Assessing the Democratic Effects of Groundwater User Associations in Mexico: The Case of Guanajuato

The Mexican water polity underwent a deep process of Neo-liberal Statetransformation, oriented at modifying the relationship between the State and society and through the implementation of a range of State-strategies. These Statestrategies produced a number of drawback and contradictions. One of such strategies was the establishment and institutional development of multi-stakeholder platforms for groundwater resources management (MSPs), a form of socio-political governance arrangement allegedly created to enable a more democratic social participation and stakeholder cooperation throughout the water resources management process. As a result of a ‘critical juncture’ two models of MSPs were established, one supported by the central-State and another by the state-level authorities in the state of Guanajuato. They had important differences in that the latter represented a more serious attempt to truly enable a socio-political governance arrangement. Today, regardless of the initiative, these MSPs remain extremely weak and their contribution to a more participatory, cooperative and democratic groundwater governance is very limited. The central hypothesis of the thesis is that the principle factor –the culprit– behind these drawbacks and limitations is the State, but that still the MSPs for groundwater governance have generated some form of ‘countervailing power’ –an opportunity inherent to these governance arrangements–that supports some small, but important democratic effects. Through the integration of a ‘heuristic-analytical’ device supported by various theoretical developments –including governance and democratic studies, but mainly underpinned by a Historical Institutionalist approach–, this thesis analyses different critical aspects of this phenomenon. Accordingly, this device is structured in six different moments of analysis that focus on different aspects of the process of Neoliberal State transformation and the institutional development of the MSPs. The device ultimately seeks to develop and understanding of the prospects and challenges of the MSPs, assess their democratic performance, and investigate the role of the State in the process –including the reasons or factors that determine this role

Lymph-vascular Space Involvement and Outer One-third Myometrial Invasion Are Strong Predictors of Distant Haematogeneous Failures in Patients with Stage I-II Endometrioid-type Endometrial Cancer

The aim of this retrospective study was to assess the predictive value of different clinicopathological variables (patient age, tumour size, FIGO grade, myometrial invasion, lymph-vascular space involvement [LVSI], invasion margins, peri-tumour phlogistic infiltrate and mitotic activity) for the risk of distant haematogenous recurrences in patients with endometrioid-type stage Ib-II endometrial cancer. Between August 1990 and April 2005, 259 patients had undergone laparotomy, peritoneal washing, total abdominal hysterectomy and bilateral salpingo-oophorectomy, with or without pelvic +/- para-aortic lymphadenectomy for endometrioid-type endometrial cancer. Thirty-six (13.9%) patients had developed recurrent disease after a median time of 17 months (range, 2-128 months). The relapse had been locoregional in 9, distant in 21 and both locoregional plus distant in 6 cases. This study assessed 12 patients with FIGO stage Ib-II disease who had developed distant haematogenous recurrences and 20 randomly chosen control patients with FIGO stage Ib-II disease who had remained recurrence-free after a median follow-up of 52 months (range, 37-66 months). Adjuvant therapy had been: no further treatment in 15 patients, external pelvic irradiation in 14 patients, adjuvant external pelvic irradiation plus brachytherapy in 2 patients and platinum-based chemotherapy followed by external pelvic irradiation in I patient. The site of distant failure had been the lung in 9 patients, liver in 2 patients and lung plus liver in I patient. A concomitant locoregional relapse (vagina or lymph nodes) had occurred in 3 patients. The median interval between surgery and the development of distant failure had been 16.5 months (range, 5-113 months). On univariate analysis, a higher incidence of FIGO grade 3 (50% versus 10%, p=0.0114), outer one-third myometrial invasion (91.7% versus 35.0%, p=0.0051) and LVSI (75.0.% versus 20.0%, p=0.0022) was found in the patients who had developed distant haematogeneous metastases compared to the recurrence-free women. Multivariate analysis showed that LVSI (p=0.0264) and deep myometrial invasion (p=0.0345) were independent predictive variables for the risk of distant haematogeneous failure. Patients with these pathological findings should be enrolled in randomised trials designed to assess the role of adjuvant chemotherapy alone or combined with sequential and /or concomitant external pelvic irradiation

Morphological and cellular basis for airflow limitation in smokers

Airflow limitation has two well-defined components, increased resistance, which is found predominantly in the small airways, and loss of elastic recoil. Small airways contribute to the increased resistance to flow by the narrowing of the airway lumen. Morphometric studies have shown that smokers have increased epithelial abnormalities, cellular inflammatory infiltrates in the airway wall, increased muscle and fibrosis, when compared with nonsmokers. Along with these anatomical changes, an increased percentage of airway

Label-free electrochemical immunosensor as a reliable point-of-care device for the detection of Interleukin-6 in serum samples from patients with psoriasis

interleukin-6 (IL-6) plays a crucial role in autoimmunity and chronic inflammation. this study aims to develop a low-cost, simple-to-manufacture, and user-friendly label-free electrochemical point-of-care device for the rapid detection of IL-6 in patients with psoriasis. precisely, a sandwich-based format immunosensor was developed using two primary antibodies (mAb-IL6 clone-5 and clone-7) and screen-printed electrodes modified with an inexpensive recycling electrochemical enhancing material, called biochar. mAb-IL6 clone-5 was used as a covalently immobilized capture bioreceptor on modified electrodes, and mAb-IL6 clone-7 was used to recognize the immunocomplex (Anti-IL6 clone-5 and IL-6) and form the sandwich. cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were used to conduct electrochemical characterization of the layer-by-layer assembly of the immunosensor, while square wave voltammetry (SWV) was used to perform the sensing. the developed immunosensor demonstrated robust analytical performance in buffer solution, with a wide linear range (LR) by varying from 2 to 250 pg/mL, a good limit of detection (LOD) of 0.78 pg/mL and reproducibility (RSD<7%). In addition, a spectrophotometric ELISA kit was employed to validate the results obtained with the label-free device by analyzing twenty-five serum samples from control and patients affected by psoriasis. a strong correlation in terms of pg/mL concentration of IL-6 was found comparing the two methods, with the advantage for our label-free biosensor of an ease use and a quicker detection time. based on IL-6 levels, the proposed immunosensor is a dependable, non-invasive screening device capable of predicting disease onset, progression, and treatment efficacy

End-to-end security in embedded system for modern mobile communication technologies

Modern mobile electronic devices such as smartphones or cell phones can now be used for distant devices such as technical systems to monitor and control. While surveillance systems do not require high standards navigating about the time of transfer of the displayed data. More real-time data are needed for a remote mobile robot transfer. Therefore, it has investigated and measured not only the possibilities of employing mobile devices. But also, the supported data transmission channels, such as UMTS, GSM, Wireless LAN, and Bluetooth. The remotecontrol system is used in many applications such as smart homes, cities, smart hospitals, etc., but it must be today updated to ensure fast-changing technology. Extensive coverage, remote control, and reliable operation in realtime in the deployment of wireless security knowledge. The home automation control system delivers significant features together with a user-friendly interface. A secure remote-based end-to-end security system NTMobile, a technique that enables NAT to provide transverse and encrypted communication from end to end. This confirmed that evaluating the performance of the system in the ECHONET lite compatible smartphone ecosystem. This gives flexibility in configuring time-sensitive industrial networks and enables them to be secured. A safe and reliable remote-control system is also conceivable under the privacy of the user

Trifarotene: a current review and perspectives in dermatology

Retinoids have numerous applications in inflammatory, dyskeratotic, and oncohematology diseases. Retinoids have now reached the fourth generation, progressively reducing toxicity whilst increasing their efficacy. Trifarotene is a new fourth-generation retinoid with a selective action on RAR-γ. In this review, we reported the trials—both concluded and in progress—including the use of trifarotene in dermatological diseases. Studies were identified by searching electronic databases (MEDLINE, EMBASE, PubMed, Cochrane, Trials.gov) from 2012 to today and reference lists of respective articles. Only articles published in English language were included. Randomized trials evaluating trifarotene tolerability, safety, and efficacy in congenital ichthyosis and acne have demonstrated great results and mild side effects, leading to the approval by the FDA of trifarotene for the treatment of lamellar ichthyosis in 2014, and of acne vulgaris in October 2019. No high-quality randomized clinical trials have evaluated the treatment of primary cutaneous lymphomas with trifarotene. Finally, we are hypothesizing future perspectives in the treatment of non-melanoma skin cancers, fungal infections, photoaging, and hand-foot skin reactions with trifarotene