Inovações Inclusivas em Regiões Periféricas: um estudo do Arranjo Produtivo Local de Mandioca no Agreste alagoano

The activity of mandioculture consists of one of the oldest activities linked to agriculture, when analyzing the Brazilian market, it becomes evident the participation of 5 states in the productive concentration of this activity, being these Pará, Paraná, Bahia, Maranhão and São Paulo with 58 % of production. When we check the state of Alagoas, it occupies only 16th place in the national ranking, with 1% in the ranking of the Brazilian Northeast, this position is the 5th with 6%, always accompanied by the increase of production and national prices. The study sought to analyze the impacts of the inclusive innovations in the Local Productive Arrangement of Mandioculture in Alagoas, from the initial verifications, it became possible to perceive innovations in levels occurred, besides the possibility of increment in production, given the improvement of new productive varieties developed by EMBRAPA. With this, it is verified that the APL presents potentials, and potentialities for the development of new products, due to the improvement of the cultivars.A atividade de mandiocultura consiste em uma das atividades mais antigas ligadas a agricultura, no Brasil, impulsionada pelo Pará, Paraná, Bahia, Maranhão e São Paulo, produzindo 58% da produção nacional, segundo dados da Produção Agrícola Municipal (PAM/IBGE, 2018). Alagoas ocupa a 16ª posição no ranking nacional com 1% da produção, no Nordeste é o 5º em produção, com 6%, sempre acompanhado o aumento da produção e preços nacionais. O estudo buscou analisar os impactos das inovações inclusivas no APL de Mandiocultura em Alagoas, a partir das verificações iniciais, foi possível perceber que as inovações ocorridas, conforme níveis de inclusão apontados por Heeks et. al. (2013), seja do nível 1 ao nível 4, além da possibilidade de incremento na produção, dada a melhoria de novas variedades produtivas desenvolvidas pela EMBRAPA. Com isso, constata-se que o APL apresenta potencialidades, e potencialidades para o desenvolvimento de novos produtos, devido à melhoria dos cultivares

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

Estudo‌ ‌de‌ ‌Prospecção‌ ‌Tecnológica‌ ‌sobre‌ ‌Embalagens‌ ‌Ativas‌ ‌para‌ ‌Vegetais‌

This work aims to map the scientific and technological development of active packaging for vegetables. From the identification of patent documents and articles, an analysis of the technological scenario on the subject was carried out, with identification and appreciation of the evolution over time, in order to point out the dynamics of this market in different parts of the world. To do so, searches were made of patent and article databases, based on a set of selected keywords. The bases used were the software  Orbit, which identified 620 patents and Scopus, with 350 articles, from which analyzes and projections were performed in the graphs. Finally, the merging of keywords and the main IPC codes allowed for a more targeted analysis of active packaging technologies, with a view to identifying trends and targeting the market.ResumoEste trabalho tem por objetivo mapear o desenvolvimento científico e tecnológico de embalagens ativas para vegetais. A partir da identificação de documentos de patentes e de artigos, foi realizada uma análise do cenário tecnológico sobre o tema, com identificação e apreciação da evolução ao longo do tempo, para apontamento da dinâmica deste mercado em diversas partes do mundo. Para tanto, foram realizadas buscas em bases de patentes e de artigos, a partir de um conjunto de palavras-chave selecionadas. As bases utilizadas foram o software Orbit, que identificou 620 patentes, e a base de dados Scopus, com 350 artigos, a partir dos quais foram realizadas análises e projeções apresentadas nos Gráficos. Por fim, a junção de palavras-chave com os principais códigos IPC permitiu uma análise mais direcionada às tecnologias de embalagens ativas, com vistas à identificação de tendências e direcionamento de mercado

Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies

Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies. Methods: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality. Findings: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42·4% vs 44·2%; absolute difference -1·69 [-9·58 to 6·11] p=0·67; data available in 3174 [82%] of 3852 patients). The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5-8] vs 6 [5-8] cm H2O; p=0·0011). ICU mortality was higher in MICs than in HICs (30·5% vs 19·9%; p=0·0004; adjusted effect 16·41% [95% CI 9·52-23·52]; p<0·0001) and was inversely associated with gross domestic product (adjusted odds ratio for a US$10 000 increase per capita 0·80 [95% CI 0·75-0·86]; p<0·0001). Interpretation: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in MICs than in HICs, with a strong association with country-level economic status

Risk Categorization Using New American College of Cardiology/American Heart Association Guidelines for Cholesterol Management and Its Relation to Alirocumab Treatment Following Acute Coronary Syndromes

10.1161/CIRCULATIONAHA.119.042551CIRCULATION140191578-158

Effect of Alirocumab on Mortality After Acute Coronary Syndromes An Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial

10.1161/CIRCULATIONAHA.118.038840CIRCULATION1402103-11