Scaling in Complex Systems: Analytical Theory of Charged Pores

In this paper we find an analytical solution of the equilibrium ion distribution for a toroidal model of a ionic channel, using the Perfect Screening Theorem (PST). The ions are charged hard spheres, and are treated using a variational Mean Spherical Approximation (VMSA) . Understanding ion channels is still a very open problem, because of the many exquisite tuning details of real life channels. It is clear that the electric field plays a major role in the channel behaviour, and for that reason there has been a lot of work on simple models that are able to provide workable theories. Recently a number of interesting papers have appeared that discuss models in which the effect of the geometry, excluded volume and non-linear behaviour is considered. We present here a 3D model of ionic channels which consists of a charged, deformable torus with a circular or elliptical cross section, which can be flat or vertical (close to a cylinder). Extensive comparisons to MC simulations were performed. The new solution opens new possibilities, such as studying flexible pores, and water phase transformations inside the pores using an approach similar to that used on flat crystal surfaces

Vibrational Spectra of a Mechanosensitive Channel

We report the simulated vibrational spectra of a mechanosensitive membrane channel in different gating states. Our results show that while linear absorption is insensitive to structural differences, linear dichroism and sum-frequency generation spectroscopies are sensitive to the orientation of the transmembrane helices, which is changing during the opening process. Linear dichroism cannot distinguish an intermediate structure from the closed structure, but sum-frequency generation can. In addition, we find that two-dimensional infrared spectroscopy can be used to distinguish all three investigated gating states of the mechanosensitive membrane channel.

Nature and the international: towards a materialist understanding of societal multiplicity

The global environmental crisis requires a grasp of how human society interacts with nature, but also, simultaneously, how the world is divided into multiple societies. International Relations has a weak grasp of nature treating it as external to the international – an ‘environment’ to be managed – while environmentalism has a planetary epistemology that occludes the significance of the international. How to break this impasse? While neither Geopolitics nor ‘new materialism’ capture the complex conjuncture of socio-natural and inter-societal dynamics, I argue that Justin Rosenberg’s theorization of the international as ‘the consequences of societal multiplicity’ provides a theoretical opening. If a materialist notion of societal is adopted, ‘societal multiplicity’ allows human-natural and international dynamics to be grasped together. Thus, climate change is not a problem arising exogenously to the international, but something emerging through international dynamics, reciprocally affecting the units, structure and processes of the international system itself

National Security Risks? Uncertainty, Austerity and Other Logics of Risk in the UK government’s National Security Strategy

Risk scholars within Security studies have argued that the concept of security has gone through a fundamental transformation away from a threat-based conceptualisation of defence, urgency and exceptionality to one of preparedness, precautions and prevention of future risks, some of which are calculable, others of which are not. This article explores whether and how the concept of security is changing due to this ‘rise of risk’, through a hermeneutically grounded conceptual and discourse analysis of the United Kingdom government’s national security strategy (NSS) from 1998 to 2011. We ask how risk-security language is employed in the NSS; what factors motivate such discursive shifts; and what, if any, consequences of these shifts can be discerned in UK national security practices. Our aim is twofold: to better understand shifts in the security understandings and policies of UK authorities; and to contribute to the conceptual debate on the significance of the rise of risk as a component of the concept of security

Shedding light on the elusive role of endothelial cells in cytomegalovirus dissemination.

Cytomegalovirus (CMV) is frequently transmitted by solid organ transplantation and is associated with graft failure. By forming the boundary between circulation and organ parenchyma, endothelial cells (EC) are suited for bidirectional virus spread from and to the transplant. We applied Cre/loxP-mediated green-fluorescence-tagging of EC-derived murine CMV (MCMV) to quantify the role of infected EC in transplantation-associated CMV dissemination in the mouse model. Both EC- and non-EC-derived virus originating from infected Tie2-cre(+) heart and kidney transplants were readily transmitted to MCMV-naïve recipients by primary viremia. In contrast, when a Tie2-cre(+) transplant was infected by primary viremia in an infected recipient, the recombined EC-derived virus poorly spread to recipient tissues. Similarly, in reverse direction, EC-derived virus from infected Tie2-cre(+) recipient tissues poorly spread to the transplant. These data contradict any privileged role of EC in CMV dissemination and challenge an indiscriminate applicability of the primary and secondary viremia concept of virus dissemination

Existential Security: Safeguarding Humanity or Globalising Power?

Sears’ ‘Existential Security: Towards a Security Framework for the Survival of Humanity’ (2020) is the first account within the field of ERS of how scholars in the field might explicitly define ‘security’ and translate it into a framework for motivating policy choices geared towards existential risks. His essay identifies and critiques two extant frameworks for security policy – human security and national security – contrasting them in terms of scale, referent object, threat prioritisation and means of enactment. He also reflects on a number of competing definitions of what security is, and how it relates to other aspects of politics and human values, constructing an account of what security is and what its political status might allow and legitimate in approaches to policy. Ultimately, he presents a largely positive picture of both the attainability and desirability of security, and of the utility of deploying security as a framework to elevate the importance and urgency of existential risks in contemporary political decision-making

Pandemic politics—lessons for solar geoengineering

Responses to the COVID-19 emergency have exposed break-points at the interface of science, media, and policy. We summarize five lessons that should be heeded if climate change ever enters a state of emergency perceived to warrant stratospheric aerosol injection

SPARC 2017 retrospect & prospects : Salford postgraduate annual research conference book of abstracts

Welcome to the Book of Abstracts for the 2017 SPARC conference. This year we not only celebrate the work of our PGRs but also the 50th anniversary of Salford as a University, which makes this year’s conference extra special. Once again we have received a tremendous contribution from our postgraduate research community; with over 130 presenters, the conference truly showcases a vibrant PGR community at Salford. These abstracts provide a taster of the research strengths of their works, and provide delegates with a reference point for networking and initiating critical debate. With such wide-ranging topics being showcased, we encourage you to exploit this great opportunity to engage with researchers working in different subject areas to your own. To meet global challenges, high impact research inevitably requires interdisciplinary collaboration. This is recognised by all major research funders. Therefore engaging with the work of others and forging collaborations across subject areas is an essential skill for the next generation of researchers