Children with neonatal Hypoxic Ischemic Encephalopathy (HIE) treated with therapeutic hypothermia are not as school ready as their peers

Aim: We aimed to determine whether children with neonatal hypoxic-ischaemic encephalopathy (HIE) treated with therapeutic hypothermia (TH) differ from their peers on measures of fine motor skills, executive function, language and general cognitive abilities; factors that are important for school readiness. Methods: We compared school readiness in 31children with HIE treated with TH (without Cerebral Palsy; mean age 5 years 4 months) with 20 typically developing children without HIE (mean age 5 years 6 months). Results: Children with HIE scored significantly lower than typically developing children on fine motor skills, executive functions, memory and language. Conclusion: While general cognitive abilities and attainment were in the normal range, our findings suggest those scores mask specific underlying difficulties identified by more focussed assessments. Children with HIE treated with TH may not be as “school ready” as their typically developing classmates and may benefit from long-term follow-up until starting school

The integrated database for African policymakers

The Integrated Database for African Policymakers (IDAPs; http://www.walker.ac.uk/projects/idaps-integrated-database-for-african-policy-makers/), is a technological initiative to intended to provide valuable insight and quantitative evidence to policy makers, planners and doers, at international, national and local levels to inform scenario planning and support investment interventions for early action and adaptation. It also provides a rich source of data for researchers exploring the impacts of climate change in rural African communities, and potentially beyond. IDAPS is jointly led by the Walker Institute and Evidence for Development, our embedded NGO partner

Development of an Integrated Governance Strategy for the Voluntary and Community Sector

This report on governance provides a framework for thinking about how policy makers, funders,regulators and advisers can all work with Board members and staff to enhance the effectiveness of nonprofit organisations. It was commissioned by the Active Community Unit (ACU) of the Home Office, in parallel with other reviews designed to improve the capacity of the voluntary and community sector, at a time when the sector plays an increasingly important role in the delivery of services using public funds. That role has recently been investigated in two Government reports, the Cross Cutting Review carried out by the Treasury, and the Strategy Unit review of charities and nonprofits. Our report proposes actions of three types: some that can be taken immediately, some that require further discussion with key interests, and some integration with the other ACU reviews. Taken together they provide the starting point for an evolving strategy to improve governance across the sector. We recommend ACU chairs a group charged with the responsibility for planning and implementing this. Our focus is on governance as 'the systems and processes concerned with ensuring the overall direction, supervision and accountability of an organisation'. This is often taken to mean the way that a Board, management committee or other governing body steers the overall development of an organisation, where day-to-day management is in the hands of staff or volunteers. Sometimes, of course, the committee and volunteers are the same. They – like all governing bodies – have to balance the interests of the organisation and those they are trying to serve, while being conscious of financial and legal responsibilities, and the requirements of funders and other supporters

Exploring the Design of mHealth Systems for Health Behavior Change using Mobile Biosensors

A person’s health behavior plays a vital role in mitigating their risk of disease and promoting positive health outcomes. In recent years, mHealth systems have emerged to offer novel approaches for encouraging and supporting users in changing their health behavior. Mobile biosensors represent a promising technology in this regard; that is, sensors that collect physiological data (e.g., heart rate, respiration, skin conductance) that individuals wear, carry, or access during their normal daily activities. mHealth system designers have started to use the health information from physiological data to deliver behavior-change interventions. However, little research provides guidance about how one can design mHealth systems to use mobile biosensors for health behavior change. In order to address this research gap, we conducted an exploratory study. Following a hybrid approach that combines deductive and inductive reasoning, we integrated a body of fragmented literature and conducted 30 semi-structured interviews with mHealth stakeholders. From this study, we developed a theoretical framework and six general design guidelines that shed light on the theoretical pathways for how the mHealth interface can facilitate behavior change and provide practical design considerations

Building resilience through improving groundwater management for sustainable agricultural intensification in African Sahel

Background: This paper examines the role of improved groundwater access and management in providing opportunities for sustainable agricultural intensification and building the resilience of community farmers in Southern Burkina Faso. The findings contribute to current debates about pathways of commercialisation and adaptation in the African Sahel, especially those seeking to find responses to managing the impacts of climate change and delivering on the Sustainable Development Goals. Methods: This paper presents data that has been thematically analysed based on the Framework for Sustainable Intensification developed by Pretty and Bharucha (Ann Bot 114:1571–1596, 2014). The data used includes 144 Vulnerability Baseline Assessments which were conducted at the start of the project with the four target Burkinabe communities (Kado, Poa, Tomo, and Zhilivele), and 33 monitoring interviews and vulnerability assessments from the Burkinabe communities of Poa and Tomo to track progress and behaviour change resulting from the BRAVE project interventions. Results: The data analysis showed that Burkinabe communities are already making some use of groundwater to support their agricultural livelihoods; most do this through accessing groundwater from shallow wells. It was also shown that there were improvements in the four main themes Identified by the Sustainable Intensification Framework. These included improved information sharing through increased peer-to-peer learning and improvements in confidence levels; improved social cohesion through reduction in community conflict over water resource management; asset improvements shown by tangible improvement of yields; and increased awareness exemplified by behaviour change. Conclusions: Through using the Sustainable Intensification framework, this paper argues that such an approach improves essential aspects of resilience building such as information sharing, improved local governance and increased social capital and income. We argue that such changes provide essential pathways to reducing vulnerability and increasing resilience of at-risk communities in the Sahel, but that national policy alignment and investment is essential for long term change and sustainability

Communitarian perspectives on social enterprise

Concepts of social enterprise have been debated repeatedly, and continue to cause confusion. In this paper, a meta-theoretical framework is developed through discussion of individualist and communitarian philosophy. Philosophers from both traditions build social theories that emphasise either consensus (a unitarist outlook) or diversity (a pluralist outlook). The various discourses in corporate governance reflect these assumptions and create four distinct approaches that impact on the relationship between capital and labour. In rejecting the traditional discourse of private enterprise, social enterprises have adopted other approaches to tackle social exclusion, each derived from different underlying beliefs about the purpose of enterprise and the nature of governance. The theoretical framework offers a way to understand the diversity found within the sector, including the newly constituted Community Interest Company (CIC).</p

Event attribution science in adaptation decision-making: the context of extreme rainfall in urban Senegal

Event attribution assesses the effect of climate change on individual extreme events. While scientists have suggested that results could be relevant for climate adaptation policy, this has had little empirical investigation, particularly in developing regions. Taking the case of Senegal, the national adaptation policy context regarding extreme precipitation and flooding in urban areas, and the scientific information needed to support this policy, is investigated using key informant interviews, a workshop and document analysis. Flooding in Senegal was found to be viewed primarily as an urban planning concern rather than a climate change issue, with actions to address the impacts focussing on current vulnerabilities of urban communities without considering changing climate risks. While stakeholders thought event attribution might be useful to inform about climate change impacts and future risks of extreme events, it is unclear whether there would be opportunity for this at present, due to the limited role climate information has in adaptation decision-making. While addressing vulnerability to extremes is necessary whether or not the risk is climate change-related, if long-term planning is to be resilient then knowledge about future changes in risks of extremes will need to be considered, even if individual events are not attributed to climate change

Economic Implications of New Crops, Row Damming and Land Clearing in the Texas Winter Garden

The chief sources of groundwater for the Texas Winter Garden are the Carrizo (Dimmit, Zavala, Frio, and LaSalle Counties) and Edwards (Uvalde County) Aquifers. The major user of groundwater in the region is irrigation. However, insufficient aquifer recharge relative to groundwater use has stimulated interest in alternatives to ease adjustments to diminished groundwater supplies. The impact on net revenue, groundwater utilization, and land use of new crops (guar, guayule, and short-season irrigated cotton), row damming, and conversion of range to cropland was evaluated using a regional linear programming model. Temporal analysis, 1981-2001, incorporated changes in groundwater availability, static groundwater levels, and corresponding fixed and variable costs. Introduction of guar and short-season irrigated cotton (base solution) was associated with increased groundwater pumpage from the Carrizo Aquifer, increased net revenue, and increased irrigated acreages. Edwards Aquifer pumpage remained constant at an upper limit. When guayule entered the base solution, net revenue rose by four million dollars and groundwater pumpage and irrigated acreages declined only in the Carrizo Aquifer. Land clearing without guayule added 17, 25.2, and 26.3 million dollars to net revenue for light; light and medium; and light, medium, and heavy brush clearing; respectively. Under light brush clearing about 480,000 acres were added to cropland and groundwater pumpage remained steady. Pumpage increased under the other land clearing activities. Land clearing with guayule almost doubled net revenue compared to land clearing without guayule. Row damming was the most effective alternative in reducing dependence on groundwater. Row damming in dryland grain sorghum and dryland cotton decreased groundwater pumpage and increased net returns above the base by 6.7 million dollars without land clearing and 18.6, 30.3, and 32.9 million dollars with the respective land clearing alternatives. Carrizo Aquifer groundwater pumpage was significantly reduced in each of the four alternatives and Edwards pumpage was reduced in all but the heavy brush clearing alternative. Under temporal and static analysis for projected (forecast) groundwater pumpage, net revenue, groundwater pumpage, and irrigated acres exceeded those of solutions with restricted (forced conservation) groundwater. Carrizo Aquifer groundwater pumpage was greater under restricted than in the projected groundwater scenarios

Combinatorial quorum sensing allows bacteria to resolve their social and physical environment

Quorum sensing (QS) is a cell–cell communication system that controls gene expression in many bacterial species, mediated by diffusible signal molecules. Although the intracellular regulatory mechanisms of QS are often well-understood, the functional roles of QS remain controversial. In particular, the use of multiple signals by many bacterial species poses a serious challenge to current functional theories. Here, we address this challenge by showing that bacteria can use multiple QS signals to infer both their social (density) and physical (mass-transfer) environment. Analytical and evolutionary simulation models show that the detection of, and response to, complex social/physical contrasts requires multiple signals with distinct half-lives and combinatorial (nonadditive) responses to signal concentrations. We test these predictions using the opportunistic pathogen Pseudomonas aeruginosa and demonstrate significant differences in signal decay betweeallyn its two primary signal molecules, as well as diverse combinatorial responses to dual-signal inputs. QS is associated with the control of secreted factors, and we show that secretome genes are preferentially controlled by synergistic “AND-gate” responses to multiple signal inputs, ensuring the effective expression of secreted factors in high-density and low mass-transfer environments. Our results support a new functional hypothesis for the use of multiple signals and, more generally, show that bacteria are capable of combinatorial communication

Accountability in Nonprofit Governance: A Process-Based Study

Accountability is a crucial element of governance. Non-profit organisations are typically accountable to multiple stakeholders and often ‘do’ accountability in multiple ways. But what happens when a non-profit organisation is highly dependent on a single source of funding? This paper provides an empirical exploration of this issue. It draws on a longitudinal case study of one non-profit organisation in the UK that is highly dependent on a single funder to examine how accountability is constructed and enacted, with a focus on the board. It critically examines accountability processes through direct observation of board and committee meetings and in-depth interviews with board members. The analysis shows how board members work to construct broader forms of accountability beyond accountability to the funder, but then struggle to enact them. This paper provides in-depth insight into the challenges that non-profit board members face and offers a rare example of observational research on board behaviour