18 research outputs found
Clinical predictors of 3- and 6-month outcome for mild traumatic brain injury patients with a negative head CT scan in the emergency department: A TRACK-TBI pilot study
Aconsiderable subset of mild traumatic brain injury (mTBI) patients fail to return to baseline functional status at or beyond 3 months postinjury. Identifying at-risk patients for poor outcome in the emergency department (ED) may improve surveillance strategies and referral to care. Subjects with mTBI (Glasgow Coma Scale 13–15) and negative ED initial head CT < 24 h of injury, completing 3- or 6-month functional outcome (Glasgow Outcome Scale-Extended; GOSE), were extracted from the prospective, multicenter Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Pilot study. Outcomes were dichotomized to full recovery (GOSE = 8) vs functional deficits (GOSE < 8). Univariate predictors with p < 0.10 were considered for multivariable regression. Adjusted odds ratios (AOR) were reported for outcome predictors. Significance was assessed at p < 0.05. Subjects who completed GOSE at 3- and 6-month were 211 (GOSE < 8: 60%) and 185 (GOSE < 8: 65%). Risk factors for 6-month GOSE < 8 included less education (AOR = 0.85 per-year increase, 95% CI: (0.74–0.98)), prior psychiatric history (AOR = 3.75 (1.73–8.12)), Asian/minority race (American Indian/Alaskan/Hawaiian/Pacific Islander) (AOR = 23.99 (2.93–196.84)), and Hispanic ethnicity (AOR = 3.48 (1.29–9.37)). Risk factors for 3-month GOSE < 8 were similar with the addition of injury by assault predicting poorer outcome (AOR = 3.53 (1.17–10.63)). In mTBI patients seen in urban trauma center EDs with negative CT, education, injury by assault, Asian/minority race, and prior psychiatric history emerged as risk factors for prolonged disability
Pre-injury Comorbidities Are Associated With Functional Impairment and Post-concussive Symptoms at 3-and 6-Months After Mild Traumatic Brain Injury: A TRACK-TBI Study
Introduction: Over 70% of traumatic brain injuries (TBI) are classified as mild (mTBI),
which present heterogeneously. Associations between pre-injury comorbidities and
outcomes are not well-understood, and understanding their status as risk factors may
improve mTBI management and prognostication.
Methods: mTBI subjects (GCS 13–15) from TRACK-TBI Pilot completing 3- and
6-month functional [Glasgow Outcome Scale-Extended (GOSE)] and post-concussive
outcomes [Acute Concussion Evaluation (ACE) physical/cognitive/sleep/emotional
subdomains] were extracted. Pre-injury comorbidities >10% incidence were included
in regressions for functional disability (GOSE ≤ 6) and post-concussive symptoms by
subdomain. Odds ratios (OR) and mean differences (B) were reported. Significance was
assessed at p < 0.0083 (Bonferroni correction).
Results: In 260 subjects sustaining blunt mTBI, mean age was 44.0-years and 70.4%
were male. Baseline comorbidities >10% incidence included psychiatric-30.0%, cardiac
(hypertension)-23.8%, cardiac (structural/valvular/ischemic)-20.4%, gastrointestinal15.8%, pulmonary-15.0%, and headache/migraine-11.5%. At 3- and 6-months
separately, 30.8% had GOSE ≤ 6. At 3-months, psychiatric (GOSE ≤ 6: OR = 2.75,
95% CI [1.44–5.27]; ACE-physical: B = 1.06 [0.38–1.73]; ACE-cognitive: B = 0.72
[0.26–1.17]; ACE-sleep: B = 0.46 [0.17–0.75]; ACE-emotional: B = 0.64 [0.25–1.03]), headache/migraine (GOSE ≤ 6: OR = 4.10 [1.67–10.07]; ACE-sleep: B = 0.57
[0.15–1.00]; ACE-emotional: B = 0.92 [0.35–1.49]), and gastrointestinal history
(ACE-physical: B = 1.25 [0.41–2.10]) were multivariable predictors of worse outcomes.
At 6-months, psychiatric (GOSE ≤ 6: OR = 2.57 [1.38–4.77]; ACE-physical: B = 1.38
[0.68–2.09]; ACE-cognitive: B = 0.74 [0.28–1.20]; ACE-sleep: B = 0.51 [0.20–0.83];
ACE-emotional: B = 0.93 [0.53–1.33]), and headache/migraine history (ACE-physical:
B = 1.81 [0.79–2.84]) predicted worse outcomes.
Conclusions: Pre-injury psychiat
Measurement of the WW production cross section in p anti-p collisions at s**(1/2) = 1.96 TeV
We present a measurement of the W boson pair-production cross section in p
anti-p collisions at a center-of-mass energy of sqrt{s}=1.96 TeV. The data,
collected with the Run II DO detector, correspond to an integrated luminosity
of 224-252 pb^-1 depending on the final state (ee, emu or mumu). We observe 25
candidates with a background expectation of
8.1+/-0.6(stat)+/-0.6(syst)+/-0.5(lum) events. The probability for an upward
fluctuation of the background to produce the observed signal is 2.3x10^-7,
equivalent to 5.2 standard deviations.The measurement yields a cross section of
13.8+4.3/-3.8(stat)+1.2/-0.9(syst)+/-0.9(lum) pb, in agreement with predictions
from the standard model.Comment: submitted to PR
Measurement of the Lambda^0_b lifetime in the decay Lambda^0_b -> J/psi Lambda^0 with the D0 Detector
We present measurements of the Lambda^0_b lifetime in the exclusive decay
channel Lambda^0_{b}->J/psi Lambda^0, with J/psi to mu+ mu- and Lambda^0 to p
pi-, the B^0 lifetime in the decay B^0 -> J/psi K^0_S with J/psi to mu+ mu- and
K^0_S to pi+ pi-, and the ratio of these lifetimes. The analysis is based on
approximately 250 pb^{-1} of data recorded with the D0 detector in pp(bar)
collisions at sqrt{s}=1.96 TeV. The Lambda^0_b lifetime is determined to be
tau(Lambda^0_b) = 1.22 +0.22/-0.18 (stat) +/- 0.04 (syst) ps, the B^0 lifetime
tau(B^0) = 1.40 +0.11/-0.10 (stat) +/- 0.03 (syst) ps, and the ratio
tau(Lambda^0_b)/tau(B^0) = 0.87 +0.17/-0.14 (stat) +/- 0.03 (syst). In contrast
with previous measurements using semileptonic decays, this is the first
determination of the Lambda^0_b lifetime based on a fully reconstructed decay
channel.Comment: 7 pages, 4 figures, Submitted to Physical Review Letters, v2: Added
FNAL Pub-numbe
Erratum to Measurement of at 1.96 TeV, published in Phys. Rev. D {71}, 072004 (2005)
A change in estimated integrated luminosity (from 226 pb^{-1}{\sigma (p \bar p \to Z)
\cdot}{(Z \to \tau \tau)}209\pm13(stat.)\pm16(syst.)\pm13(lum) pb