Investigation of laser frequency stabilization

Frequency stabilization of far infrared lase

FOOTER: a web tool for finding mammalian DNA regulatory regions using phylogenetic footprinting

FOOTER is a newly developed algorithm that analyzes homologous mammalian promoter sequences in order to identify transcriptional DNA regulatory ‘signals’. FOOTER uses prior knowledge about the binding site preferences of the transcription factors (TFs) in the form of position-specific scoring matrices (PSSMs). The PSSM models are generated from known mammalian binding sites from the TRANSFAC database. In a test set of 72 confirmed binding sites (most of them not present in TRANSFAC) of 19 TFs, it exhibited 83% sensitivity and 72% specificity. FOOTER is accessible over the web at

Branching ratios of Bc Meson Decaying to Pseudoscalar and Axial-Vector Mesons

We study Cabibbo-Kobayashi-Maskawa (CKM) favored weak decays of Bc mesons in the Isgur-Scora-Grinstein-Wise (ISGW) quark model. We present a detailed analysis of the Bc meson decaying to a pseudoscalar meson (P) and an axial-vector meson (A). We also give the form factors involving transition in the ISGW II framework and consequently, predict the branching ratios of decays.Comment: 19 pages,7 table

Providing Personalized Interest-Based Activities to Prevent Delirium: A Multicomponent Quality Improvement Initiative in an Acute Care Setting

Background: Hospital-induced delirium is a prevalent condition across inpatient settings, frequently impacting older adults’ recovery. A 10-week multi-component quality improvement (QI) project was designed for an existing delirium prevention program in four acute care units, aiming to support patient and caregiver engagement in delirium prevention activities. Method: The participants were hospitalized adults who were 70 years of age and older and met specific inclusion criteria. The project provided personalized interest-based activities, orientation stimulation, and caregiver education. An abbreviated version of the Modified Interest Checklist was used to identify the participants’ activity choices. Activity daily logs, satisfaction survey, and delirium and fall incidence were collected to measure project participation and outcomes. Results: Thirty-two older adults participated in the QI project (mean age = 79.63 years). The most frequently selected interest-based activities were cognitive stimulation activities, such as word searches, and reading activities related to instrumental activities of daily living. Among 25 satisfaction surveys completed, 24 (96%) participants reported feeling “very supported” by the project. Only two QI participants developed delirium, and none of them had a fall during the hospital stay. Conclusion: This QI project showed high participant use and satisfaction with promising low rates of delirium incidence and falls indicating further investigation

Optical spectroscopy of X-MEGA targets I. CPD -59 2635: A New Double-Lined O type Binary in the Carina Nebula

Optical spectroscopy of CPD -59 2635, one of the O-type stars in the open cluster Trumpler 16 in the Carina Nebula, reveals this star to be a double-lined binary system. We have obtained the first radial velocity orbit for this system, consisting of a circular solution with a period of 2.2999 days and semi amplitudes of 208 and 273 km/s. This results in minimum masses of 15 and 11 Msol for the binary components of CPD -59 2635, which we classified as O8V and O9.5V, though spectral type variations of the order of 1 subclass, that we identify as the Struve-Sahade effect, seem to be present in both components. From ROSAT HRI observations of CPD -59 2635 we determine a luminosity ratio log(L_x/L_bol)~ -7, which is similar to that observed for other O-type stars in the Carina Nebula region. No evidence of light variations is present in the available optical or X-rays data sets

Dimensional crossover of a boson gas in multilayers

We obtain the thermodynamic properties for a non-interacting Bose gas constrained on multilayers modeled by a periodic Kronig-Penney delta potential in one direction and allowed to be free in the other two directions. We report Bose-Einstein condensation (BEC) critical temperatures, chemical potential, internal energy, specific heat, and entropy for different values of a dimensionless impenetrability $P\geqslant 0$ between layers. The BEC critical temperature $T_{c}$ coincides with the ideal gas BEC critical temperature $T_{0}$ when $P=0$ and rapidly goes to zero as $P$ increases to infinity for any finite interlayer separation. The specific heat $C_{V}$ \textit{vs} $T$ for finite $P$ and plane separation $a$ exhibits one minimum and one or two maxima in addition to the BEC, for temperatures larger than $T_{c}$ which highlights the effects due to particle confinement. Then we discuss a distinctive dimensional crossover of the system through the specific heat behavior driven by the magnitude of $P$. For $T<T_{c}$ the crossover is revealed by the change in the slope of $\log C_{V}(T)$ and when $T>T_{c}$, it is evidenced by a broad minimum in $C_{V}(T)$.Comment: Ten pages, nine figure

Unoccupied Band Structure of NbSe2 by Very-Low-Energy Electron Diffraction: Experiment and Theory

A combined experimental and theoretical study of very-low-energy electron diffraction at the (0001) surface of 2H-NbSe2 is presented. Electron transmission spectra have been measured for energies up to 50 eV above the Fermi level with k|| varying along the GammaK line of the Brillouin zone. Ab initio calculations of the spectra have been performed with the extended linear augmented plane wave k-p method. The experimental spectra are interpreted in terms of three-dimensional one-electron band structure. Special attention is paid to the quasi-particle lifetimes: by comparing the broadening of the spectral structures in the experimental and calculated spectra the energy dependence of the optical potential Vi is determined. A sharp increase of Vi at 20 eV is detected, which is associated with a plasmon peak in the Im(-1/epsilon) function. Furthermore, the electron energy loss spectrum and the reflectivity of NbSe2 are calculated ab initio and compared with optical experiments. The obtained information on the dispersions and lifetimes of the unoccupied states is important for photoemission studies of the 3D band structure of the valence band.Comment: 17 pages, 11 Postscript figures, submitted to Phys. Rev.

Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival

Oct-2, a POU homeo domain transcription factor, is believed to stimulate B-cell-restricted expression of immunoglobulin genes through binding sites in immunoglobulin gene promoters and enhancers. To determine whether Oct-2 is required for B-cell development or function, or has other developmental roles, the gene was disrupted by homologous recombination. Oct-2^(-/-) mice develop normally but die within hours of birth for undetermined reasons. Mutants contain normal numbers of B-cell precursors but are somewhat deficient in IgM+ B cells. These B cells have a marked defect in their capacity to secrete immunoglobulin upon mitogenic stimulation in vitro. Thus, Oct-2 is not required for the generation of immunoglobulin-bearing B cells but is crucial for their maturation to immunoglobulin-secreting cells and for another undetermined organismal function

enoLOGOS: a versatile web tool for energy normalized sequence logos

enoLOGOS is a web-based tool that generates sequence logos from various input sources. Sequence logos have become a popular way to graphically represent DNA and amino acid sequence patterns from a set of aligned sequences. Each position of the alignment is represented by a column of stacked symbols with its total height reflecting the information content in this position. Currently, the available web servers are able to create logo images from a set of aligned sequences, but none of them generates weighted sequence logos directly from energy measurements or other sources. With the advent of high-throughput technologies for estimating the contact energy of different DNA sequences, tools that can create logos directly from binding affinity data are useful to researchers. enoLOGOS generates sequence logos from a variety of input data, including energy measurements, probability matrices, alignment matrices, count matrices and aligned sequences. Furthermore, enoLOGOS can represent the mutual information of different positions of the consensus sequence, a unique feature of this tool. Another web interface for our software, C2H2-enoLOGOS, generates logos for the DNA-binding preferences of the C2H2 zinc-finger transcription factor family members. enoLOGOS and C2H2-enoLOGOS are accessible over the web at