16,161 research outputs found
Anisotropic simplicial minisuperspace model
The computation of the simplicial minisuperspace wavefunction in the case of
anisotropic universes with a scalar matter field predicts the existence of a
large classical Lorentzian universe like our own at late timesComment: 19 pages, Latex, 6 figure
HD60532, a planetary system in a 3:1 mean motion resonance
In a recent paper it was reported a planetary system around the star HD60532,
composed by two giant planets in a possible 3:1 mean motion resonance, that
should be confirmed within the next decade. Here we show that the analysis of
the global dynamics of the system allows to confirm this resonance. The present
best fit to data already corresponds to this resonant configuration and the
system is stable for at least 5Gry. The 3:1 resonance is so robust that
stability is still possible for a wide variety of orbital parameters around the
best fit solution and also if the inclination of the system orbital plane with
respect to the plane of the sky is as small as 15 deg. Moreover, if the
inclination is taken as a free parameter in the adjustment to the observations,
we find an inclination ~ 20 deg, which corresponds to M_b =3.1 M_Jup and M_c =
7.4 M_Jup for the planetary companions.Comment: 4 Pages, 4 Figures, accepted by A&
Complete determination of the orbital parameters of a system with N+1 bodies using a simple Fourier analysis of the data
Here we show how to determine the orbital parameters of a system composed of
a star and N companions (that can be planets, brown-dwarfs or other stars),
using a simple Fourier analysis of the radial velocity data of the star. This
method supposes that all objects in the system follow keplerian orbits around
the star and gives better results for a large number of observational points.
The orbital parameters may present some errors, but they are an excellent
starting point for the traditional minimization methods such as the
Levenberg-Marquardt algorithms.Comment: 4 page
On the equilibrium rotation of Earth-like extra-solar planets
The equilibrium rotation of tidally evolved "Earth-like" extra-solar planets
is often assumed to be synchronous with their orbital mean motion. The same
assumption persisted for Mercury and Venus until radar observations revealed
their true spin rates. As many of these planets follow eccentric orbits and are
believed to host dense atmospheres, we expect the equilibrium rotation to
differ from the synchronous motion. Here we provide a general description of
the allowed final equilibrium rotation states of these planets, and apply this
to already discovered cases in which the mass is lower than twelve
Earth-masses. At low obliquity and moderate eccentricity, it is shown that
there are at most four distinct equilibrium possibilities, one of which can be
retrograde. Because most presently known "Earth-like" planets present eccentric
orbits, their equilibrium rotation is unlikely to be synchronous.Comment: 4 pages, 2 figures. accepted for publication in Astronomy and
Astrophysics. to be published in Astronomy and Astrophysic
Tidal Evolution of Exoplanets
Tidal effects arise from differential and inelastic deformation of a planet
by a perturbing body. The continuous action of tides modify the rotation of the
planet together with its orbit until an equilibrium situation is reached. It is
often believed that synchronous motion is the most probable outcome of the
tidal evolution process, since synchronous rotation is observed for the
majority of the satellites in the Solar System. However, in the 19th century,
Schiaparelli also assumed synchronous motion for the rotations of Mercury and
Venus, and was later shown to be wrong. Rather, for planets in eccentric orbits
synchronous rotation is very unlikely. The rotation period and axial tilt of
exoplanets is still unknown, but a large number of planets have been detected
close to the parent star and should have evolved to a final equilibrium
situation. Therefore, based on the Solar System well studied cases, we can make
some predictions for exoplanets. Here we describe in detail the main tidal
effects that modify the secular evolution of the spin and the orbit of a
planet. We then apply our knowledge acquired from Solar System situations to
exoplanet cases. In particular, we will focus on two classes of planets,
"Hot-Jupiters" (fluid) and "Super-Earths" (rocky with atmosphere).Comment: 30 pages, 19 figures. Chapter in Exoplanets, ed. S. Seager, to be
published by University of Arizona Pres
Efficacy of Combination of Immunotherapies in a Murine in a Murine Squamous Cell Carcinoma Model
Introduction: Head and neck squamous cell carcinomas (HNSCCs) are a type of neoplasm found in the epithelium of the oral cavity, oropharynx, nasopharynx, larynx, or hypopharynx. Recent evidence has demonstrated that 70-90% of HNSCC are associated with Human Papillomavirus (HPV), particularly strain 16 producing oncogenic proteins E6/E7. Currently, HNSCCs are treated with surgery, chemotherapy, and radiation, however immunotherapy with immune checkpoint (PD-1) blocking agents promises to improve outcomes in HNSCC.
Objective: This study examined the therapeutic effects of dual and triple combination immunotherapies in a mouse model of HPV-associated HNSCC.
Methods: Treatment modalities included a tumor vaccine (attenuated Listeria monocytogenes based vaccine encoding HPV16 E6/E7 (AXAL)), an immune checkpoint inhibitor targeting PD1 (RMP1-14) and topical subtherapeutic radiation. Mice were injected subcutaneously with tumor cells expressing HPV16 E6/E7 (TC-1). When tumors were established, mice were vaccinated with AXAL (3 injections) either alone and/or with anti-PDi and/or with a single dose of radiation.
Results: Partial responses were observed in some mice receiving dual combination therapies. Most mice treated with triple immunotherapy revealed complete tumor regression.
Discussion: Combination immunotherapy is effective in the TC-1 HNSCC model system. The results obtained set the stage for investing immune mechanism underpinning treatment-associated tumor regression
Spin-orbit coupling and chaotic rotation for coorbital bodies in quasi-circular orbits
Coorbital bodies are observed around the Sun sharing their orbits with the
planets, but also in some pairs of satellites around Saturn. The existence of
coorbital planets around other stars has also been proposed. For close-in
planets and satellites, the rotation slowly evolves due to dissipative tidal
effects until some kind of equilibrium is reached. When the orbits are nearly
circular, the rotation period is believed to always end synchronous with the
orbital period. Here we demonstrate that for coorbital bodies in quasi-circular
orbits, stable non-synchronous rotation is possible for a wide range of mass
ratios and body shapes. We show the existence of an entirely new family of
spin-orbit resonances at the frequencies , where is the
orbital mean motion, the orbital libration frequency, and an integer.
In addition, when the natural rotational libration frequency due to the axial
asymmetry, , has the same magnitude as , the rotation becomes
chaotic. Saturn coorbital satellites are synchronous since , but
coorbital exoplanets may present non-synchronous or chaotic rotation. Our
results prove that the spin dynamics of a body cannot be dissociated from its
orbital environment. We further anticipate that a similar mechanism may affect
the rotation of bodies in any mean-motion resonance.Comment: 6 pages. Astrophysical Journal (2013) 6p
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