The Rhone Caesar

It was probably between 49 and 46 BC, when Caesar had close relationships with Arles that, according to the French archaeologist Luc Long, who found it in 2007 after struggling with poor visibility, strong currents and the catfishes of Rhone, the famous marble bust of Arles had been carved. This beautiful portrait, discovered in the depths of the right bank of the river near Arles, has been undoubtedly attributed by Long to Julius Caesar. ... Here we compare the Arles bust with some others and propose the application of image processing and multimodal biometric systems to the ancient artifac

The Rhone Caesar

It was probably between 49 and 46 BC, when Caesar had close relationships with Arles that, according to the French archaeologist Luc Long, who found it in 2007 after struggling with poor visibility, strong currents and the catfishes of Rhone, the famous marble bust of Arles had been carved. This beautiful portrait, discovered in the depths of the right bank of the river near Arles, has been undoubtedly attributed by Long to Julius Caesar. ... Here we compare the Arles bust with some others and propose the application of image processing and multimodal biometric systems to the ancient artifact

The use of building performance simulation to support architectural design: a case study

Abstract Considering the complex interaction between energy performance, lighting, acoustic and thermal comfort in contemporary design, building performance simulation [BPS] shall play a key role in addressing decision making process and technical choices towards optimized configuration during the whole design phase. The paper reports the outcomes of a case study – performed in the framework of Ma Final Design Lab at the Department of Architecture, University of Bologna – where BPS was adopted from the very beginning as a tool to support the design process from the concept validation to the final architectural configuration to fit with passive house standards

Improvement of functional bloating by an enterovaccine: a preliminary study

Background: bloating is a fastidious symptom reported by many patients who also have other gastrointestinal functional dis orders. Bloating is more common in women, and it is often asso ciated with meals and improves or disappears overnight. No spe cific treatments are to date available for this disturbing symptom. Aims: to evaluate the effects of an oral enterovaccine (Colifag ina ® ) on bloating and other abdominal symptoms in patients with prevalent complaints of functional bloating. Patients and methods: one hundred and forty-eight patients with functional bloating according to Rome III criteria were re cruited. Questionnaires and a VAS scale on their symptoms were administered at baseline and after four weeks of therapy with Colifagina ® . Results: after treatment, a significant amelioration of bloating (p < 0.0001), abdominal pain (p < 0.0001) and flatus (p < 0.0001) was observed; nausea and vomiting scores were not sig nificantly different at the end of the treatment. Subjective wellbe ing was also generally improved (p < 0.001) in treated patients. Conclusion: treatment with an enterovaccine may help im prove symptoms in patients with functional bloating

Eosinophilic esophagitis: an Italian experience.

Background: eosinophilic esophagitis is an esophageal disor der characterized by esophageal and/or upper gastrointestinal tract symptoms, and by dense esophageal eosinophilia associated with a normal gastric and duodenal mucosa. Prevalently reported in children, eosinophilic esophagitis has recently been reported with increased frequency also in adults. Aims: the purpose of this study was to report our experience with eosinophilic esophagitis in Italy, since there are only very few series of such patients in our country. Patients and methods: we retrospectively reviewed the his tological data of consecutive patients with a diagnosis of esophagitis or reflux disease in the period September 2004-September 2008. Eosinophils were counted where they appeared most nu merous in the biopsy, with a cutoff > 15 eosinophils in more than one high-power field as diagnostic of eosinophilic esophagitis. Pa tients were excluded if gastric or duodenal biopsies showed a prominent eosinophilic infiltrate. Results: twenty two patients (14 adults, 8 children, age range 2-59 years) were identified according to the above criteria. The average eosinophil count was 86/ high-power field (range 31150), associated with other pathologic features (eosinophilic microabscesses eosinophil degranulation, basal zone hyperplasia, papillary elongation). The main clinical complaints were dyspha gia, food impaction, and heartburn, and endoscopic findings con sisted of mucosal thickening and inelasticity, longitudinal shearing, rings, and white specks, without difference between adults and children for both clinical and endoscopic variables. Conclusions: eosinophilic esophagitis is not rare in Italy, and displays clinical, endoscopic, and pathologic features similar to those described in other countries

Mechanism of action of novel NO-releasing furoxan derivatives of aspirin in human platelets

1. Incorporation of a nitric oxide (NO)-releasing moiety in aspirin can overcome its gastric side effects. 2. We investigated the NO-release patterns and antiplatelet effects of novel furoxan derivatives of aspirin (B8 and B7) in comparison to existing antiplatelet agents. 3. Cyclooxygenase (COX) activity was investigated in purified enzyme using an electron paramagnetic resonance-based technique. Concentration–response curves for antiplatelet agents±the soluble guanylate cyclase inhibitor, ODQ (50 μM) were generated in platelet-rich plasma (PRP) and washed platelets (WP) activated with collagen using turbidometric aggregometry. NO was detected using an isolated NO electrode. 4. The furoxan derivatives of aspirin (B8, B7) and their NO-free furazan equivalents (B16, B15; all 100 μM) significantly inhibited COX activity (P<0.01; n=6) in vitro and caused aspirin-independent, cGMP-dependent inhibition of collagen-induced platelet aggregation in WP. B8 was more potent than B7 (PRP IC(50)=0.62±0.1 μM for B8; 400±89 μM for B7; P<0.0001. WP IC(50)s=0.6±0.1 and 62±10 μM, respectively). The NO-free furazan counterparts were less potent antiplatelet agents (WP IC(50)s=54±3 μM and 62±10 μM, respectively; P<0.0001, B8 vs B16). Of the hybrids investigated, only B8 retained antiplatelet activity in PRP. 5. NO release from furoxan–aspirin hybrids was undetectable in buffer alone, but was accelerated in the presence of either plasma or plasma components, albumin (4%), glutathione (GSH; 3 μM) and ascorbate (50 μM), the effects of which were additive for B7 but not B8. NO generation from furoxans was greatly enhanced by platelet extract, an effect that could largely be explained by the synergistic effect of intracellular concentrations of GSH (3 mM) and ascorbate (1 mM). 6. We conclude that the decomposition of furoxan–aspirin hybrids to generate biologically active NO is catalysed by endogenous agents which may instil a potential for primarily intracellular delivery of NO. The blunting of the aspirin effects of furoxan hybrids is likely to be due to loss of the acetyl moiety in plasma; the observed antiplatelet effects are thereby primarily mediated via NO release. Compounds of this class might represent a novel means of inhibiting platelet aggregation by a combination of NO generation and COX inhibition

Il Cesare di Arles

L'inizio del 49 avanti Cristo vide la prima fase della guerra civile tra Giulio Cesare e Pompeo Magno. I due generali si stavano cimentando in un logorante conflitto armato a "distanza", durante il quale si venivano progressivamente definendo gli schieramenti in campo. Sia Cesare che Pompeo (i loro profili in Fig.1) sono interessati ad ottenere l'appoggio di Marsiglia, una delle più importanti città del bacino del Mediterraneo occidentale. .

Il Cesare di Arles

L'inizio del 49 avanti Cristo vide la prima fase della guerra civile tra Giulio Cesare e Pompeo Magno. I due generali si stavano cimentando in un logorante conflitto armato a "distanza", durante il quale si venivano progressivamente definendo gli schieramenti in campo. Sia Cesare che Pompeo (i loro profili in Fig.1) sono interessati ad ottenere l'appoggio di Marsiglia, una delle più importanti città del bacino del Mediterraneo occidentale. ..

Progettazione di un sentiero didattico e di un giardino botanico nei pressi di Reggio Calabria

Convenzione con la società ‘Acquatecno’ per la progettazione, nel rispetto della natura, di un sentiero didattico e un giardino botanico nell' area di Bivongi (Reggio Calabria, Italy) per l'incentivazione e promozione dell'are