1,226 research outputs found

    Ethics and Christian Musicking

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    A book review is presented for Ethics and Christian Musicking, a book edited by Nathan Myrick and Mark Porter, by Kathryn Minyoung Cooke

    This enterprise non shall partake with me. : Milton\u27s conquering of his precursors through orphean allusions

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    Within his poetry and prose, John Milton shows a respect for the authors of antquity while simultaneously seeking his own voice, a style that makes him different from and better than his predecessors. Milton\u27s works contain expressions of these Renaissance characteristics: the appreciation of the Classics, the search for a more personal relationship with God, and the attempt to achieve some individuality; however, even in the smallest of literary figures such as the Orphean allusions, the need to combine a respect for the past with the ambition for a uniquely personal voice as a poet exists. The isolation of the Classical literary figure of Orpheus shows Milton\u27s struggle to combine his respect for the past and need to be freed from its influence

    Models of Forgiveness and Adult Romantic Attachment in Ended Relationships: Forgiveness Over Time

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    This study examined models of self and other as they relate to attachment, forgiveness, emotional and cognitive reactions to a breakup, relationship variables, and positive and negative feelings toward the self and former partner after a romantic relationship is ended. This study also tested how these variables change over time. Data were collected over a period of five weeks from 130 undergraduates who had experienced a breakup within the two weeks prior to beginning the study. Data were analyzed with a series of univariate and multivariate analyses of variance. Results found that there were differences in how participants reacted to the relationship breakup based on attachment style. There were some changes over time in the variables for all the attachment styles, and there was only one interaction between time and attachment style. Results are discussed in terms of previous research findings. Limitations of the current study are discussed and suggestions for future research are presented

    Cultivating Delight, Crossing Divides, and Solving Impossible Problems: Lessons Learned from a Year of Virtual Conferences

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    This chapter highlights some of the lessons learned from a year of virtual conferences held by three different honors organizations, the Southern Regional Honors Council (SRHC), the Northeast Regional Honors Council (NRHC), and the Kentucky Honors Roundtable (KHR) during the COVID-19 pandemic

    Short-term and long-term effects of transient exogenous cortisol manipulation on oxidative stress in juvenile brown trout

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    In the wild, animals are exposed to a growing number of stressors with increasing frequency and intensity, as a result of human activities and human-induced environmental change. To fully understand how wild organisms are affected by stressors, it is crucial to understand the physiology that underlies an organism’s response to a stressor. Prolonged levels of elevated glucocorticoids are associated with a state of chronic stress and decreased fitness. Exogenous glucocorticoid manipulation reduces an individual’s ability to forage, avoid predators and grow, thereby limiting the resources available for physiological functions like the defence against oxidative stress. Using the brown trout (Salmo trutta), we evaluated the short-term (2 weeks) and long-term (4 months over winter) effects of exogenous cortisol manipulations (as well as relevant shams and controls) on the oxidative status of wild juveniles. Cortisol caused an increase in glutathione over a two-week period and appeared to reduce glutathione over winter. Cortisol treatment did not affect oxidative stress levels or low-molecular weight antioxidants. Cortisol caused a significant decrease in growth rates but did not affect predation risk. Over winter survival in the stream was associated with low levels of oxidative stress and glutathione. Thus, oxidative stress may be a mechanism by which elevated cortisol causes negative physiological consequences.</jats:p

    A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

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    Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the elderly with limited therapeutic options. Here, we report on a study of \u3e12 million variants including 163,714 directly genotyped, most rare, protein-altering variant. Analyzing 16,144 patients and 17,832 controls, we identify 52 independently associated common and rare variants (P \u3c 5×10–8) distributed across 34 loci. While wet and dry AMD subtypes exhibit predominantly shared genetics, we identify the first signal specific to wet AMD, near MMP9 (difference-P = 4.1×10–10). Very rare coding variants (frequency \u3c 0.1%) in CFH, CFI, and TIMP3 suggest causal roles for these genes, as does a splice variant in SLC16A8. Our results support the hypothesis that rare coding variants can pinpoint causal genes within known genetic loci and illustrate that applying the approach systematically to detect new loci requires extremely large sample sizes

    Strategies for effective unmanned aerial vehicle use in geological field studies based on cognitive science principles

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    Field geologists are increasingly using unmanned aerial vehicles (UAVs or drones), although their use involves significant cognitive challenges for which geologists are not well trained. On the basis of surveying the user community and documenting experts’ use in the field, we identified five major problems, most of which are aligned with well-documented limits on cognitive performance. First, the images being sent from the UAV portray the landscape from multiple different view directions. Second, even with a constant view direction, the ability to move the UAV or zoom the camera lens results in rapid changes in visual scale. Third, the images from the UAVs are displayed too quickly for users, even experts, to assimilate efficiently. Fourth, it is relatively easy to get lost when flying, particularly if the user is unfamiliar with the area or with UAV use. Fifth, physical limitations on flight time are a source of stress, which renders the operator less effective. Many of the strategies currently employed by field geologists, such as postprocessing and photogrammetry, can reduce these problems. We summarize the cognitive science basis for these issues and provide some new strategies that are designed to overcome these limitations and promote more effective UAV use in the field. The goal is to make UAV-based geological interpretations in the field possible by recognizing and reducing cognitive loa

    Patterns of emergency admission for IBD patients over the last 10 years in Lothian, Scotland: A retrospective prevalent cohort analysis

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    OBJECTIVE: It is unclear how the compounding prevalence of inflammatory bowel disease (IBD) has translated into the causes and rates of hospitalisation, particularly in an era of increased biologic prescribing. We aimed to analyse these trends in a population-based IBD cohort over the last 10 years. DESIGN: The Lothian IBD registry is a complete, validated, prevalent database of IBD patients in NHS Lothian, Scotland. ICD-10 coding of hospital discharge letters from all IBD patient admissions to secondary care between 1 January 2010 and 31 December 2019 was interrogated for admission cause, with linkage to local/national data sets on death and prescribed drugs. RESULTS: Fifty-seven per cent (4673/8211) of all IBD patients were admitted to secondary care for >24 h between 1 January 2010 and 31 December 2019. In patients 60 years (19% of admissions). Three per cent (243/8211) of IBD patients accounted for 50% of the total IBD bed-days over the study period. Age-standardised IBD admission rates fell from 39.4 to 25.5 admissions per 100,000 population between 2010 and 2019, an average annual percentage reduction of 3% (95% CI -4.5% to -2.1%, p < 0.0001). Non-IBD admission rates were unchanged overall (145-137 per 100,000 population) and specifically for serious (hospitalisation) and severe (ITU admission or death) infection over the same period. CONCLUSION: Despite compounding prevalence and increased biologic use, IBD admission rates are falling. The cause of admission varies with age, with infection the predominant cause in older patients
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