Massive Pericardial Effusion in a 14-Year-Old Girl with Mild Fatigue and Neck Pain

Pericardial effusion is rare in pediatric patients and is characterized by a variable clinical presentation. Mild symptoms may be present despite severe effusion. We here report the case of a patient with massive pericardial effusion with mild clinical presentation. Our case points out the need not to exclude this diagnosis in patients with mild general impairment. This clinical suspicion can be lifesaving

Chandra observations of NGC4698: a Seyfert-2 with no absorption

We present Chandra ACIS-S observations of the enigmatic Seyfert-2 galaxy NGC4698. This object together with several other bona-fide Seyfert-2 galaxies show no absorption in the low spatial resolution ASCA data, in contrast to the standard unification models. Our Chandra observations of NGC4698 probe directly the nucleus allowing us to check whether nearby sources contaminate the ASCA spectrum. Indeed, the Chandra observations show that the ASCA spectrum is dominated by two nearby AGN. The X-ray flux of NGC4698 is dominated by a nuclear source with luminosity L(0.3-8 keV) ~ 10^39, erg s-1 coincident with the radio nucleus. Its spectrum is well represented by a power-law, ~ 2.2, obscured by a small column density of 5x10^20 cm-2 suggesting that NGC4698 is an atypical Seyfert galaxy. On the basis of its low luminosity we then interpret NGC4698 as a Seyfert galaxy which lacks a broad-line region.Comment: 12 pages, to appear in Ap

Activity of a Pediatric Emergency Department of a Tertiary Center in Bologna, Italy, during SARS-CoV-2 Pandemic

During the SARS-CoV-2 pandemic, the pediatric emergency department (ED) of Bologna, Emilia-Romagna, Italy faced a reorganization to better deal with the new clinical needs. We herein describe the main changes in the organization and in the attendances to our pediatric ED. From the 1 March 2020 to the 31 January 2022, 796 children positive for SARS-CoV-2 presented to our pediatric ED, but only 26 required hospitalizations, of which only 9 for COVID-19 related reasons. During this period, we also registered a temporal correlation between multisystem inflammatory syndrome in children (MIS-C) admissions and the peaks of SARS-CoV-2 infection in the Italian population. Respiratory syncytial virus (RSV) remained during last year the viral infection with the highest hospitalization rate. The analysis and description of the changes in the activity of the pediatric ED during the SARS-CoV-2 pandemic may help to better understand the routinary activity and be prepared for any possible new challenge

Studies on the RF Deflectors for CTF3

The bunch train compression scheme for the CLIC Test Facility CTF3 relies on the feasibility of fast RF deflectors. They are essentially RF cavities or TW sections working on transverse. deflecting mode. The most demanding issues in the deflector design are those related to the beam dynamics, including the beam loading effects on the fundamental deflecting mode, while the efficiency required by the CTF3 parameters can be met by already existing structures. The analysis of the beam dynamics, which addresses the deflector design is reported in this paper, and different structures representing possible solutions are compared

Spatially resolved spectroscopy of Coma cluster early-type galaxies IV. Completing the dataset

The long-slit spectra obtained along the minor axis, offset major axis and diagonal axis are presented for 12 E and S0 galaxies of the Coma cluster drawn from a magnitude-limited sample studied before. The rotation curves, velocity dispersion profiles and the H_3 and H_4 coefficients of the Hermite decomposition of the line of sight velocity distribution are derived. The radial profiles of the Hbeta, Mg, and Fe line strength indices are measured too. In addition, the surface photometry of the central regions of a subsample of 4 galaxies recently obtained with Hubble Space Telescope is presented. The data will be used to construct dynamical models of the galaxies and study their stellar populations.Comment: 40 pages, 7 figures, 6 tables. Accepted for publication in ApJ

Forecasting Causes of Death in Northern Iraq Using Neural Network

The availability of models for predicting future events is essential for enhancing the efficiency of systems. This paper attempts to predict demographic variation by employing multi-layer perceptron network. Here we present the implementation of a system for predicting the number and causes of deaths, for a future 2-year period. The system was built using predictive models and data that is as accurate as possible under the current conditions of the northern Region of Iraq (the Autonomous Region of Kurdistan). Our predictive model is based on quarterly periods, with the intention of providing predictions on the number of deaths, classified by gender, cause of death, age at death, administrative district (governorate), and hospital where the death occurred. The data was collected from birth and death registry bureaus and forensic medicine departments for the years 2009-2020. The python programming language was used to test the designed multi-layer perceptron network with backpropagation training algorithm. With learning rate 0.01 and 500 epochs we were able to obtain good results, as the neural network was able to represent the string, and predict future values well, with a mean squared error of 0.43, and we found that number of deaths is quite stable, with a slight increase

Post-Traumatic Headache in Children after Minor Head Trauma: Incidence, Phenotypes, and Risk Factors

Minor head trauma (MHT) is very frequent in children and post-traumatic headache (PTH) is one of its most common complications; however, its management is still a challenge. We aimed to assess the incidence and clinical characteristics of, and risk factors for, PTH among children referred to our pediatric emergency department (PED) for MHT. A total of 193 patients aged 3–14 years evaluated for MTH were enrolled and followed up for 6 months through phone calls and/or visits. PTH occurred in 25/193 patients (13%). PTH prevalence was significantly higher in school-aged (≥6 years) than in pre-school-aged children (21.6% vs. 4.9%, respectively, p < 0.009). Females were found to be more affected. The median time of onset was 4.6 days after MHT; resolution occurred in a median of 7 weeks. In 83.3% of patients, PTH subsided in <3 months, while in 16.7% it persisted longer. A total of 25% of children exhibited the migraine and 75% the tension-type variant. Our analysis indicates the presence of headache upon arrival in PED, isolated or associated with nausea and dizziness, as a factor predisposing the patient to the development of PTH. Our findings could be useful to identify children at risk for PTH for specific follow-up, family counseling, and treatment

Perfluorooctanoic acid alters progesterone activity in human endometrial cells and induces reproductive alterations in young women

Female fecundity is finely regulated by hormonal signaling, representing a potential target for endocrine-disrupting chemicals. Among the chemicals of most concern are the perfluoroalkyl substances (PFAS), widely used in consumer goods, that are associated with adverse effects on reproductive health. In this context, the endometrium clearly represents an important fertility determining factor. The aim of this study was to investigate PFAS interference on hormonal endometrial regulation. This study was performed within a screening protocol to evaluate reproductive health in high schools. We studied a cohort of 146 exposed females aged 18\u201321 from the Veneto region in Italy, one of the four areas worldwide heavily polluted with PFAS, and 1080 non-exposed controls. In experiments on Ishikawa cells included UV\u2013Vis spectroscopy, microarray analysis and qPCR. We report a significant dysregulation of the genetic cascade leading to embryo implantation and endometrial receptivity. The most differentially-expressed genes upon PFOA coincubation were ITGB8, KLF5, WNT11, SULT1E1, ALPPL2 and G0S2 (all p < 0.01). By qPCR, we confirmed an antagonistic effect of PFOA on all these genes, which was reversed at higher progesterone levels. Molecular interference of PFOA on progesterone was confirmed by an increase in the intensity of absorption spectra at 250 nm in a dose-dependent manner, but not in the presence of \u3b2-estradiol. Age at menarche (+164 days, p = 0.006) and the frequency of girls with irregular periods (29.5% vs 21.5%, p = 0.022) were significantly higher in the exposed group. Our results are indicative of endocrine-disrupting activity of PFAS on progesterone-mediated endometrial function

Molecular basis of FIR-mediated c-myc transcriptional control

The far upstream element (FUSE) regulatory system promotes a peak in the concentration of c-Myc during cell cycle. First, the FBP transcriptional activator binds to the FUSE DNA element upstream of the c-myc promoter. Then, FBP recruits its specific repressor (FIR), which acts as an on/off transcriptional switch. Here we describe the molecular basis of FIR recruitment, showing that the tandem RNA recognition motifs of FIR provide a platform for independent FUSE DNA and FBP protein binding and explaining the structural basis of the reversibility of the FBP-FIR interaction. We also show that the physical coupling between FBP and FIR is modulated by a flexible linker positioned sequentially to the recruiting element. Our data explain how the FUSE system precisely regulates c-myc transcription and suggest that a small change in FBP-FIR affinity leads to a substantial effect on c-Myc concentration.MRC Grant-in-aid U11757455