Donor KIR B Genotype Improves Progression-Free Survival of Non-Hodgkin Lymphoma Patients Receiving Unrelated Donor Transplantation

Donor killer immunoglobulin-like receptor (KIR) genotypes are associated with relapse protection and survival after allotransplantation for acute myelogenous leukemia. We examined the possibility of a similar effect in a cohort of 614 non-Hodgkin lymphoma (NHL) patients receiving unrelated donor (URD) T cell-replete marrow or peripheral blood grafts. Sixty-four percent (n = 396) of donor-recipient pairs were 10/10 allele HLA matched and 26% were 9/10 allele matched. Seventy percent of donors had KIR B/x genotype; the others had KIR A/A genotype. NHL patients receiving 10/10 HLA-matched URD grafts with KIR B/x donors experienced significantly lower relapse at 5 years (26%; 95% confidence interval [CI], 21% to 32% versus 37%; 95% CI, 27% to 46%; P = .05) compared with KIR A/A donors, resulting in improved 5-year progression-free survival (PFS) (35%; 95% CI, 26% to 44% versus 22%; 95% CI, 11% to 35%; P = .007). In multivariate analysis, use of KIR B/x donors was associated with significantly reduced relapse risk (relative risk [RR], .63, P = .02) and improved PFS (RR, .71, P = .008). The relapse protection afforded by KIR B/x donors was not observed in HLA-mismatched transplantations and was not specific to any particular KIR-B gene. Selecting 10/10 HLA-matched and KIR B/x donors should benefit patients with NHL receiving URD allogeneic transplantation

The Iowa Homemaker vol.26, no.6

Extracurricular Activities Provide Training, Tony DeLay, page 2 Home Service Program for Young America, Doris Adams, page 3 The Home Economist in Business, Beth Bailey McLean, page 4 How to Become a Career Girl, Frances Kerekes, page 6 Clubs Combine as Future Homemakers of America, Barbara Bates, page 7 1947 Vicky Turns the Page of Fashion, Ann Fuhs, page 8 Christmas Lighting, Ann Rozeboom, page 9 Homemaking is a Challenging Career, Martha Coover, page 10 Good Professional Attitude, Mary Elizabeth Lush, page 11 Alum Head Product Testing Program, Lydia Cooley, page 12 Keeping Up With Today, Joyce Edgar, page 14 Festival Book Aids Party Planning, Luanne Madsen, page 1

Central Asia and the globalisation of the contemporary legal consciousness

What is the logic which governs the processes of legal globalization? How does the transnational proliferation of legal forms operate in the contemporary geo-juridical space? What are the main defining characteristics of the currently dominant mode of transnational legal consciousness and how can the concept of legal consciousness help us understand better the historical ebb and flow of the Western-led projects of good governance promotion in regions like Central Asia after the fall of the Soviet Union? Using Duncan Kennedy’s seminal essay Three Globalizations of Law and Legal Thought as its starting platform, this essay seeks to explore these and a series of other related questions, while also drawing on the work of the Greek Marxist lawyer-philosopher Nicos Poulantzas to help elucidate some latent analytical stress-points in Kennedy’s broader theoretical framework. Reacting against the neo-Orientalist tone adopted across much of the contemporary field of Central Asian studies, it develops an alternative account of the internal history of the legal-globalizational encounter between the Western-based reform entrepreneurs and the national legal-political elites in Central Asia in the post-1991 period, complementing it with a detailed description of the general institutional and discursive structures within which this encounter took place

Social Movements and International Relations: A Relational Framework

Social movements are increasingly recognized as significant features of contemporary world politics, yet to date their treatment in international relations theory has tended to obfuscate the considerable diversity of these social formations, and the variegated interactions they may establish with state actors and different structures of world order. Highlighting the difficulties conventional liberal and critical approaches have in transcending conceptions of movements as moral entities, the article draws from two under-exploited literatures in the study of social movements in international relations, the English School and Social Systems Theory, to specify a wider range of analytical interactions between different categories of social movements and of world political structures. Moreover, by casting social movement phenomena as communications, the article opens international relations to consideration of the increasingly diverse trajectories and second-order effects produced by social movements as they interact with states, intergovernmental institutions, and transnational actors

KarplusPAndrewBiochemistryBiophysicsCysteineDioxygenaseStructures(SupplementaryInformation).pdf

Mammalian cysteine dioxygenase (CDO) is a mononuclear non-heme iron protein that catalyzes 2 the conversion of cysteine (Cys) to cysteine sulfinic acid (CSA) by an unclarified mechanism. 3 One structural study revealed a Cys-persulfenate (or Cys-persulfenic acid) formed in the active 4 site, but quantum mechanical calculations have been used to support arguments that it is not an 5 energetically feasible reaction intermediate. Here, we report a series of high-resolution structures 6 of CDO soaked with Cys at pH values from 4 to 9. Cys binding is minimal at pH≤5 and 7 persulfenate formation is consistently seen at pH values between 5.5 and 7. Also, a structure 8 determined using laboratory-based X-ray diffraction shows that the persulfenate, with an 9 apparent average O-O separation distance of ~1.8 Å is not an artifact of synchrotron radiation. At 10 pH≥8, the active site iron shifts from 4- to 5-coordinate, and Cys soaks reveal a complex with 11 Cys, but no dioxygen, bound. This ‘Cys-only’ complex differs in detail from a previously 12 published ‘Cys-only’ complex which we reevaluate and conclude is not reliable. The high-13 resolution structures presented here do not resolve the CDO mechanism, but do imply that an 14 iron-bound persulfenate (or persulfenic acid) is energetically accessible in the CDO active site, 15 and that CDO active site chemistry in the crystals is influenced by protonation/deprotonation 16 events with effective pKa values near ~5.5 and ~7.5 that influence Cys binding and oxygen 17 binding/reactivity, respectively. Furthermore, this work provides reliable ligand-bound models 18 for guiding future mechanistic considerations

KarplusPAndrewBiochemistryBiophysicsCysteineDioxygenaseStructures.pdf

Mammalian cysteine dioxygenase (CDO) is a mononuclear non-heme iron protein that catalyzes 2 the conversion of cysteine (Cys) to cysteine sulfinic acid (CSA) by an unclarified mechanism. 3 One structural study revealed a Cys-persulfenate (or Cys-persulfenic acid) formed in the active 4 site, but quantum mechanical calculations have been used to support arguments that it is not an 5 energetically feasible reaction intermediate. Here, we report a series of high-resolution structures 6 of CDO soaked with Cys at pH values from 4 to 9. Cys binding is minimal at pH≤5 and 7 persulfenate formation is consistently seen at pH values between 5.5 and 7. Also, a structure 8 determined using laboratory-based X-ray diffraction shows that the persulfenate, with an 9 apparent average O-O separation distance of ~1.8 Å is not an artifact of synchrotron radiation. At 10 pH≥8, the active site iron shifts from 4- to 5-coordinate, and Cys soaks reveal a complex with 11 Cys, but no dioxygen, bound. This ‘Cys-only’ complex differs in detail from a previously 12 published ‘Cys-only’ complex which we reevaluate and conclude is not reliable. The high-13 resolution structures presented here do not resolve the CDO mechanism, but do imply that an 14 iron-bound persulfenate (or persulfenic acid) is energetically accessible in the CDO active site, 15 and that CDO active site chemistry in the crystals is influenced by protonation/deprotonation 16 events with effective pKa values near ~5.5 and ~7.5 that influence Cys binding and oxygen 17 binding/reactivity, respectively. Furthermore, this work provides reliable ligand-bound models 18 for guiding future mechanistic considerations