Modeling the RXTE light curve of η\eta Carinae from a 3-D SPH simulation of its binary wind collision

The very massive star system $\eta$ Carinae exhibits regular 5.54-year (2024-day) period disruptive events in wavebands ranging from the radio to X-ray. There is a growing consensus that these events likely stem from periastron passage of an (as yet) unseen companion in a highly eccentric ($\epsilon \sim 0.9$) orbit. This paper presents three-dimensional (3-D) Smoothed Particle Hydrodynamics (SPH) simulations of the orbital variation of the binary wind-wind collision, and applies these to modeling the X-ray light curve observed by the Rossi X-ray Timing Explorer (RXTE). By providing a global 3-D model of the phase variation of the density of the interacting winds, the simulations allow computation of the associated variation in X-ray absorption, presumed here to originate from near the apex of the wind-wind interaction cone. We find that the observed RXTE light curve can be readily fit if the observer's line of sight is within this cone along the general direction of apastron. Specifically, the data are well fit by an assumed inclination $i = 45^{\circ}$ for the orbit's polar axis, which is thus consistent with orbital angular momentum being along the inferred polar axis of the Homunculus nebula. The fits also constrain the position angle $\phi$ that an orbital-plane projection makes with the apastron side of the semi-major axis, strongly excluding positions $\phi < 9^{\circ}$ along or to the retrograde side of the axis, with the best fit position given by $\phi = 27^{\circ}$. Overall the results demonstrate the utility of a fully 3-D dynamical model for constraining the geometric and physical properties of this complex colliding-wind binary system.Comment: 5 pages, 4 figures, accepted to MNRAS Letter

Acute complete heart block in dogs

A study has been conducted immediately and up to 18 days after the surgical production of complete heart block in dogs. Immediately after surgery cardiac output, coronary flow, and mean arterial pressure were reduced in rough proportion to the degree of bradycardia. In time, these measures began to return toward preoperative levels. Paralleling the diminished left ventricular work was a diminished left ventricular oxygen consumption with little consequent change in myocardial efficiency. Small rises were detected in central venous pressure. At autopsy, the only unequivocal abnormality was myocardial hypertrophy which became measurable between 2 and 18 days after operation

aristotle's demonstrative logic

Demonstrative logic, the study of demonstration as opposed to persuasion, is the subject of Aristotle's two-volume Analytics. Many examples are geometrical. Demonstration produces knowledge (of the truth of propositions). Persuasion merely produces opinion. Aristotle presented a general truth-and-consequence conception of demonstration meant to apply to all demonstrations. According to him, a demonstration, which normally proves a conclusion not previously known to be true, is an extended argumentation beginning with premises known to be truths and containing a chain of reasoning showing by deductively evident steps that its conclusion is a consequence of its premises. In particular, a demonstration is a deduction whose premises are known to be true. Aristotle's general theory of demonstration required a prior general theory of deduction presented in the Prior Analytics. His general immediate-deduction-chaining conception of deduction was meant to apply to all deductions. According to him, any deduction that is not immediately evident is an extended argumentation that involves a chaining of intermediate immediately evident steps that shows its final conclusion to follow logically from its premises. To illustrate his general theory of deduction, he presented an ingeniously simple and mathematically precise special case traditionally known as the categorical syllogisti

Getting Jobs, Keeping Jobs, and Earning a Living Wage: Can Welfare Reform Work?

Most discussions of welfare and work have focused on how demographic characteristics, schooling, training, and work experience limit welfare mothers’ employment and wages, but they have largely ignored factors such as inappropriate workplace behaviors, expectations of discrimination and harassment, depression, alcoholism, and domestic violence, all of which may affect welfare mothers and make employment difficult. In this paper we review the prevalence of these individual-level barriers and argue that they, in combination with an economy which does not pay low-skill workers well, are likely to impede employment and self-sufficiency for a large proportion of welfare mothers. At the end of the review, we summarize the current state of knowledge about barriers to the employment of welfare recipients and suggest several ways in which welfare-to-work programs might address these barriers.

Barriers to the Employment of Welfare Recipients

Dramatic reductions in welfare caseloads since passage of the Personal Responsibility and WorkOpportunity Reconciliation Act of 1996 have not allayed policy concerns about the employability of recipients remaining on the rolls. Analysis of potential barriers to employment can address whether current recipients have problems that either singly or in combination make it difficult for them to comply with the new requirements for getting and keeping jobs. In this paper, we explore the prevalence and work effects of 14 potential barriers in a new survey of a representative sample of 753 urban single-mother recipients. We report the prevalence of the barriers and how their number predicts employment rates, controlling for demographic characteristics. We also analyze which individual barriers are associated with employment and how a model inclusive of a comprehensive array of barriers improves upon a traditional human capital model of the work effects of education and work and welfare history. Single mothers who received welfare in 1997 had higher rates of personal health and mental health problems, domestic violence, and children’s health problems than do women in national samples, but they were no more likely than the general population to be drug or alcohol dependent. Only 15 percent of respondents had none of the barriers and almost two-thirds had two or more barriers. The numbers of multiple barriers were strongly and negatively associated with working, and among the individual barriers, low education, lack of access to transportation, poor health, having drug dependence or a major depressive disorder, and several experiences of workplace discrimination reduced employment. Welfare-to-work programs need to be more finely targeted with respect to exemptions and service provision, and states should consider providing longer-term and enhanced supports for those who face low prospects of leaving welfare for employment.

Density of states of a type-II superconductor in a high magnetic field: Impurity effects

We have calculated the density of states $N(\omega)$ of a dirty but homogeneous superconductor in a high magnetic field. We assume a dilute concentration of scalar impurities and find how $N(\omega)$ behaves as one crosses from the weak scattering to the strong scattering limit. At low energies, $N(\omega)\sim \omega ^2$ for small values of the impurity concentration and scattering strength. When the disorder becomes stronger than some critical value, a finite density of states is created at the Fermi surface. These results are a consequence of the gapless nature of the quasiparticle excitation spectrum in a high magnetic field.Comment: 20 pages in RevTeX, 4 figures, to appear in Phys. Rev. B (July 1, 1997

Waiting in the Wings: Reflected X-ray Emission from the Homunculus Nebula

We report the first detection of X-ray emission associated with the Homunculus Nebula which surrounds the supermassive star Eta Carinae. The emission is characterized by a temperature in excess of 100 MK, and is consistent with scattering of the time-delayed X-ray flux associated with the star. The nebular emission is bright in the northwestern lobe and near the central regions of the Homunculus, and fainter in the southeastern lobe. We also report the detection of an unusually broad Fe K fluorescent line, which may indicate fluorescent scattering off the wind of a companion star or some other high velocity outflow. The X-ray Homunculus is the nearest member of the small class of Galactic X-ray reflection nebulae, and the only one in which both the emitting and reflecting sources are distinguishable.Comment: 17 pages, 5 figures, accepted by Ap

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice

We have examined the regulatory role of the individual components of the immunoglobulin antigen receptor in B-cell development by transgenic complementation of Rag-1 deficient (Rag-1⁻) mice. Complementation with a membrane µ heavy chain (µHC) gene allows progression of developmentally arrested Rag-1⁻ pro-B-cells to the small pre-B cell stage, whereas the introduction of independently integrated µHC and κ light chain (κLC) transgenes promotes the appearance of peripheral lymphocytes which, however, remain unresponsive to external stimuli. Complete reconstitution of the B-cell lineage and the emergence of functionally nature Rag-1⁻ peripheral B cells is achieved by the introduction of cointegrated heavy and light chain transgenes encoding an anti-H-2^k antibody. This experimental system demonstrates the competence of the µHC and κLC to direct and regulate the sequential stages of B-cell differentiation, defines the time at which negative selection of self-reactive B cells occurs, and shows that elimination of these cells occurs equally well in the absence of Rag-1 as in its presence. These data also support the hypothesis that Rag-1 directly participates in the V(D)J recombination process

Development of a common carp (Cyprinus carpio) pregnane X receptor (cPXR) transactivation reporter assay and its activation by azole fungicides and pharmaceutical chemicals.

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.In mammals, the pregnane X receptor (PXR) is a transcription factor with a key role in regulating expression of several genes involved in drug biotransformation. PXR is present in fish and some genes known to be under its control can be up-regulated by mammalian PXR ligands. Despite this, direct involvement of PXR in drug biotransformation in fish has yet to be established. Here, the full length PXR sequence was cloned from carp (Cyprinus carpio) and used in a luciferase reporter assay to elucidate its role in xenobiotic metabolism in fish. A reporter assay for human PXR (hPXR) was also established to compare transactivation between human and carp (cPXR) isoforms. Rifampicin activated hPXR as expected, but not cPXR. Conversely, clotrimazole (CTZ) activated both isoforms and was more potent on cPXR, with an EC50 within the range of concentrations of CTZ measured in the aquatic environment. Responses to other azoles tested were similar between both isoforms. A range of pharmaceuticals tested either failed to activate, or were very weakly active, on the cPXR or hPXR. Overall, these results indicate that the cPXR may differ from the hPXR in its responses and/or sensitivity to induction by different environmental chemicals, with implications for risk assessment because of species differences.JC was funded by a Biotechnology and Biological Sciences Research Council Case studentship supported by AstraZeneca UK Ltd. (grant reference BB/G529332), and co-supported by the AstraZeneca Safety Health and Environment Research Program. AL was supported by grants from the Natural Environment Research Council (NE/D002818/1 and NE/E016634/1) and DEFRA awarded to CRT. Defra (UK) funded a research visit of SM to the University of Exeter under the UK-J programme. COS-7 cells were a gift from Inês Castro, University of Exeter. AstraZeneca Ltd. develops, produces, and markets a wide range of pharmaceutical agents