Stimulus-respons relaties van de optokinetische nystagmus van de mens

In dit proefschrift wordt onderzoek beschreven naar de menselijke OKN met speciale aandacht voor de spatiêle relatie tussen verschillende retinadelen en de visuele stimulus. De horizontale OKN werd opgewekt bij tien normale proefpersonen en drie pati~nten met gezichtsvelduit val. Stimulatie was monoculair met streeppatronen die zich over het gehele gezichtsveld of over retinaal gestabiliseerde delen daarvan uitstrekten. De bewegingen van het ziende oog werden nauwkeurig geregistreerd met de methode van de sclerale inductiespoel in een magnetisch veld. De localisatie van de stimulus was aan de oogbewegingen gekoppeld. Ook bij optimale stimulatie van het gehele gezichtsveld volgde het lage stimulussnelheden (6 oog o;s de en stimulus 12 o/s) niet perfect. Bij was de "gain" (zie addendum) o.s - Q.9. De "gain" was lager bij hoge stimulussnelheden en bij afscherming van delen van de stimulus. Toenemende symmetrische afscherming van de periferie deed de "gain" slechts in geringe ma-te dalen. Centrale afscherming had echter een sterk reducerend effect. Om een zelfde reductie te verkrijgen moest een perifere afscherming zeer omvangrijk, maar een centrale afscherming slechts klein zijn. Deze gelijke reductie werd bereikt door stimulatie slechts 5° resp. afscherming breed ( "gain" 0.6). van een centrale sector van De conclusie dat de centrale retina het belangrijkst is voor de totstandkoming van de OKN werd bevestigd door onderzoek in sectopische omstandigheden (waarbij het centrale deel van de fovea niet functioneert en alleen stimulatie via de staafjes plaatsvindt) en door onderzoek bij pati~nten met een cehtraal scotoom. De spatiêle frequentie van het gebruikte stimuluspatroon was binnen zekere grenzen (0.5 tot 0.05 perioden per graad) irrelevant

Shared Decision Making in mental health care using Routine Outcome Monitoring as a source of information: a cluster randomised controlled trial

FSW - Self-regulation models for health behavior and psychopathology - ou

1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.

HapMap imputed genome-wide association studies (GWAS) have revealed >50 loci at which common variants with minor allele frequency >5% are associated with kidney function. GWAS using more complete reference sets for imputation, such as those from The 1000 Genomes project, promise to identify novel loci that have been missed by previous efforts. To investigate the value of such a more complete variant catalog, we conducted a GWAS meta-analysis of kidney function based on the estimated glomerular filtration rate (eGFR) in 110,517 European ancestry participants using 1000 Genomes imputed data. We identified 10 novel loci with p-value < 5 × 10(-8) previously missed by HapMap-based GWAS. Six of these loci (HOXD8, ARL15, PIK3R1, EYA4, ASTN2, and EPB41L3) are tagged by common SNPs unique to the 1000 Genomes reference panel. Using pathway analysis, we identified 39 significant (FDR < 0.05) genes and 127 significantly (FDR < 0.05) enriched gene sets, which were missed by our previous analyses. Among those, the 10 identified novel genes are part of pathways of kidney development, carbohydrate metabolism, cardiac septum development and glucose metabolism. These results highlight the utility of re-imputing from denser reference panels, until whole-genome sequencing becomes feasible in large samples

Assessing associations between the AURKAHMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers

While interplay between BRCA1 and AURKA-RHAMM-TPX2-TUBG1 regulates mammary epithelial polarization, common genetic variation in HMMR (gene product RHAMM) may be associated with risk of breast cancer in BRCA1 mutation carriers. Following on these observations, we further assessed the link between the AURKA-HMMR-TPX2-TUBG1 functional module and risk of breast cancer in BRCA1 or BRCA2 mutation carriers. Forty-one single nucleotide polymorphisms (SNPs) were genotyped in 15,252 BRCA1 and 8,211 BRCA2 mutation carriers and subsequently analyzed using a retrospective likelihood appr

Corrigendum: 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.

This corrects the article DOI: 10.1038/srep45040

Classification of current anticancer immunotherapies

During the past decades, anticancer immunotherapy has evolved from a promising therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now approved by the US Food and Drug Administration and the European Medicines Agency for use in cancer patients, and many others are being investigated as standalone therapeutic interventions or combined with conventional treatments in clinical studies. Immunotherapies may be subdivided into “passive” and “active” based on their ability to engage the host immune system against cancer. Since the anticancer activity of most passive immunotherapeutics (including tumor-targeting monoclonal antibodies) also relies on the host immune system, this classification does not properly reflect the complexity of the drug-host-tumor interaction. Alternatively, anticancer immunotherapeutics can be classified according to their antigen specificity. While some immunotherapies specifically target one (or a few) defined tumor-associated antigen(s), others operate in a relatively non-specific manner and boost natural or therapy-elicited anticancer immune responses of unknown and often broad specificity. Here, we propose a critical, integrated classification of anticancer immunotherapies and discuss the clinical relevance of these approaches

1000 Genomes-based metaanalysis identifies 10 novel loci for kidney function

HapMap imputed genome-wide association studies (GWAS) have revealed >50 loci at which common variants with minor allele frequency >5% are associated with kidney function. GWAS using more complete reference sets for imputation, such as those from The 1000 Genomes project, promise to identify novel loci that have been missed by previous efforts. To investigate the value of such a more complete variant catalog, we conducted a GWAS meta-Analysis of kidney function based on the estimated glomerular filtration rate (EGFR) in 110,517 European ancestry participants using 1000 Genomes imputed data. We identified 10 novel loci with p-value < 5 × 10-8 previously missed by HapMap-based GWAS. Six of these loci (HOXD8, ARL15, PIK3R1, EYA4, ASTN2, and EPB41L3) are tagged by common SNPs unique to the 1000 Genomes reference panel. Using pathway analysis, we identified 39 significant (FDR < 0.05) genes and 127 significantly (FDR < 0.05) enriched gene sets, wh

Die boek Josua gelees teen 'n na-eksiliese agtergrond (Afrikaans)

Please read the abstract in the section 00front of this documentThesis (DD)--University of Pretoria, 2006.Old Testament Studiesunrestricte

Transaction Evidence Appraisal: Competition in British Columbia's Stumpage Markets

As a potential resolution to the softwood lumber dispute, the US Department of Commerce recommends that administered stumpage prices in Canada be determined using information from competitive timber auctions. Previous research indicates that the degree of competition significantly influences bidding behavior. In this article, therefore, a truncated hedonic timber sale model was developed to investigate the influence of competition on stumpage markets in the interior of British Columbia. Results indicate that lower bids in several northern zones of the province are due, at least in part, to lack of competition, but that market power appears limited by spatial arbitrage. In one zone characterized by monopsony, we estimate bids are shaded below their true valuation by $12.56/m3, which approximates the calculated transportation costs ($14.90/m3) to an adjacent more competitive zone. Furthermore, the significance of the inverse mills ratio suggests that ordinary least-squares regression leads to biased estimates. Our findings have policy implications for the future development and use of transaction evidence appraisal models as a potential solution to the long-standing softwood lumber trade dispute