Détection et analyse d'un problème de congestion réseau

Ce travail a pour but de mettre en place une solution qui permette de détecter et alerter des problèmes de congestion réseau. Il est divisé en deux étapes bien distinctes : La première étape est une démarche de recherche/analyse sur les méthodes de détection de la congestion réseau dans laquelle on trouve trois parties distinctes : 1. Introduction à la problématique de la congestion réseau 2. Détection de la congestion 3. Transmission / alerte de la congestion La deuxième étape (pratique) consiste au montage de trois schémas prototypes type afin de générer de la congestion et d’y appliquer la démarche de la première étape. Le trafic sera créé avec le générateur de trafic Iperf. La congestion sera détectée par l’équipement, signalée avec le protocole SNMP et analysée avec NetFlow. La mise en oeuvre et les différents outils utilisés pour la réalisation du montage seront décrits en détail dans ce rapport

Application of the Waveform Relaxation Technique to the Co-Simulation of Power Converter Controller and Electrical Circuit Models

In this paper we present the co-simulation of a PID class power converter controller and an electrical circuit by means of the waveform relaxation technique. The simulation of the controller model is characterized by a fixed-time stepping scheme reflecting its digital implementation, whereas a circuit simulation usually employs an adaptive time stepping scheme in order to account for a wide range of time constants within the circuit model. In order to maintain the characteristic of both models as well as to facilitate model replacement, we treat them separately by means of input/output relations and propose an application of a waveform relaxation algorithm. Furthermore, the maximum and minimum number of iterations of the proposed algorithm are mathematically analyzed. The concept of controller/circuit coupling is illustrated by an example of the co-simulation of a PI power converter controller and a model of the main dipole circuit of the Large Hadron Collider

High expression of octamer-binding transcription factor 4A, prominin-1 and aldehyde dehydrogenase strongly indicates involvement in the initiation of lung adenocarcinoma resulting in shorter disease-free intervals†

OBJECTIVES The increasing relevance of the cancer stem cell (CSC) hypothesis and the impact of CSC-associated markers in the carcinogenesis of solid tumours may provide potential prognostic implications in lung cancer. We propose that a collective genetic analysis of established CSC-related markers will generate data to better define the role of putative CSCs in lung adenocarcinoma (LAC). METHODS Sixty-four paired tumour and non-tumour biopsies from LAC patients were included in this study. Using the quantitative reverse transcriptase-polymerase chain reaction, we assessed the expression profiles of established CSC-related biomarkers: octamer-binding transcription factor 4 (OCT4A), CD133, aldehyde dehydrogenase (ALDH), BMI-1, ATP-binding cassette subfamily G, member 2 (ABCG2), SRY (sex-determining region Y)-box 2 (SOX2) and uPAR, and evaluated their relation to clinicopathological parameters and disease prognosis. RESULTS All of the above-mentioned CSC-related markers were detectable in both tumour and corresponding normal tissues. Importantly, expression levels of OCT4A, CD133, BMI-1, SOX2 and uPAR were significantly higher (OCT4A, P=0.0003; CD133, P=0.002; BMI-1, P=0.04; SOX2, P=0.0003; uPAR, P=0.03) in the tumour compared with those in the non-tumour tissues. By contrast, the quantities of ACBG2 and ALDH were markedly reduced (ACBG2, P=0.0006; ALDH, P=0.007) in the tumour relative to those in the normal biopsies. Using multivariate analysis, elevated ALDH and CD133 revealed significant associations in tumour stage (ALDH, P=0.03; CD133, P=0.007) and differentiation (ALDH, P=0.03; CD133, P=0.018). We observed that ALDH and OCT4A were associated with nodal status (ALDH, P=0.05; OCT4A, P=0.03) having lower mRNA levels in tumours with lymph node metastasis, N+, compared with that in N0. High OCT4A levels were significantly correlated with tumour size of 3cm (P=0.03). Kaplan-Meier correlation analyses, showed that OCT4A and CD133 were correlated to short disease-free intervals (OCT4A, P=0.047; CD133, P=0.033) over a period of 29 months. CONCLUSIONS Our study reveals that CSC-associated markers: OCT4A, CD133 and ALDH are involved in the initial phase of carcinogenesis of LAC, and can be used as predictors of early stage LAC and poor disease-free intervals. In addition, this work validates the relevance of the CSC hypothesis in LA

LA COMPETITIVIDAD DE LA MICRO Y PEQUEÑA EMPRESA DESDE LA TRIPLE HÉLICE EN LA REGIÓN DE HUANCAYO, PERÚ.

geográficos, de servicios y de mercancías; estos últimos, tienen como destino el mercado. Así, de manera paralela aparece el Estado, quien tiene como una de sus funciones el articular el desarrollo innovador de las empresas a nivel de región. Esto como un contrapeso a las funciones propias del mercado, espacio donde las microempresas tienen por azares del destino su mejor forma de reproducirse y mantenerse en las funciones sustantivas del mercado. La investigación realizada en la región de Huancayo Perú se planteó como objetivo un análisis comparativo de la competitividad de la región, en el cual interactuará la Universidad, las empresas y el Gobierno conocida como la triple hélice que, en lo posterior del trabajo, nos vamos a referir con mayor intensidad. Por lo tanto, la investigación realizada es cuantitativa y cualitativa no experimental y su diseño transeccional o transversal de tipo descriptivo. Así, para conocer los niveles de competitividad de las microempresas en la región, fue necesario elaborar cuestionarios, los cuales fueron dirigidos a las personas que concentran la toma de decisiones en la empresa, con la finalidad de encontrar determinados niveles de competitividad de las microempresas en la región planteada como objeto de estudio y que hoy se cuentan con resultados interesantes sobre el tema, los cuales se encuentran plasmados en este trabajo

Invariants for the Smale space associated to an expanding endomorphism of a flat manifold

We study invariants associated to Smale spaces obtained from an expanding endomorphism on a (closed connected Riemannian) flat manifold. Specifically, the relevant invariants are the $K$-theory of the associated $C^*$-algebras and Putnam's homology theory for Smale spaces. The latter is isomorphic to the groupoid homology of the groupoids used to construct the $C^*$-algebras.Comment: 21 page

SSDSS IV MaNGA - Properties of AGN host galaxies

We present here the characterization of the main properties of a sample of 98 AGN host galaxies, both type-II and type-I, in comparison with those of about 2700 non-active galaxies observed by the MaNGA survey. We found that AGN hosts are morphologically early-type or early-spirals. For a given morphology AGN hosts are, in average, more massive, more compact, more central peaked and rather pressurethan rotational-supported systems. We confirm previous results indicating that AGN hosts are located in the intermediate/transition region between star-forming and non-star-forming galaxies (i.e., the so-called green valley), both in the ColorMagnitude and the star formation main sequence diagrams. Taking into account their relative distribution in terms of the stellar metallicity and oxygen gas abundance and a rough estimation of their molecular gas content, we consider that these galaxies are in the process of halting/quenching the star formation, in an actual transition between both groups. The analysis of the radial distributions of the starformation rate, specific star-formation rate, and molecular gas density shows that the quenching happens from inside-out involving both a decrease of the efficiency of the star formation and a deficit of molecular gas. All the intermediate data-products used to derive the results of our analysis are distributed in a database including the spatial distribution and average properties of the stellar populations and ionized gas, published as a Sloan Digital Sky Survey Value Added Catalog being part of the 14th Data Release: http://www.sdss.org/dr14/manga/manga-data/manga-pipe3d-value-added-catalog/Comment: 48 pages, 14 figures, in press in RMxA

Hemorragia digestiva e insuficiencia cardiaca como forma de presentación de mieloma múltiple

AL cardiac amyloidosis is caused by extracellular deposition of immunoglobulin light chains in the heart. It is a multisystemic disease that can affect multiple organs, and around 10% of the cases are associated with multiple myeloma. The presence of AL amyloidosis is an independent factor of poor prognosis, not only for symptomatic multiple myeloma but also for latent multiple myeloma. We present below an unusual case of IgA-lambda multiple myeloma that manifested with recurrent gastrointestinal bleeding and heart failure.La amiloidosis cardiaca AL está causada por el depósito extracelular de cadenas ligeras de inmunoglobulinas en el corazón. Se trata de una enfermedad multisistémica que puede afectar a múltiples órganos y alrededor del 10% de los casos se asocia a mieloma múltiple. La presencia de amiloidosis AL es un factor independiente de mal pronóstico, no solo para el mieloma múltiple sintomático sino también para el mieloma múltiple latente. A continuación, presentamos un caso inusual de mieloma múltiple IgA-lambda que debutó con hemorragias digestivas de repetición e insuficiencia cardiaca

Brief Report: Hispanic Patients\u27 Trajectory of Cancer Symptom Burden, Depression, Anxiety, and Quality of Life

Background: Anxiety and depression symptoms are known to increase cancer symptom burden, yet little is known about the longitudinal integrations of these among Hispanic/Latinx patients. The goal of this study was to explore the trajectory and longitudinal interactions among anxiety and depression, cancer symptom burden, and health-related quality of life in Hispanic/Latinx cancer patients undergoing chemotherapy. METHODS: Baseline behavioral assessments were performed before starting chemotherapy. Follow-up behavioral assessments were performed at 3, 6, and 9 months after starting chemotherapy. Descriptive statistics, chi-square tests, Fisher\u27s exact tests, and Mann-Whitney tests explored associations among outcome variables. Adjusted multilevel mixed-effects linear regression models were also used to evaluate the association between HADS scores, follow-up visits, FACT-G scale, MDASI scale, and sociodemographic variables. RESULTS: Increased cancer symptom burden was significantly related to changes in anxiety symptoms\u27 scores (adjusted beta^ = 0.11 [95% CI: 0.02, 0.19]. Increased quality of life was significantly associated with decreased depression and anxiety symptoms (adjusted beta^ = -0.33; 95% CI: -0.47, -0.18, and 0.38 adjusted beta^= -0.38; 95% CI: -0.55, -0.20, respectively). CONCLUSIONS: Findings highlight the need to conduct periodic mental health screenings among cancer patients initiating cancer treatment