Selected pages from Characteristicks of men, manners, opinions, times.

3 v. illus., port. 2d. ed., corr. Some of the pages in this document were selected as part of a class project for Professor Garth Bond’s History of the Book seminar, Spring 2012. The abstract was prepared by Alexis VanZalen.https://lux.lawrence.edu/selections/1006/thumbnail.jp

Dobro i zło

Przekład i opracowanie:Adam GrzelińskiUniwersytet Mikołaja Kopernika w Toruniue-mail: [email protected]: 0000-0002-4007-6507Dawid WincławUniwersytet Mikołaja Kopernika w Toruniue-mail: [email protected]: 0000-0002-0738-4057Przekład i opracowanie:Adam GrzelińskiUniwersytet Mikołaja Kopernika w Toruniue-mail: [email protected]: 0000-0002-4007-6507Dawid WincławUniwersytet Mikołaja Kopernika w Toruniue-mail: [email protected]: 0000-0002-0738-405

Sensus communis. Esej o wolności dowcipu i humoru – część pierwsza

Przełożyła Monika Michałowic

The silence of self-knowledge

Gareth Evans famously affirmed an explanatory connection between answering the question whether p and knowing whether one believes that p. This is commonly interpreted in terms of the idea that judging that p constitutes an adequate basis for the belief that one believes that p. This paper formulates and defends an alternative, more modest interpretation, which develops from the suggestion that one can know that one believes that p in judging that p

The fables of pity: Rousseau, Mandeville and the animal-fable

Copyright @ 2012 Edinburgh University PressPrompted by Derrida’s work on the animal-fable in eighteenth-century debates about political power, this article examines the role played by the fiction of the animal in thinking of pity as either a natural virtue (in Rousseau’s Second Discourse) or as a natural passion (in Mandeville’s The Fable of the Bees). The war of fables between Rousseau and Mandeville – and their hostile reception by Samuel Johnson and Adam Smith – reinforce that the animal-fable illustrates not so much the proper of man as the possibilities and limitations of a moral philosophy that is unable to address the political realities of the state

“Lest we forget” : An overview of Australia’s response to the recovery and identification of unrecovered historic military remains

Peer reviewedPostprin

Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies

A preventive HIV-1 vaccine should induce HIV-1–specific broadly neutralizing antibodies (bnAbs). However, bnAbs generally require high levels of somatic hypermutation (SHM) to acquire breadth, and current vaccine strategies have not been successful in inducing bnAbs. Because bnAbs directed against a glycosylated site adjacent to the third variable loop (V3) of the HIV-1 envelope protein require limited SHM, the V3-glycan epitope is an attractive vaccine target. By studying the cooperation among multiple V3-glycan B cell lineages and their coevolution with autologous virus throughout 5 years of infection, we identify key events in the ontogeny of a V3-glycan bnAb. Two autologous neutralizing antibody lineages selected for virus escape mutations and consequently allowed initiation and affinity maturation of a V3-glycan bnAb lineage. The nucleotide substitution required to initiate the bnAb lineage occurred at a low-probability site for activation-induced cytidine deaminase activity. Cooperation of B cell lineages and an improbable mutation critical for bnAb activity defined the necessary events leading to breadth in this V3-glycan bnAb lineage. These findings may, in part, explain why initiation of V3-glycan bnAbs is rare, and suggest an immunization strategy for inducing similar V3-glycan bnAbs