Impact du natalizumab sur le profil des sous-populations lymphocytaires dans le traitement de la sclérose en plaques

AIX-MARSEILLE2-BU Pharmacie (130552105) / SudocSudocFranceF

Why using events in a high-level specification

International audienc

Applying Object-Oriented Analysis on a case study

International audienc

Object-Oriented Analysis in Practice

International audienc

Gautier, la danse et l'art du costume ", Gautier et les Arts de la danse, actes du colloque organisé par Corinne Saminadayar-Perrin et François Brunet, Université de Montpellier, Bulletin de la Société Théophile Gautier, n° 31, 2009, p. 99-117.

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Modélisation orientée objet : bilan d'une expérience

National audienc

Inhibition of the Mitogen-activated Protein Kinase Pathway Triggers B16 Melanoma Cell Differentiation

International audienc

Effect of Immunosuppression on Target Blood Immune Cells Within 1 Year After Lung Transplantation: Influence of Age on T Lymphocytes

International audienceBackground: Lymphocytes are targeted by immunosuppressive therapy in solid organ transplantation and they influence allograft outcome.Material/Methods: Peripheral blood lymphocyte subsets (PBLS) determined by flow cytometry during the first year post-transplant from patients who underwent a first lung transplantation in a French University Hospital between December 2011 and July 2013 were retrospectively analyzed according to recipient characteristics and allograft outcome.Results: Fifty-seven recipients were enrolled and 890 PBLS were collected. T lymphocytes and NK cells were rapidly decreased, below normal range, from the first postoperative days. B cells decreased more gradually, remaining within normal range, with the lowest level reached after day 100. In multivariate analysis, greater T lymphopenia was found in older recipients (-414 [-709 to -119] cells/mu L, p=0.007). According to the outcome, multivariate analysis evidenced lower levels of lymphocytes when bacterial and viral infection occurred (-177 [-310 to -44] cells/mu L, p= 0.009 and (-601 [-984 to -218] cells/mu L, p=0.002, respectively), higher CD8+ T lymphocytes with BOS (+324 [+94 to + 553] cells/mu L, p=0.006), and higher leukocytes with restrictive allograft syndrome (+3770 [+418 to +7122] cells/mu L, p= 0.028).Conclusions: Aging is associated in our cohort with more severe T lymphopenia after induction therapy for lung transplantation. The analysis of leukocytes and PBLS is associated with specific profile according to the allograft outcome

Circadian Rhythm Disruption and Sepsis in Severe Trauma Patients

International audienc