When Learning Counts: Rethinking Licenses for School Leaders

Recommends restructuring state licensing systems to focus on the skills and knowledge leaders need to improve learning, and better aligning licenses with the current job demands on principals

Leading for Learning: Reflective Tools for School and District Leaders

Provides reflective ideas and tools for educators to enhance leadership in learning. Includes key ideas, real examples, and reflective questions that leaders can use can use to assess their organizations, enact strategic plans, and teach colleagues

Contemporary Glacier Processes and Global Change: Recent Observations from Kaskawulsh Glacier and the Donjek Range, St. Elias Mountains

With an extensive ice cover and rich display of glacier behaviour, the St. Elias Mountains continue to be an enviable natural laboratory for glaciological research. Recent work has been motivated in part by the magnitude and pace of observed glacier change in this area, which is so ice-rich that ice loss has a measurable impact on global sea level. Both detection and attribution of these changes, as well as investigations into fundamental glacier processes, have been central themes in projects initiated within the last decade and based at the Kluane Lake Research Station. The scientific objectives of these projects are (1) to quantify recent area and volume changes of Kaskawulsh Glacier and place them in historical perspective, (2) to investigate the regional variability of glacier response to climate and the modulating influence of ice dynamics, and (3) to characterize the hydromechanical controls on glacier sliding. A wide range of methods is being used, from ground-based manual measurements to space-based remote sensing. The observations to date show glaciers out of equilibrium, with significant ongoing changes to glacier area, volume, and dynamics. Computer models are being used to generalize these results, and to identify the processes most critical to our understanding of the coupled glacier-climate system.Grâce à leur importante couverture de glace et au riche étalage de comportement des glaciers, les monts St. Elias continuent de servir de laboratoire naturel enviable pour la recherche glaciologique. Des études récentes ont été motivées, en partie, par la magnitude et la vitesse des changements observés dans les glaciers de l’endroit, qui sont riches en glace au point que la perte de glace a une incidence mesurable sur le niveau général de la mer. La détection et l’attribution de ces changements de même que les recherches à l’égard des processus des glaciers ont servi de thème central à des projets qui ont été mis en oeuvre au cours de la dernière décennie à la station de recherche du lac Kluane. Les objectifs scientifiques de ces projets consistent (1) à quantifier les changements récents relativement à l’aire et au volume du glacier Kaskawulsh, puis à les mettre dans une perspective historique, (2) à faire enquête sur la variabilité générale de la réaction du glacier vis-à-vis du climat et de l’influence modulatrice de la dynamique de la glace, et (3) à caractériser le contrôle hydromécanique par rapport au glissement du glacier. Une vaste gamme de méthodes est employée pour parvenir à ces fins, allant des mesures manuelles sur le terrain à la télédétection spatiale. Jusqu’à maintenant, les observations indiquent que les glaciers ne sont pas en équilibre et que d’importants changements se produisent quant à l’aire, au volume et à la dynamique du glacier. Des modèles informatiques sont utilisés pour généraliser ces résultats ainsi que pour cerner les processus les plus critiques à notre compréhension du système couplé glacier-climat

The Process of Developing a Multi-Cell KEMS Instrument

Multi-cell KEMS offers many advantages over single cell instruments in regard to in-situ temperature calibration and studies on high temperature alloys and oxides of interest to NASA. The instrument at NASA Glenn is a 90 deg magnetic sector instrument originally designed for single cell operation. The conversion of this instrument to a multi-cell instrument with restricted collimation is discussed. For restricted collimation, the 'field aperture' is in the copper plate separating the Knudsen Cell region and the ionizer and the 'source aperture' is adjacent to the ionizer box. A computer controlled x-y table allows positioning of one of the three cells into the sampling region. Heating is accomplished via a Ta sheet element and temperature is measured via an automatic pyrometer from the bottom of the cells. The computer control and data system have been custom developed for this instrument and are discussed. Future improvements are also discussed

Holographic Thermalization

Using the AdS/CFT correspondence, we probe the scale-dependence of thermalization in strongly coupled field theories following a quench, via calculations of two-point functions, Wilson loops and entanglement entropy in d=2,3,4. In the saddlepoint approximation these probes are computed in AdS space in terms of invariant geometric objects - geodesics, minimal surfaces and minimal volumes. Our calculations for two-dimensional field theories are analytical. In our strongly coupled setting, all probes in all dimensions share certain universal features in their thermalization: (1) a slight delay in the onset of thermalization, (2) an apparent non-analyticity at the endpoint of thermalization, (3) top-down thermalization where the UV thermalizes first. For homogeneous initial conditions the entanglement entropy thermalizes slowest, and sets a timescale for equilibration that saturates a causality bound over the range of scales studied. The growth rate of entanglement entropy density is nearly volume-independent for small volumes, but slows for larger volumes.Comment: 39 pages, 24 figure

Interleukin-33 regulates tissue remodelling and inhibits angiogenesis in the eye

Age-related macular degeneration (AMD) is the leading cause of central vision loss worldwide. Loss of retinal pigment epithelium (RPE) is a major pathological hallmark in AMD with or without pathological neovascularization. Although activation of the immune system is implicated in disease progression, pathological pathways remain diverse and unclear. Here, we report an unexpected protective role of a pro-inflammatory cytokine, interleukin-33 (IL-33) in ocular angiogenesis. IL-33 and its receptor (ST2) are expressed constitutively in human and murine retina and choroid. When RPE was activated, IL-33 expression was markedly elevated in vitro. We found that IL-33 regulated tissue remodelling by attenuating wound-healing responses, including reduction in migration of choroidal fibroblasts and retinal microvascular endothelial cells, and inhibition of collagen gel contraction. In vivo, local administration of recombinant IL-33 inhibited murine choroidal neovascularization (CNV) formation, a surrogate of human neovascular AMD, and this effect was ST2-dependent. Collectively, these data demonstrate IL-33 as a potential immunotherapy and distinguishes pathways for subverting AMD pathology

Dexamphetamine boosts naming treatment effects in chronic aphasia

To date, minimal research has investigated the effect of combining dexamphetamine with standard naming therapy after stroke. The present study used a double-blind, placebo-controlled, multiple baseline, crossover design with two individuals in the chronic stage of stroke recovery. Each individual attended two 4-week blocks of naming therapy (two to three treatment sessions per week). Dexamphetamine (10 mg) was administered at the start of each session during one therapy block, while a placebo was administered during the other therapy block. Therapy progress on treated and untreated items was assessed by a confrontation naming task during and after each therapy block. Both individuals showed greater progress in therapy and maintenance of therapy gains when behavioral treatment was combined with dexamphetamine rather than placebo, although this gain was only statistically significant in one individual. There was no significant improvement on a control task (nonword reading) in either individual. The results provide preliminary evidence that dexamphetamine paired with combined semantic and phonological therapy may be beneficial for the treatment of naming disorders in chronic aphasia

MTSS1 is a critical epigenetically regulated tumor suppressor in CML

Chronic myeloid leukemia (CML) is driven by malignant stem cells that can persist despite therapy. We have identified Metastasis suppressor 1 (Mtss1/MIM) to be downregulated in hematopoietic stem and progenitor cells from leukemic transgenic SCLtTA/Bcr-Abl mice and in patients with CML at diagnosis, and Mtss1 was restored when patients achieved complete remission. Forced expression of Mtss1 decreased clonogenic capacity and motility of murine myeloid progenitor cells and reduced tumor growth. Viral transduction of Mtss1 into lineage depleted SCLtTA/Bcr-Abl bone marrow cells decreased leukemic cell burden in recipients, and leukemogenesis was reduced upon injection of Mtss1 overexpressing murine myeloid 32D cells. Tyrosine kinase inhibitor (TKI) therapy and reversion of Bcr-Abl expression increased Mtss1 expression but failed to restore it to control levels. CML patient samples revealed higher DNA methylation of specific Mtss1 promoter CpG sites that contain binding sites for Kaiso and Rest transcription factors. In summary, we identified a novel tumor suppressor in CML stem cells that is downregulated by both Bcr-Abl kinase-dependent and -independent mechanisms. Restored Mtss1 expression markedly inhibits primitive leukemic cell biology in vivo, providing a therapeutic rationale for the Bcr-Abl-Mtss1 axis to target TKI resistant CML stem cells in patients

Ramond-Ramond Cohomology and O(D,D) T-duality

In the name of supersymmetric double field theory, superstring effective actions can be reformulated into simple forms. They feature a pair of vielbeins corresponding to the same spacetime metric, and hence enjoy double local Lorentz symmetries. In a manifestly covariant manner --with regard to O(D,D) T-duality, diffeomorphism, B-field gauge symmetry and the pair of local Lorentz symmetries-- we incorporate R-R potentials into double field theory. We take them as a single object which is in a bi-fundamental spinorial representation of the double Lorentz groups. We identify cohomological structure relevant to the field strength. A priori, the R-R sector as well as all the fermions are O(D,D) singlet. Yet, gauge fixing the two vielbeins equal to each other modifies the O(D,D) transformation rule to call for a compensating local Lorentz rotation, such that the R-R potential may turn into an O(D,D) spinor and T-duality can flip the chirality exchanging type IIA and IIB supergravities.Comment: 1+37 pages, no figure; Structure reorganized, References added, To appear in JHEP. cf. Gong Show of Strings 2012 (http://wwwth.mpp.mpg.de/members/strings/strings2012/strings_files/program/Talks/Thursday/Gongshow/Lee.pdf