Efecto de la estrategia PBR (Purpose Built And Rebuilt) en la reparación de motores de camiones CAT 793, para incrementar la disponibilidad y mejorar el costo horario de la flota de acarreo en Minera Yanacocha SRL., 2018

RESUMEN El presente trabajo detalla el efecto de la nueva estrategia de reparación de motores de camiones CAT 973 usados en una mina a tajo abierto en el norte del Perú. Esta implementación de la nueva estrategia de reparación, se soporta con la revisión de la data de las fallas recurrentes de los motores y los análisis de fallas de los componentes del motor, con un involucramiento del Dealer de Caterpillar en el Perú y el fabricante de los motores Caterpillar. El objetivo de la investigación es mejorar la confiabilidad y disponibilidad presupuestada de la flota de acarreo, asimismo reducir los costos adicionales debido a estas fallas, que impactan directamente al presupuesto general del área de Producción y Mantenimiento Mina; estableciendo una nueva estrategia de reparación de los motores CAT para la flota de acarreo aplicando una forma de reparación personalizada en este componente denominada PBR. Esta nueva estrategia permitirá mejorar la confiabilidad de las partes internas del motor y lograr que este componente logre trabajar su ciclo de vida esperado (PCR) de 14,000 horas. La investigación se realiza recopilando data de 10 equipos analizando los modos de falla de los mismos, con dicha información definir la vida útil total del motor antes de ser dado de baja definitiva y el tipo de reparación a realizar en el motor en cada reparación, demostrando el buen performance del motor que con la nueva estrategia aplicada en su reparación.ABSTRACT The present work details the effect of the new repair strategy of CAT 973 truck engines used in an open-pit mine in northern Peru. This implementation of the new repair strategy is supported by the revision of the data of the recurring engine failures and failure analysis of the engine components, with an involvement of the Caterpillar Dealer in Peru and the manufacturer of the Caterpillar engines. The objective of the research is to improve the reliability and budgeted availability of the haulage fleet, as well as to reduce the additional costs due to these faults, which directly impact the general budget of the Mine Production and Maintenance area; establishing a new repair strategy for CAT engines for the haulage fleet by applying a customized repair method in this component called PBR. This new strategy will improve the reliability of the internal parts of the engine and ensure that this component manages to work its expected life cycle (PCR) of 14,000 hours. The research is done by collecting data from 10 teams analyzing the modes of failure of the same, with this information define the total life of the engine before being definitively discharged and the type of repair to be performed on the engine at each repair, demonstrating the good performance of the engine that with the new strategy applied in its repair

TiN/Ti/HfO2/TiN memristive devices for neuromorphic computing: from synaptic plasticity to stochastic resonance

The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fnins.2023. 1271956/full#supplementary-materialFunding The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. The authors thank the support of the Consejeria de Conocimiento, Investigacion y Universidad, Junta de Andalucia (Spain), and the FEDER program through project B-TIC-624-UGR20. They also thank the support of the Federal Ministry of Education and Research of Germany under Grant 16ME0092.We characterize TiN/Ti/HfO2/TiN memristive devices for neuromorphic computing. We analyze different features that allow the devices to mimic biological synapses and present the models to reproduce analytically some of the data measured. In particular, we have measured the spike timing dependent plasticity behavior in our devices and later on we have modeled it. The spike timing dependent plasticity model was implemented as the learning rule of a spiking neural network that was trained to recognize the MNIST dataset. Variability is implemented and its influence on the network recognition accuracy is considered accounting for the number of neurons in the network and the number of training epochs. Finally, stochastic resonance is studied as another synaptic feature. It is shown that this effect is important and greatly depends on the noise statistical characteristics.Consejería de Conocimiento, Investigación y Universidad, Junta de Andalucía (Spain), and the FEDER program through project B-TIC-624-UGR20Federal Ministry of Education and Research of Germany under Grant 16ME009

Anestesia em paciente com trauma peniano. Apresentação de um caso

Se reportó un caso de paciente masculino, blanco, 34 años de edad, con antecedentes de salud, fumador inveterado, que durante relación sexual con su esposa escuchó un chasquido, presentó dolor agudo e intenso en el pene, acompañado de pérdida de erección, rápido aumento de volumen y cambio de coloración, por lo que acudió al Hospital Universitario “Manuel Ascunce Domenech” de Camagüey, diagnosticándose fractura de pene. Mediante anestesia regional espinal se realizó tratamiento quirúrgico, obteniendo resultados favorables con egreso 24 horas después. La fractura de pene es una entidad poco frecuente en nuestro medio, de no ser diagnosticada y tratada de forma precoz, podría influir en el futuro del paciente.A case of male patient was reported, white, 34 years old, with health history, inveterate smoker, who during sexual intercourse with his wife, heard a click, presented acute and intense pain in the penis, accompanied by loss of erection, rapid increase in volume and color change, so he went to the University Hospital "Manuel Ascunce Domenech" Camagüey, diagnosed penile fracture. Through spinal regional anesthesia, surgical treatment was performed, obtaining favorable results with discharge 24 hours later. The fracture of the penis is a rare entity in our environment, if not diagnosed and treated early, it could influence the future of the patient.Um caso de paciente do sexo masculino, branco, 34 anos, com uma história de saúde, fumador inveterado, que durante a relação sexual com sua mulher, ouviu um estalo, apresentou dor aguda e intensa no pênis, acompanhada de perda da ereção foi relatada, rápido aumento no volume e mudança de cor, então ele foi para o Hospital Universitário "Manuel Ascunce Domenech" Camagüey, diagnosticado fratura peniana. Através de anestesia regional espinhal, foi realizado o tratamento cirúrgico, obtendo-se resultados favoráveis com alta 24 horas após. A fratura do pênis é uma entidade rara em nosso meio, se não diagnosticada e tratada precocemente, poderia influenciar o futuro do paciente

Anestesia para cirurgia abdominal urgente na síndrome de Down e tetralogia de Fallot não reparada

Introduction: surgery in patients with Down syndrome and unrepaired tetralogy of Fallot is infrequent, but sometimes the anesthesiologist must provide services to these patients for non-cardiac emergency surgeries.Case presentation: white male patient, 36 years old, with a history of Down syndrome and unrepaired Fallot's tetralogy, with abdominal pain of three days of evolution in the epigastrium and irradiation to the right iliac fossa, without relief at rest or at rest. administration of analgesics; accompanied by nausea, vomiting and catarrhal symptoms.Discussion: it was evaluated by surgery and an acute surgical abdomen was diagnosed for possible acute appendicitis and under general or tracheal anesthesia it was operated with favorable results.Conclusions: the administration of general anesthesia in the anesthesiological conduction of the patient with Down syndrome and unrepaired tetralogy of Fallot for urgent abdominal surgery allows satisfactory results during the procedure. Introducción: la cirugía en pacientes con síndrome de Down y tetralogía de Fallot no reparada es infrecuente, pero en ocasiones el anestesiólogo debe prestar servicio a estos pacientes para cirugías de urgencia no cardiaca.Presentación de caso: paciente blanco, masculino, 36 años de edad, con antecedentes de síndrome de Down y tetralogía de Fallot no reparada, con dolor abdominal de tres días de evolución en epigastrio e irradiación a fosa ilíaca derecha, sin alivio al reposo ni a la administración de analgésicos; acompañado de náuseas, vómitos y síntomas catarrales.Discusión: fue valorado por cirugía y se diagnosticó abdomen agudo quirúrgico por posible apendicitis aguda y mediante anestesia general orotraqueal fue intervenido con resultados favorables.Conclusiones: la administración de anestesia general en la conducción anestesiológica del paciente con síndrome de Down y tetralogía de Fallot no reparada para cirugía abdominal urgente, permite resultados satisfactorios durante el proceder.Introdução: a cirurgia em pacientes com síndrome de Down e tetralogia de Fallot não reparada é pouco frequente, mas às vezes o anestesiologista deve fornecer serviços a esses pacientes para cirurgias de emergência não cardíaca.Apresentação do caso: paciente branco do sexo masculino, 36 anos, com história de síndrome de Down e tetralogia de Fallot não corrigida, com dor abdominal de três dias de evolução em epigástrio e irradiação para fossa ilíaca direita, sem alívio em repouso ou na administração de analgésicos; acompanhada de náuseas, vômitos e sintomas catarrais.Discussão: foi avaliado cirurgicamente e diagnosticado abdome cirúrgico agudo para possível apendicite aguda e sob anestesia geral orotraqueal operado com resultados favoráveis.Conclusões: a administração de anestesia geral na condução anestesiológica do paciente com síndrome de Down e tetralogia de Fallot não reparada para cirurgia abdominal de urgência permite resultados satisfatórios durante o procedimento

Análisis de la producción científica del Sistema Sanitario Público de Andalucía

YesEn 2008, se introducen por primera vez indicadores de actividad científica dentro de los objetivos de investigación, y se encomienda a la BV-SSPA la recopilación, análisis y evaluación de la producción científica con visibilidad internacional de los profesionales del SSPA. Impactia se desarrolla para dar una respuesta inmediata y automatizada a las necesidades de información que tienen los gerentes sobre la actividad científica de su centro. Permite además analizar la actividad científica que se contempla en los objetivos del Contrato Programa y en el plan de I+D+i y realizar detallados estudios bibliométricos. Utilizando Impactia se ha llevado a cabo el análisis, la descripción y el seguimiento de la producción científica del Sistema Sanitario Público de Andalucía, estimado a través de sus publicaciones científicas con visibilidad internacional, recogidas en las principales bases de datos bibliográficas, con la finalidad de conocer el volumen, la estructura y dinámica de la actividad científica desarrollada en un periodo determinado y su evolución a lo largo del tiempo

Análisis de la producción científica del Sistema Sanitario Público de Andalucía

Ante la necesidad de facilitar a los gestores del Sistema Sanitario Público de Andalucía (SSPA) una herramienta para el análisis de la producción científica de las instituciones y sus profesionales, así como realizar la evaluación de su calidad a través de los indicadores bibliométricos y no bibliométricos, la BV-SSPA desarrolla Impactia. Impactia proporciona información precisa y detallada de la producción científica y facilita una respuesta inmediata y automatizada a las necesidades de información que tienen los gestores para la toma de decisiones en su actividad asistencial e investigadora.info:eu-repo/semantics/publishedVersio

Targeting the gut microbiota with dietary fibers: a novel approach to prevent the development cardiovascular complications linked to systemic lupus erythematosus in a preclinical study.

This study is to investigate whether dietary fiber intake prevents vascular and renal damage in a genetic mouse model of systemic lupus erythematosus (SLE), and the contribution of gut microbiota in the protective effects. Female NZBWF1 (SLE) mice were treated with resistant-starch (RS) or inulin-type fructans (ITF). In addition, inoculation of fecal microbiota from these experimental groups to recipient normotensive female C57Bl/6J germ-free (GF) mice was performed. Both fiber treatments, especially RS, prevented the development of hypertension, renal injury, improved the aortic relaxation induced by acetylcholine, and the vascular oxidative stress. RS and ITF treatments increased the proportion of acetate- and butyrate-producing bacteria, respectively, improved colonic inflammation and integrity, endotoxemia, and decreased helper T (Th)17 proportion in mesenteric lymph nodes (MLNs), blood, and aorta in SLE mice. However, disease activity (splenomegaly and anti-ds-DNA) was unaffected by both fibers. T cell priming and Th17 differentiation in MLNs and increased Th17 infiltration was linked to aortic endothelial dysfunction and hypertension after inoculation of fecal microbiota from SLE mice to GF mice, without changes in proteinuria and autoimmunity. All these effects were lower in GF mice after fecal inoculation from fiber-treated SLE mice. In conclusion, these findings support that fiber consumption prevented the development of hypertension by rebalancing of dysfunctional gut-immune system-vascular wall axis in SLE.This work was supported by Grants from Ministry of Science and Innovation of Spain (MCIN) (Ref. PID2020-116347RBI00 funded by MCIN/AEI/10.13039/501100011033, PID2021- 122490NB-I00 funded by MCIN/AEI/10.13039/ 501100011033) co-funded by the European Regional Development Fund FEDER, Consejería de Universidad, Investigación e Innovación de la Junta de Andalucía (Ref. CTS 164, P20_00193) with funds from the European Union, and by the Instituto de Salud Carlos III (CIBER-CV). IR-V is postdoctoral funded by MINECO (FJC2021-048099-I). JM is a predoctoral fellow of MINECO (FPU18/02561), and CG-C and SM are predoctoral fellow of Junta de Andalucía. The cost of this publication was paid in part with funds from the European Union (Fondo Europeo de Desarrollo Regional, FEDER, “FEDER una manera de hacer Europa”).S

Targeting the gut microbiota with dietary fibers: a novel approach to prevent the development cardiovascular complications linked to systemic lupus erythematosus in a preclinical study

This work was supported by Grants from Ministry of Science and Innovation of Spain (MCIN) (Ref. PID2020-116347RB- I00 funded by MCIN/AEI/10.13039/501100011033, PID2021- 122490NB-I00 funded by MCIN/AEI/10.13039/ 501100011033) co-funded by the European Regional Development Fund FEDER, Consejería de Universidad, Investigación e Innovación de la Junta de Andalucía (Ref. CTS 164, P20_00193) with funds from the European Union, and by the Instituto de Salud Carlos III (CIBER-CV). IR-V is postdoctoral funded by MINECO (FJC2021-048099-I). JM is a predoctoral fellow of MINECO (FPU18/02561), and CG-C and SM are predoctoral fellow of Junta de Andalucía. The cost of this publication was paid in part with funds from the European Union (Fondo Europeo de Desarrollo Regional, FEDER, “FEDER una manera de hacer Europa”).This study is to investigate whether dietary fiber intake prevents vascular and renal damage in a genetic mouse model of systemic lupus erythematosus (SLE), and the contribution of gut microbiota in the protective effects. Female NZBWF1 (SLE) mice were treated with resistantstarch (RS) or inulin-type fructans (ITF). In addition, inoculation of fecal microbiota from these experimental groups to recipient normotensive female C57Bl/6J germ-free (GF) mice was performed. Both fiber treatments, especially RS, prevented the development of hypertension, renal injury, improved the aortic relaxation induced by acetylcholine, and the vascular oxidative stress. RS and ITF treatments increased the proportion of acetate- and butyrate-producing bacteria, respectively, improved colonic inflammation and integrity, endotoxemia, and decreased helper T (Th)17 proportion in mesenteric lymph nodes (MLNs), blood, and aorta in SLE mice. However, disease activity (splenomegaly and anti-ds-DNA) was unaffected by both fibers. T cell priming and Th17 differentiation in MLNs and increased Th17 infiltration was linked to aortic endothelial dysfunction and hypertension after inoculation of fecal microbiota from SLE mice to GF mice, without changes in proteinuria and autoimmunity. All these effects were lower in GF mice after fecal inoculation from fiber-treated SLE mice. In conclusion, these findings support that fiber consumption prevented the development of hypertension by rebalancing of dysfunctional gutimmune system-vascular wall axis in SLE.Grants from Ministry of Science and Innovation of Spain (MCIN) (Ref. PID2020-116347RB- I00 funded by MCIN/AEI/10.13039/501100011033, PID2021- 122490NB-I00 funded by MCIN/AEI/10.13039/ 501100011033)European Regional Development Fund FEDER, Consejería de Universidad, Investigación e Innovación de la Junta de Andalucía (Ref. CTS 164, P20_00193) with funds from the European Union, and by the Instituto de Salud Carlos III (CIBER-CV)MINECO (FJC2021-048099-I)MINECO (FPU18/02561)Junta de AndalucíaEuropean Union (Fondo Europeo de Desarrollo Regional, FEDER, “FEDER una manera de hacer Europa”

Protective effect of microbiota-derived short chain fatty acids on vascular dysfunction in mice with systemic lupus erythematosus induced by toll like receptor 7 activation

https://pubmed.ncbi.nlm.nih.gov/37972724/https://www.sciencedirect.com/science/article/pii/S1043661823003535?via%3DihubOur objective was to investigate whether short-chain fatty acids (SCFAs), specifically acetate and butyrate, could prevent vascular dysfunction and elevated blood pressure (BP) in mice with systemic lupus erythematosus (SLE) induced by TLR7 activation using imiquimod (IMQ). Treatment with both SCFAs and dietary fibers rich in resistant starch (RS) or inulin-type fructans (ITF) effectively prevented the development of hypertension and cardiac hypertrophy. Additionally, these treatments improved aortic relaxation induced by acetylcholine and mitigated vascular oxidative stress. Acetate and butyrate treatments also contributed to the maintenance of colonic integrity, reduced endotoxemia, and decreased the proportion of helper T (Th)17 cells in mesenteric lymph nodes (MLNs), blood, and aorta in TLR7-induced SLE mice. The observed changes in MLNs were correlated with increased levels of GPR43 mRNA in mice treated with acetate and increased GPR41 levels along with decreased histone deacetylase (HDAC)- 3 levels in mice treated with butyrate. Notably, the effects attributed to acetate, but not butyrate, were nullified when co-administered with the GPR43 antagonist GLPG-0974. T cell priming and differentiation into Th17 cells in MLNs, as well as increased Th17 cell infiltration, were linked to aortic endothelial dysfunction and hypertension subsequent to the transfer of faecal microbiota from IMQ-treated mice to germ-free (GF) mice. These effects were counteracted in GF mice through treatment with either acetate or butyrate. To conclude, these findings underscore the potential of SCFA consumption in averting hypertension by restoring balance to the interplay between the gut, immune system, and vascular wall in SLE induced by TLR7 activation.This work was supported by Grants from Ministry of Science and Innovation of Spain (MCIN) (Ref. PID2020-116347RB-I00 funded by MCIN/AEI/ 10.13039/501100011033) co-funded by the European Regional Development Fund FEDER, Consejería de Universidad, Investigación e Innovación de la Junta de Andalucía (Ref. CTS 164, P20_00193, and A-CTS-318-UGR20) with funds from the European Union, and by the Instituto de Salud Carlos III (PI22/01046, CIBER-CV). IR-V is postdoctoral funded by MINECO (FJC2021-048099-I). J.M. is a predoctoral fellow of MINECO (FPU18/02561), and C.G.-C. and S.M. are predoctoral fellow of Junta de Andalucía. The cost of this publication was paid in part with funds from the European Union (Fondo Europeo de Desarrollo Regional, FEDER, “FEDER una manera de hacer Europa”). The authors thank N. Rodríguez and V. Plaza for technical assistance

Differing contributions of the gut microbiota to the blood pressure lowering effects induced by first-line antihypertensive drugs

https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16410This work was supported by Grants from Agencia Estatal de Investigación (AEI), Ministerio de Ciencia e Innovación (MCIN) (PID2020-116347RB-I00 funded by MCIN/AEI/10.13039/501100011033) and Junta de Andalucía (CTS 164, P20_00193 and A-CTS-318-UGR20) with funds from the European Union and by the Ministerio de Economia y Competitividad, Instituto de Salud Carlos III (CIBER-CV), Spain. M.T. and I.R.-V. are postdoctoral fellow of Spanish Ministerio de Ciencia e Innovación (Juan de la Cierva Incorporación Program, IJC2020-044581-I, and Juan de la Cierva Formación Program, respectively). J. M. is a predoctoral fellow of MCIN, and C. G.-C. and S. M. are predoctoral fellow of Junta de Andalucía. The cost of this publication was paid in part with funds from the European Union (Fondo Europeo de Desarrollo Regional, FEDER, ‘FEDER una manera de hacer Europa’).Background and Purpose: This study analyses whether first-line antihypertensive drugs ameliorate the dysbiosis state in hypertension, and to test if this modification contributes to their blood pressure (BP) lowering properties in a genetic model of neurogenic hypertension. Experimental Approach: Twenty-week-old male Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were untreated or treated with captopril, amlodipine or hydrochlorothiazide. A faecal microbiota transplantation (FMT) experiment was also performed by gavage of faecal content from donor SHR-treated groups to SHR recipients for 3 weeks. Key results: Faeces from SHR showed gut dysbiosis, characterized by lower acetate- and higher lactate-producing bacteria and lower strict anaerobic bacteria. All three drugs increased the anaerobic bacteria proportion, captopril and amlodipine restored the proportion of acetate-producing bacterial populations to WKY levels, whereas hydrochlorothiazide decreased butyrate-producing bacteria. Captopril and amlodipine decreased gut pathology and permeability and attenuated sympathetic drive in the gut. Both drugs decreased neuroinflammation and oxidative stress in the hypothalamic paraventricular nuclei. Hydrochlorothiazide was unable to reduce neuroinflammation, gut sympathetic tone and gut integrity. FMT from SHR-amlodipine to SHR decreased BP, ameliorated aortic endothelium-dependent relaxation to acetylcholine, lowered NADPH oxidase activity, aortic Th17 infiltration and reduced neuroinflammation, whereas FMT from SHR-hydrochlorothiazide did not have these effects. Conclusions and Implications: First-line antihypertensive drugs induced different modifications of gut integrity and gut dysbiosis in SHR, which result in no contribution of microbiota in the BP lowering effects of hydrochlorothiazide, whereas the vasculo-protective effect induced by amlodipine involves gut microbiota reshaping and gut-immune system communication.Universidad de GranadaMCIN/AEI/10.13039/501100011033 PID2020-116347RB-I00Junta de Andalucía (CTS 164, P20_00193 and A-CTS-318-UGR20)European UnionMinisterio de Economía y Competitividad, Instituto de Salud Carlos III (CIBER-CV)Spanish Ministerio de Ciencia e Innovación IJC2020-044581-IJunta de AndalucíaFondo Europeo de Desarrollo Regional, FEDE