Crossing the death valley to transfer environmental decision support systems to the water market

Environmental decision support systems (EDSSs) are attractive tools to cope with the complexity of environmental global challenges. Several thoughtful reviews have analyzed EDSSs to identify the key challenges and best practices for their development. One of the major criticisms is that a wide and generalized use of deployed EDSSs has not been observed. The paper briefly describes and compares four case studies of EDSSs applied to the water domain, where the key aspects involved in the initial conception and the use and transfer evolution that determine the final success or failure of these tools (i.e., market uptake) are identified. Those aspects that contribute to bridging the gap between the EDSS science and the EDSS market are highlighted in the manuscript. Experience suggests that the construction of a successful EDSS should focus significant efforts on crossing the death-valley toward a general use implementation by society (the market) rather than on development.The authors would like to thank the Catalan Water Agency (Agència Catalana de l’Aigua), Besòs River Basin Regional Administration (Consorci per la Defensa de la Conca del Riu Besòs), SISLtech, and Spanish Ministry of Science and Innovation for providing funding (CTM2012-38314-C02-01 and CTM2015-66892-R). LEQUIA, KEMLG, and ICRA were recognized as consolidated research groups by the Catalan Government under the codes 2014-SGR-1168, 2013-SGR-1304 and 2014-SGR-291.Peer ReviewedPostprint (published version

Analysing similarity assessment in feature-vector case representations

Case-Based Reasoning (CBR) is a good technique to solve new problems based in previous experience. Main assumption in CBR relies in the hypothesis that similar problems should have similar solutions. CBR systems retrieve the most similar cases or experiences among those stored in the Case Base. Then, previous solutions given to these most similar past-solved cases can be adapted to fit new solutions for new cases or problems in a particular domain, instead of derive them from scratch. Thus, similarity measures are key elements in obtaining reliable similar cases, which will be used to derive solutions for new cases. This paper describes a comparative analysis of several commonly used similarity measures, including a measure previously developed by the authors, and a study on its performance in the CBR retrieval step for feature-vector case representations. The testing has been done using six-teen data sets from the UCI Machine Learning Database Repository, plus two complex environmental databases.Postprint (published version

Using entropy-based local weighting to improve similarity assessment

This paper enhances and analyses the power of local weighted similarity measures. The paper proposes a new entropy-based local weighting algorithm to be used in similarity assessment to improve the performance of the CBR retrieval task. It has been carried out a comparative analysis of the performance of unweighted similarity measures, global weighted similarity measures, and local weighting similarity measures. The testing has been done using several similarity measures, and some data sets from the UCI Machine Learning Database Repository and other environmental databases.Postprint (published version

Coaching para directivos

El objetivo de realizar este proyecto ha sido conocer los beneficios que el Coaching puede aportar a las personas en su vida cotidiana y más concretamente al mundo de la empresa. Desde un primer momento me pareció que era un buen tema para realizar mi proyecto final de carrera ya que era un tema del cual había leído algunos artículos, comentarios,… pero no tenía bien definidos sus beneficios, lo que nos puede aportar, en qué puntos nos puede ayudar y sobre todo cómo se consiguen estos cambios. Considero que cuando empezamos a tratar sobre un tema nuevo, primero debemos saber de dónde ha surgido esta nueva metodología y por eso, el proyecto empieza hablando sobre los inicios del Coaching, pasando posteriormente a tratar las características generales tanto del Coaching como del mismo coach. Uno de los objetivos finales de este proyecto era tratar el Coaching orientado para directivos de empresa. Como veremos en este escrito, se dan las pautas que debe seguir una persona que quiera llegar a ser un buen coach y diferentes estrategias muy útiles según los tipos de problemas que se puedan encontrar en sus terapias

Addressing the evaluation of EDSS-maintenance

Daily operation and maintenance tasks are needed to guarantee the correct performance of constructed wetlands. The definition of these activities is a complex task since these actions vary according to the characteristics of each facility. To support the definition of these operation and maintenance protocols an Environmental Decision Support System (EDSS) has been constructed (EDSS-maintenance). The methodology used to develop EDSS-maintenance is based on the following five steps: environmental problem analysis, data and knowledge acquisition, model selection, model implementation and evaluation process. The first four steps have been finished; however, the evaluation process is ongoing. This document presents a new approach for this step: two numerical indices allow (a) verifying the performance of the EDSS-maintenance and (b) validating the compliance of the protocols with the user requirements. Moreover, another index enables an easy revision and improvement of the knowledge bases (problems, causes and actions) and so enhances the decision support system.Postprint (published version

Breaking persistent working group partnerships: a social experiment

Facing multidisciplinary projects is becoming quite common in companies worldwide, meaning that experts from a specific area must team up with experts from other areas in a dynamic, ad hoc manner. For a professional to meet such requirements successfully, it is important that teamwork skills are developed during college. However, such issue is usually not addressed thoroughly, and most students end up teaming with the same partners over and over again, thereby failing to achieve the critical adaptability skills expected from them. To address this drawback, in this paper we present the results of a study where students were forced to team up with other partners based on the results of a computer networking skills-ranking exam. Experimental results confirm the repeating pattern in terms of past partnerships, and student resistance to partner changes. On the positive side, results show that having new partners indeed help at achieving a more even task distribution, and that students are moderately aware of the upcoming challenges in their future professional activity, recognizing the benefits of teaming up with new people.This work was partially supported by the School of Informatics (ETSINF) and the Department of Computer Engineering (DISCA) at the Universitat Politècnica de València.Tavares De Araujo Cesariny Calafate, CM.; Arlandis, J.; Torres Cortes, A. (2015). Breaking persistent working group partnerships: a social experiment. En INTED2015 Proceedings. IATED. 1329-1337. http://hdl.handle.net/10251/70447S1329133

Host-Derived Molecules as Novel Chagas Disease Biomarkers: Hypercoagulability Markers in Plasma

The most severe clinical symptomatology of Chagas disease affects ~30% of those chronically infected with the Trypanosoma cruzi parasite. The pathogenic mechanisms that lead to life-threatening heart and gut tissue disruptions occur "silently" for a longtime in a majority of cases. As a result, despite there are several serological and molecular methods available to diagnose the infection in its acute and chronic stages, diagnosis is often achieved only after the onset of clinical symptoms in the chronic phase of the disease. Furthermore, although there are two drugs to treat it, the assessment of their performance is impractical with current parasite-derived diagnostics, and therapeutic efficacy cannot be acknowledged in a timely manner.In this chapter we present two procedures to measure host-derived molecules as surrogates of therapeutic response against chronic T. cruzi infection. Their outputs relate to the generation and activity of thrombin, a major component of the blood coagulation cascade. This is due to the fact that a hypercoagulability state has been described to occur in chronic Chagas disease patients and revert after treatment with benznidazole

Diagnosis of Trypanosoma cruzi Infection Status using Saliva of Infected Subjects

Chagas disease has the highest prevalence of any parasitic disease in the Americas, affecting 6-7 million people. Conventional diagnosis requires a well-equipped laboratory with experienced personnel. The development of new diagnostic tools that are easy to use and adapted to the reality of affected populations and health systems is still a significant challenge. The main objective of this study was to measure Trypanosoma cruzi infection status using saliva samples of infected subjects. Blood and saliva samples from 20 T. cruzi-seropositive individuals and 10 controls were tested for T. cruzi infection using two different commercial serological tests. We have shown that detection of T. cruzi infection is possible using saliva samples, supporting the potential use of saliva to diagnose Chagas disease in humans. This method could provide a simple, low-cost but effective tool for the diagnosis of T. cruzi infection. Its noninvasive nature makes it particularly well suited for endemic areas

State-of-the-art in host-derived biomarkers of Chagas disease prognosis and early evaluation of anti-Trypanosoma cruzi treatment response

Chagas disease is caused by infection with the parasite Trypanosoma cruzi, which might lead to a chronic disease state and drive to irreversible damage to the heart and/or digestive tract tissues. Endemic in 21 countries in the Americas, it is the neglected disease with a highest burden in the region. Current estimates point at ~6 million people infected, of which ~30% will progress onto the symptomatic tissue disruptive stage. There is no vaccine but there are two anti-parasitic drugs available: benznidazole and nifurtimox. However, their efficacy is variable at the chronic symptomatic stage and both have frequent adverse effects. Since there are no prognosis markers, drugs should be administered to all T. cruzi-infected individuals in the indeterminate and early symptomatic stages. Nowadays, there are no tests-of-cure either, which greatly undermines patients' follow-up and the search of safer and more efficacious drugs. Therefore, the identification and validation of biomarkers of disease progression and/or treatment response on which to develop tests of prognosis and/or cure is a major research priority. Both parasite- and host-derived markers have been investigated. In the present manuscript we present an updated outlook of the latter

Amaryllidaceae alkaloids with anti-Trypanosoma cruzi activity

Background: Chagas disease, caused by the protozoan Trypanosoma cruzi, is a neglected disease that afects ~7 million people worldwide. Development of new drugs to treat the infection remains a priority since those currently available have frequent side efects and limited efcacy at the chronic stage. Natural products provide a pool of diver sity structures to lead the chemical synthesis of novel molecules for this purpose. Herein we analyzed the anti-T. cruzi activity of nine alkaloids derived from plants of the family Amaryllidaceae. Methods: The activity of each alkaloid was assessed by means of an anti-T. cruzi phenotypic assay. We further evalu ated the compounds that inhibited parasite growth on two distinct cytotoxicity assays to discard those that were toxic to host cells and assure parasite selectivity. Results: We identifed a single compound (hippeastrine) that was selectively active against the parasite yielding selectivity indexes of 12.7 and 35.2 against Vero and HepG2 cells, respectively. Moreover, it showed specifc activity against the amastigote stage (IC50=3.31 μM). Conclusions: Results reported here suggest that natural products are an interesting source of new compounds for the development of drugs against Chagas disease. Keywords: Chagas disease, Trypanosoma cruzi, Alkaloids, Amaryllidaceae, Hippeastrine, Phenotypic assays, Cytotoxicit