavica, 67, pp. 85-93Karolyhazy, K., Kivovics, P., Fejerdy, P., Aranyi, Z., Prosthodontic status and recommended care of patients with epilepsy (2005) Journal of Prosthetic Dentistry, 93, pp. 177-182Károlyházy, K., Kivovics, P., Hermann, P., Fejérdy, P., Arányi, Z., Five-year follow-up of oral health and seizure condition of patients with epilepsy: A prospective observational study (2010) Community Dental Health, 27, pp. 233-237Károlyházy, K., Kovács, E., Kivovics, P., Fejérdy, P., Arányi, Z., Dental status and oral health of patients with epilepsy: An epidemiologic study (2003) Epilepsia, 44, pp. 1103-1108Silness, J., Löe, H., Periodontal disease in pregnanc. II: Correlation between oral hygiene and periodontal condition (1964) Acta Odontologica Scandinavica, 22, pp. 121-135Löe, H., The gingival index, the plaque index and the retention index systems (1967) Journal of Periodontoly, 38, pp. 610-616Einarsdóttir, E.R., Gunnsteinsdóttir, H., Hallsdóttir, M.H., Sveinsson, S., Jónsdóttir, S.R., Olafsson, V.G., Dental health of patients with Parkinson's disease in Iceland (2009) Special Care in Dentistry, 29, pp. 123-127Slavkin, H.C., Baum, B.J., Relationship of dental and oral pathology to systemic illness (2000) Journal of the American Medical Association, 284, pp. 1215-1217Costa, A.L., Yasuda, C.L., Franca, Jr.M.C., Morita, M.E., Cendes, F., Epilepsy is highly associated with severe dentoalveolar and maxillofacial injuries (2011) Epileptic Disorders, 13, pp. 61-64Tellez-Zenteno, J.F., Nguyen, R., Hernadez-Ronquillo, L., Injuries, accidents and mortality in epilepsy: A review of its prevalence risk factors and prevention (2010) Revista de Investigación Clínica, 62, pp. 466-479Coventry, J., Griffiths, G., Scully, C., Tonetti, M., ABC of oral health: Periodontal disease (2000) British Medical Journal, 321, pp. 36-39Pihlstrom, B.L., Michalowicz, B.S., Johnson, N.W., Periodontal diseases (2005) Lancet, 366, pp. 1809-1820Aragon, C.E., Burneo, J.G., Understanding the patient with epilepsy and seizures in the dental practice (2007) Journal of the Canadian Dental Association, 73, pp. 71-76Tonetti, M.S., Claffey, N., Advances in the progression of periodontitis and proposal of definitions of a periodontitis case and disease progression for use in risk factor research. Group c consensus report of the 5th European workshop in periodontology (2005) Journal of Clinical Periodontology, 32 (SUPPL. 6), pp. 210-213Reali, L., Zuliani, E., Gabutti, L., Schönholzer, C., Marone, C., Poor oral hygiene enhances gingival overgrowth caused by calcineurin inhibitors (2009) Clinical Pharmacology & Therapeutics, 34, pp. 255-260Cornacchio, A.L., Burneo, J.G., Aragon, C.E., The effects of antiepileptic drugs on oral health (2011) Journal of the Canadian Dental Association, 77, p. 14

Temporomandibular Dysfunction Post-craniotomy: Evaluation Between Pre- And Post-operative Status

Objective To identify risk factors associated with post-operative temporomandibular joint dysfunction after craniotomy. Methods The study sample included 24 patients, mean age of 37.3 ± 10 years; eligible for surgery for refractory epilepsy, evaluated according to RDC/TMD before and after surgery. The primary predictor was the time after the surgery. The primary outcome variable was maximal mouth opening. Other outcome variables were: disc displacement, bruxism, TMJ sound, TMJ pain, and pain associated to mandibular movements. Data analyses were performed using bivariate and multiple regression methods.Results The maximal mouth opening was significantly reduced after surgery in all patients (p = 0.03). In the multiple regression model, time of evaluation and pre-operative bruxism were significantly (p <.05) associated with an increased risk for TMD post-surgery. Conclusion A significant correlation between surgery follow-up time and maximal opening mouth was found. Pre-operative bruxism was associated with increased risk for temporomandibular joint dysfunction after craniotomy.42714751479Adada, B., Selective amygdalohippocampectomy via the transsylvian approach (2008) Neurosurg Focus, 25 (3), p. 5Alomar, X., Medrano, J., Cabratosa, J., Clavero, J.A., Lorente, M., Serra, I., Anatomy of the temporomandibular joint (2007) Semin Ultrasound CT MR, 28 (3), pp. 170-183Bravetti, P., Membre, H., El, H.A., Gerard, H., Fyard, J.P., Mahler, P., Histological study of the human temporo-mandibular joint and its surrounding muscles (2004) Surg Radiol Anat, 26 (5), pp. 371-378Cairns, B.E., Pathophysiology of TMD pain - Basic mechanisms and their implications for pharmacotherapy (2010) J Oral Rehabil, 37 (6), pp. 391-410Costa, A.L., D'Abreu, A., Cendes, F., Temporomandibular joint internal derangement: Association with headache, joint effusion, bruxism, and joint pain (2008) J Contemp Dent Pract, 9 (6), pp. 9-16De Andrade Junior, F.C., De Andrade, F.C., De Araujo Filho, C.M., Carcagnolo, F.J., Dysfunction of the temporalis muscle after pterional craniotomy for intracranial aneurysms. 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A review of predictive factors (2000) Anesthesiology, 93 (4), pp. 1123-1133Rauhala, K., Oikarinen, K.S., Raustia, A.M., Role of temporomandibular disorders (TMD) in facial pain: Occlusion, muscle and TMJ pain (1999) Cranio, 17 (4), pp. 254-261Rocha-Filho, P.A., Fujarra, F.J., Gherpelli, J.L., Rabello, G.D., De Siqueira, J.T., The long-term effect of craniotomy on temporalis muscle function (2007) Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 104 (5), pp. 17-e21Schellhas, K.P., Wilkes, C.H., Baker, C.C., Facial pain, headache, and temporomandibular joint inflammation (1989) Headache, 29 (4), pp. 229-232Seoane, E., Tedeschi, H., De Oliveira, E., Wen, H.T., Rhoton, A.L., Jr., The pretemporal transcavernous approach to the interpeduncular and prepontine cisterns: Microsurgical anatomy and technique application (2000) Neurosurgery, 46 (4), pp. 891-898Summers, L., False ankylosis of the temporo-mandibular joint following craniotomy (1980) Br J Oral Surg, 18 (2), pp. 138-140Tallents, R.H., Katzberg, R.W., Murphy, W., Proskin, H., Magnetic resonance imaging findings in asymptomatic volunteers and symptomatic patients with temporomandibular disorders (1996) J Prosthet Dent, 75 (5), pp. 529-533Truelove, E.L., Sommers, E.E., Leresche, L., Dworkin, S.F., Von, K.M., Clinical diagnostic criteria for TMD. 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Recovery Of White Matter Atrophy After Epilepsy Surgery: Structural Evidences Through Voxel-based Morphometry [regeneração De Atrofia De Substância Branca Após A Cirurgia De Epilesia: Evidências Estruturais Através Da Morfometria Baseada Em Voxel]

Objectives: To study pre and postoperative WMA in MTLE patients. Methods: We performed Voxel-Based Morphometry (VBM) with volume of interest (VOI) in 69 controls (mean age, 34.3±11.1 years) and 67 operated patients (mean age, 34.1±10.4 years) with unilateral MTLE. 34 became seizure-free (SzFree-Group), 23 improved (Engel IB-IIA [Partial recovery-group]) and 10 did not improve (Engel III-IV [Failure-Group]). All had pre and postoperative MRIs (one year minimum). We flipped MRIs of right MTLE patients in order to avoid right-to-left analysis cancelation. VBM was performed on SPM2/MATLAB7.0 with individual masks for surgical lacunae and 1% false-discovery-rate to control for multiple comparisons. We used MARSbar 〈www.marsbar.sourceforge.net〉 routine to select ROIs and t-test for statistical analyses. Results: Mean postoperative follow-up was 60.2 (±SD 30.7) months. On baseline MRI, SzFree-Group showed White Matter Atrophy (WMA) involving temporal lobes [TL], ipsilateral occipital, parietal and frontal regions, with areas of significant recovery of WMA on postoperative MRI. Partial recovery-Group presented a more restricted pattern of WMA, involving ipsilateral temporal lobe, contralateral superior temporal gyrus and few areas in bilateral cingulated and orbitofrontal areas. In this group we also identified areas with relative increase of WM after surgery. By contrast, Failure-Group showed more widespread bi-hemispheric areas of WMA on baseline MRI without postoperative improvement. Conclusions: Although we have identified some differences in baseline WMA, we were unable to correlate a more widespread pattern with a worse prognosis, as SzFree-Group, also presented a bilateral distribution of WMA. 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Production and characterization of a biosurfactant produced by Streptomyces sp. DPUA 1559 isolated from lichens of the Amazon region

<div><p>Surfactants are amphipathic compounds containing both hydrophilic and hydrophobic groups, capable to lower the surface or interfacial tension. Considering the advantages of the use of biosurfactants produced by microorganisms, the aim of this paper was to develop and characterize a biosurfactant produced by Streptomyces sp. DPUA1559 isolated from lichens of the Amazon region. The microorganism was cultured in a mineral medium containing 1% residual frying soybean oil as the carbon source. The kinetics of biosurfactant production was accompanied by reducing the surface tension of the culture medium from 60 to values around 27.14 mN/m, and by the emulsification index, which showed the efficiency of the biosurfactant as an emulsifier of hydrophobic compounds. The yield of the isolated biosurfactant was 1.74 g/L, in addition to the excellent capability of reducing the surface tension (25.34 mN/m), as observed from the central composite rotational design when the biosurfactant was produced at pH 8.5 at 28°C. The critical micelle concentration of the biosurfactant was determined as 0.01 g/mL. The biosurfactant showed thermal and pH stability regarding the surface tension reduction, and tolerance under high salt concentrations. The isolated biosurfactant showed no toxicity to the micro-crustacean Artemia salina, and to the seeds of lettuce (Lactuca sativa L.) and cabbage (Brassica oleracea L.). The biochemistry characterization of the biosurfactant showed a single protein band, an acid character and a molecular weight around 14.3 kDa, suggesting its glycoproteic nature. The results are promising for the industrial application of this new biosurfactant.</p></div