Editorial. Still searching for the origin of migraine. From comorbidities to chronicization

Migraine is amultifactorial disorder with huge ramifications in the central nervous system. Despite the enormous progress made in recent years in understanding the pathophysiological mechanisms underlying this painful condition, little is known about the factors behind the evolution from the episodic to the chronic form of migrain

Data of postoperative complications related to fibrinogen-to-albumin ratio in pancreatic resections

Pancreatic surgery is one of the surgeries burdened with the highest mortality and morbidity rate. This is due both to the aggressive biological nature of the pathology affecting the organ and to the technical difficulties associated with surgery. A further aspect on which research is focusing is represented by inflammation related to oncological pathology. Inflammation plays an important role in tumor progression, and growing evidence has confirmed that the fibrinogen-to-albumin ratio (FAR) is an important prognostic factor for overall survival (OS) in malignant tumors. Inflammatory markers had demonstrated also a role in the prediction of postoperative complication after pancreatic surgery. We speculate that FAR, as an easily available, cost-effective, and non-invasive prognostic indicator for pancreatic cancer patients, could help to identify patients at increased risk of postoperative pancreatic fistula (POPF). We therefore retrospectively analyzed the data relating to 117 pancreatic resections relating direct and indirect markers of inflammation with the incidence of post-operative complications. (c) 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/

Dendroclimatic relevance of “Bosco Antico”, the most ancient living European larch wood in the southern Rhaetian Alps (Italy).

The ongoing increase in the global mean temperature at an unprecedented recorded rate is well documented. Nevertheless, knowledge of past climate variations is fundamental for a better understanding of ongoing climate change. This need is crucial in high mountain areas, where the effects of global warming are amplified and induce an accelerated glacial retreat. Thus, the use of climatic proxies such as tree-ring width offers tools to better understand the environmental dynamics in remote, sensitive sites. Here, we present the “Bosco Antico” site chronology, a six-century long dataset from the most ancient living stand in the Val di Sole area (southern Rhaetian Alps, Italy), and its relationship with summer mean temperatures. The analyses were performed on earlywood and latewood separately, as well as on tree-ring widths using static and moving correlations. The results showed that tree-rings and earlywood width are linked with June temperatures, whereas latewood width is mainly driven by July temperatures. All the analysed series were greatly influenced by June to July and June to August temperatures. Finally, a mean summer latewood-based temperature reconstruction since 1525 is proposed. It highlighted that during the last six hundred years, the summer temperatures span between -2.3 to +1.9 °C compared to the 1960–90 mean temperature (between 6.2 and 10.4 °C at the stand elevation). The coolest phase is recorded in the 1810s-20s underlining the strongest pulse of the Little Ice Age; other phases of negative anomalies are recorded in the first half of the 17th century, around 1700, and 1900 and during the 1970s. Our results add an important dataset for a specific climatic area, providing new information that will contribute to a better understanding of the climate dynamics for the study site as well as on a larger scale

Unusual compulsive motor activity during treatment with clothiapine in a mentally retarded adolescent

Atypical antipsychotic agents, specifically those with a high hyposerotonergic activity such as clozapine and clothiapine, have been associated with de novo obsessive–compulsive symptoms. We report the case of a 16-year-old adolescent male with severe mental impairment and disruptive behaviour who developed a compulsive head and body turning disorder on clothiapine. Such a symptom had to be distinguished from epileptic partial seizures; it promptly disappeared with the drug discontinuation

Characterisation of wine yeasts isolated at different temperatures using the enrichment technique

Research NoteSaccharomyces cerevisiae strains isolated from fermenting grape must incubated at extreme fermentation temperatures (40 and 5 degrees C) were oenologically characterised. These cultures compared with S. cerevisiae wine strains, show a wider optimum temperature for growth and can ferment vigorously in a wider temperature range (27 to 35 degrees C)

International earth science information network for global change decision making

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/77259/1/AIAA-1991-154-296.pd

Non-equilibrium h-2 formation in the early universe: energy exchanges, rate coefficients, and spectral distortions

Energy exchange processes play a crucial role in the early universe, affecting the thermal balance and the dynamical evolution of the primordial gas. In the present work we focus on the consequences of a non-thermal distribution of the level populations of H2: first, we determine the excitation temperatures of vibrational transitions and the non-equilibrium heat transfer; second, we compare the modifications to chemical reaction rate coefficients with respect to the values obtained assuming local thermodynamic equilibrium; and third, we compute the spectral distortions to the cosmic background radiation generated by the formation of H2 in vibrationally excited levels. We conclude that non-equilibrium processes cannot be ignored in cosmological simulations of the evolution of baryons, although their observational signatures remain below current limits of detection. New fits to the equilibrium and non-equilibrium heat transfer functions are provided