41,580 research outputs found

    Letter Written by Corinne Blodgett to Private First Class John A. Albanese dated February 20, 1945

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    My dearest Johnny: — How is my favorite man today? I hope you’re happy and greet this letter with a great big smile! Thanks for wishing this year to be the best for me, however I agree with you that next year will be tops for then we’ll meet! I can’t wait to see my brother and you, but I guess I’ll have to. When I hear that you and Walt are coming home, I’ll probably get so excited that I’ll be unable to eat, sleep or talk properly!.

    Letter Written by Corinne Blodgett to Private First Class John A. Albanese dated September 30, 1945

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    My dearest Johnny!— First, I want to thank you for sending me those books that you obtained on Okinawa, as well as the pictures. Now I’ll be able to study Japanese, with the use of the Jap-American dictionary!! Seriously, I really appreciate your thoughtfulness in sending the books and I’ll take your advice and read them. Thanks again, sweets..

    Book Review: In Search of Identity: Debates on Religious Conversion in India

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    A review of In Search of Identity: Debates on Religious Conversion in India by Sebastian C. H. Kim

    A cross sectional analysis of the association between FGF19 tumor expression and serum AFP levels in advanced HCC patients

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    PURPOSE: HCC is a complicated disease with high mortality rates and limited treatment options. No universal clinical or molecular classification established to inform better treatment options. There has been very limited success in determining a molecular profile that represent valid drivers in HCC patients and thus no targeted agents have obtained marketing approval. However, emerging data suggest the FGF19-pathway as a HCC driver and a potential therapeutic target. This research study aims to investigate whether the HCC prognostic risk factor, serum AFP, is predictive of FGF19 protein expression as assessed by immunohistochemistry in advanced HCC patients. METHODS: A cross-sectional analysis was performed from baseline data collected in a Phase 1 study conducted at various centers across the US, EU, and Asia. Only advanced HCC patients with adequate liver function were eligible for enrollment. Demographic data, detailed history of HCC, and any prior treatments or surgeries were recorded. Baseline laboratory values and prognostic factors including performance status (ECOG), lab values (i.e. bilirubin, albumin), and the number, size and biomarker status of the tumor(s) were collected. Differences between groups were assessed by t test, or Chi-square test, as appropriate. Multivariate logistic stepwise regression analyses were performed including all parameters with highly significant correlations in the multivariate analysis. RESULTS: Only AFP, metastatic disease, and prior surgery met the criteria to be incorporated into the final model. Results indicated that high AFP had a statistically significant (p-value = .01) positive association (Wald chi-square statistic = 6.601) with positive FGF19 IHC status. The odds ratio for being FGF19 IHC+ was 12.216 among the high AFP subjects as compared to low AFP subjects, and also statistically significant but had a very wide 95% confidence interval (1.811, 82.79). CONCLUSIONS: The results indicated that HCC patients with high serum AFP levels have a twelve fold higher chance of having a positive FGF19 IHC status than those with low AFP levels. Further studies are warranted in order to replicate the data in a larger sample size to understand future clinical implications once treatment options become available for FGF19 IHC positive patients

    Book Review: Christian Inculturation in India

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    A review of Christian Inculturation in India by Paul Collins

    Book Review: Spiritual But Not Religious? An Oar Stroke Closer to the Farther Shore

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    A review of Spiritual But Not Religious? An Oar Stroke Closer to the Farther Shore by Reid B. Locklin

    Scientist - performers - audiences. Different modes of meaning-making

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    This paper provides a brief overview of the emergence of dance in the field of cognitive neuroscience and sustains the importance to understand-ing how dance is conceptualised in other disciplines in order to design valuable future research employing dance. It is proposed that recognising the distinct modes of meaning-making will undoubtedly affect and advance the scientific progress understanding by modes of meaning-making the phenomenological difference in how a dancer relates to a movement phrase from how a scientist or a choreographer watches, interprets, and experiences a dance phrase. The overall message is that the different modes of meaning-making requires consideration in scientific studies where a new generation of artists-scientists is needed, driven to excel in both, data handling and artistic purposes.//Abstract in Spanish:Este artículo proporciona una breve descripción de la aparición de la danza en el campo de la neurociencia cognitiva y sostiene que es importante entender cómo se conceptualiza la danza en otras disciplinas para diseñar in-vestigaciones futuras que la empleen. Se propone que reconocer los distintos modos de creación de significado afectará y avanzará el progreso científico entendiendo por modos de creación de significado la diferencia fenomenológica en la forma en que un bailarín se relaciona con una frase de movimiento de cómo lo hace un científico o un coreógrafo. El mensaje general es que los dif-erentes modos de creación de significado requieren consideración en estudios científicos donde son necesarios una nueva generación de artistas-científicos, impulsados a sobresalir tanto en el manejo de datos como en los propósitos artísticos

    Letter Written by Corinne Blodgett to Private First Class John A. Albanese dated October 12, 1944

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    My darling Johnny: Here I am at long last! I hope you’re in the best of spirits, honey. In your letter of Sept. 14 you said that you’d meet me at the airport being you noted in my letter that I’d hop the next plane to the Pacific to cheer you up in case you were not feeling so cheerful. Well, I’ll have to break that date now for the thought of meeting a Man (and a Marine at that) was too much for me! So, now I’m a physical wreck. Honestly, life plays tricks on humans! Oh well, I’d only be added trouble to you anyway..

    Letter Written by Corinne Blodgett to Private First Class John A. Albanese dated November 10, 1944

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    My very dear Johnny: Well, how are you today? I hope feeling swell. I suppose you often wonder why I put your complete address on my letters, being that usually is for business letters—not social! But you see, I am a very exacting and worrisome person so I think that if anything happened to the envelope etc. going overseas, the letter would be identification enough! Silly? Yes I guess so, but anyway I hope you’ll overlook my whim!.

    Hollingsworth v. Perry: Expressive Harm and the Stakes of Marriage

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    This commentary previews an upcoming Supreme Court case, Hollingsworth v. Perry, in which the Court may decide whether Proposition 8 violates either the Equal Protection Clause or the Due Process Clause of the Fourteenth Amendment of the United States Constitution
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