Design Patterns for Board-Based Collaborative Work Management Tools

Board-based software tools for managing collaborative work (e.g. Trello or Microsoft Planner) are highly configurable information systems. Their structure is based on boards that contain cards organized in lists. This structure allows users to organize a wide variety of formal or informal information and work processes in a very flexible way. How ever, this flexibility means that in every situation the user is required to make decisions to design a new board from scratch, which is not a straightforward task, specially if performed by non-technical users. In this paper, we carried out a study following an inductive approach con sisting of analyzing 91 Trello board designs from both research works and board templates proposed by Trello users, which cover a wide variety of domains and use cases. The result is twofold. First, we propose a meta model for designing boards that takes into account not only the structure of the board but also other decisions like the type of information cards manage and behavioural aspects of how cards flow. Second, we use this metamodel to identify and characterize 8 patterns that are commonly used in board designs. These results, applicable to all board-based tools, provide insights that can be useful for users to design solutions more effectively and efficiently and help us to better understand the roles that these information systems may play in the current enterprise information systems ecosystem.Ministerio de Ciencia, Innovación y Universidades OPHELIA RTI2018-101204-B-C22Ministerio de Ciencia, Innovación y Universidades Horatio RTI2018-101204-B-C21Junta de Andalucía EKIPMENT-PLUS (P18-FR-2895

miR-203 drives breast cancer cell differentiation

Breast cancer; Cell differentiationCáncer de mama; Diferenciación celularCàncer de mama; Diferenciació cel·lularA hallmark of many malignant tumors is dedifferentiated (immature) cells bearing slight or no resemblance to the normal cells from which the cancer originated. Tumor dedifferentiated cells exhibit a higher capacity to survive to chemo and radiotherapies and have the ability to incite tumor relapse. Inducing cancer cell differentiation would abolish their self-renewal and invasive capacity and could be combined with the current standard of care, especially in poorly differentiated and aggressive tumors (with worst prognosis). However, differentiation therapy is still in its early stages and the intrinsic complexity of solid tumor heterogeneity demands innovative approaches in order to be efficiently translated into the clinic. We demonstrate here that microRNA 203, a potent driver of differentiation in pluripotent stem cells (ESCs and iPSCs), promotes the differentiation of mammary gland tumor cells. Combining mouse in vivo approaches and both mouse and human-derived tridimensional organoid cultures, we report that miR-203 influences the self-renewal capacity, plasticity and differentiation potential of breast cancer cells and prevents tumor cell growth in vivo. Our work sheds light on differentiation-based antitumor therapies and offers miR-203 as a promising tool for directly confronting the tumor-maintaining and regeneration capability of cancer cells.This work has been in part financed by the crowdfunding project “Match point against breast cancer” (PRECIPITA PR242, 2019; FECYT; Spanish Ministry of Science and Innovation, MICINN, led by MS-R) and donations to Asociación Española contra el Cáncer (AECC). The work has been funded also by the Comunidad de Madrid (Y2020/BIO-6519 and S2022/BMD-7437) to MM, the Spanish Ministry of Science and Innovation through CNS2022-135364 to MS-R and PID2021-128726 to MM and the Spanish Ministry of Economy and Competitiveness by Instituto de Salud Carlos III (ISC III) through PI20/00590 to CS and co-funded by the European Union. MS-R was supported by AECC (AIOA120833SALA and INVES18005SALA), a Juan de la Cierva Incorporación and a Ramón y Cajal contract (RYC2020-028929-I, from the MICINN, FSE/ Agencia Estatal de Investigación). NGM-I was supported by AECC (PRDMA19003GARC)

Ejercicio profesional del diseño industrial 2 : un acercamiento al análisis de algunas de las especialidades más dinámicas en México

1 archivo PDF (153 páginas)Con este segundo tomo de este título, renace el espíritu de un proyecto académico del Grupo de Investigación DeiGmas que busca promover el diálogo entre la comunidad del diseño, en torno a la construcción de conceptos disciplinarios propios. El valor esencial de la presente publicación radica en que ofrece a los lectores una conjunción de ideas de profesionales experimentados en diversas especialidades del diseño industrial, sustentadas en su experiencia concreta del quehacer cotidiano en organizaciones nacionales de distinta índole

Professional quality of life and organizational changes: a five-year observational study in Primary Care

<p>Abstract</p> <p>Background</p> <p>The satisfaction and the quality of life perceived by professionals have implications for the performance of health organizations. We have assessed the variations in professional quality of life (PQL) and their explanatory factors during a services management decentralization process.</p> <p>Methods</p> <p>It was designed as a longitudinal analytical observational study in a Health Area in Madrid, Spain. Three surveys were sent out during an ongoing management decentralization process between 2001 and 2005. The professionals surveyed were divided into three groups: Group I (97.3% physicians), group II (92.5% nurses) and group III (auxiliary personnel). Analysis of the tendency and elaboration of an explanatory multivariate model was made. The PQL -35 questionnaire, based on Karasek's demand-control theory, was used to measure PQL. This questionnaire recognizes three PQL dimensions: management support (MS), workload (WL) and intrinsic motivation (IM).</p> <p>Results</p> <p>1444 responses were analyzed. PQL increased 0.16 (CI 95% 0.04 – 0.28) points in each survey. Group II presents over time a higher PQL score than group I of 0.38 (IC 95% 0.18 – 0.59) points. There is no difference between groups I and III.</p> <p>For each point that MS increases, PQL increases between 0.44 and 0.59 points. PQL decreases an average of between 0.35 and 0.49 point, for each point that WL increases.</p> <p>Age appears to have a marginal association with PQL (CI 95% 0.00 – 0.02), as it occurs with being single or not having a stable relationship (CI 95% 0.01 – 0.41). Performing management tasks currently or in the past is related to poorer PQL perception (CI 95% -0.45 – -0.06), and the same occurs with working other than morning shifts (CI 95% -0.03 – -0.40 points).</p> <p>PQL is not related to sex, location of the centre (rural/urban), time spent working in the organization or contractual situation.</p> <p>Conclusion</p> <p>With the improvement in work control and avoiding increases in workloads, PQL perception can be maintained despite deep organizational changes at the macro-management level. Different professional groups experience different perceptions depending on how the changes impact their position in the organization.</p

Temas Socio-Jurídicos. Volumen 17 No. 37 Diciembre 1999

Al cierre de la edición número 37 de la Revista Temas Socio- Jurídicos, registramos la desaparición de la profesora de la Universidad Nacional de Colombia Virginia Gutierrez De Pineda, antropóloga santandereana, profesora, quien en varias oportunidades honró con su presencia y su prestancia a la Universidad Autónoma de Bucaramanga, en especial la Maestría en Derecho de Familia, en la cual atendió el área relacionada con los conflictos entre los géneros, la pareja y la familia. Gus enseñanzas, su acción vital, su permanente indagación de la realidad del país han de servir de ejemplo a quienes deseen seguir la senda de la ciencia y conquistar horizontes de conocimiento. Como homenaje a esta mujer pionera, la revista publica una de sus últimas conferencias pronunciadas en la Universidad, denominada el conflicto en la relación de los géneros. Dos escritos salidos de la pluma del profesor Alfonso Gómez Gómez, el primero sobre el resurgimiento de las provincias, el segundo sobre las Asambleas Departamentales, incitan a la reflexión cobre la necesidad de una reconfiguración de la estructura político-administrativa de las regiones en el País. Proseguimos con la divulgación del ensayo sobre Institutos Jurídicos Básicos, la segunda parte, donde se exponen los fundamentos económico-sociales de las instituciones jurídicas y sus expresiones abstractas en el orden de los conceptos.At the close of the 37th edition of the Socio-Legal Issues Magazine, we recorded the disappearance of the professor at the National University of Colombia, Virginia Gutierrez De Pineda, an anthropologist from Santander, professor, who on several occasions honored the Autonomous University of Bucaramanga, especially the Master's Degree in Family Law, in which he dealt with the area related to conflicts between genders, couples and family. Gus teachings, his vital action, his permanent investigation of the reality of the country must serve as an example to those who wish to follow the path of science and conquer horizons of knowledge. As a tribute to this pioneering woman, the magazine publishes one of her last lectures given at the University, called the conflict in the relationship between genders. Two writings from the pen of Professor Alfonso Gómez Gómez, the first on the resurgence of the provinces, the second on the Departmental Assemblies, encourage reflection on the need for a reconfiguration of the political-administrative structure of the regions in the Country . We continue with the disclosure of the essay on Basic Legal Institutes, the second part, where the socio-economic foundations of legal institutions and their abstract expressions in the order of concepts are exposed

Innovación empresarial : nueva era de las agroempresas con gestión tecnológica

Este libro aborda la contextualización de las empresas del sector agrícola del occidente del Huila, desde un diagnóstico empresarial, el diseño de estrategias administrativas, contables y de mercadeo, hasta la innovación con desarrollo tecnológico aplicado a este sector.This book addresses the contextualization of companies in the agricultural sector in western Huila, from a business diagnosis, the design of administrative, accounting and marketing strategies, to innovation with technological development applied to this sector.Estrategias empresariales para el sector cafetero -- Innovación empresarial y sistema contable aplicado en la producción agrícola y pecuaria de la granja Juan Bosco -- Revisión bibliográfica para el desarrollo de productos electrónicos cumpliendo con estándares internacionales -- Evaluación de la eficiencia de un biofiltro para el tratamiento de aguas residuales del Café -- Fortalecimiento empresarial cafetero: una mirada hacia el cambio generacional, nuevos desafíos de responsabilidad social y liderazgo organizacional en el occidente del Huila -- Hábitos de consumo, mercado e importancia del café en el municipio de La Plata, Huila.na146 página

Obstetricia integral siglo XXI. Tomo II

El libro Obstetricia Integral siglo XXI, Tomo II, es una publicación virtual de la Facultad de Medicina, se trata de la continuación sobre el análisis detallado de los principales tópicos en el área de la obstetricia, realizada por un grupo interdisciplinario de investigadores comprometidos con el mejoramiento de la calidad en el cuidado de la salud de la mujer gestante. Se ha procurado un balance entre los aspectos básicos de fisiopatología y las guías de atención clínica soportadas en evidencias científicas, con el ánimo de brindarle al lector un equilibrio entre las bases biopsico-sociales de la salud y la enfermedad y los aspectos prácticos de la atención clínica.Vargas Fiesco, Diana Carolina and Rubio Romero, Jorge Andrés and Ruiz Parra, Ariel Iván and Rodríguez, Luis Martín and Aragón, Miguel Eduardo and Arteaga Díaz, Clara Eugenia and Riaño, Jorge Enrique and Arenas Gamboa, Jaime and Ramírez Martínez, Javier Andrés and Amaya Guío, Jairo and Gaitán , Magda Alexandry and Gallego Arbeláez, Jaime and Cortés Díaz, Daniel Otálvaro and Ángel Müller, Edith and Bracho Ch., Alcides C. and Bautista Charry, Alejandro and Rodríguez Ramos, Marcela and Navarro Milanés, Alfonso and Díaz Cruz, Luz Amparo and Mercado Pedroza, Manuel Esteban and Gaitán Duarte, Hernando and Gómez Sánchez, Pio Iván and Peña, Diana Marcela and Calvo Gómez, José Manuel and Parra Pineda, Mario Orlando and Cárdenas Muñoz, María Luisa (2010) Obstetricia integral siglo XXI. Tomo II. Facultad de Medicina, Universidad Nacional de Colombia, Bogotá. ISBN 978958447618

Inter-acciones: apuestas regionales de la investigación en comunicación

Transformación social, desarrollo y gestión de la comunicación en investigación; Educación y comunicación en procesos de transformación cultural; y Medios, convergencia y cibercultura. Además, responde a la pregunta: ¿qué líneas aborda la investigación en Comunicación Social desde la modalidad virtual y a distancia de UNIMINUTO? Lo anterior, con el objetivo de acoplar la investigación básica y aplicada desde el nivel de pregrado, en atención a los retos que afronta la formación del nuevo comunicador social con respecto al componente de investigación e innovación desde los semilleros de investigación; además, en consideración a que los semilleros son un espacio institucional para el fomento de la cultura investigativa institucional y de programas, propiciar la interacción entre la comunidad académica con miras al fortalecimiento de la excelencia académica, el desarrollo social y el progreso científico de la comunidad, así como la generación de la capacidad de trabajo en grupo, la interdisciplinariedad y el establecimiento de redes de investigación

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection