Structural Calculations for Take Heart School in Kenya

Take heart is a new organization focused on helping widows with small business opportunities, it has continued to grow over the years and now also provides orphans safe living conditions and education opportunities. This is Take Heart’s first construction project; Take Heart bought a three-acre piece of land in Migori county in Kenya, where a Missionary base school will be built to provide care for orphans and windows. The overall project is a multistep project that when completed will have a primary school( pre k – 8th grade), dormitories , training center, guest house, and a cafeteria that will have a feeding program. There are currently 100 students that are being helped by take Heart 35 high school age, 30 widows, and 35 elementary age. The outcome of this project will provide orphans and aged out orphans with education opportunities and safe living conditions. This will help Prevent human trafficking, child marriages, and crime. The microfinance loans, small business opportunities and access to the healthcare and clean water helps widows provide for their families through entrepreneurship opportunities and financial independence

“Estudio de la formación de pirrolo[2,1-a]3,4- dihidroisoquinolinas a través del uso de energía alternativa de radiación de microondas, partiendo de la síntesis de chalconas intermediarias”

En el presente trabajo de investigación se describe la síntesis de derivados de pirrolo[2,1- a]isoquinolinas. La parte medular de este proceso de síntesis involucra reacciones de acoplamiento C-C tipo Heck, a través de procesos de catálisis mediadas con radiación de microondas. La síntesis inició con la reacción de condensación aldólica entre un aldehído aromático y derivados de acetofenona, produciendo los correspondientes compuestos carbonílicos α,β-insaturados también conocidos como chalconas. En el segundo paso de la ruta de síntesis, las chalconas se transformaron a los correspondientes derivados heterocíclicos de pirrol utilizando la metodología de van Leussen. En el tercer paso se llevó a cabo la Nalquilación del pirrol utilizando como agente alquilante al 4-metilbencensulfonato (22) producto obtenido a partir de la reacción de sulfonación del 2-bromofenetilo, para de esa manera generar la estructura adecuada en los derivados alquilados. Finalmente, la última etapa de la ruta de síntesis involucró la reacción intermolecular de Heck para llevar a cabo la ciclación de los derivados alquilados de pirrol, en presencia de sales de paladio y radiación de microondas, obteniendo buenos rendimientos del producto final (dihidroisoquinolina). Todos los compuestos de la ruta de síntesis fueron identificados utilizando la espectroscopia de Resonancia Magnética Nuclear de hidrógeno (RMN 1H) y de carbono- 13 (RMN 13C) como la herramienta principal de elucidación estructural además de Espectroscopia de Infrarrojo (IR)

Potential health effects of Champagne wine consumption

Epidemiological studies have suggested an inverse correlation between red wine consumption and the incidence of cardiovascular and neurodegenerative disorders. Although white wines are generally low in polyphenol content as compared to red wines, champagne has been shown to contain relatively high amounts of phenolic acids that may exert protective cellular actions in vivo. In this study, we have investigated the potential cardioprotective and neuroprotective effects of champagne. Our data suggest that a daily moderate consumption of champagne may improve vascular performance via the delivery of phenolic constituents capable of improving NO bioavailability and the modulation of metalloproteinase. Moreover, champagne intervention significantly increased spatial working memory in aged animals, whilst no improvement was observed in the presence of alcohol. Together, these data indicate that polyphenols present in champagne may induce cardioprotective and neuroprotective effects, delaying the onset of degenerative disorders

Evaluating significant effects from alternative seeding systems : a Bayesian approach, with an application to the UEFA Champions League

The paper discusses how to evaluate alternative seeding systems in sports competitions. Prior papers have developed an approach which uses a forecasting model at the level of the individual match and then applies Monte Carlo simulation of the whole tournament to estimate the probabilities associated with various outcomes or combinations of outcomes. This allows, for example, a measure of outcome uncertainty to be attached to each proposed seeding regime. However, this established approach takes no note of the uncertainty surrounding the parameter estimates in the underlying match forecasting model and this precludes testing for statistically significant differences between probabilities or outcome uncertainty measures under alternative regimes. We propose a Bayesian approach which resolves this weakness in standard methodology and illustrate its potential by examining the effect of seeding rule changes implemented in the UEFA Champions League, a major football tournament, in 2015. The reform appears to have increased outcome uncertainty. We identify which clubs and which sorts of clubs were favourably or unfavourably affected by the reform, distinguishing effects on probabilities of progression to different phases of the competition.The fourth author acknowledge financial support from the Spanish Ministry of Education and Science, research project ECO2012-32401

Developing Guidelines for Assessing the Effectiveness of Intelligent Compaction Technology

Many factors affect pavement compaction quality, which can vary. Such variability may result in an additional number of passes required, extended working hours, higher energy consumption, and negative environmental impacts. The use of Intelligent Compaction (IC) technology during construction can improve the quality and longevity of pavement structures while reducing risk for contractors and project owners alike. This study develops guidelines for the implementation of IC in the compaction of pavement layers as well as performing a preliminary life-cycle cost analysis (LCCA) of IC technology compared to the conventional compaction approach. The environmental impacts of the improved construction process were quantified based on limited data available from the case studies. The LCCA performed in this study consisted of different scenarios in which the number of operating hours was evaluated to estimate the cost efficiency of the intelligent compaction technique during construction. The analyses showed a reduction in energy consumption and the production of greenhouse gas (GHG) emissions with the use of intelligent compaction. The LCCA showed that the use of IC technology may reduce the construction and maintenance costs in addition to enhancing the quality control and quality assurance (QC/QA) process. However, a more comprehensive analysis is required to fully quantify the benefits and establish more accurate performance indicators. A draft version of the preliminary guidelines for implementation of IC technology and long-term monitoring of the performance of pavement layers compacted thereby is also included in this report

The Grizzly, March 15, 2018

Ursinus Evacuates Main Street Houses as Winter Storm Cuts Collegeville Power • Blomberg Hires New Special Assistant • Student Government Holds Elections This Week • SASA to Host Philly Lion Dancers • Clybourne Park Comes to Ursinus • Opinions: Diversity Monologues Reflect Lack of Racial Diversity; Students Should Use Art as a Form of Political Protest • Softball Wins Seven Straight in Florida • Champions: Women\u27s Swimming 5-peatshttps://digitalcommons.ursinus.edu/grizzlynews/1640/thumbnail.jp