Student Recital (December 7, 2015)

Choro de Saudade / Agustin Barrios Mangore Nolan Driscoll, guitar My mother bids me bind my hair / Franz Josef Haydn Willow Song (The Ballad of Baby Doe) / Douglas Moore Elizabeth Lach, soprano Thoughts of Love / Arthur Pryor I. Tempo di valse II. Tempo di valse III. Tempo di valse Nicholas Grisolia, euphonium Che gelida manina (La Boheme) / Giacomo Puccini Richard Moran, tenor Sonata 5 in F Major, Opus 24 / Ludwig van Beethoven Allegro Megan Polk, violin O vos omnes (The Seven Last Words of Christ) / Theodore Dubois Colleen McDonough, soprano Hommage a Villa-Lobos / Roland Dyens Andantinostalgie Tuhu Austin DeAndrade, guitar Morgen, Opus 21, No. 4 / Richard Strauss Justine Smigel, soprano Nature beyond art / Thomas Arne Xavier Cosme, tenor Violin Concerto No. 3 in G Major, K. 216 / W. A. Mozart Allegro Gail Colombo, violin Yu Guang Qu (Song of the Fisherman) / Guang Ran Jiaying Zhu, soprano El Decameron Negro / Leo Brouwer El arpa del guerrero Killian Kerrigan, guitar Una donna quindici anni (Cosi fan tutte), K. 588 / Wolfgang Amadeus Mozart Angela Maloney, soprano Concert Etude, Opus 49 / Alexander Goedicke Lindsey Cook, trumpethttps://vc.bridgew.edu/student_concerts/1101/thumbnail.jp

Study of forward Z + jet production in pp collisions at √s=7 TeV

A measurement of the $Z(\rightarrow\mu^+\mu^-)$+jet production cross-section in $pp$ collisions at a centre-of-mass energy $\sqrt{s} = 7$ TeV is presented. The analysis is based on an integrated luminosity of $1.0\,\text{fb}^{-1}$ recorded by the LHCb experiment. Results are shown with two jet transverse momentum thresholds, 10 and 20 GeV, for both the overall cross-section within the fiducial volume, and for six differential cross-section measurements. The fiducial volume requires that both the jet and the muons from the Z boson decay are produced in the forward direction ($2.0<\eta<4.5$). The results show good agreement with theoretical predictions at the second-order expansion in the coupling of the strong interaction.A measurement of the $Z(\rightarrow\mu^+\mu^-)$+jet production cross-section in $pp$ collisions at a centre-of-mass energy $\sqrt{s} = 7$ TeV is presented. The analysis is based on an integrated luminosity of $1.0\,\text{fb}^{-1}$ recorded by the LHCb experiment. Results are shown with two jet transverse momentum thresholds, 10 and 20 GeV, for both the overall cross-section within the fiducial volume, and for six differential cross-section measurements. The fiducial volume requires that both the jet and the muons from the Z boson decay are produced in the forward direction ($2.0<\eta<4.5$). The results show good agreement with theoretical predictions at the second-order expansion in the coupling of the strong interaction

Evaluation of the capillary assay of C-reactive protein (CRP) through the lenght of consultation in pediatric emergencies and its economic impact.

International audienceFever is a frequent reason for consultation in pediatric emergency departments and raises the question of biological and radiological examinations. Rapidly obtaining the result of C-reactive protein (CRP) level is essential in front of the steady increase of the number of visits. We carried out a prospective study within the pediatric emergency department of the University Hospital of Clermont-Ferrand from January to April 2017, in order to evaluate the interest of the capillary CRP in point of care (POCT). In two periods, 68 patients (28 controls without and 40 cases with capillary CRP assayed on a Afinion® AS100) with naked fever greater than 48 hours were included. After a study of the analytical performances of Afinion® and a verification of the homogeneity and the comparability of the two groups on clinical criteria (age, sex, duration of the fever, antibiotics treatment) and biological (values of CRP), the interest of the CRP in POCT was evaluated. In the POCT group, a significant drop in the median of the emergency room consultation time (60 (IQR 33-125) versus 180 (IQR 158-208) minutes), the number of biological acts by patient (1 (IQR 1-3) versus 7 (IQR 3-8)), the global cost of biological and radiological examinations per patient (5.4 (IQR 5.4-32.6) versus 153.8 (IQR 46.9-180.4) euros), and the cost of reagents spent by the laboratory per patient (5.2 (IQR 5.2-6.4) versus 33.2 (IQR 2.3-34.2) euros). Thus, in the context of a clinical-biological partnership, the use of CRP in POCT present a practical and an economic interest

Student Recital (April 29, 2016)

O Isis und Osiris (Die Zauberjlote, K. 620) / Wolfgang Amadeus Mozart Thus saith the Lord (Messiah) / Georg Friederich Handel Robert Gariepy III, bass An Chloe, K.524 / Wolfgang Amadeus Mozart At the River (114 Songs) / Charles Ives Marie Doyon, mezzo-soprano Amarilli, mia bella / Giulio Caccini Joshua Estrada, tenor Fandanguillo, Opus 36 / Joaquin Turina Nicholas Moreira, guitar Mi chiamano Mimi (La Bohème) / Giacomo Puccini Autumn – Pami’er, My Beautiful Hometown / Quifeng Zheng Jiaying Zhu, soprano An Chloe, K.524 / W.A. Mozart Diaphenia / Domenic Argento Angela Maloney, soprano Sonata for Trombone and Piano / George Frederick McKay Andante poetico Sarah Emanuel, trombone The K’e / Celius Doherty Justine Smigel, mezzo-soprano Wehmut / Robert Schumann Xavier Cosme, tenor Ah! Je veux vivre (Roméo et Juliette) / Charles Gounod Elizabeth Lach, soprano Quando m’en vo (La Bohème) / G. Puccini Taylor Eckstrom, sopranohttps://vc.bridgew.edu/student_concerts/1116/thumbnail.jp

Increase over time of antibody levels 3 months after a booster dose as an indication of better protection against Omicron infection

International audienceThe third, "booster", vaccination increases the overall immune response against SARS-CoV-2 variants. However, after the initial peak at around 3 weeks post-vaccination, anti-spike antibody levels decline. Post-booster kinetics of cellular response has been less investigated and there is no documented evidence of a true boosting effect. Furthermore, multiple studies underline the less effective immune responses against Omicron, the latest variant of concern, at both humoral and cellular levels. In this letter, we analyse humoral (anti-RBD IgG levels) and cellular (IFN-? release assay) immune response in 205 health care workers 3 weeks and 3 months after administration of an mRNA-based booster dose, either mRNA-1273 or BNT162b2. Since all subjects were SARS-CoV-2 infection-naive, we also looked at the incidence of Omicron infection between 3 and 6 months post-booster.At both timepoints, 3x mRNA-1273 vaccination had the highest overall antibody and IFN-? levels, followed by 3x BNT162b2 vaccination and heterologous mRNA-based regimens. Heterologous ChAdOx1-mRNA-based regimen had the lowest antibody levels while cellular response equal to that of 3x BNT162b2 vaccination and heterologous mRNA-based regimens. Our results show that both humoral and cellular responses waned at 3 months for all vaccination regimens. However, we identified three trajectories of dosage variation. Interestingly, the subgroup of subjects with increasing anti-RBD IgG levels over time had a lower incidence of Omicron infection. Whether increasing humoral response at 3 months post-booster is more indicative of protection than a high initial peak remains to be confirmed in a larger cohort

Decline of Humoral and Cellular Immune Responses Against SARS-CoV-2 6 Months After Full BNT162b2 Vaccination in Hospital Healthcare Workers

International audienceClinical trials and real-world evidence on COVID-19 vaccines have shown their effectiveness against severe disease and death but the durability of protection remains unknown. We analysed the humoral and T-cell immune responses in 110 healthcare workers (HCWs) vaccinated according to the manufacturer’s recommended schedule of dose 2 three weeks after dose 1 from a prospective on-going cohort in early 2021, 3 and 6 months after full vaccination with the BNT162b2 mRNA vaccine. Anti-RBD IgG titres were lower in HCWs over 60 years old 3 months after the second dose (p=0.03) and declined in all the subjects between 3 and 6 months with a median percentage change of -58.5%, irrespective of age and baseline comorbidities. Specific T-cell response measured by IGRA declined over time by at least 42% (median) in 91 HCWs and increased by 33% (median) in 17 others. Six HCWs had a negative T-cell response at 6 months. Ongoing follow-up should provide correlates of long-term protection according to the different immune response profiles observed. COVIDIM study was registered under the number NCT04896788 on clinicaltrials.gov

Comparative T and B immune responses of four different anti-COVID-19 vaccine strategies 6 months after vaccination

International audienc

Spring Voice Recital (April 24, 2015)

Never Weather Beaten Sail / Thomas Campion Dylan Mowry, tenor Someone to Watch Over Me / George Gershwin Cassandra Gilbert, soprano Hello, Young Lovers (The King and I) / Richard Rodgers So Far (Allegro) / Richard Rodgers Victoria Shannon, mezzo-soprano Milkmaids / Peter Warlock Rêve d’Amour / Gabriel Fauré Patrick J. Murphy, baritone Just Like That (A Day in Hollywood/A Night in Ukraine) / Frank Lazarus Hailley King, soprano I Whistle a Happy Tune (The King and I) / Richard Rodgers I Loved You Once in Silence (Camelot) / Frederick Loewe Marissa Stanley, mezzo-soprano Lullaby (The Consul) / Giancarlo Menotti Aprés un Rêve / Gabriel Fauré Justine Smigel, mezzo-soprano People Will Say We’re in Love (Oklahoma) / Richard Rodgers Kristen Mauro, mezzo-soprano Michael Bradley, baritone Spring Sorrow / John Ireland I’ll Know (Guys and Dolls / Frank Loesser Rose Deggendorf, mezzo-soprano Sento nel core / Alessandro Scarlatti Multitudes of Amy (Company) / Stephen Sondheim Dana Reid, baritone Bist Du Bei Mir / Hohann Sebastian Bach Ici-bas / Gabriel Fauré Emily Mills, soprano An Die Musik / Franz Schubert How Much I Love Her / Henry Purcell Xavier Cosme, tenor Come Ready and See Me / Richard Hundley Think of Me (Phantom of the Opera) / Andrew Lloyd Webber Kate Morin, soprano Far From the Home I Love (Fiddler on the Roof) / Jerry Bock Something Wonderful (The King and I) / Richard Rodgers Kristen Mauro, mezzo-soprano Bring Him Home (Lés Misérables) / Claude-Michel Schonberg Santa Fe / Jack Feldman Jack Cappadona, tenor El majo discreto / Enrique Granados Vergebliches Ständchen / Johannes Brahms Brittany Churchill, soprano Se (Cinema Paradiso) / Ennio Morricon Is This What You Call Love? (Passion) / Stephen Sondheim Michael Bradley, baritonehttps://vc.bridgew.edu/student_concerts/1089/thumbnail.jp

Studies of beauty baryon decays to D0ph−D^0 ph^- and Λc+h−\Lambda_c^+ h^- final states

Decays of beauty baryons to the $D^0 p h^-$ and $\Lambda_c^+ h^-$ final states (where $h$ indicates a pion or a kaon) are studied using a data sample of $pp$ collisions, corresponding to an integrated luminosity of 1.0 fb$^{-1}$, collected by the LHCb detector. The Cabibbo-suppressed decays $\Lambda_b^0\to D^0 p K^-$ and $\Lambda_b^0\to \Lambda_c^+ K^-$ are observed and their branching fractions are measured with respect to the decays $\Lambda_b^0\to D^0 p \pi^-$ and $\Lambda_b^0\to \Lambda_c^+ \pi^-$. In addition, the first observation is reported of the decay of the neutral beauty-strange baryon $\Xi_b^0$ to the $D^0 p K^-$ final state, and a measurement of the $\Xi_b^0$ mass is performed. Evidence of the $\Xi_b^0\to \Lambda_c^+ K^-$ decay is also reported.Decays of beauty baryons to the D0ph− and Λc+h− final states (where h indicates a pion or a kaon) are studied using a data sample of pp collisions, corresponding to an integrated luminosity of 1.0  fb−1, collected by the LHCb detector. The Cabibbo-suppressed decays Λb0→D0pK− and Λb0→Λc+K− are observed, and their branching fractions are measured with respect to the decays Λb0→D0pπ− and Λb0→Λc+π−. In addition, the first observation is reported of the decay of the neutral beauty-strange baryon Ξb0 to the D0pK− final state, and a measurement of the Ξb0 mass is performed. Evidence of the Ξb0→Λc+K− decay is also reported.Decays of beauty baryons to the $D^0 p h^-$ and $\Lambda_c^+ h^-$ final states (where $h$ indicates a pion or a kaon) are studied using a data sample of $pp$ collisions, corresponding to an integrated luminosity of 1.0 fb$^{-1}$, collected by the LHCb detector. The Cabibbo-suppressed decays $\Lambda_b^0\to D^0 p K^-$ and $\Lambda_b^0\to \Lambda_c^+ K^-$ are observed and their branching fractions are measured with respect to the decays $\Lambda_b^0\to D^0 p \pi^-$ and $\Lambda_b^0\to \Lambda_c^+ \pi^-$. In addition, the first observation is reported of the decay of the neutral beauty-strange baryon $\Xi_b^0$ to the $D^0 p K^-$ final state, and a measurement of the $\Xi_b^0$ mass is performed. Evidence of the $\Xi_b^0\to \Lambda_c^+ K^-$ decay is also reported